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Conserved domains on  [gi|6324954|ref|NP_015023|]
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Amf1p [Saccharomyces cerevisiae S288C]

Protein Classification

MFS transporter( domain architecture ID 13024647)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 48-493 2.03e-159

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 457.11  E-value: 2.03e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   48 VLCSAQLMTQAGLGQSLAPLHIIGNSFGTtNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLA 127
Cdd:cd17476   2 TISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  128 GFSVysNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWI 207
Cdd:cd17476  81 GFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  208 MGIACFVLAVAGYFVIphtpmpsrdassfklleridfagsvtgvvglilfnfawnqgpvvgwqtpytyallivgtfflvi 287
Cdd:cd17476 159 LAILAAIVAVAAIFWT---------------------------------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  288 fayiesraafpllpfaalSSDTAFVLSCIAAGWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLL 367
Cdd:cd17476 175 ------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLI 236

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  368 SHTPPSTVMLFAMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNY 447
Cdd:cd17476 237 ARLPPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNY 316

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 6324954  448 SISIGLGIAGTIESRVNDGGAKPLKGYRCSWYMGIGLSGLGIFVAA 493
Cdd:cd17476 317 GISIGLGIAGTVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
 
Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 48-493 2.03e-159

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 457.11  E-value: 2.03e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   48 VLCSAQLMTQAGLGQSLAPLHIIGNSFGTtNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLA 127
Cdd:cd17476   2 TISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  128 GFSVysNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWI 207
Cdd:cd17476  81 GFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  208 MGIACFVLAVAGYFVIphtpmpsrdassfklleridfagsvtgvvglilfnfawnqgpvvgwqtpytyallivgtfflvi 287
Cdd:cd17476 159 LAILAAIVAVAAIFWT---------------------------------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  288 fayiesraafpllpfaalSSDTAFVLSCIAAGWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLL 367
Cdd:cd17476 175 ------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLI 236

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  368 SHTPPSTVMLFAMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNY 447
Cdd:cd17476 237 ARLPPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNY 316

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 6324954  448 SISIGLGIAGTIESRVNDGGAKPLKGYRCSWYMGIGLSGLGIFVAA 493
Cdd:cd17476 317 GISIGLGIAGTVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
36-446 2.38e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.68  E-value: 2.38e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   36 PKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVL 115
Cdd:COG2814   2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  116 GFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSML 195
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLA--ARFLQGLGAGALFPAALALIADLVPPERR-GRALGLLGAGLGLGPALGPLLGGLL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  196 GQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLEridfagsvtgvvglilfnfawnqgpvvgwqtpyty 275
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE----------------------------------- 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  276 allivgtfflvifayiesraafpllpfaaLSSDTAFVLSCIAAGWASFGIWIFYTW--QFMEDSRGQTPLLSSAQFSPVA 353
Cdd:COG2814 203 -----------------------------LLRRPRLLLLLLLAFLLGFGFFALFTYlpLYLQEVLGLSASAAGLLLALFG 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  354 ISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATAPVhqtyWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEH 433
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS----LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329

                       410
                ....*....|...
gi 6324954  434 QGLAASLVNTVVN 446
Cdd:COG2814 330 RGRASGLYNSAFF 342
MFS_1 pfam07690
Major Facilitator Superfamily;
69-452 1.08e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 96.33  E-value: 1.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954     69 IIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMG 148
Cdd:pfam07690  22 LLAEDLGIS-PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGLG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    149 PAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPM 228
Cdd:pfam07690  99 AGALFPAALALIADWFPPEER-GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    229 PSRDASSFKLLERIDFAGSVTGVVGLILFnfawnqgpvvgwqtpytYALLIVGTFFLVIFAYIEsraafpllpfaalssd 308
Cdd:pfam07690 178 KRPKPAEEARLSLIVAWKALLRDPVLWLL-----------------LALLLFGFAFFGLLTYLP---------------- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    309 tafvlsciaagwasfgiwifytwqFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTI 388
Cdd:pfam07690 225 ------------------------LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954    389 LIATAPVhQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIG 452
Cdd:pfam07690 281 GLLLLSL-TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
2_A_01_02 TIGR00880
Multidrug resistance protein;
83-226 8.47e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 62.67  E-value: 8.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954     83 SWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGR 162
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII--ARFLQGFGAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954    163 TYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHT 226
Cdd:TIGR00880  79 IYPPEER-GVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK14995 PRK14995
SmvA family efflux MFS transporter;
79-302 1.12e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 54.35  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    79 AGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFfdCCRAFQGMGPAFLLPNAIA 158
Cdd:PRK14995  40 GNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI--ATRALLAIGAAMIVPATLA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   159 ILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMpsrdassfKL 238
Cdd:PRK14995 118 GIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAG--------RR 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954   239 LERIDFAGSVTGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIFAYIESRAAFPLLPF 302
Cdd:PRK14995 190 DQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDM 253
 
Name Accession Description Interval E-value
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 48-493 2.03e-159

