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Conserved domains on  [gi|6324999|ref|NP_015067|]
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cyclin CLN2 [Saccharomyces cerevisiae S288C]

Protein Classification

cyclin family protein( domain architecture ID 11472088)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Saccharomyces cerevisiae S288C G1/S-specific cyclins and G2/mitotic-specific cyclins

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
33-524 2.00e-125

Cyclin [Cell division and chromosome partitioning];


:

Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 374.50  E-value: 2.00e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   33 HFEMLQEYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPVETRSNIITFLFELSVVTRVTNGIFFHSVRlydrycskrivl 112
Cdd:COG5024   1 HSESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLSTVTRLSNGINFHSSK------------ 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  113 rdQAKLVVATCLWLAAKTWGgcnhiinnvVIPTGgrfyGPNPRARIPRLSElvhycgdgQVFDESMFLQMerhildTLNW 192
Cdd:COG5024  69 --STKLVVGTCLWLAKKTWG---------IISSG----ESNERARIPRLSE--------CNLDSILFIQM------TLNE 119

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  193 NIYEPMInDYVLNVDENCLMQYELYENQVTYDK-QCSEKRQSQLSQDSDATVDERPYQNeeeeeEDLKLKIKLINLKKFL 271
Cdd:COG5024 120 DSYEPMI-DYILKKDENSLSPYELDENQLALDEkQAESKRESQSWQDLDATDQEDPLMV-----PEYASDIFEYLLKLEL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  272 IDVSAWQYdLLRYELFEVSHgiFSIINQFTNQDHGPFLMTPMTSESKNGeilstLMNGIVSIPNSLMEVYKTVNGVLPFI 351
Cdd:COG5024 194 IDLPNPNY-LIKQSLYEWSM--RSILVDWLVEVHGKFGLLPETLFLAIN-----IIDRFLSSRVVSLEKYQLVGISALFI 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  352 N-QVKEYHLDLQRKLQIASNLNISRKLTISTPSCSFENSNST-SIPSPASSsqshtpMRNMSSLSDNSVFSR-NMEQSSP 428
Cdd:COG5024 266 AsKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNiSWPSPMSF------LRRISKASDYDIFSRtPAKFSSE 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  429 ITPSMYQFGQQQsNSICGSTVSVNSLVNTNNKQriYEQITGPNSNNATNDyiDLLNLNESNKENQNPATAHYlNGGPPKT 508
Cdd:COG5024 340 ISPVDYKFIQIS-PSWCAAAAMYLSRKILSQNQ--WDRTLIHYSGNYTNP--DLKPLNESNKENLQNPSVHH-DAIFPKY 413

                       490
                ....*....|....*.
gi 6324999  509 SFINHGMFPSPTGTIN 524
Cdd:COG5024 414 PSPTFGKASSPTGEWI 429
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
33-524 2.00e-125

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 374.50  E-value: 2.00e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   33 HFEMLQEYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPVETRSNIITFLFELSVVTRVTNGIFFHSVRlydrycskrivl 112
Cdd:COG5024   1 HSESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLSTVTRLSNGINFHSSK------------ 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  113 rdQAKLVVATCLWLAAKTWGgcnhiinnvVIPTGgrfyGPNPRARIPRLSElvhycgdgQVFDESMFLQMerhildTLNW 192
Cdd:COG5024  69 --STKLVVGTCLWLAKKTWG---------IISSG----ESNERARIPRLSE--------CNLDSILFIQM------TLNE 119

