NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6324612|ref|NP_014681|]
View 

Hir2p [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 and Hira domain-containing protein( domain architecture ID 13236803)

WD40 and Hira domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
581-824 2.57e-106

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 326.88  E-value: 2.57e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    581 GRKLMAPLVLGVSISFLEACGTYLLCLTSIGELYCWNIEQKKLAFPTNTIYPLLNPSLRYSDDiLTRAENITLCSITKKG 660
Cdd:pfam07569   1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSSRYSDK-LTRAPTITSASLTSNG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    661 VPLVTLSNGDGYLFDKNMETWLLVSDGWWAYGSQYWDTTNTTGLSSSkantdsfngsesnineivsdikNDNQSIINFLE 740
Cdd:pfam07569  80 VPIVTLSNGDGYLYDKSLETWLRISDSWWALGSQYWDSTGSSRSSSQ----------------------SSAAGILSFLE 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    741 CKTNDELNRKGRIKNLQRFARTILMKEGFENMEEIVTLSHLENKILISIRLEEPEEFSKLMMVYCIRLSELGYMDRLNDV 820
Cdd:pfam07569 138 RKTNEELLRKGRGRLLQRLAKTLLMKEGFENFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLREL 217

                  ....
gi 6324612    821 FQWL 824
Cdd:pfam07569 218 CKEL 221
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
172-350 6.26e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 6.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  172 IDPTGQTFTVMTSDRSILVYQINktgTHKLINKLTQHVQmyplhyrismspqadilpVINSVKGVPNNATSCTALLDRN- 250
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLR---TGKCVATLTGHTG------------------EVNSVAFSPDGEKLLSSSSDGTi 201
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  251 -----NNYKVTKTLVtpssnGCRVLVYSPAFYekPNlkkgtstryNLIATSGSTDGTILVWNTKRMKPLFnALQVSSTAI 325
Cdd:cd00200 202 klwdlSTGKCLGTLR-----GHENGVNSVAFS--PD---------GYLLASGSEDGTIRVWDLRTGECVQ-TLSGHTNSV 264
                       170       180
                ....*....|....*....|....*
gi 6324612  326 NDMSWSQDGFTLFAISNDATLYTFA 350
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
581-824 2.57e-106

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 326.88  E-value: 2.57e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    581 GRKLMAPLVLGVSISFLEACGTYLLCLTSIGELYCWNIEQKKLAFPTNTIYPLLNPSLRYSDDiLTRAENITLCSITKKG 660
Cdd:pfam07569   1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSSRYSDK-LTRAPTITSASLTSNG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    661 VPLVTLSNGDGYLFDKNMETWLLVSDGWWAYGSQYWDTTNTTGLSSSkantdsfngsesnineivsdikNDNQSIINFLE 740
Cdd:pfam07569  80 VPIVTLSNGDGYLYDKSLETWLRISDSWWALGSQYWDSTGSSRSSSQ----------------------SSAAGILSFLE 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    741 CKTNDELNRKGRIKNLQRFARTILMKEGFENMEEIVTLSHLENKILISIRLEEPEEFSKLMMVYCIRLSELGYMDRLNDV 820
Cdd:pfam07569 138 RKTNEELLRKGRGRLLQRLAKTLLMKEGFENFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLREL 217

                  ....
gi 6324612    821 FQWL 824
Cdd:pfam07569 218 CKEL 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
172-350 6.26e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 6.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  172 IDPTGQTFTVMTSDRSILVYQINktgTHKLINKLTQHVQmyplhyrismspqadilpVINSVKGVPNNATSCTALLDRN- 250
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLR---TGKCVATLTGHTG------------------EVNSVAFSPDGEKLLSSSSDGTi 201
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  251 -----NNYKVTKTLVtpssnGCRVLVYSPAFYekPNlkkgtstryNLIATSGSTDGTILVWNTKRMKPLFnALQVSSTAI 325
Cdd:cd00200 202 klwdlSTGKCLGTLR-----GHENGVNSVAFS--PD---------GYLLASGSEDGTIRVWDLRTGECVQ-TLSGHTNSV 264
                       170       180
                ....*....|....*....|....*
gi 6324612  326 NDMSWSQDGFTLFAISNDATLYTFA 350
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
133-346 2.40e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  133 GILFVLLSNENKILLFRHKTfdKLSEITIDKASKPITGI-IDPTGQTFTVMTSDRSILVYQInktGTHKLINKLTQHVQM 211
Cdd:COG2319  90 GRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRLWDL---ATGKLLRTLTGHSGA 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  212 YplhYRISMSPQADILpvinsvkgvpnnATSC---TALLDRNNNYKVTKTLvTPSSNGCRVLVYSPafyekpnlkKGtst 288
Cdd:COG2319 165 V---TSVAFSPDGKLL------------ASGSddgTVRLWDLATGKLLRTL-TGHTGAVRSVAFSP---------DG--- 216
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6324612  289 ryNLIAtSGSTDGTILVWNTKRMKPLFnALQVSSTAINDMSWSQDGFTLFAISNDATL 346
Cdd:COG2319 217 --KLLA-SGSADGTVRLWDLATGKLLR-TLTGHSGSVRSVAFSPDGRLLASGSADGTV 270
 