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 457.11  E-value: 2.03e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   48 VLCSAQLMTQAGLGQSLAPLHIIGNSFGTtNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLA 127
Cdd:cd17476   2 TISGAQLLNQAGLGSVIVILPIIGDSFGT-SPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  128 GFSVysNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWI 207
Cdd:cd17476  81 GFSP--NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  208 MGIACFVLAVAGYFVIphtpmpsrdassfklleridfagsvtgvvglilfnfawnqgpvvgwqtpytyallivgtfflvi 287
Cdd:cd17476 159 LAILAAIVAVAAIFWT---------------------------------------------------------------- 174

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  288 fayiesraafpllpfaalSSDTAFVLSCIAAGWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLL 367
Cdd:cd17476 175 ------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLI 236

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  368 SHTPPSTVMLFAMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNY 447
Cdd:cd17476 237 ARLPPSYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNY 316

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 6324954  448 SISIGLGIAGTIESRVNDGGAKPLKGYRCSWYMGIGLSGLGIFVAA 493
Cdd:cd17476 317 GISIGLGIAGTVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 49-459 9.69e-50

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 174.67  E-value: 9.69e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   49 LCSAQLMTQAGLGQSLAPLHIIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAG 128
Cdd:cd17321   1 LLLAVFLAALDVTIVNVALPTIARDLGAS-PSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  129 FSvySNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIM 208
Cdd:cd17321  80 LA--PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERR-GRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  209 GIACFVLAVAGyfviphtpmpsrdassfklleridfAGSVTGVVGLILFNFAwnqgpvvgwqtpytyallivgtfflvif 288
Cdd:cd17321 157 VPIGLVALLLA-------------------------RTFSGAVLAAFLLGAA---------------------------- 183

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  289 ayiesraafpllpfaalssdtafvlsciaagwasFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLS 368
Cdd:cd17321 184 ----------------------------------LGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD 229

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  369 HTPPSTVMLFAMTAFTVGTILIATAPVHQTYWaQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYS 448
Cdd:cd17321 230 RFGPRLVLVAGLLLTAVGLLLLALLGADSSVW-LLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG 308

                       410
                ....*....|.
gi 6324954  449 ISIGLGIAGTI 459
Cdd:cd17321 309 GALGVALLGAL 319
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
36-446 2.38e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.68  E-value: 2.38e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   36 PKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVL 115
Cdd:COG2814   2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  116 GFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSML 195
Cdd:COG2814  81 GLLLFALGSLLCALAPSLWLLLA--ARFLQGLGAGALFPAALALIADLVPPERR-GRALGLLGAGLGLGPALGPLLGGLL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  196 GQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLEridfagsvtgvvglilfnfawnqgpvvgwqtpyty 275
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE----------------------------------- 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  276 allivgtfflvifayiesraafpllpfaaLSSDTAFVLSCIAAGWASFGIWIFYTW--QFMEDSRGQTPLLSSAQFSPVA 353
Cdd:COG2814 203 -----------------------------LLRRPRLLLLLLLAFLLGFGFFALFTYlpLYLQEVLGLSASAAGLLLALFG 253

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  354 ISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATAPVhqtyWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEH 433
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS----LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329

                       410
                ....*....|...
gi 6324954  434 QGLAASLVNTVVN 446
Cdd:COG2814 330 RGRASGLYNSAFF 342
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 67-328 6.90e-23

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 98.73  E-value: 6.90e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   67 LHIIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSvySNQIFFDCCRAFQG 146
Cdd:COG0477  37 LPSIAADLGAS-SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQG 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  147 MGPAFLLPNAIAILGRTYkPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHT 226
Cdd:COG0477 114 IGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESR 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  227 PMPSRDASSFKLLERIDFAGSVTGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIFAYIESRAAFPLLPFAALS 306
Cdd:COG0477 193 GLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLL 272

                       250       260
                ....*....|....*....|..
gi 6324954  307 SDTAFVLSCIAAGWASFGIWIF 328
Cdd:COG0477 273 ALLLALLLLLLLLLLLLLLALL 294
MFS_1 pfam07690
Major Facilitator Superfamily;
69-452 1.08e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 96.33  E-value: 1.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954     69 IIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMG 148
Cdd:pfam07690  22 LLAEDLGIS-PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGLG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    149 PAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPM 228
Cdd:pfam07690  99 AGALFPAALALIADWFPPEER-GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    229 PSRDASSFKLLERIDFAGSVTGVVGLILFnfawnqgpvvgwqtpytYALLIVGTFFLVIFAYIEsraafpllpfaalssd 308
Cdd:pfam07690 178 KRPKPAEEARLSLIVAWKALLRDPVLWLL-----------------LALLLFGFAFFGLLTYLP---------------- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    309 tafvlsciaagwasfgiwifytwqFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTI 388
Cdd:pfam07690 225 ------------------------LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954    389 LIATAPVhQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIG 452
Cdd:pfam07690 281 GLLLLSL-TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 48-459 7.28e-19

