GTPase BMS1 [Saccharomyces cerevisiae S288C]
Protein Classification
BMS1 family protein( domain architecture ID 11474123)
BMS1 family protein similar to Saccharomyces cerevisiae ribosome biogenesis protein BMS1, which may act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||||||||||
| BMS1 | COG5192 | GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ... |
1-1182 | 0e+00 | ||||||||||||||||
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; : Pssm-ID: 227519 [Multi-domain] Cd Length: 1077 Bit Score: 1656.02 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||
| BMS1 | COG5192 | GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ... |
1-1182 | 0e+00 | ||||||||||||||||
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227519 [Multi-domain] Cd Length: 1077 Bit Score: 1656.02 E-value: 0e+00
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| BMS1 | cd01882 | Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ... |
30-261 | 2.06e-151 | ||||||||||||||||
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes. Pssm-ID: 206669 [Multi-domain] Cd Length: 231 Bit Score: 452.56 E-value: 2.06e-151
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| RIBIOP_C | pfam04950 | 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal; RIBIOP_C is a family of eukaryotic ... |
709-1009 | 1.31e-104 | ||||||||||||||||
40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal; RIBIOP_C is a family of eukaryotic proteins from the C-terminus of pre-rRNA-processing protein or ribosome biogenesis proteins BMS1 and TSR1. These proteins act, in the nucleolus, as a molecular switch during maturation of the 40S ribosomal subunit. This domain, domain IV of translation elongation factor selb, adopts the same fold as translation proteins such as domain II of GTP-elongation factor Tu proteins. Pssm-ID: 461497 [Multi-domain] Cd Length: 284 Bit Score: 330.96 E-value: 1.31e-104
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| AARP2CN | smart00785 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
219-308 | 2.87e-37 | ||||||||||||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 129021 [Multi-domain] Cd Length: 83 Bit Score: 134.61 E-value: 2.87e-37
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||
| BMS1 | COG5192 | GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ... |
1-1182 | 0e+00 | ||||||||||||||||
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227519 [Multi-domain] Cd Length: 1077 Bit Score: 1656.02 E-value: 0e+00
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| BMS1 | cd01882 | Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ... |
30-261 | 2.06e-151 | ||||||||||||||||
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes. Pssm-ID: 206669 [Multi-domain] Cd Length: 231 Bit Score: 452.56 E-value: 2.06e-151
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| RIBIOP_C | pfam04950 | 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal; RIBIOP_C is a family of eukaryotic ... |
709-1009 | 1.31e-104 | ||||||||||||||||
40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal; RIBIOP_C is a family of eukaryotic proteins from the C-terminus of pre-rRNA-processing protein or ribosome biogenesis proteins BMS1 and TSR1. These proteins act, in the nucleolus, as a molecular switch during maturation of the 40S ribosomal subunit. This domain, domain IV of translation elongation factor selb, adopts the same fold as translation proteins such as domain II of GTP-elongation factor Tu proteins. Pssm-ID: 461497 [Multi-domain] Cd Length: 284 Bit Score: 330.96 E-value: 1.31e-104
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| AARP2CN | pfam08142 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
219-307 | 8.95e-41 | ||||||||||||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 462369 Cd Length: 86 Bit Score: 144.57 E-value: 8.95e-41
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| AARP2CN | smart00785 | AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to ... |
219-308 | 2.87e-37 | ||||||||||||||||
AARP2CN (NUC121) domain; This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU. Pssm-ID: 129021 [Multi-domain] Cd Length: 83 Bit Score: 134.61 E-value: 2.87e-37
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| GTP_translation_factor | cd00881 | GTP translation factor family primarily contains translation initiation, elongation and ... |
71-222 | 2.21e-22 | ||||||||||||||||
GTP translation factor family primarily contains translation initiation, elongation and release factors; The GTP translation factor family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function. Pssm-ID: 206647 [Multi-domain] Cd Length: 183 Bit Score: 95.82 E-value: 2.21e-22
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| COG5177 | COG5177 | Uncharacterized conserved protein [Function unknown]; |
586-1003 | 1.07e-17 | ||||||||||||||||
Uncharacterized conserved protein [Function unknown]; Pssm-ID: 227504 [Multi-domain] Cd Length: 769 Bit Score: 88.60 E-value: 1.07e-17
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| Ras_like_GTPase | cd00882 | Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ... |
73-176 | 5.22e-08 | ||||||||||||||||
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions. Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 53.61 E-value: 5.22e-08
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| MMR_HSR1 | pfam01926 | 50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ... |
72-168 | 1.29e-07 | ||||||||||||||||
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide. Pssm-ID: 460387 [Multi-domain] Cd Length: 113 Bit Score: 51.08 E-value: 1.29e-07
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| GTP_EFTU | pfam00009 | Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in ... |
71-201 | 2.50e-06 | ||||||||||||||||
Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains. Pssm-ID: 425418 [Multi-domain] Cd Length: 187 Bit Score: 49.06 E-value: 2.50e-06
