|
Name |
Accession |
Description |
Interval |
E-value |
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
5-416 |
0e+00 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 580.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 5 VIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQlTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAY 84
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQ-LFLKEAAEALREEISALGNLRFTDDEIEYLKQELPYLKSDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 85 IKYISssNYKLHPEEQISFTSeeIEGKpthyKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKK- 163
Cdd:TIGR01514 80 IDYLR--NFRFHPEEQVEVGI--DDKG----KLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKl 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 164 --------AETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGnpdrnksLLLGTSNILFAKKYGVKPIGTVAHEWV 235
Cdd:TIGR01514 152 dqlkaeiaAETMFENGFRFSEFGTRRRFSLEVQDLVTQGLKQAAPS-------WLLGTSNVHLAKKLGLKPIGTVAHEWF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 236 MGVASISEdYLHANKNAMDCWINTFGAKnAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVL 315
Cdd:TIGR01514 225 QGHQAISE-YRNAQKVALECWINEYDGD-LGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 316 KLPKfSKIICYSDSLNVEKAITYSHAAKEnGMLATFGIGTNFTNDFRkksepqvKSEPLNIVIKLLEVNGNHAIKISDNL 395
Cdd:TIGR01514 303 IDPK-SKIIIFSDSLDVEKAIELSHYFKG-RVKASFGIGTNLTNDFG-------KVEPLNIVIKLVECNGNPVAKLSDSP 373
|
410 420
....*....|....*....|.
gi 6324783 396 GKNMGDPATVKRVKEELGYTE 416
Cdd:TIGR01514 374 GKTMGEPATFLRALRELFDTP 394
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
7-399 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 557.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 7 KSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLtFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIK 86
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPED-FLEEAAEALREQIDHLANLRFSEEELAYLRRSLPFLKPDYLD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 87 YISssNYKLHPEEQISFTSEeiegkpTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAET 166
Cdd:cd01401 80 YLE--LFRLNPEEVVVRLDT------GKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLER 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 167 LFD-------NGIRFSEFGTRRRRSLKAQDLIMQGIMKAVngnpdrnKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVA 239
Cdd:cd01401 152 LLEeakrrdlNGFRFSDFGTRRRFSYEVQETVLKGLKQAA-------PGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 240 SISEDYLHANKNAMDCWINTFGaKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDvLKLPK 319
Cdd:cd01401 225 ALTGDLKDSQKAALERWVREYG-GDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEK-LGIDP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 320 FSKIICYSDSLNVEKAITYSHAAKEnGMLATFGIGTNFTNDFRKKsepqVKSEPLNIVIKLLEVNGNHAIKISDNLGKNM 399
Cdd:cd01401 303 KTKTLVFSDGLDVEKALELYEYFKG-RIKVSFGIGTNLTNDFGNK----EKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
1-407 |
2.40e-130 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 381.42 E-value: 2.40e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 1 MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLtFNKEAINWLKEQFSYLGNLRFTEEEIEYLKqEIPYL 80
Cdd:PRK05321 4 KADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEV-DLAEYIDEIREQLDHLCTLRLTDDELDYLR-GLPFF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 81 PSAYIKYISssNYKLHPEE-QISFTSEEIEgkpthyklkILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQ 159
Cdd:PRK05321 82 KPDFLDWLR--LFRLNPYEvTVSIDDGQLD---------IRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 160 AEKKAETLFD----NGIRFSEFGTRRRRSLKAQDLIMQgIMKAvnGNPDRnkslLLGTSNILFAKKYGVKPIGTVAHEWV 235
Cdd:PRK05321 151 LWEKIELLKAlpdlSGFKIADFGTRRRFSFEWQEEVVE-ALKE--GLPGA----FVGTSNVHLAMKLGLTPIGTMAHEWF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 236 MGVASISEDYLHANKNAMDCWINTFGaKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHdvl 315
Cdd:PRK05321 224 MAHQALGPRLRDSQYAALEDWVREYR-GDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYE--- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 316 KL---PKfSKIICYSDSLNVEKAI-TYSHAAKENGMlaTFGIGTNFTNDFRkksepqvKSEPLNIVIKLLEVNGNHAIKI 391
Cdd:PRK05321 300 KLgidPR-TKTLVFSDGLDFDKALeLYRHFKGRIKL--SFGIGTNLTNDFP-------GVKPLNIVIKLVECNGRPVAKL 369
|
410
....*....|....*.