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 89.61  E-value: 7.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   48 VLCSAQLMTQAGLGQSLAP-LHIIGNSFGttNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLL 126
Cdd:cd06179   1 AALCLAYFAQLFGVTLPAAvLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  127 AGFSVYSN-----QIFFDCCRAFQGMGPAFLLpnaiAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQlawW 201
Cdd:cd06179  79 AGTAKSVNmliggQALIGIGAGTQGLGAAVAS----ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAG---W 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  202 PWAYWIMgIACFVLAVAGYFVI---PHTPMPSRDASSFKLLeRIDFAGSVTGVVGLILF--NFAWNQGPvVGWQTPYTYA 276
Cdd:cd06179 152 RWIFYIN-AIFNALALILLFFFyhpPPRPQLHGSSTRQKLK-RLDWVGLFLLIAGLVLFllGLSWGGNP-YPWSSAHVIA 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  277 LLIVGTFFLVIFAYIESRAA-FPLLPFAALSSDTAFVLSCIAA---GWASFGIWIFYTWQFMEdSRGQTPLLSSAQFSPV 352
Cdd:cd06179 229 PLVIGGVLLIAFGLYEWKGTkDGLLPPRLLFRGRNFALILIVAfveGMIFYSLNIFWPQQISL-LFTTDPLKAGLYQLPF 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  353 AISGFCAAVTTGFLLSHTPPST-VMLFAMTAFTVGTILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLsdSMPH 431
Cdd:cd06179 308 GLGTLFGAILAGLLLTKIKHIKwQLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQL--SVPP 385

                       410       420
                ....*....|....*....|....*...
gi 6324954  432 EHQGLAASLVNTVVNYSISIGLGIAGTI 459
Cdd:cd06179 386 EDIGTASGLLGSARALGGAVGTAIFTSI 413
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 77-493 8.20e-17

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 81.86  E-value: 8.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   77 TNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSvySNQIFFDCCRAFQGMGPAfLLPNA 156
Cdd:cd17504  28 TSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA--PNLPVLIAGRALQGIGGA-VFPLA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  157 IAILgRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAgyfviphTPMPSRDassf 236
Cdd:cd17504 105 FALV-REEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL-------VPLIDLR---- 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  237 klleriDFAGSVTGVVGLIlfnfawnqgpvvgwqtpytyALLIVGTFFLVIFayiesraAFPLLpfAALSSDTAFVLSCI 316
Cdd:cd17504 173 ------LLRRRNVLLANIT--------------------ALLAGFGMFMVFQ-------LLPQL--LQLPTPTGFGLGIT 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  317 AAGWASFgiwifytwqfmedsrgqtpllssaqfsPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATapVH 396
Cdd:cd17504 218 EAGLLLL---------------------------PGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL--LH 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  397 QTYWaQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTIES----RVNDGGAKPLK 472
Cdd:cd17504 269 SSLW-ALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTtytvSITSGGVPTEG 347

                       410       420
                ....*....|....*....|.
gi 6324954  473 GYRCSWYMGIGLSGLGIFVAA 493
Cdd:cd17504 348 AYVLAFLIGAALALAALLLSL 368
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 70-463 2.85e-16

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 80.31  E-value: 2.85e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   70 IGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQ-IFFdccRAFQGMG 148
Cdd:cd17503  22 IMGDLGASLD-TVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASlIIF---RILQGFG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  149 PAFLLPNAIAILGRTYKPGRRKNM--VFSLFGASAPggfFLGAVFSSMLGQLAWWPWAYWI---MGIACFVLAvagyfvi 223
Cdd:cd17503  98 GGVLIPLAQTILLRIYPPEKRGAAmgLVGLVILLAP---AIGPTLGGWLTDNLSWRWIFYInlpIGILALLLA------- 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  224 phtpmpsrdassfklleridfagsvtgvvglilfnfawnqgpvvgwqtpytyallivgtfflvifayiesraafPLLPFA 303
Cdd:cd17503 168 --------------------------------------------------------------------------PLLDLR 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  304 ALSSD--TAFVLSCIAAGWASFGIwIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMT 381
Cdd:cd17503 174 LFKDRnfTLGLLLSFLLGLGLFGA-MFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLL 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  382 AFTVGTILIATAPVHQTYWAQTFVSIIVMpWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTIES 461
Cdd:cd17503 253 LLALGTLLLAFLTPDTSLWLIILPLFIRG-LGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331


                ..
gi 6324954  462 RV 463
Cdd:cd17503 332 NR 333
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
70-223 1.27e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 75.29  E-value: 1.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   70 IGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGP 149
Cdd:COG2271  36 LQADLGLSAA-QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLL--LRFLLGLGE 112

