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Conserved domains on  [gi|398365545|ref|NP_014815|]
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Yrm1p [Saccharomyces cerevisiae S288C]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637801)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0008270|GO:0003700
PubMed:  9290251|16959962

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 25-68 2.71e-12

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 61.61  E-value: 2.71e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 398365545    25 RKPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSgCLYTEKFTHK 68
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLE-CTYSDSKKRK 43
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 307-579 1.47e-06

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 51.29  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 307 IERAQ-FLLLKYYHReliwACGDDSHMISLVDLLCSTAIMLGLHlniREIYKNQENIVGSMESLENLWVWIILSDFNVSL 385
Cdd:cd12148   97 LETLQaLLLLALYLL----GTGDPSSAWLLLGLAIRLAQSLGLH---RDPSSLPGLSPFERELRRRLWWSLYILDRLLSL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 386 NIGRCLAINSSYFQVDE-CENGERLPKNTNNYSSTVFFDQSNSCMGKLKRFLRLARPMLDQIYDRSAFP------DLAEN 458
Cdd:cd12148  170 SLGRPPSISDEDIDVPLpSNEDDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLLYSPRASSpedsleTILEL 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 459 CKKLRNFvETEFHPISYYTDSELISKVPLCEIKVLAQVLNLLLTFYSLRYLIYKEKSVVLENNILQTILVSFSLVINTTI 538
Cdd:cd12148  250 DAELEEW-RASLPPELRLDSSSLESPSLLPQRLLLHLLYHLLLILLHRPFLLRSLSSLSPSSSSAESRRACLEAAREILE 328

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 398365545 539 LCFNLDEKHFPEFFDHNCVHlPPFMALSLVYTNFLFPRAST 579
Cdd:cd12148  329 LLRLLLSSSLLLLLWWFLLY-YLFSAALVLLLALLLRPSSS 368
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 25-68 2.71e-12

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 61.61  E-value: 2.71e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 398365545    25 RKPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSgCLYTEKFTHK 68
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLE-CTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 26-62 4.16e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 55.36  E-value: 4.16e-10
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 398365545  26 KPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSgCLYT 62
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLE-CTYS 36
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
29-64 2.32e-08

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 50.37  E-value: 2.32e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 398365545   29 KSCAFCRKRKLRCDQQKPMCSTCKTRGrSGCLYTEK 64
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNG-LECTYSRK 35
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 307-579 1.47e-06

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 51.29  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 307 IERAQ-FLLLKYYHReliwACGDDSHMISLVDLLCSTAIMLGLHlniREIYKNQENIVGSMESLENLWVWIILSDFNVSL 385
Cdd:cd12148   97 LETLQaLLLLALYLL----GTGDPSSAWLLLGLAIRLAQSLGLH---RDPSSLPGLSPFERELRRRLWWSLYILDRLLSL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 386 NIGRCLAINSSYFQVDE-CENGERLPKNTNNYSSTVFFDQSNSCMGKLKRFLRLARPMLDQIYDRSAFP------DLAEN 458
Cdd:cd12148  170 SLGRPPSISDEDIDVPLpSNEDDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLLYSPRASSpedsleTILEL 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 459 CKKLRNFvETEFHPISYYTDSELISKVPLCEIKVLAQVLNLLLTFYSLRYLIYKEKSVVLENNILQTILVSFSLVINTTI 538
Cdd:cd12148  250 DAELEEW-RASLPPELRLDSSSLESPSLLPQRLLLHLLYHLLLILLHRPFLLRSLSSLSPSSSSAESRRACLEAAREILE 328

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 398365545 539 LCFNLDEKHFPEFFDHNCVHlPPFMALSLVYTNFLFPRAST 579
Cdd:cd12148  329 LLRLLLSSSLLLLLWWFLLY-YLFSAALVLLLALLLRPSSS 368
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 307-405 4.87e-03

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 37.05  E-value: 4.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545   307 IERAQFLLLKYYHreliWACGDDSHMISLVDLLCSTAIMLGLHLNIReiYKNQEnivgSMESLENLWVWIILSDFNVSLN 386
Cdd:smart00906   2 LETVQALLLALLS----LYLGGRDAAWMLLGLAIRLAQALGLHRDPS--NSDLE----ERERRRRRFWWLYILDRLLSLS 71

                           90
                   ....*....|....*....
gi 398365545   387 IGRCLAINSSYFQVDECEN 405
Cdd:smart00906  72 LGRPPLIDDDDIDVPLPSD 90
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 25-68 2.71e-12

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 61.61  E-value: 2.71e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 398365545    25 RKPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSgCLYTEKFTHK 68
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLE-CTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 26-62 4.16e-10

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 55.36  E-value: 4.16e-10
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 398365545  26 KPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSgCLYT 62
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLE-CTYS 36
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
29-64 2.32e-08

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 50.37  E-value: 2.32e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 398365545   29 KSCAFCRKRKLRCDQQKPMCSTCKTRGrSGCLYTEK 64
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNG-LECTYSRK 35
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 307-579 1.47e-06

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 51.29  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 307 IERAQ-FLLLKYYHReliwACGDDSHMISLVDLLCSTAIMLGLHlniREIYKNQENIVGSMESLENLWVWIILSDFNVSL 385
Cdd:cd12148   97 LETLQaLLLLALYLL----GTGDPSSAWLLLGLAIRLAQSLGLH---RDPSSLPGLSPFERELRRRLWWSLYILDRLLSL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 386 NIGRCLAINSSYFQVDE-CENGERLPKNTNNYSSTVFFDQSNSCMGKLKRFLRLARPMLDQIYDRSAFP------DLAEN 458
Cdd:cd12148  170 SLGRPPSISDEDIDVPLpSNEDDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLLYSPRASSpedsleTILEL 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545 459 CKKLRNFvETEFHPISYYTDSELISKVPLCEIKVLAQVLNLLLTFYSLRYLIYKEKSVVLENNILQTILVSFSLVINTTI 538
Cdd:cd12148  250 DAELEEW-RASLPPELRLDSSSLESPSLLPQRLLLHLLYHLLLILLHRPFLLRSLSSLSPSSSSAESRRACLEAAREILE 328

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 398365545 539 LCFNLDEKHFPEFFDHNCVHlPPFMALSLVYTNFLFPRAST 579
Cdd:cd12148  329 LLRLLLSSSLLLLLWWFLLY-YLFSAALVLLLALLLRPSSS 368
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 307-405 4.87e-03

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 37.05  E-value: 4.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365545   307 IERAQFLLLKYYHreliWACGDDSHMISLVDLLCSTAIMLGLHLNIReiYKNQEnivgSMESLENLWVWIILSDFNVSLN 386
Cdd:smart00906   2 LETVQALLLALLS----LYLGGRDAAWMLLGLAIRLAQALGLHRDPS--NSDLE----ERERRRRRFWWLYILDRLLSLS 71

                           90
                   ....*....|....*....
gi 398365545   387 IGRCLAINSSYFQVDECEN 405
Cdd:smart00906  72 LGRPPLIDDDDIDVPLPSD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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