gi 6324783 392 SDNLGKNMGDPATVKR 407
Cdd:PRK05321 370 SDSPGKTMCDDPEFLR 385
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
172-416 |
2.80e-100 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 298.53 E-value: 2.80e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 172 IRFSEFGTRRRRSLKAQDLIMQgimkavngnpdRNKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVASISEDYLHANKN 251
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVGL-----------AHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKD 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 252 AMDCWINTFGAkNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVLKLPKFSKIICYSDSLN 331
Cdd:pfam04095 70 ALDLWHAEYRG-NLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTLNIDGYTKRLIFSDGLD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 332 VEKAITYSHAAKENGMLATFGIGTNFTNDF-RKKSEPQVKSEPLNIVIKLLEVNGNHAIKISDNLGKNM-GDPATVKRVK 409
Cdd:pfam04095 149 VEKIIELLEYFKGKGFNIAFGIGTNLTQDLnRDTLGFAVKATPLNIVIKLVEVNGDPVAKISDSSGKGRcGDPAFVALLR 228
|
....*..
gi 6324783 410 EELGYTE 416
Cdd:pfam04095 229 TVFDNGE 235
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
8-397 |
2.41e-19 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 89.82 E-value: 2.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 8 SLLDTDMYKITMHAAVF-TNFPDVTVTYKYTNRSsqLTFNK--------EAInwLKeqfsYLGNLRFTEEEIEYLKQEiP 78
Cdd:COG1488 4 LALLTDLYKLTMAQAYLpEGTANRRAVFELFFRR--LPFGRgyvvfaglQRF--LK----YLENLRFTEEDIAYLRSL-G 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 79 YLPSAYIKYISssNYKLH------PEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLI-------SEAYfk 145
Cdd:COG1488 75 VFDEDFLDYLA--DFRFPgdiravPEGTVVFPGEPL----------LTVEGTLPEAQLLETLLLNILnyptliaTKAA-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 146 fvdidwdyenQLEQAekkAEtlfdnGIRFSEFGTRRRRSLKAqdlimqGIMKA-----VNgnpdrnkslLLGTSNILFAK 220
Cdd:COG1488 141 ----------RIVQA---AG-----GRPLHDFGLRRAHGLEA------AVAAAraaylAG---------FAGTSNVLAGR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 221 KYGVKPIGTVAHEWVMgvasisedyLHAN-KNAMDCWINTFGAKNAglALTDTFGT-----------DDFLKSFRPpysd 288
Cdd:COG1488 188 YYGIPSVGTMAHSFVQ---------AHDDeLEAFRAFAEAYPDGTT--LLVDTYDTlsgvpnaielaKELLARGGL---- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 289 ayVGVRQDSGDPVEYTKKI-----SHHYHDVlklpkfsKIIcYSDSLNVEKAIT-YSHAAKENGmlatFGIGTNFTndfr 362
Cdd:COG1488 253 --LGIRLDSGDLAYLSKQArelldEAGLPDV-------RII-ASDDLDEYRIAAlLEQGAPIDV----FGVGTRLV---- 314
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 6324783 363 kksepQVKSEP-LNIVIKLLEVNGNHA----IKISDNLGK 397
Cdd:COG1488 315 -----TSSDRPtLGFVYKLVAVEGDGEwrpvIKLSETPGK 349
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
5-416 |
0e+00 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 580.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 5 VIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQlTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAY 84
Cdd:TIGR01514 1 IIRSLLDTDLYKITMHQAVFHNFPDVHVTYEFICRSSQ-LFLKEAAEALREEISALGNLRFTDDEIEYLKQELPYLKSDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 85 IKYISssNYKLHPEEQISFTSeeIEGKpthyKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKK- 163
Cdd:TIGR01514 80 IDYLR--NFRFHPEEQVEVGI--DDKG----KLDIRISGSWRDTILYEIPLLAIISELYFRFRDAEADYEQQLEVLESKl 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 164 --------AETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGnpdrnksLLLGTSNILFAKKYGVKPIGTVAHEWV 235
Cdd:TIGR01514 152 dqlkaeiaAETMFENGFRFSEFGTRRRFSLEVQDLVTQGLKQAAPS-------WLLGTSNVHLAKKLGLKPIGTVAHEWF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 236 MGVASISEdYLHANKNAMDCWINTFGAKnAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVL 315
Cdd:TIGR01514 225 QGHQAISE-YRNAQKVALECWINEYDGD-LGIALTDTFTTDAFLRDFRPPFADAYDGLRHDSGDPVEWGDKAIAHYQKLG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 316 KLPKfSKIICYSDSLNVEKAITYSHAAKEnGMLATFGIGTNFTNDFRkksepqvKSEPLNIVIKLLEVNGNHAIKISDNL 395
Cdd:TIGR01514 303 IDPK-SKIIIFSDSLDVEKAIELSHYFKG-RVKASFGIGTNLTNDFG-------KVEPLNIVIKLVECNGNPVAKLSDSP 373
|
410 420
....*....|....*....|.