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954  150 AFLLPNAIAILGRTYkPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVI 223
Cdd:COG2271 113 AGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLL 185
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 78-459 2.74e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 74.53  E-value: 2.74e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAI 157
Cdd:cd17325  29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL--ARFLQGLASAAVWPAAM 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  158 AILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASsfk 237
Cdd:cd17325 107 ALIADIAPPEER-GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA--- 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  238 lleriDFAGSVTGVVGLILFNfawnqgpvvgwqtPYTYALLIVGTFFLVIFAYIEsraafPLLPFaalssdtafvlscia 317
Cdd:cd17325 183 -----VSAARLRSGLRLLLRD-------------RRLLALFLAIFVLAFAFGALE-----PFLPL--------------- 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  318 agwasfgiwifytwqFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATAPVhq 397
Cdd:cd17325 225 ---------------YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS-- 287

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6324954  398 tyWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTI 459
Cdd:cd17325 288 --FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 70-442 4.22e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 70.28  E-value: 4.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   70 IGNSFGTTNagQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGP 149
Cdd:cd17502  22 IVAEFGGLS--LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIV--GRAIQGIGG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  150 AFLLPNAIAILGRTYKPGRR---KNMVFSLFGASAPGGFFLGAVFSSMLGqlawWPWAYWImgiacfvlavagyfvipht 226
Cdd:cd17502  98 GGLMSLAFIIIADLVPPRERgkyQGYIGAVFGIASVAGPLIGGAFTDHLS----WRWCFYI------------------- 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  227 pmpsrdassfklleridfagsvtgvvglilfnfawnQGPVVGwqtpytyallivgtfflvifayiesrAAFPLLPFAALS 306
Cdd:cd17502 155 ------------------------------------NLPIGG--------------------------LALALLRTILLS 172

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  307 SDTAFVLSciaagwASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTP-PSTVMLFAMTAFTV 385
Cdd:cd17502 173 SIFGFLFG------GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSV 246

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324954  386 GTILIATAPVHQTYWAQTFVSIIVMpWGMDMSFPAATIMLSDSMPHEHQGLAASLVN 442
Cdd:cd17502 247 GAGLLTTLTLDTSKWLLIGYLILLG-LGLGIGFQQPLVAVQNAVPPADVGVATATNT 302
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 46-452 6.34e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 70.29  E-value: 6.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   46 VGVLCSAQLMtqAGLGQSL-AP-LHIIGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALW 123
Cdd:cd17474   1 LYAVFFATLL--AVLGVSIvDPiLPAIAEALGASPA-QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  124 SLLAGFSV-YSNQIFFdccRAFQGMGPAFLLPNAIAILGRTYKPGRRKNmVFSLFGASapggFFLGAVFSSMLGQL---A 199
Cdd:cd17474  78 GLLCGLSDsFALLLAG---RALQGIGAAGLGPLALTLIGDLFEGGERAK-AMGLYEAA----LGLGIAVGPLLGGLlaaI 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  200 WWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLERIdfagsvtgvvglILFNFAWnqgpvvgwqtpytyALLI 279
Cdd:cd17474 150 SWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLK------------KALRGRG--------------LLTF 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  280 VGTFFLVIFAYiesraaFPLLPFAALSSDTAFVLSCIAAGWASFGiwifytwqfmedsrgqtPLLSSAQFSPVAisgfcA 359
Cdd:cd17474 204 LVSAFLYFFLY------FAFLTYLPFLLELLYGISPIIIGLLFAG-----------------WSVLLALGSLFV-----G 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  360 AVTTGFLLSHtppsTVMLFAMTAFTVGtiLIATAPVHQTYWAqtFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAAS 439
Cdd:cd17474 256 RLLKKRFGAR----RILVIGLLLYALS--LLLLGFVPSLALL--LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327

                       410
                ....*....|...
gi 6324954  440 LVNTVVNYSISIG 452
Cdd:cd17474 328 LYNFVRFLGQAVG 340
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-459 6.07e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 67.19  E-value: 6.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   67 LHIIGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQG 146
Cdd:cd17324  22 LPDIARDFGVS-VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL--ARALAG 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  147 MGPAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHt 226
Cdd:cd17324  99 LAHGGFWAIAAAYAADLVPPEKR-GRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS- 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  227 pMPSRDASSFKLLERIDFAGSVTGVVGLILfnfawnqgpvvgwqtpytYALLIVGTFFlVIFAYIesraafpllpfaals 306
Cdd:cd17324 177 -LPPKKPGSLGLLSSLLLLLRNPRLRLAYL------------------ITFLLFGGFF-ALYTYL--------------- 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  307 sdtAFVLSCIAAGWASFGIWIFYTwqfmedsrgqtpllssaqfspVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVG 386
Cdd:cd17324 222 ---APFLTDVPGFSSSAIIGLLLL---------------------FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324954  387 TILIATAPvhqtYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPhEHQGLAASLVNTVVNYSISIGLGIAGTI 459
Cdd:cd17324 278 LLLTLLGP----SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLV 345
2_A_01_02 TIGR00880
Multidrug resistance protein;
83-226 8.47e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 62.67  E-value: 8.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954     83 SWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGR 162
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII--ARFLQGFGAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954    163 TYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHT 226
Cdd:TIGR00880  79 IYPPEER-GVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 70-457 1.05e-11