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| Gem1 | COG1100 | GTPase SAR1 family domain [General function prediction only]; |
72-208 | 6.21e-06 | ||||||||||||||||
GTPase SAR1 family domain [General function prediction only]; Pssm-ID: 440717 [Multi-domain] Cd Length: 177 Bit Score: 48.05 E-value: 6.21e-06
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| Era | cd04163 | E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ... |
72-208 | 1.96e-05 | ||||||||||||||||
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA. Pssm-ID: 206726 [Multi-domain] Cd Length: 168 Bit Score: 46.30 E-value: 1.96e-05
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| Era_like | cd00880 | E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ... |
73-176 | 2.04e-05 | ||||||||||||||||
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Pssm-ID: 206646 [Multi-domain] Cd Length: 161 Bit Score: 46.08 E-value: 2.04e-05
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| AAA | pfam00004 | ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
74-143 | 2.49e-05 | ||||||||||||||||
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 44.89 E-value: 2.49e-05
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| EF-G_bact | cd04170 | Elongation factor G (EF-G) family; Translocation is mediated by EF-G (also called translocase). ... |
72-193 | 4.75e-05 | ||||||||||||||||
Elongation factor G (EF-G) family; Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so that it mimics the shape of a tRNA molecule. EF-G in the GTP form binds to the ribosome, primarily through the interaction of its EF-Tu-like domain with the 50S subunit. The binding of EF-G to the ribosome in this manner stimulates the GTPase activity of EF-G. On GTP hydrolysis, EF-G undergoes a conformational change that forces its arm deeper into the A site on the 30S subunit. To accommodate this domain, the peptidyl-tRNA in the A site moves to the P site, carrying the mRNA and the deacylated tRNA with it. The ribosome may be prepared for these rearrangements by the initial binding of EF-G as well. The dissociation of EF-G leaves the ribosome ready to accept the next aminoacyl-tRNA into the A site. This group contains only bacterial members. Pssm-ID: 206733 [Multi-domain] Cd Length: 268 Bit Score: 46.43 E-value: 4.75e-05
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| AAA_22 | pfam13401 | AAA domain; |
71-168 | 1.50e-04 | ||||||||||||||||
AAA domain; Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 42.71 E-value: 1.50e-04
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
68-143 | 2.31e-04 | ||||||||||||||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 42.75 E-value: 2.31e-04
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| DEXXQc_Upf1-like | cd17934 | DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
71-112 | 4.81e-04 | ||||||||||||||||
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 41.07 E-value: 4.81e-04
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| AAA_33 | pfam13671 | AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ... |
72-193 | 7.59e-04 | ||||||||||||||||
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif. Pssm-ID: 463952 [Multi-domain] Cd Length: 143 Bit Score: 41.14 E-value: 7.59e-04
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| ExeA | COG3267 | Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ... |
71-93 | 1.42e-03 | ||||||||||||||||
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]; Pssm-ID: 442498 [Multi-domain] Cd Length: 261 Bit Score: 41.70 E-value: 1.42e-03
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| AAA | cd00009 | The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
67-143 | 1.56e-03 | ||||||||||||||||
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases. Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 40.21 E-value: 1.56e-03
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| AAA_16 | pfam13191 | AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
59-116 | 2.63e-03 | ||||||||||||||||
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 40.18 E-value: 2.63e-03
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| MobB | COG1763 | Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ... |
71-139 | 3.01e-03 | ||||||||||||||||
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis Pssm-ID: 441369 [Multi-domain] Cd Length: 162 Bit Score: 39.78 E-value: 3.01e-03
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| MK0520 | COG2401 | ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ... |
40-141 | 4.77e-03 | ||||||||||||||||
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 39.94 E-value: 4.77e-03
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| DUF5401 | pfam17380 | Family of unknown function (DUF5401); This is a family of unknown function found in ... |
1056-1181 | 5.98e-03 | ||||||||||||||||
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea. Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 40.88 E-value: 5.98e-03
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| NACHT | pfam05729 | NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
72-144 | 6.08e-03 | ||||||||||||||||
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931. Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 38.83 E-value: 6.08e-03
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| HypB | COG0378 | Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ... |
69-93 | 8.75e-03 | ||||||||||||||||
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440147 [Multi-domain] Cd Length: 200 Bit Score: 38.89 E-value: 8.75e-03
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| AAA_11 | pfam13086 | AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
69-104 | 9.40e-03 | ||||||||||||||||
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 39.25 E-value: 9.40e-03
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