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Conserved domains on  [gi|6325010|ref|NP_015078|]
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putative rhomboid protease RBD2 [Saccharomyces cerevisiae S288C]

Protein Classification

rhomboid family protein( domain architecture ID 10483871)

rhomboid family protein may be an intramembrane serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors, or an inactive rhomboid protein that lacks the conserved active sites and has no peptidase activity

CATH:  1.20.1540.10
Gene Ontology:  GO:0016020
MEROPS:  S54
PubMed:  24099005|22035660|26527717|12620104
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 47-196 1.49e-25

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 98.06  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010     47 SLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALFAGILYCLLGKLLYPealVAGASGW 126
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTP---SVGASGA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325010    127 CFTLFAYYSFKESQIRPRTRIFrtdYSIPTLYTPLVLLVAIAVVIPGS--SFWGHFFGLCVGYAIGYKESWF 196
Cdd:pfam01694  78 IFGLLGALLVLGPRNRILLFGL---IGALLALLLFILLNLVLGLLPGNgvSNLAHLGGLLVGLLLGFILLRR 146
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 47-196 1.49e-25

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 98.06  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010     47 SLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALFAGILYCLLGKLLYPealVAGASGW 126
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTP---SVGASGA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325010    127 CFTLFAYYSFKESQIRPRTRIFrtdYSIPTLYTPLVLLVAIAVVIPGS--SFWGHFFGLCVGYAIGYKESWF 196
Cdd:pfam01694  78 IFGLLGALLVLGPRNRILLFGL---IGALLALLLFILLNLVLGLLPGNgvSNLAHLGGLLVGLLLGFILLRR 146
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 17-191 7.96e-16

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 73.35  E-value: 7.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010   17 LTTGLVVFLTAIYLLSFIF--ALREDLSLAPESLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGV 94
Cdd:COG0705   5 VTLALIALNVLVFLLQLLLggELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010   95 FLNLSALFAGILYCLLGklLYPEALVAGASGWCFTLFAYYSFkesqIRPRTRIFRTDYSIPTLYTpLVLLVAIAVVI--- 171
Cdd:COG0705  85 LYLLSGLGGGLLQLLFS--PGSGYPLVGASGAIFGLLGALLV----LGPRRRVLLLFIPIPALLF-LLVWLLLGLLFgll 157

                       170       180
                ....*....|....*....|..
gi 6325010  172 --PGSSFWGHFFGLCVGYAIGY 191
Cdd:COG0705 158 ggGGIAWEAHLGGLLAGLLLAL 179
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 47-196 1.49e-25

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 98.06  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010     47 SLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALFAGILYCLLGKLLYPealVAGASGW 126
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLSTP---SVGASGA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325010    127 CFTLFAYYSFKESQIRPRTRIFrtdYSIPTLYTPLVLLVAIAVVIPGS--SFWGHFFGLCVGYAIGYKESWF 196
Cdd:pfam01694  78 IFGLLGALLVLGPRNRILLFGL---IGALLALLLFILLNLVLGLLPGNgvSNLAHLGGLLVGLLLGFILLRR 146
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 17-191 7.96e-16

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 73.35  E-value: 7.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010   17 LTTGLVVFLTAIYLLSFIF--ALREDLSLAPESLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGV 94
Cdd:COG0705   5 VTLALIALNVLVFLLQLLLggELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325010   95 FLNLSALFAGILYCLLGklLYPEALVAGASGWCFTLFAYYSFkesqIRPRTRIFRTDYSIPTLYTpLVLLVAIAVVI--- 171
Cdd:COG0705  85 LYLLSGLGGGLLQLLFS--PGSGYPLVGASGAIFGLLGALLV----LGPRRRVLLLFIPIPALLF-LLVWLLLGLLFgll 157

                       170       180
                ....*....|....*....|..
gi 6325010  172 --PGSSFWGHFFGLCVGYAIGY 191
Cdd:COG0705 158 ggGGIAWEAHLGGLLAGLLLAL 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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