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 66.45  E-value: 1.05e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   70 IGNSFGTTnAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGP 149
Cdd:cd17320  25 IARDLGAS-ASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI--ARFLQGLGA 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  150 AFLLPNAIAILgRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMP 229
Cdd:cd17320 102 AAGSVVARAIV-RDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPE 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  230 SRdassfklleRIDFAGSVTGVVGLILFNfawnqgpvvgwqTPYTYALLIVGTFFLVIFAYIesrAAFPLLPFAALssdt 309
Cdd:cd17320 181 EK---------RKPLLSSLLRAYKRVLKN------------RRFLGYALALGLSFAGLFAYL---AAAPFIYIEQL---- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  310 afvlsciaagwasfgiwifytwqfmedsrGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTI- 388
Cdd:cd17320 233 -----------------------------GLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALv 283

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954  389 LIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHqGLAASLVNTVVNYSISIGLGIAG 457
Cdd:cd17320 284 LLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVG 351
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
70-391 1.97e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 65.67  E-value: 1.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   70 IGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGP 149
Cdd:COG2223  31 LAEEFGLSAA-QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL--LGLLLGIGG 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  150 AFLLPNAIAILGRTYkPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMP 229
Cdd:COG2223 108 GGSFAVGIALVSKWF-PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAG 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  230 SRDASSFKLLERID-------------FAGSVTGVVGLILF--NFAWNQGPVVGWQTPYTYALL-IVGTFFLVIFAYIES 293
Cdd:COG2223 187 AAAAAKASLRDQLEalrdprfwllsllYFGTFGSFIGFSSWlpPYLVDQFGLSAATAGLLAALFaLLGALGRPLGGWLSD 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  294 R-------------AAFPLLPFAALSSDTAFVLSCIAAGWASFGIWIFYTWQFMED--SRGQTPLLSSAQFSPVAISGFC 358
Cdd:COG2223 267 RiggrrvllivfalMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDifPTKNAGAVYGLVGAAGGLGGFL 346

                       330       340       350
                ....*....|....*....|....*....|...
gi 6324954  359 AAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIA 391
Cdd:COG2223 347 GPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 78-492 4.26e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 61.67  E-value: 4.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAI 157
Cdd:cd06174  29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL--GRFLLGLGSGLIDPAVL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  158 AILGRTYkPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAW--WPWAYWIMGIACFVLAVAGYFVIPHTP-MPSRDAS 234
Cdd:cd06174 107 ALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAALALLAAILLLLVVPDPPeSARAKNE 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  235 SFKLLERIDFAGSVTGVVGLILFNFAWnqgpvvgwqtpytyallivgtfflvifayiesraafpllpfaalssdtafvls 314
Cdd:cd06174 186 EASSKSVLKLLKRVLKNPGLWLLLLAI----------------------------------------------------- 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  315 ciAAGWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLS-HTPPSTVMLFAMTAFTVGTILIATA 393
Cdd:cd06174 213 --FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLA 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  394 PVHQTYWAQTFVSIIVMPWGmdmsFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTIESRVNdggakplkG 473
Cdd:cd06174 291 PSLLLLLLLLLLLGFGLGGL----LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--------G 358

                       410
                ....*....|....*....
gi 6324954  474 YRCSWYMGIGLSGLGIFVA 492
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILL 377
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 48-443 1.56e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 59.51  E-value: 1.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   48 VLCSAQLMTQAGlGQSLAP-LHIIGNSFGTTNAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLL 126
Cdd:cd17473   3 TLLLASTLTVMA-GAAIAPaLPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  127 AGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGRTYKPGRRKNMvFSLFGASAPGGfflGAVFSSMLGQLAW--WPWA 204
Cdd:cd17473  82 GLFLDSLYALLA--SRALLGIGVAGIMTLATALIGDYFEGEERAKM-LGLQSAAMSLG---GVVFLLLGGALAEigWRAP 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  205 YWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLERIDFAGSVTGVVGLIlfnfawnqgpvvgwqtpytyalLIVGTFF 284
Cdd:cd17473 156 FLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLA----------------------FLAMLLF 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  285 LVIFAYiesraafplLPFaalssdtafvlsciaagwasfgiwifytwqFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTG 364
Cdd:cd17473 214 YVIPIQ---------LPF------------------------------LLQERGGGSAALIGLALAIASLAGAIGALLFG 254