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  193 NIYEPMInDYVLNVDENCLMQYELYENQVTYDK-QCSEKRQSQLSQDSDATVDERPYQNeeeeeEDLKLKIKLINLKKFL 271
Cdd:COG5024 120 DSYEPMI-DYILKKDENSLSPYELDENQLALDEkQAESKRESQSWQDLDATDQEDPLMV-----PEYASDIFEYLLKLEL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  272 IDVSAWQYdLLRYELFEVSHgiFSIINQFTNQDHGPFLMTPMTSESKNGeilstLMNGIVSIPNSLMEVYKTVNGVLPFI 351
Cdd:COG5024 194 IDLPNPNY-LIKQSLYEWSM--RSILVDWLVEVHGKFGLLPETLFLAIN-----IIDRFLSSRVVSLEKYQLVGISALFI 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  352 N-QVKEYHLDLQRKLQIASNLNISRKLTISTPSCSFENSNST-SIPSPASSsqshtpMRNMSSLSDNSVFSR-NMEQSSP 428
Cdd:COG5024 266 AsKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNiSWPSPMSF------LRRISKASDYDIFSRtPAKFSSE 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  429 ITPSMYQFGQQQsNSICGSTVSVNSLVNTNNKQriYEQITGPNSNNATNDyiDLLNLNESNKENQNPATAHYlNGGPPKT 508
Cdd:COG5024 340 ISPVDYKFIQIS-PSWCAAAAMYLSRKILSQNQ--WDRTLIHYSGNYTNP--DLKPLNESNKENLQNPSVHH-DAIFPKY 413

                       490
                ....*....|....*.
gi 6324999  509 SFINHGMFPSPTGTIN 524
Cdd:COG5024 414 PSPTFGKASSPTGEWI 429
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 76-193 1.33e-42

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 147.15  E-value: 1.33e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   76 NIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVATCLWLAAKTWGGCNhiinnvviptggrfygpnpr 155
Cdd:cd20559   1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKA-------------------- 60

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6324999  156 aRIPRLSELVHYCGDGQvfDESMFLQMERHILDTLNWN 193
Cdd:cd20559  61 -RVPLLSELSKMCCNSY--GEELFIQMEMHILNTLNWD 95
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 43-194 6.81e-29

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 111.07  E-value: 6.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999     43 EISTNVIAQSCKFKPNPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVAT 122
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINP-KMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6324999    123 CLWLAAKTwggcnhiinnvviptggrfygpnPRARIPRLSELVHYCGDgqVFDESMFLQMERHILDTLNWNI 194
Cdd:pfam00134  80 CLFIAAKY-----------------------EEIYPPTVEDLVYITDN--AYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 79-188 3.73e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.92  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999      79 TFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVATCLWLAAKTWGGCnhiinnvviptggrfygpnprari 158
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP------------------------ 56

                           90       100       110
                   ....*....|....*....|....*....|
gi 6324999     159 PRLSELVHYCGDgqvFDESMFLQMERHILD 188
Cdd:smart00385  57 PWTKELVHYTGY---FTEEEILRMERLLLE 83
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
33-524 2.00e-125

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 374.50  E-value: 2.00e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   33 HFEMLQEYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPVETRSNIITFLFELSVVTRVTNGIFFHSVRlydrycskrivl 112
Cdd:COG5024   1 HSESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLSTVTRLSNGINFHSSK------------ 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  113 rdQAKLVVATCLWLAAKTWGgcnhiinnvVIPTGgrfyGPNPRARIPRLSElvhycgdgQVFDESMFLQMerhildTLNW 192
Cdd:COG5024  69 --STKLVVGTCLWLAKKTWG---------IISSG----ESNERARIPRLSE--------CNLDSILFIQM------TLNE 119

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  193 NIYEPMInDYVLNVDENCLMQYELYENQVTYDK-QCSEKRQSQLSQDSDATVDERPYQNeeeeeEDLKLKIKLINLKKFL 271
Cdd:COG5024 120 DSYEPMI-DYILKKDENSLSPYELDENQLALDEkQAESKRESQSWQDLDATDQEDPLMV-----PEYASDIFEYLLKLEL 193