gi 6324783 396 GKNMGDPATVKRVKEELGYTE 416
Cdd:TIGR01514 374 GKTMGEPATFLRALRELFDTP 394
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
7-399 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 557.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 7 KSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLtFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIK 86
Cdd:cd01401 1 RSLLDTDLYKLTMQQAVLHHYPDVQVTYEFTNRSPED-FLEEAAEALREQIDHLANLRFSEEELAYLRRSLPFLKPDYLD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 87 YISssNYKLHPEEQISFTSEeiegkpTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAET 166
Cdd:cd01401 80 YLE--LFRLNPEEVVVRLDT------GKGQLDIRISGPWKDTILYEVPLLAIVSEVYFRFRDADWDYEEQLEKLEEKLER 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 167 LFD-------NGIRFSEFGTRRRRSLKAQDLIMQGIMKAVngnpdrnKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVA 239
Cdd:cd01401 152 LLEeakrrdlNGFRFSDFGTRRRFSYEVQETVLKGLKQAA-------PGYLTGTSNVHFAMKYGLTPIGTVAHEWFMAHQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 240 SISEDYLHANKNAMDCWINTFGaKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDvLKLPK 319
Cdd:cd01401 225 ALTGDLKDSQKAALERWVREYG-GDLGIALTDTFGTDAFLRDFDLYFAKLFDGVRHDSGDPFEWGEKAIAHYEK-LGIDP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 320 FSKIICYSDSLNVEKAITYSHAAKEnGMLATFGIGTNFTNDFRKKsepqVKSEPLNIVIKLLEVNGNHAIKISDNLGKNM 399
Cdd:cd01401 303 KTKTLVFSDGLDVEKALELYEYFKG-RIKVSFGIGTNLTNDFGNK----EKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
1-407 |
2.40e-130 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 381.42 E-value: 2.40e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 1 MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLtFNKEAINWLKEQFSYLGNLRFTEEEIEYLKqEIPYL 80
Cdd:PRK05321 4 KADPIIRSLLDTDFYKLTMQQAVLHHYPDAQVEYEFICRNDEV-DLAEYIDEIREQLDHLCTLRLTDDELDYLR-GLPFF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 81 PSAYIKYISssNYKLHPEE-QISFTSEEIEgkpthyklkILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQ 159
Cdd:PRK05321 82 KPDFLDWLR--LFRLNPYEvTVSIDDGQLD---------IRIEGPWLETILWEVPLLAIISELYFRARSPEVLYAQAKRR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 160 AEKKAETLFD----NGIRFSEFGTRRRRSLKAQDLIMQgIMKAvnGNPDRnkslLLGTSNILFAKKYGVKPIGTVAHEWV 235
Cdd:PRK05321 151 LWEKIELLKAlpdlSGFKIADFGTRRRFSFEWQEEVVE-ALKE--GLPGA----FVGTSNVHLAMKLGLTPIGTMAHEWF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 236 MGVASISEDYLHANKNAMDCWINTFGaKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHdvl 315
Cdd:PRK05321 224 MAHQALGPRLRDSQYAALEDWVREYR-GDLGIALTDTIGMDAFLRDFDLYFAKLFDGLRHDSGDPIEWGEKAIAHYE--- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 316 KL---PKfSKIICYSDSLNVEKAI-TYSHAAKENGMlaTFGIGTNFTNDFRkksepqvKSEPLNIVIKLLEVNGNHAIKI 391
Cdd:PRK05321 300 KLgidPR-TKTLVFSDGLDFDKALeLYRHFKGRIKL--SFGIGTNLTNDFP-------GVKPLNIVIKLVECNGRPVAKL 369
|
410
....*....|....*.