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954  365 FLLSHTPPSTVMLFAMTAFTVGTILIATAPvhqTYWAqTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNT 443
Cdd:cd17473 255 RLKRRLGKRRLLAIGFALMALGFLLLALAS---GLWV-VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTS 329
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
165-459 2.99e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.06  E-value: 2.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  165 KPGRRKnmvFSLFGASAPGGFFLGAVFSSMlgqlAWWPWAYWIMGIACFVLAVAGY--FVIPHTPMPSRDASSFKLLERI 242
Cdd:COG2211  76 RWGRRR---PWILIGAIPLALSFVLLFTAP----DLSPTGKLIYALVTYLLLGLAYtlVNIPYSALGAELTPDYEERTRL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  243 -------DFAGSVTGVVGLILFNFAWNQGPVVGWQTP-YTYALLIVGTFFLVIF----AYIESRAAFPLLP-FAALSSDT 309
Cdd:COG2211 149 sswrfafAGLGGLLASVLPPPLVAAFGGDAALGYRLTaLIFAVLGLLAFLLTFFgtkeRPVPEEEKVSLKEsLKALLKNR 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  310 AFVLSCIAAGWASFGIWIFYTWQ--FMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGT 387
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLlyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6324954  388 ILIATAPVHQTYWAQTFVSIIVMPWGMDMSFPAAtiMLSDSMPHEHQGL---AASLVNTVVNYSISIGLGIAGTI 459
Cdd:COG2211 309 LLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA--MLADVVDYDEWKTgrrREGLYFGIFTFAIKLGQALAGAL 381
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 99-224 4.59e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 55.32  E-value: 4.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   99 IAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGRTYKPGRRkNMVFSLFG 178
Cdd:cd17328  53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL--FRALVGIGEASYSPIAPTIIADLFPKEKR-TRALGVFY 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6324954  179 ASAPGGFFLGAVFSSMLGQLAW-WPWAYWIMGIACFVLAVAGYFVIP 224
Cdd:cd17328 130 FAIPLGSGLGYVVGGLVAQATGgWRWAFRVTGVLGVLLAILLLLFVR 176
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 78-226 1.11e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 1.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAI 157
Cdd:cd17319  36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV--LRFLLGVAEAGFFPGAI 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954  158 AILGRTYkPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHT 226
Cdd:cd17319 114 KALAEWF-PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV 181
PRK14995 PRK14995
SmvA family efflux MFS transporter;
79-302 1.12e-07

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 54.35  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    79 AGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFfdCCRAFQGMGPAFLLPNAIA 158
Cdd:PRK14995  40 GNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI--ATRALLAIGAAMIVPATLA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   159 ILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMpsrdassfKL 238
Cdd:PRK14995 118 GIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAG--------RR 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324954   239 LERIDFAGSVTGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIFAYIESRAAFPLLPF 302
Cdd:PRK14995 190 DQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDM 253
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 70-222 4.23e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 51.94  E-value: 4.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   70 IGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALwsLLAGFSVYSNQIFFDCCRAFQGMGP 149
Cdd:cd17333  22 LEEAFNLNVA-DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISL--ALALIFATPSIYLFVVLMFLAGLGA 98

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6324954  150 AFLLPNAIAILGRTY--KPGRRKNMVFSLFGAsapGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFV 222
Cdd:cd17333  99 GILDTGANTFVGALFeeSSATRLNVLHGFFGL---GALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLT 170
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
78-222 8.23e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 8.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALwsLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAI 157
Cdd:COG0738  41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL--GLLLFALAPSYPLLLLALFLLGLGLGLLDVAAN 118

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6324954  158 AILGRTYKPGRRKNMvfSLFGASAPGGFFLGAVFSSML---GQLAWWPWAYWIMGIACFVLAVAGYFV 222
Cdd:COG0738 119 PYVAALGPETAASRL--NLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALLFLRS 184
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 86-224 2.14e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 49.88  E-value: 2.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   86 ASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAILGRTYK 165
Cdd:cd17323  40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLII--LRFLQGFFGSSPLAIGAGTIADLFT 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954  166 PGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIP 224
Cdd:cd17323 118 PEER-GKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 78-218 2.69e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.51  E-value: 2.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASA--YSLTVGTfiLIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQifFDCCRAFQGMGPAFLLPN 155
Cdd:cd17365  32 SPAQLGPVGSAalFGMAIGA--LLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPN 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324954  156 AIAILgRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVA 218
Cdd:cd17365 108 AITLV-SEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 82-224 2.08e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 46.78  E-value: 2.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   82 LSWFASAYSLTVgtfiLIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAIAILG 161
Cdd:cd17380  40 LSSFFWGYALTQ----VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFS 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324954  162 RTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIP 224
Cdd:cd17380 116 RWVPVSER-SRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 36-316 6.34e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 45.81  E-value: 6.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954     36 PKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFGTtnagqlSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVL 115
Cdd:pfam06609  40 PRIIASFAAFSLNVCATYFVLQASASALPNILQDIGQSENQ------GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    116 GFFWYALWSLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAIAILGRTykpgrrKNMVFSLFGASAP------GGFFLGA 189
Cdd:pfam06609 114 THIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGASPLFIGELMSN------KTKFLGLLIVSAPtiamngAGPYFGQ 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    190 VFsSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRDASSFKLLERIDFAGSVTGVVG--LILFNFAWNQGPVV 267
Cdd:pfam06609 188 RL-AIQGNWRWIFYIYIIMSAIAVLLIIIWYHPPSFAQLHGKKARKRDELAKLDWIGIFLVIAGtsLFLLGVSWGGKPNN 266