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  272 IDVSAWQYdLLRYELFEVSHgiFSIINQFTNQDHGPFLMTPMTSESKNGeilstLMNGIVSIPNSLMEVYKTVNGVLPFI 351
Cdd:COG5024 194 IDLPNPNY-LIKQSLYEWSM--RSILVDWLVEVHGKFGLLPETLFLAIN-----IIDRFLSSRVVSLEKYQLVGISALFI 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  352 N-QVKEYHLDLQRKLQIASNLNISRKLTISTPSCSFENSNST-SIPSPASSsqshtpMRNMSSLSDNSVFSR-NMEQSSP 428
Cdd:COG5024 266 AsKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNiSWPSPMSF------LRRISKASDYDIFSRtPAKFSSE 339

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  429 ITPSMYQFGQQQsNSICGSTVSVNSLVNTNNKQriYEQITGPNSNNATNDyiDLLNLNESNKENQNPATAHYlNGGPPKT 508
Cdd:COG5024 340 ISPVDYKFIQIS-PSWCAAAAMYLSRKILSQNQ--WDRTLIHYSGNYTNP--DLKPLNESNKENLQNPSVHH-DAIFPKY 413

                       490
                ....*....|....*.
gi 6324999  509 SFINHGMFPSPTGTIN 524
Cdd:COG5024 414 PSPTFGKASSPTGEWI 429
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 76-193 1.33e-42

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 147.15  E-value: 1.33e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   76 NIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVATCLWLAAKTWGGCNhiinnvviptggrfygpnpr 155
Cdd:cd20559   1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKA-------------------- 60

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6324999  156 aRIPRLSELVHYCGDGQvfDESMFLQMERHILDTLNWN 193
Cdd:cd20559  61 -RVPLLSELSKMCCNSY--GEELFIQMEMHILNTLNWD 95
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 43-194 6.81e-29

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 111.07  E-value: 6.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999     43 EISTNVIAQSCKFKPNPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVAT 122
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINP-KMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6324999    123 CLWLAAKTwggcnhiinnvviptggrfygpnPRARIPRLSELVHYCGDgqVFDESMFLQMERHILDTLNWNI 194
Cdd:pfam00134  80 CLFIAAKY-----------------------EEIYPPTVEDLVYITDN--AYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 79-188 3.73e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.92  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999      79 TFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVATCLWLAAKTWGGCnhiinnvviptggrfygpnprari 158
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP------------------------ 56

                           90       100       110
                   ....*....|....*....|....*....|
gi 6324999     159 PRLSELVHYCGDgqvFDESMFLQMERHILD 188
Cdd:smart00385  57 PWTKELVHYTGY---FTEEEILRMERLLLE 83
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 77-192 7.09e-10

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 56.07  E-value: 7.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   77 IITFLFELSVVTRvtngiffH-SVRLYDRYCSKRIVLRDQAKLVVATCLWLAAKTWGGCnhiinnvviptggrfygpnpr 155
Cdd:cd20528  16 VVSERLKLSDTTL-------HlAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELD--------------------- 67

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6324999  156 ARIPRLSELVHYCGDGQVFdESMFLQMERHILDTLNW 192
Cdd:cd20528  68 DNIPKISDLNRYLCNSVYS-KQEYLQMELLILEFFQW 103
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 39-191 6.70e-09

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 54.07  E-value: 6.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   39 EYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPVeTRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKL 118
Cdd:cd20507   3 EYVKDIYKYLRQLEKKYAIDPDYLSGQPEITER-MRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324999  119 VVATCLWLAAKtwggcnhiinnvviptggrfYgpnPRARIPRLSELVHYCGDgqVFDESMFLQMERHILDTLN 191
Cdd:cd20507  82 VGVTALLIASK--------------------Y---EEIYPPEIKDFVYITDN--AYTREEILQMERDILKTLD 129
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 39-129 1.29e-08

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 53.41  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   39 EYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKL 118
Cdd:cd20504   1 EYADDIYEYLRESELKHRPKPDYMRKQPDINP-SMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQL 79

                        90
                ....*....|.
gi 6324999  119 VVATCLWLAAK 129
Cdd:cd20504  80 VGTACMFIAAK 90
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 36-192 8.85e-08

