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Conserved domains on  [gi|398365565|ref|NP_014817|]
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Med4p [Saccharomyces cerevisiae S288C]

Protein Classification

mediator of RNA polymerase II transcription subunit 4( domain architecture ID 4324)

mediator of RNA polymerase II transcription subunit 4 (Med4) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Symbol:  MED4
Gene Ontology:  GO:0061629|GO:0016592
PubMed:  15175151|16263706

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med4 super family cl10818
Vitamin-D-receptor interacting Mediator subunit 4; Members of this family function as part of ...
 67-208 5.40e-37

Vitamin-D-receptor interacting Mediator subunit 4; Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter.


The actual alignment was detected with superfamily member pfam10018:

Pssm-ID: 401849  Cd Length: 184  Bit Score: 129.85  E-value: 5.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365565   67 LDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFeKNTILQQRS 146
Cdd:pfam10018   1 PKLAEKLLDADDELTKTLKELEEHQKNEARILQLRAEAESLDEKIKEIVKTLKEYEKELRALPFQANQKL-ASINLANKR 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365565  147 KINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFI-------WPAEDALRRGMLAMASLHSKELTRIPG 208
Cdd:pfam10018  80 EVDSEELLDYAHRISKYTHVPPAEPVASKAPTTWLrgdyfrpWPAEDEIRMGLLAMSQLQVAEGEEPPG 148
 
Name Accession Description Interval E-value
Med4 pfam10018
Vitamin-D-receptor interacting Mediator subunit 4; Members of this family function as part of ...
 67-208 5.40e-37

Vitamin-D-receptor interacting Mediator subunit 4; Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter.


Pssm-ID: 401849  Cd Length: 184  Bit Score: 129.85  E-value: 5.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365565   67 LDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFeKNTILQQRS 146
Cdd:pfam10018   1 PKLAEKLLDADDELTKTLKELEEHQKNEARILQLRAEAESLDEKIKEIVKTLKEYEKELRALPFQANQKL-ASINLANKR 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365565  147 KINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFI-------WPAEDALRRGMLAMASLHSKELTRIPG 208
Cdd:pfam10018  80 EVDSEELLDYAHRISKYTHVPPAEPVASKAPTTWLrgdyfrpWPAEDEIRMGLLAMSQLQVAEGEEPPG 148
 
Name Accession Description Interval E-value
Med4 pfam10018
Vitamin-D-receptor interacting Mediator subunit 4; Members of this family function as part of ...
 67-208 5.40e-37

Vitamin-D-receptor interacting Mediator subunit 4; Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter.


Pssm-ID: 401849  Cd Length: 184  Bit Score: 129.85  E-value: 5.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365565   67 LDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFeKNTILQQRS 146
Cdd:pfam10018   1 PKLAEKLLDADDELTKTLKELEEHQKNEARILQLRAEAESLDEKIKEIVKTLKEYEKELRALPFQANQKL-ASINLANKR 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365565  147 KINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFI-------WPAEDALRRGMLAMASLHSKELTRIPG 208
Cdd:pfam10018  80 EVDSEELLDYAHRISKYTHVPPAEPVASKAPTTWLrgdyfrpWPAEDEIRMGLLAMSQLQVAEGEEPPG 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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