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6324954    268 GWQTPYTYALLIVGTFFLVIFAYIE--SRAAFPLLPFAALSSDTAFVlsCI 316
Cdd:pfam06609 267 PWNSAKIIGLISSGAGSLVIFALYEvfGKPEQPIIPPALFKDTRGFV--CI 315
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 73-223 1.08e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.51  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   73 SFGTTNAGQLSWFASAYsltVGTFI--LIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSvySNQIFFDCCRAFQGMGPA 150
Cdd:cd17316  30 SLGLSLLQTGLLFAAGF---LGRPIgaLLFGYLGDRIGRKKALILTLLLFGLATLLIGLL--PTPILLLVLRFLQGIGIG 104

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324954  151 FLLPNAIAILGrTYKPGRRKNMVFSLFGASAPGGFFLGA----VFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVI 223
Cdd:cd17316 105 GEYPGASTYVA-EFAPSKRRGFALGLLQSGWALGALLAAlvasLLIPLLSGDWGWRILFLIGALPALLALLLRRRTL 180
PRK10504 PRK10504
putative transporter; Provisional
 88-457 1.95e-04

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 43.95  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    88 AYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPnaiaiLGR--TYK 165
Cdd:PRK10504  53 SYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLL--ARVLQGVGGAMMVP-----VGRltVMK 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   166 PGRRKNMVFSLFGASAPG--GFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTPMPSRdassfklleRID 243
Cdd:PRK10504 126 IVPREQYMAAMTFVTLPGqvGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQTR---------RFD 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   244 FAGSVTGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIF---AYIESRAAFPLlpfaALSSDTAFVLSCIA--A 318
Cdd:PRK10504 197 LSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYllhARNNNRALFSL----KLFRTRTFSLGLAGsfA 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   319 GWASFGIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILIATAPVHQT 398
Cdd:PRK10504 273 GRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLALVSLLFMLVALLGW 352

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6324954   399 YWAQTFVSIIVmpwGM--DMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAG 457
Cdd:PRK10504 353 YYLLPFVLFLQ---GMvnSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAG 410
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 98-224 2.07e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.50  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954     98 LIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcCRAFQGMGPAFLLPNAIAiLGRTYKPGRRKNMVFSLF 177
Cdd:TIGR00895  70 LFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI--LRFLAGLGLGGLMPNLNA-LVSEYAPKRFRGTAVGLM 146

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6324954    178 GASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIP 224
Cdd:TIGR00895 147 FCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 249-459 2.46e-04

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 43.45  E-value: 2.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  249 TGVVGLILFNFAWNQGPVVGWQTPYTYALLIVGTFFLVIFAYIESR-AAFPLLPFAALSSDTAFVLSCIAAGW-ASFGIW 326
Cdd:cd17322 225 TAGLGLILVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKfAKYPFLPFRLLKDRTILAACLIDFFYfFSYYIF 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  327 IFYTWQFM-----EDSRGQTPLLSSAQFSPVaisgfCAAVTTGFLLSHTPPSTVMLFA-MTAFTVGTILIATAPVHQTYW 400
Cdd:cd17322 305 SDYLYTVLqvavgESITSATRITNLYSFVST-----VAGIFVGFLIRKTRRYKVLVIIgVPLYIVGMGLLIRYRGGSGSH 379

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954  401 AQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTI 459
Cdd:cd17322 380 GGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAI 438
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 81-227 4.98e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 42.26  E-value: 4.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   81 QLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFF--DCCRAFQGMGpaflLPNAIA 158
Cdd:cd17312  39 DLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVlwGLNGLFQSMG----WPPCVK 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954  159 ILGRTYKPGRRKNMvFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIPHTP 227
Cdd:cd17312 115 LLGNWFSKKERGTV-YGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
63-235 5.00e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.55  E-value: 5.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   63 SLAP-LHIIGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFdcC 141
Cdd:COG2807  36 SVGPlLPEIRADLGLSAT-QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA--G 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  142 RAFQGMGPAFLLPNAIAILGRTYkpGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYF 221
Cdd:COG2807 113 TALIGAGIAVGNVLLPGLIKRWF--PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190

                       170
                ....*....|....
gi 6324954  222 VIPHTPMPSRDASS 235
Cdd:COG2807 191 LLRRRPAAAAAAPA 204
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 98-224 7.16e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.84  E-value: 7.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   98 LIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRknmvfSLF 177
Cdd:cd17318  74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLER-----SRL 148

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6324954  178 GASAPGGFFLGAVF----SSMLGQLAWWPWAYWIMGIACFVLAVAGYFVIP 224
Cdd:cd17318 149 TSIAYSGSQFGTVIamplSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 78-221 9.39e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.45  E-value: 9.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASAYSltVGTFI--LIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCcrAFQGMGPAFLLPN 155
Cdd:cd06173 242 GAAGYGLLLAAFG--VGALLgaLLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL--FLLGLAGGLFNVP 317

