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Conserved domains on  [gi|6324832|ref|NP_014901|]
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DNA 5'-adenosine monophosphate hydrolase [Saccharomyces cerevisiae S288C]

Protein Classification

HIT family protein( domain architecture ID 11112766)

HIT (Histidine triad) family protein, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), is part of a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HIT pfam01230
HIT domain;
15-139 1.99e-21

HIT domain;


:

Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324832     15 ETVNDDTVTYFDDKVSIIRDSFPKSECHLLILPRTmQLSRSHPTkvidakfKNEFESYVNSAIDHIFRHFQEKFrikksd 94
Cdd:pfam01230   1 RGEIPSTVVYEDDLVLAFLDIDPQAPGHILVIPKK-HIRELHDL-------TPEELGDLMSVAQKVARALGKVF------ 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6324832     95 ddkdpcwddilkdKNKFVRNFVQVGIHSVPSMANLHIHVISKDFH 139
Cdd:pfam01230  67 -------------KADGYRIVINNGAHAGQSVPHLHIHVIPRRKH 98
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 153-212 8.73e-09

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


:

Pssm-ID: 465082  Cd Length: 60  Bit Score: 50.37  E-value: 8.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324832    153 NTGFFISWDDLPlngKNLGTDKEIET----TYLKEHDLLCCYCqRNFSNKFSLLKKHLELEFNS 212
Cdd:pfam16278   1 NTPFFVPLDDVP---EWLEEDGKIELlpseVLLLKTPLKCHRC-GNFGNNFPKLKAHLEEHFEK 60
 
Name Accession Description Interval E-value
HIT pfam01230
HIT domain;
15-139 1.99e-21

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324832     15 ETVNDDTVTYFDDKVSIIRDSFPKSECHLLILPRTmQLSRSHPTkvidakfKNEFESYVNSAIDHIFRHFQEKFrikksd 94
Cdd:pfam01230   1 RGEIPSTVVYEDDLVLAFLDIDPQAPGHILVIPKK-HIRELHDL-------TPEELGDLMSVAQKVARALGKVF------ 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6324832     95 ddkdpcwddilkdKNKFVRNFVQVGIHSVPSMANLHIHVISKDFH 139
Cdd:pfam01230  67 -------------KADGYRIVINNGAHAGQSVPHLHIHVIPRRKH 98
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 153-212 8.73e-09

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 50.37  E-value: 8.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324832    153 NTGFFISWDDLPlngKNLGTDKEIET----TYLKEHDLLCCYCqRNFSNKFSLLKKHLELEFNS 212
Cdd:pfam16278   1 NTPFFVPLDDVP---EWLEEDGKIELlpseVLLLKTPLKCHRC-GNFGNNFPKLKAHLEEHFEK 60
 
Name Accession Description Interval E-value
HIT pfam01230
HIT domain;
15-139 1.99e-21

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324832     15 ETVNDDTVTYFDDKVSIIRDSFPKSECHLLILPRTmQLSRSHPTkvidakfKNEFESYVNSAIDHIFRHFQEKFrikksd 94
Cdd:pfam01230   1 RGEIPSTVVYEDDLVLAFLDIDPQAPGHILVIPKK-HIRELHDL-------TPEELGDLMSVAQKVARALGKVF------ 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6324832     95 ddkdpcwddilkdKNKFVRNFVQVGIHSVPSMANLHIHVISKDFH 139
Cdd:pfam01230  67 -------------KADGYRIVINNGAHAGQSVPHLHIHVIPRRKH 98
DcpS_C pfam11969
Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA ...
 20-148 2.31e-09

Scavenger mRNA decapping enzyme C-term binding; This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.


Pssm-ID: 463415 [Multi-domain]  Cd Length: 114  Bit Score: 53.38  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324832     20 DTVTYFDDKVSIIRDSFPKSECHLLILPrtmqlsrshptkvidakfKNEFES--YVNSAIDHIFRHFQEKFRIkksdddk 97
Cdd:pfam11969  14 ERVVYEDEGFVVFKDIKPKAPLHLLVIP------------------KRHIKSlrDLTPEHLPLLEHMREVAKK------- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6324832     98 dpcwddILKDKNKFV-RNFVQVGIHSVPSMANLHIHVISKDFHSVRLKNKKH 148
Cdd:pfam11969  69 ------VIEEKYIGVdRDELRLGFHYPPSVYHLHLHVISPDFESLGLGRKKG 114
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 153-212 8.73e-09

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 50.37  E-value: 8.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324832    153 NTGFFISWDDLPlngKNLGTDKEIET----TYLKEHDLLCCYCqRNFSNKFSLLKKHLELEFNS 212
Cdd:pfam16278   1 NTPFFVPLDDVP---EWLEEDGKIELlpseVLLLKTPLKCHRC-GNFGNNFPKLKAHLEEHFEK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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