gi 6324783 392 SDNLGKNMGDPATVKR 407
Cdd:PRK05321 370 SDSPGKTMCDDPEFLR 385
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
172-416 |
2.80e-100 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 298.53 E-value: 2.80e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 172 IRFSEFGTRRRRSLKAQDLIMQgimkavngnpdRNKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVASISEDYLHANKN 251
Cdd:pfam04095 1 FKLHDFGTRRRSSLESQEIVGL-----------AHLVNFLGTSNVHFAAKYSIPPAGTSAHEWWGAHQELDANLRQFQKD 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 252 AMDCWINTFGAkNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVLKLPKFSKIICYSDSLN 331
Cdd:pfam04095 70 ALDLWHAEYRG-NLGIALTDTVTMDAFLKDFDLYFAKLYLGVRPDSGDPVEWGEKLIAHYGSTLNIDGYTKRLIFSDGLD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 332 VEKAITYSHAAKENGMLATFGIGTNFTNDF-RKKSEPQVKSEPLNIVIKLLEVNGNHAIKISDNLGKNM-GDPATVKRVK 409
Cdd:pfam04095 149 VEKIIELLEYFKGKGFNIAFGIGTNLTQDLnRDTLGFAVKATPLNIVIKLVEVNGDPVAKISDSSGKGRcGDPAFVALLR 228
|
....*..
gi 6324783 410 EELGYTE 416
Cdd:pfam04095 229 TVFDNGE 235
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
9-379 |
4.78e-92 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 281.47 E-value: 4.78e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 9 LLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPS-AYIKY 87
Cdd:cd01567 1 LLDTDLYKLTMMQAYLYPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLIFGEFfLYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 88 ISSSNYKLH--PEEQISFTSEeiegkpthykLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAE 165
Cdd:cd01567 81 LGKLPLEIYalPEGTVVFPKE----------PLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLLETKDN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 166 tLFDNGIRFSEFGTRRRRSLKAQdliMQGIMKA-VNGnpdrnkslLLGTSNILFAKKYGVKPIGTVAHEWVMGVASIsed 244
Cdd:cd01567 151 -LEELGFKLHDFGTRRRHSPEAA---LSGGRAAlIGG--------FGGTSNVAAAKKLGIPPIGTMAHSWIQAFGAL--- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 245 yLHANKNAMDCWINTFGAKNaGLALTDTFGTD-DFLKSFRPPYS----DAYVGVRQDSGDPVEYTKKISHHYHDVLKLPK 319
Cdd:cd01567 216 -EEAAFEAFARWLPQFGGGL-GIALIDTYDTDnGFLNALKLAKAlgagGGLLGVRLDSGDPVELIKKVRKHLDELGIDLN 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 320 fSKIICYSDSLNVEKAITYSHAAKEnGMLATFGIGTNFTNDFRkksepqvkSEPLNIVIK 379
Cdd:cd01567 294 -KKKIIISGDLDTEEAIELLLEQGA-SPNDAFGVGTSLTNDLG--------RPPLGFVYK 343
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
10-140 |
3.11e-43 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 147.66 E-value: 3.11e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 10 LDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIKYIs 89
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPYFKPDFLDYL- 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 6324783 90 sSNYKLHPEEqISFTSEEIegkPTHYKLKILVSGSWKDTILYEIPLLSLIS 140
Cdd:pfam17767 80 -RNFRFDPSI-VAVPEGEV---VFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
13-379 |
2.47e-39 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 142.38 E-value: 2.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 13 DMYKITMHAAvfTNFPDVTVTYKYTNRSSQLTFnkeaINWLKEQFSYLGNLRFTEEEIEYLKqeipylpsayikyisssn 92
Cdd:cd00516 1 DLYKLTMIQA--YPPPDTRATAEFTAREDPYGV----LAGLEEALELLELLRFPGPLVILAV------------------ 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 93 yklhPEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLISEAYFKFVDidwdyenqleqAEKKAETLFDNGI 172
Cdd:cd00516 57 ----PEGTVVEPGEPL----------LTIEGPARELLLLERVLLNLLQRLSGIATA-----------TARYVEAAKGANT 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 173 RFSEFGTRRRRSlkaqDLIMQGIMKAVNGNpdrnkslLLGTSNILFAKKYGVKPIGTVAHEWVMGvasiseDYLHANKNA 252
Cdd:cd00516 112 KVHDFGTRKTTP----GLRLLEKYAVLIGG-------GDGHRNGLSDAILIKDNHGTMAHSIIQA------FGELAAVKA 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 253 MDCWINtfgakNAGLALTDTFgTDDFLKSFRPPYSDAYVGVRQDSG-----DPVEYTKKISHHYhDVLKLPKfsKIICYS 327
Cdd:cd00516 175 LRRWLP-----ELFIALIDVE-VDTLEEALEAAKAGGADGIRLDSGspeelDPAVLILKARAHL-DGKGLPR--VKIEAS 245
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 6324783 328 DSLNVEKAITYSHAAKEngmlaTFGIGTNFTNDfrkksepqvksEPLNIVIK 379
Cdd:cd00516 246 GGLDEENIRAYAETGVD-----VFGVGTLLHSA-----------PPLDIVLK 281
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
8-397 |
2.41e-19 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 89.82 E-value: 2.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 8 SLLDTDMYKITMHAAVF-TNFPDVTVTYKYTNRSsqLTFNK--------EAInwLKeqfsYLGNLRFTEEEIEYLKQEiP 78
Cdd:COG1488 4 LALLTDLYKLTMAQAYLpEGTANRRAVFELFFRR--LPFGRgyvvfaglQRF--LK----YLENLRFTEEDIAYLRSL-G 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 79 YLPSAYIKYISssNYKLH------PEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLI-------SEAYfk 145
Cdd:COG1488 75 VFDEDFLDYLA--DFRFPgdiravPEGTVVFPGEPL----------LTVEGTLPEAQLLETLLLNILnyptliaTKAA-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 146 fvdidwdyenQLEQAekkAEtlfdnGIRFSEFGTRRRRSLKAqdlimqGIMKA-----VNgnpdrnkslLLGTSNILFAK 220
Cdd:COG1488 141 ----------RIVQA---AG-----GRPLHDFGLRRAHGLEA------AVAAAraaylAG---------FAGTSNVLAGR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 221 KYGVKPIGTVAHEWVMgvasisedyLHAN-KNAMDCWINTFGAKNAglALTDTFGT-----------DDFLKSFRPpysd 288
Cdd:COG1488 188 YYGIPSVGTMAHSFVQ---------AHDDeLEAFRAFAEAYPDGTT--LLVDTYDTlsgvpnaielaKELLARGGL---- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 289 ayVGVRQDSGDPVEYTKKI-----SHHYHDVlklpkfsKIIcYSDSLNVEKAIT-YSHAAKENGmlatFGIGTNFTndfr 362
Cdd:COG1488 253 --LGIRLDSGDLAYLSKQArelldEAGLPDV-------RII-ASDDLDEYRIAAlLEQGAPIDV----FGVGTRLV---- 314
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 6324783 363 kksepQVKSEP-LNIVIKLLEVNGNHA----IKISDNLGK 397
Cdd:COG1488 315 -----TSSDRPtLGFVYKLVAVEGDGEwrpvIKLSETPGK 349
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
10-357 |
2.54e-17 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 82.24 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 10 LDTDMYKITMHAAVFT-NFPDVTVTYKYTNRSsqLTFNKEAINW--LKEQFSYLGNLRFTEEEIEYLKQEIPYLPsAYIK 86
Cdd:cd01570 2 LLTDLYQLTMAQAYWKeGKHNKPAVFELFFRK--LPFGGGYAVFagLEELLEYLENFRFTEEDIDYLRSLGIFDE-EFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 87 YISSSNYKL----HPEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLISeayfkfvdidwdYENQLeqAEK 162
Cdd:cd01570 79 YLRGFRFTGtiyaIPEGEVVFPNEPL----------LTVEGPLIEAQLLETLLLNLIN------------FQTLI--ATK 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 163 KAE-TLFDNGIRFSEFGTRRrrslkAQDliMQGIMKAvngnpdrNKSLLLG----TSNILFAKKYGVKPIGTVAHEWVMG 237
Cdd:cd01570 135 AARvRLAAGGRPLLEFGLRR-----AQG--PDAALSA-------ARAAYIGgfdgTSNVLAGKLYGIPVSGTMAHSFVQA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 238 VASisedylhaNKNAMDCWINTFgaKNAGLALTDTF-----GTDDFLKSFRPPYSDAY--VGVRQDSGDPVEYTKKISHH 310
Cdd:cd01570 201 FDD--------ELAAFRAFAEAY--PDNFTLLVDTYdtlrsGLPNAIAVAKELGALGYrlVGVRIDSGDLAYLSKEARKM 270
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 6324783 311 YhDVLKLPKFSkiICYSDSLNvEKAITYshAAKENGMLATFGIGTNF 357
Cdd:cd01570 271 L-DEAGLTKVK--IVASNDLD-EYTIAA--LNAQGAPIDAFGVGTRL 311
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
10-397 |
2.99e-16 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 80.48 E-value: 2.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 10 LDTDMYKITMHAAVFTNFPDVTVTYkYTNRSSQLTFNKEAINW--LKEQFSYLGNLRFTEEEIEYLKQeIPYLPSAYIKY 87
Cdd:TIGR01513 2 LLTDLYELTMAQGYFREGKANQPAV-FEVFFRKLPFGRGYAVFagLEDLLEFLENFRFDAEDIEYLAS-LGIFDDAFLDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 88 ISSSNYKLH----PEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLISeayfkfvdidwdYENQLeqAEKK 163
Cdd:TIGR01513 80 LREFRFSGTvralPEGSLVFPNEPL----------LQVEGPLIEAQLLETLVLNIIN------------FQTLI--ATKA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 164 AE-TLFDNGIRFSEFGTRRRRSLKAQdliMQGIMKAVNGNPDrnkslllGTSNILFAKKYGVKPIGTVAHEWVMGVASiS 242
Cdd:TIGR01513 136 ARiVLAAGGKPLLEFGLRRAQGPDAA---LKAARAAYIGGAD-------GTSNVLAGRLYGIPVSGTMAHSFVMSFDN-E 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 243 EDYLHA-----NKNAM------DCWinTFGAKNAgLALTDTFGTDDFLksfrppysdayVGVRQDSGDPVEYTKKISHHY 311
Cdd:TIGR01513 205 LAAFRAyaklyPKATVllvdtyDTL--RSGLPNA-IAVAKELGEQGKV-----------VGVRIDSGDLLYLSKQARKQL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 312 hDVLKLPKfSKIICySDSLNvEKAITYSHAakENGMLATFGIGTNFTNdfrkksepqVKSEP-LNIVIKLLEVNGNHAIK 390
Cdd:TIGR01513 271 -DAAGLTQ-VKIVV-SNDLD-ENSIAALKA--EGAPIDVYGVGTSLVT---------ASDAPaLGGVYKLVAYEGRPVMK 335
|
....*..
gi 6324783 391 ISDNLGK 397
Cdd:TIGR01513 336 LSENPEK 342
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
4-397 |
8.09e-15 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 76.23 E-value: 8.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 4 PVIKSLLdTDMYKITMHAAVFTNfpdvtvtYKYTNRSS-QLTFNKEAINW-------LKEQFSYLGNLRFTEEEIEYLKQ 75
Cdd:PLN02885 8 PMVTPLL-TDLYQFTMAYAYWKA-------GKHLDRAVfDLFFRKNPFGGeytvfagLEECLRFIANFKFTDDDIDFLRS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 76 EIP-YLPSAYIKYISS---SNYKLH--PEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLIS--------E 141
Cdd:PLN02885 80 VMPsGCEDAFFDYLRGldcSDVEVYaiPEGSVVFPRVPL----------MRIEGPLAVVQLLETTFLTLVNyaslvatnA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 142 AYFKFVdidwdyenqleqAEKKAETLfdngirfsEFGTRRrrslkAQdlimqgimkAVNGNPDRNKSLLLG----TSNIL 217
Cdd:PLN02885 150 ARHRLV------------AGKSKVLL--------EFGLRR-----AQ---------GPDGGISASKYCYLGgfdaTSNVE 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 218 FAKKYGVKPIGTVAHEWV---MGVASISEDYLHANKNAMDC---------WIN----------TFGAKNAG--------- 266
Cdd:PLN02885 196 AGRLFGIPVRGTHSHAFVssyMGLDEIVDKTLRSADGSSVCedfvslvqeWLSklqessslrgVFSETNQSelaaftsya 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 267 -------LALTDTFgtdDFLKSFRPPY--------SDAY--VGVRQDSGDpVEY----TKKISHHYHDVLKLPKFSK-II 324
Cdd:PLN02885 276 lafpnsfLALVDTY---DVMKSGIPNFcavalalnDLGYkaVGIRLDSGD-LAYlsleARKFFRTIEEELGVPGFGKmSI 351
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324783 325 CYSDSLNvEKAItysHAAKENGMLAT-FGIGTNFTNDFRKKSepqvksepLNIVIKLLEVNGNHAIKISDNLGK 397
Cdd:PLN02885 352 TASNDIN-EETL---DALNKQGHEIDaFGIGTHLVTCYAQPA--------LGCVYKLVEINGQPRIKLSEDVEK 413
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
10-397 |
3.95e-14 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 74.04 E-value: 3.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 10 LDTDMYKITM-----------HAAVFtnfpDVTVtykytnRssQLTFN---------KEAINWLKeqfsylgNLRFTEEE 69
Cdd:PRK09243 11 LLTDLYELTMaqaylrdgihnRRAVF----ELFF------R--KLPFGrgyavfaglERLLEYLE-------NLRFTEED 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 70 IEYLKQEIPYLPsAYIKYISssNYKL------HPEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLI---- 139
Cdd:PRK09243 72 IEYLRSLGIFDE-DFLDYLR--NFRFtgdvraVPEGELVFPNEPL----------LRVEGPLAEAQLLETLLLNIInfqt 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 140 ---SEAyfkfvdidwdyeNQLEQAekkAEtlfdnGIRFSEFGTRRrrslkaqdliMQGIMKAVNGNpdrnKSLLLG---- 212
Cdd:PRK09243 139 liaTKA------------ARIVSA---AG-----GRPLLEFGSRR----------AQGPDAAVWAA----RAAYIGgfda 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 213 TSNILFAKKYGVKPIGTVAHEWVMgvasisedyLHAN-KNAMDCWINTFGaKNAGLaLTDTFgtdDFLKS--------FR 283
Cdd:PRK09243 185 TSNVLAGKRYGIPVSGTMAHSFVQ---------AFDDeYEAFRAYAETYP-DNTVL-LVDTY---DTLKSgvpnaikvAK 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 284 PPYSDAYV-GVRQDSGDPVEYTKKI-----SHHYHDVlklpkfsKIICySDSLNvEKAITY--SHAAKENGmlatFGIGT 355
Cdd:PRK09243 251 ELGDGIELgGVRIDSGDLAYLSKKVrkmldEAGFTDT-------KIVA-SNDLD-EYTIASlkLQGAPIDG----FGVGT 317
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 6324783 356 NF-TNdfrkKSEPqvksePLNIVIKLLEVNGNHA----IKISDNLGK 397
Cdd:PRK09243 318 KLvTG----SDAP-----ALGGVYKLVAIEGEGGmipkIKLSNSPEK 355
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
10-306 |
1.85e-07 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 53.21 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 10 LDTDMYKITMHAAVFTNFPDVTVTYK--YTNRSSQLTFNKEAinWLKEQFSYLGNLRFTEEEIEYLKQEIpYLPSAYIKY 87
Cdd:PRK12484 6 LLTDLYEVTMANAYLREGMSAPATFSlfYRKLPDGRGFLIAA--GLADVVEFLEAFRFDEQDLRYLRGLN-QFSEEFLAW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 88 IS----SSNYKLHPEEQISFTSEEIegkpthyklkILVSGSWKDTILYEIPLLSLISeayfkfvdidwdyeNQLEQAEKK 163
Cdd:PRK12484 83 LAglrfTGDVRAVPEGTVVFPNEPL----------LEVTAPLIEAQLVETFLLNQIN--------------HQSLIASKA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324783 164 AE-TLFDNGIRFSEFGTRRRRSLKAQdliMQGIMKAVNGNpdrnkslLLGTSNILFAKKYGVKPIGTVAHEWVMGVAS-- 240
Cdd:PRK12484 139 ARcVLAAAGRPVVDFGARRAHGTDAA---CYVARASYLAG-------AAGTSNVLAARQYGIPASGTMAHSFVEAFPDev 208
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6324783 241 -----ISEDYLHANKNAMDCWINTFGAKNAGLALTDtfgtddfLKSFRPPysdayVGVRQDSGDPVEYTKK 306
Cdd:PRK12484 209 aafraFARLYPDATTLLVDTYDTLRGVRNAIEVAKE-------LGNRFDP-----RGVRLDSGDLAELSKA 267
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