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324954  156 AIAILGRTYKPGRRKNmVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFVLAVAGYF 221
Cdd:cd06173 318 LNTLLQLRVPDELRGR-VFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 54-289 1.08e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   54 LMTQAGLGQSLAPLHIIGNSFGTTNAGQLSwfaSAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYS 133
Cdd:cd17489   8 FFLSFYLLLPVLPLYAHDLGGSEAVAGLVV---GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  134 NQIFFdcCRAFQGMGPAFLLPNAIAILGRtYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACF 213
Cdd:cd17489  85 ALLLV--LRLIHGIGWGAFTTAAATLVAD-IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL 161

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324954  214 VLAVAGYFVIPHTPMPSRDASSFKLLERIDFAGSVTgVVGLILFNFAWNQGPVVGWQTPYTYALLIV-GTFFLVIFA 289
Cdd:cd17489 162 LALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVL-PPALILFLASIAYGAISTFLPLYAAERGISnAGLFFTVYA 237
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
48-176 3.30e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.00  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    48 VLCSAQL--MTQAGLGQSLAPLHIIGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSL 125
Cdd:PRK10473   5 LLCSFALvlLYPAGIDMYLVGLPRIAADLNASEA-QLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6324954   126 LAGFSVYSNQifFDCCRAFQGMGPAFLLPNAIAILgRTYKPGRRKNMVFSL 176
Cdd:PRK10473  84 LCSLAETSSL--FLAGRFLQGIGAGCCYVVAFAIL-RDTLDDRRRAKVLSL 131
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
78-224 3.77e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 3.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   78 NAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSVYSNQIFFDCCRAFQGMGPAFLLPNAI 157
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPW 341

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  158 AILGRT-----YKPGRRKN-MVFSLFG-----ASAPGGFFLGAV-----FSSMLGQ----LAWWPWAYWIMGIACFVLAV 217
Cdd:COG2211 342 AMLADVvdydeWKTGRRREgLYFGIFTfaiklGQALAGALAGLLlalfgYVAGAAQspsaLTGIRLLFFLLPAVLLLLAA 421


                ....*..
gi 6324954  218 AGYFVIP 224
Cdd:COG2211 422 LLLLFYP 428
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 55-235 3.99e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.53  E-value: 3.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   55 MTQAGLGqSLAPLhiIGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSvySN 134
Cdd:cd17475  10 LVAQGIP-ALAPF--LQEDLHLSLA-QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV--GS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  135 QIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPGRRkNMVFSLFGASAPGGFFLGAVFSSMLGQLAWWPWAYWIMGIACFV 214
Cdd:cd17475  84 YPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRER-GLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162

                       170       180
                ....*....|....*....|.
gi 6324954  215 LAVAGYFVIPHTPMPSRDASS 235
Cdd:cd17475 163 AAVLFWLFYREPPAASAATES 183
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 79-227 4.28e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 39.53  E-value: 4.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   79 AGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGF------SVYSNQIFFDCCRAFQGMGPAfl 152
Cdd:cd17345  37 KTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFvpsatsSVGLMFILLFLNGWFQGMGWP-- 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6324954  153 lPNAIAILgrTYKPGRRKNMVFSLFGASAP-GGFFLGAVFSSMLGQL--AWWPWAYWIMGIACFVLAVAGYFVIPHTP 227
Cdd:cd17345 115 -PSGRTMV--HWFSKKERGTWTSIWNISHNvGGGLVGPLAGLGLAIFgdGWWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 69-257 5.55e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 5.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954   69 IIGNSFGTTNAgQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLGFFWYALWSLLAGFSvySNQIFFDCCRAFQGMG 148
Cdd:cd17478  21 LLIAKLGLSYA-QAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA--PNYWLLLLLVALAGIG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954  149 PAFLLPNAIAILGRTYkpGRRKNMVFSLFGASAPGGFFLGAVFSSML----GQLAWWPWAywIMGIACFVLAVAGYFVIP 224
Cdd:cd17478  98 SAAFHPEGARLASQAA--GGRRGLAMSIFSVGGNLGFALGPLIAAALvalfGGLGLLILL--IIPGLAVALLLLRLRPLK 173

                       170       180       190
                ....*....|....*....|....*....|...
gi 6324954  225 HTPMPSRDASSFKLLERIDFAGSVTGVVGLILF 257
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFL 206
MFS_1 pfam07690
Major Facilitator Superfamily;
311-459 6.23e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324954    311 FVLSCIAAGWASFGIWIFYTWQFMEDsRGQTPLLSSAQFSPVAISGFCAAVTTGFLLSHTPPSTVMLFAMTAFTVGTILI 390
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAED-LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324954    391 ATAPVhqtyWAQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNYSISIGLGIAGTI 459
Cdd:pfam07690  80 LFASS----LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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