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 51.14  E-value: 8.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   36 MLQEYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPVeTRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQ 115
Cdd:cd20568   4 MVAEYVPEIFEYLRELELKTLPNPNYMDDQKELRWK-MRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324999  116 AKLVVATCLWLAAKtwggcnhiINNVVIPTGGRFYgpnprariprlselvhYCGDGqVFDESMFLQMERHILDTLNW 192
Cdd:cd20568  83 LQLVGISALFIASK--------YEEVNSPSIKNFA----------------YMTDG-AYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 39-191 8.49e-07

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 48.40  E-value: 8.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   39 EYHQEISTNVIAQSCKFKPnPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKL 118
Cdd:cd20508  15 EYAKDIFDYMKEREEKFVV-PDYLEKQTELTP-SMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQL 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324999  119 VVATCLWLAAKtwggcnhiinnvviptggrFYGPNPrariPRLSELVHYCGDGqvFDESMFLQMERHILDTLN 191
Cdd:cd20508  93 LGATAILIASK-------------------FDERCP----PCVDDFLYICDDA--YTREELLKMEREILKTLD 140
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 76-132 9.25e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 46.63  E-value: 9.25e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324999   76 NIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKLVVATCLWLAAKTWG 132
Cdd:cd00043   1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE 57
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 54-192 1.47e-05

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 44.61  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   54 KFKPNPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCS-KRIVLRDQAKLVVATCLWLAAKtwg 132
Cdd:cd20519  18 LYKRDRDFLNRHPSLQP-RMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLStQTNVPKTQLQLIGITCLFIAAK--- 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  133 gcnhiINNVviptggrfygpnpraRIPRLSELVhYCGDGqVFDESMFLQMERHILDTLNW 192
Cdd:cd20519  94 -----LEEI---------------YPPKLSEFA-YVTDG-ACTEDEILTMELIILKALNW 131
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 39-193 2.46e-05

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 44.28  E-value: 2.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   39 EYHQEISTNVIAQSCKFKPNPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQAKL 118
Cdd:cd20561   3 DYHEDIHTYLREMEVKCKPKVGYMKKQPDITN-SMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6324999  119 VVATCLWLAAKtwggcnhiinnvviptggrFYGPNPrariPRLSELVHYCGDgqVFDESMFLQMERHILDTLNWN 193
Cdd:cd20561  82 VGTAAMLLASK-------------------FEEIYP----PEVAEFVYITDD--TYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 39-192 1.58e-03

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 39.25  E-value: 1.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999   39 EYHQEIST---NVIAQSCkfkPNPKLIDQQPEMNPvETRSNIITFLFELSVVTRVTNGIFFHSVRLYDRYCSKRIVLRDQ 115
Cdd:cd20567  20 EYVEDIYSfyrKVEPESC---VPPYYMSQQPDINE-KMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKE 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  116 AKLVVATCLWLAAK---TWggcnhiinnvviptggrfygpnprarIPRLSELVhYCGDgQVFDESMFLQMERHILDTLNW 192
Cdd:cd20567  96 LQLVGVTAMLIASKyeeIW--------------------------APEVNDFV-YISD-NAYTRKQILVMEKTMLNTLEF 147
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 382-500 3.35e-03

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 40.00  E-value: 3.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324999  382 PSCSFENSNSTSIPSPASSSQSHTPMRNMSSLSDNSVFSRNMEQSS-PITPSMYQFGQQQSNSICGSTVSVNSLV-NTNN 459
Cdd:COG5068 220 PTVPHSNTNNGRPPAKFMIPELHSSHSTLDLPSDFISDSGFPNQSStSIFPLDSAIIQITPPHLPNNPPQENRHElYSND 299

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6324999  460 KQRIYEQITGPNSNNATNDYIDLLNLNESNKENQNPATAHY 500
Cdd:COG5068 300 SSMVSETPPPKNLPNGSPNQSPLNNLSRGNPASPNSIIREN 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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