Name Accession Description Interval E-value
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
581-824 2.57e-106

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 326.88  E-value: 2.57e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    581 GRKLMAPLVLGVSISFLEACGTYLLCLTSIGELYCWNIEQKKLAFPTNTIYPLLNPSLRYSDDiLTRAENITLCSITKKG 660
Cdd:pfam07569   1 GRRLLPPIVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPVSLAPLLDSSSRYSDK-LTRAPTITSASLTSNG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    661 VPLVTLSNGDGYLFDKNMETWLLVSDGWWAYGSQYWDTTNTTGLSSSkantdsfngsesnineivsdikNDNQSIINFLE 740
Cdd:pfam07569  80 VPIVTLSNGDGYLYDKSLETWLRISDSWWALGSQYWDSTGSSRSSSQ----------------------SSAAGILSFLE 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612    741 CKTNDELNRKGRIKNLQRFARTILMKEGFENMEEIVTLSHLENKILISIRLEEPEEFSKLMMVYCIRLSELGYMDRLNDV 820
Cdd:pfam07569 138 RKTNEELLRKGRGRLLQRLAKTLLMKEGFENFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLREL 217

                  ....
gi 6324612    821 FQWL 824
Cdd:pfam07569 218 CKEL 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
172-350 6.26e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 6.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  172 IDPTGQTFTVMTSDRSILVYQINktgTHKLINKLTQHVQmyplhyrismspqadilpVINSVKGVPNNATSCTALLDRN- 250
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLR---TGKCVATLTGHTG------------------EVNSVAFSPDGEKLLSSSSDGTi 201
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  251 -----NNYKVTKTLVtpssnGCRVLVYSPAFYekPNlkkgtstryNLIATSGSTDGTILVWNTKRMKPLFnALQVSSTAI 325
Cdd:cd00200 202 klwdlSTGKCLGTLR-----GHENGVNSVAFS--PD---------GYLLASGSEDGTIRVWDLRTGECVQ-TLSGHTNSV 264
                       170       180
                ....*....|....*....|....*
gi 6324612  326 NDMSWSQDGFTLFAISNDATLYTFA 350
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
133-346 2.40e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  133 GILFVLLSNENKILLFRHKTfdKLSEITIDKASKPITGI-IDPTGQTFTVMTSDRSILVYQInktGTHKLINKLTQHVQM 211
Cdd:COG2319  90 GRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRLWDL---ATGKLLRTLTGHSGA 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  212 YplhYRISMSPQADILpvinsvkgvpnnATSC---TALLDRNNNYKVTKTLvTPSSNGCRVLVYSPafyekpnlkKGtst 288
Cdd:COG2319 165 V---TSVAFSPDGKLL------------ASGSddgTVRLWDLATGKLLRTL-TGHTGAVRSVAFSP---------DG--- 216
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6324612  289 ryNLIAtSGSTDGTILVWNTKRMKPLFnALQVSSTAINDMSWSQDGFTLFAISNDATL 346
Cdd:COG2319 217 --KLLA-SGSADGTVRLWDLATGKLLR-TLTGHSGSVRSVAFSPDGRLLASGSADGTV 270
WD40 COG2319
WD40 repeat [General function prediction only];
296-346 5.56e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 5.56e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6324612  296 SGSTDGTILVWNTKRMKPLfNALQVSSTAINDMSWSQDGFTLFAISNDATL 346
Cdd:COG2319 347 SGSDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
160-346 1.08e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  160 TIDKASKPITGI-IDPTGQTFTVMTSDRSILVYQINktgTHKLINKLTQHVQMyplHYRISMSPQADILpvinsvkgvpn 238
Cdd:COG2319 157 TLTGHSGAVTSVaFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGA---VRSVAFSPDGKLL----------- 219
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324612  239 nATSC---TALL-DRNNNyKVTKTLVTPSSNgcrvlVYSPAFyekpnlkkgtSTRYNLIAtSGSTDGTILVWNTKRMKPL 314
Cdd:COG2319 220 -ASGSadgTVRLwDLATG-KLLRTLTGHSGS-----VRSVAF----------SPDGRLLA-SGSADGTVRLWDLATGELL 281
                       170       180       190
                ....*....|....*....|....*....|..
gi 6324612  315 FnALQVSSTAINDMSWSQDGFTLFAISNDATL 346
Cdd:COG2319 282 R-TLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
291-346 5.87e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 5.87e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6324612  291 NLIATsGSTDGTILVWNTKRMKPLFnALQVSSTAINDMSWSQDGFTLFAISNDATL 346
Cdd:cd00200  22 KLLAT-GSGDGTIKVWDLETGELLR-TLKGHTGPVRDVAASADGTYLASGSSDKTI 75
WD40 COG2319
WD40 repeat [General function prediction only];
296-347 6.06e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 6.06e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6324612  296 SGSTDGTILVWNTKRMKPLFnALQVSSTAINDMSWSQDGFTLFAISNDATLY 347
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH