|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
23-1140 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 671.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 23 CAMYGNCGKKSVfGNELPCPVPRSFEPPvlSDETSKLLVEVCGEEWKEV-RYACCTKDQVVALRDNLQKAQPLISSCPAC 101
Cdd:TIGR00917 1 CAMYDICGARSD-GKVLNCPYNIPSVKP--PDLLSSLIQSLCQYSHPTIsGNVCCTETQFDTLRSNVQQAIPFIVRCPAC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 102 LKNFNNLFCHFTCAADQGRFVNITKVEKSKeDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQ 181
Cdd:TIGR00917 78 LRNFLNLFCELTCSPDQSLFINVTSTTKVK-TNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKNFKE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 182 FLKFLGD-AKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESC-----PHLKPLKDGVC--KVG 253
Cdd:TIGR00917 157 WFNWIGQkAGVNLPGAPYGIAFLPTPCPVSSGMRPMNVSIYSCGDESLGCSCGDCPSAAtcsckAKVPTQKKHSCsiKLG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 254 pLPCFSLSVLIFYTICALFAFMWYYL----CKRKK---NGAMIVDDDIVPESGSLDESETNvfesfNNE--TNFFNGKLA 324
Cdd:TIGR00917 237 -VKCVDFILAILYIVLVSVFLGGGLLhpvrGKKKTsqmGTLSEADGEINSVNQQKDQNTPQ-----RNWgqLSTVQGHLA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 325 NLFTKVGQFSVENP-YKILITTVFSIFVFSFIIFqyATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVV--- 400
Cdd:TIGR00917 311 RFFGKYGIWVARHPtLVICLSVSVVLLLCVGLIR--FKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIAtvq 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 401 ----NETGPVLSYETLHWWFDVENFItEELQSS---ENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRE---- 469
Cdd:TIGR00917 389 tsshEKAPEILTDDNLKLLFDIQKKV-SQLFANyegELITLDSPCFKPNHPYNCFIYSTCKKLQNMYSKLKPENYDdygg 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 470 ------LQECGKFPVNCLPTFQQPLKTNLL---FSDDDILNAHAFVVTLLL------TNHTQSANRWEERLEEYLLDLKV 534
Cdd:TIGR00917 468 vdyvkyCFEHFTSPESCLSAFGGPVDPTTVlggFSGNNFSEASAFVVTFPVnnfvnkTNKTEKAVAWEKAFIQLAKDELL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 535 P-EGLRISFNTEISLEKELN--NNNDISTVAISYLMMFLYATWAL------RRKDGKTRLLLGISGLLIVLASIVCAAGF 605
Cdd:TIGR00917 548 PmVQATISFSAERSIEDELKreSTADVITIAISYLVMFAYISLTLgdsprlKSLYVTSKVLLGLSGILIVMLSVLGSVGV 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 606 LTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDR--------NCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGC 677
Cdd:TIGR00917 628 FSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYleyfyrqvGVDNEQELTLERRLSRALMEVGPSITLASLSEILA 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 678 FLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQI----------------TGNEETKES----F 737
Cdd:TIGR00917 708 FALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVdcfpciktskssisaeKGSGQRKAGlltrY 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 738 LKTFYFKMLTQ---KRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVK-NLDLT 813
Cdd:TIGR00917 788 FKEVYAPVLLHwivKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKgDYNYT 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 814 KRQNQQKICGkFTTCERDSLANVLEQerhRSTITEPLANWLDDYFMFLNPQNdQCCRLKKGTDEVCPPSFPSrrCETCFQ 893
Cdd:TIGR00917 868 DFESQNKLCT-MGGCDKDSIVNVFNN---LSYIAKPASSWLDDYLVWLSPQA-SCCCRKFTNGTFCNGPDPQ--CFRCAD 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 894 QGSwnyNMSGFPEGKDFMEYLSIWINA-PSDPCPLGGRAPYSTALVYN--ETSVSASVFRTAHHPLRSQKDFIQAYSDGV 970
Cdd:TIGR00917 941 LSS---DAQGRPSTTQFKEKLPWFLNAlPSADCAKGGHAAYSSAVDLQgyATIIQASSFRTYHTPLNTQVDFINAMRAAQ 1017
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 971 RISSSFPE---LDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQ-NIRSSFLLALVVTMIIVDIGALMAL 1046
Cdd:TIGR00917 1018 EFAAKVSRsskMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQlNALSVVNLIMSVGMAVVFCVGIMHL 1097
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1047 LGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVvpsETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIF 1126
Cdd:TIGR00917 1098 WSISLNAVSVVNSVMHKGIAIEFCTHINAQFST---GKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIF 1174
|
1210
....*....|....
gi 6325251 1127 DVFYFRMWFTLIIV 1140
Cdd:TIGR00917 1175 VVYYFRMYLALVLL 1188
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
23-257 |
7.61e-113 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 351.14 E-value: 7.61e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 23 CAMYGNCGKKSVFGNELPCPVPRsfEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACL 102
Cdd:pfam16414 3 CAWYGECGKKSLFGKDLPCPYNG--PAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 103 KNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQF 182
Cdd:pfam16414 81 KNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGACNYTRW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 183 LKFLGDAKpmLGGSPFQINYKYDLANEEKEWQEFNDEVYACD---DAQYKCACSDCQESCP---HLKPLKDGVCKVGPLP 256
Cdd:pfam16414 161 LKFMGDKK--NGGSPFQINFPDPPEEDPSGMVPLNPNTKDCNesyDASYACSCVDCPLSCPpppQLPPPPHGPCKVGGLD 238
|
.
gi 6325251 257 C 257
Cdd:pfam16414 239 G 239
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
325-1139 |
1.38e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 129.98 E-value: 1.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 325 NLFTKVGQFSVENPYKILITTVFsIFVFSFIIFQYATLETDPINlWVSKNSEKFKEKEYFDDNFGPfyrTEQIFVVNETG 404
Cdd:COG1033 2 RLMERLARFILRHRKLVLLLFLL-LTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVVAVEGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 405 P-VLSYETLHWWFDvenfITEELQSSENI----GYQDLCF-RPTEDSTCVIESFTQYFQGALPNKDSWKRELQecgkfpv 478
Cdd:COG1033 77 DdIFTPETLEALRE----LTEELEEIPGVdsvtSLTNVRAtEGTEDGLTVEPLIPDELPASPEELAELREKVL------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 479 nclptfQQPLKTNLLFSDDdiLNAHAFVVTLLLTNHTQSANRWE--ERLEEyLLDLKVPEGLRI------SFNTEI--SL 548
Cdd:COG1033 146 ------SSPLYVGRLVSPD--GKATLIVVTLDPDPLSSDLDRKEvvAEIRA-IIAKYEDPGVEVyltgfpVLRGDIaeAI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 549 EKELnnnndISTVAISYLMMFLYATWALRRkdgktrLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAeVIPFLILAI 628
Cdd:COG1033 217 QSDL-----AIFFPLALLLILLLLFLFFRS------LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 629 GIDN-IFLItHEYDRNCEQkpEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQ 707
Cdd:COG1033 285 GIDYgIHLL-NRYREERRK--GLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 708 LTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDS--- 784
Cdd:COG1033 362 LTLLPALLSLLPRPKPKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpir 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 785 YLVDYFKDVYSFLNvgpPVYMVV---KNLDLTKRQNQQKIcgkfttcerDSLANVLEQerhRSTITEPLAnwLDDYFMFL 861
Cdd:COG1033 442 QDLDFIEENFGGSD---PLEVVVdtgEPDGLKDPEVLKEI---------DRLQDYLES---LPEVGKVLS--LADLVKEL 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 862 NpqndqccrlkKGTDEVCPPSF--PSRRcETCFQQgswnYNMSGFPEGKDFMEYLSiwinapSDpcplggrapYSTALVy 939
Cdd:COG1033 505 N----------QALNEGDPKYYalPESR-ELLAQL----LLLLSSPPGDDLSRFVD------ED---------YSAARV- 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 940 netsvsasVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVF 1019
Cdd:COG1033 554 --------TVRLKDLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLA 625
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1020 LQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTvvpSETKKDANSR--VLYSLN 1097
Cdd:COG1033 626 FRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYR---EERRKGGDLEeaIRRALR 702
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 6325251 1098 TIGESVIkGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLII 1139
Cdd:COG1033 703 TTGKAIL-FTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV 743
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
1002-1083 |
1.15e-05 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 49.90 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1002 LKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVP 1081
Cdd:PRK15127 341 VKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420
|
..
gi 6325251 1082 SE 1083
Cdd:PRK15127 421 AE 422
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
1000-1068 |
3.18e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 41.93 E-value: 3.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6325251 1000 LTLKLIGSAIILIFFIssvFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVE 1068
Cdd:NF033617 334 STLLEAVALVILVVFL---FLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
23-1140 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 671.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 23 CAMYGNCGKKSVfGNELPCPVPRSFEPPvlSDETSKLLVEVCGEEWKEV-RYACCTKDQVVALRDNLQKAQPLISSCPAC 101
Cdd:TIGR00917 1 CAMYDICGARSD-GKVLNCPYNIPSVKP--PDLLSSLIQSLCQYSHPTIsGNVCCTETQFDTLRSNVQQAIPFIVRCPAC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 102 LKNFNNLFCHFTCAADQGRFVNITKVEKSKeDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQ 181
Cdd:TIGR00917 78 LRNFLNLFCELTCSPDQSLFINVTSTTKVK-TNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKNFKE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 182 FLKFLGD-AKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESC-----PHLKPLKDGVC--KVG 253
Cdd:TIGR00917 157 WFNWIGQkAGVNLPGAPYGIAFLPTPCPVSSGMRPMNVSIYSCGDESLGCSCGDCPSAAtcsckAKVPTQKKHSCsiKLG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 254 pLPCFSLSVLIFYTICALFAFMWYYL----CKRKK---NGAMIVDDDIVPESGSLDESETNvfesfNNE--TNFFNGKLA 324
Cdd:TIGR00917 237 -VKCVDFILAILYIVLVSVFLGGGLLhpvrGKKKTsqmGTLSEADGEINSVNQQKDQNTPQ-----RNWgqLSTVQGHLA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 325 NLFTKVGQFSVENP-YKILITTVFSIFVFSFIIFqyATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVV--- 400
Cdd:TIGR00917 311 RFFGKYGIWVARHPtLVICLSVSVVLLLCVGLIR--FKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIAtvq 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 401 ----NETGPVLSYETLHWWFDVENFItEELQSS---ENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRE---- 469
Cdd:TIGR00917 389 tsshEKAPEILTDDNLKLLFDIQKKV-SQLFANyegELITLDSPCFKPNHPYNCFIYSTCKKLQNMYSKLKPENYDdygg 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 470 ------LQECGKFPVNCLPTFQQPLKTNLL---FSDDDILNAHAFVVTLLL------TNHTQSANRWEERLEEYLLDLKV 534
Cdd:TIGR00917 468 vdyvkyCFEHFTSPESCLSAFGGPVDPTTVlggFSGNNFSEASAFVVTFPVnnfvnkTNKTEKAVAWEKAFIQLAKDELL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 535 P-EGLRISFNTEISLEKELN--NNNDISTVAISYLMMFLYATWAL------RRKDGKTRLLLGISGLLIVLASIVCAAGF 605
Cdd:TIGR00917 548 PmVQATISFSAERSIEDELKreSTADVITIAISYLVMFAYISLTLgdsprlKSLYVTSKVLLGLSGILIVMLSVLGSVGV 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 606 LTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDR--------NCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGC 677
Cdd:TIGR00917 628 FSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYleyfyrqvGVDNEQELTLERRLSRALMEVGPSITLASLSEILA 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 678 FLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQI----------------TGNEETKES----F 737
Cdd:TIGR00917 708 FALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVdcfpciktskssisaeKGSGQRKAGlltrY 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 738 LKTFYFKMLTQ---KRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVK-NLDLT 813
Cdd:TIGR00917 788 FKEVYAPVLLHwivKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKgDYNYT 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 814 KRQNQQKICGkFTTCERDSLANVLEQerhRSTITEPLANWLDDYFMFLNPQNdQCCRLKKGTDEVCPPSFPSrrCETCFQ 893
Cdd:TIGR00917 868 DFESQNKLCT-MGGCDKDSIVNVFNN---LSYIAKPASSWLDDYLVWLSPQA-SCCCRKFTNGTFCNGPDPQ--CFRCAD 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 894 QGSwnyNMSGFPEGKDFMEYLSIWINA-PSDPCPLGGRAPYSTALVYN--ETSVSASVFRTAHHPLRSQKDFIQAYSDGV 970
Cdd:TIGR00917 941 LSS---DAQGRPSTTQFKEKLPWFLNAlPSADCAKGGHAAYSSAVDLQgyATIIQASSFRTYHTPLNTQVDFINAMRAAQ 1017
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 971 RISSSFPE---LDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQ-NIRSSFLLALVVTMIIVDIGALMAL 1046
Cdd:TIGR00917 1018 EFAAKVSRsskMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQlNALSVVNLIMSVGMAVVFCVGIMHL 1097
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1047 LGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVvpsETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIF 1126
Cdd:TIGR00917 1098 WSISLNAVSVVNSVMHKGIAIEFCTHINAQFST---GKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIF 1174
|
1210
....*....|....
gi 6325251 1127 DVFYFRMWFTLIIV 1140
Cdd:TIGR00917 1175 VVYYFRMYLALVLL 1188
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
23-257 |
7.61e-113 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 351.14 E-value: 7.61e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 23 CAMYGNCGKKSVFGNELPCPVPRsfEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACL 102
Cdd:pfam16414 3 CAWYGECGKKSLFGKDLPCPYNG--PAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 103 KNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQF 182
Cdd:pfam16414 81 KNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGACNYTRW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 183 LKFLGDAKpmLGGSPFQINYKYDLANEEKEWQEFNDEVYACD---DAQYKCACSDCQESCP---HLKPLKDGVCKVGPLP 256
Cdd:pfam16414 161 LKFMGDKK--NGGSPFQINFPDPPEEDPSGMVPLNPNTKDCNesyDASYACSCVDCPLSCPpppQLPPPPHGPCKVGGLD 238
|
.
gi 6325251 257 C 257
Cdd:pfam16414 239 G 239
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
376-1139 |
1.65e-44 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 174.08 E-value: 1.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 376 EKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIG---YQDLCfrptedstcviesf 452
Cdd:pfam02460 28 EPLVENKFFPGDSYPEARFLIITAKGRNSNILDISYLNDIYQLNDYISTNVEIQVDGIiisFKDLC-------------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 453 TQYFQGALPNKDSWKRELQECGK----------FPVNCLPTFQQPLKTNLLFSDDDILN-AHAFVVTLLLTNHT----QS 517
Cdd:pfam02460 94 SRYCDLNCPVNKHYNGMLLSRRHntriditypiMPVLGTPIYLGPHFGGVDFEPPGNISyAKAIVLWYFLKFDEeeveED 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 518 ANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNND--ISTVAISYLMMFLYATWALRRkDGKTRLLLGISGLLIV 595
Cdd:pfam02460 174 SKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALtlTPFFVIGFFLLLTFSIIVSVT-LSSYTIDWVRSKPILA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 596 LASIVC-------AAGFLTLFGLKSTLIIAeVIPFLILAIGIDNIFLITHEYDRNceqKPEYSIDQKIISAIGRMSPSIL 668
Cdd:pfam02460 253 ALGLLSpvmaivsSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRT---TATLSVKKRMGEALSEAGVSIT 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 669 MSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKR-------------SNYKQI-------- 727
Cdd:pfam02460 329 ITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPeaegrhclfvwatSSPQRIdsegsepd 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 728 --TGNEETKESFLKTFYFKMLTQKR---LIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYS-FLNVGP 801
Cdd:pfam02460 409 ksHNIEQLKSRFFLDIYCPFLLNPSvrvCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKhFWPEGL 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 802 PVYMVVKNldltkrqnqqkiCGKFTTCE-RDSLANVLEQERHRSTITEPLAN--WLDDYFMFLNPQNDQccrlkkgtdev 878
Cdd:pfam02460 489 QIQVAVNN------------PPNLTIPEsRDRMNEMVDEFENTPYSLGPNSTlfWLREYENFLSTLNME----------- 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 879 cppsfpsrrcETCFQQGSWNYNMsgfpegkdfmeyLSIWINAPsdpcplgGRAPYSTALVYNE--TSVSASVFRTAHHPL 956
Cdd:pfam02460 546 ----------EEEDEEKEWSYGN------------LPSFLKAP-------GNSHWAGDLVWDDntTMVTKFRFTLAGKGL 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 957 RSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMI 1036
Cdd:pfam02460 597 STWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASI 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1037 IVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTvvpSETKKDANSRVLYSLNTIGESVIKGITLTkFIGVC 1116
Cdd:pfam02460 677 DIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFV---RSRGDTPAERVVDALEALGWPVFQGGLST-ILGVL 752
|
810 820
....*....|....*....|...
gi 6325251 1117 VLAFAQSKIFDVFYFRMWFTLII 1139
Cdd:pfam02460 753 VLLFVPSYMVVVFFKTVFLVVAI 775
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
595-721 |
3.94e-37 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 136.94 E-value: 3.94e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 595 VLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNceqKPEYSIDQKIISAIGRMSPSILMSLLCQ 674
Cdd:pfam12349 16 VLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRT---PRSLDVSERIAEALGEVGPSITLTSLTE 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 6325251 675 TGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKR 721
Cdd:pfam12349 93 ILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRR 139
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
325-1139 |
1.38e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 129.98 E-value: 1.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 325 NLFTKVGQFSVENPYKILITTVFsIFVFSFIIFQYATLETDPINlWVSKNSEKFKEKEYFDDNFGPfyrTEQIFVVNETG 404
Cdd:COG1033 2 RLMERLARFILRHRKLVLLLFLL-LTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVVAVEGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 405 P-VLSYETLHWWFDvenfITEELQSSENI----GYQDLCF-RPTEDSTCVIESFTQYFQGALPNKDSWKRELQecgkfpv 478
Cdd:COG1033 77 DdIFTPETLEALRE----LTEELEEIPGVdsvtSLTNVRAtEGTEDGLTVEPLIPDELPASPEELAELREKVL------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 479 nclptfQQPLKTNLLFSDDdiLNAHAFVVTLLLTNHTQSANRWE--ERLEEyLLDLKVPEGLRI------SFNTEI--SL 548
Cdd:COG1033 146 ------SSPLYVGRLVSPD--GKATLIVVTLDPDPLSSDLDRKEvvAEIRA-IIAKYEDPGVEVyltgfpVLRGDIaeAI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 549 EKELnnnndISTVAISYLMMFLYATWALRRkdgktrLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAeVIPFLILAI 628
Cdd:COG1033 217 QSDL-----AIFFPLALLLILLLLFLFFRS------LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 629 GIDN-IFLItHEYDRNCEQkpEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQ 707
Cdd:COG1033 285 GIDYgIHLL-NRYREERRK--GLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 708 LTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDS--- 784
Cdd:COG1033 362 LTLLPALLSLLPRPKPKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpir 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 785 YLVDYFKDVYSFLNvgpPVYMVV---KNLDLTKRQNQQKIcgkfttcerDSLANVLEQerhRSTITEPLAnwLDDYFMFL 861
Cdd:COG1033 442 QDLDFIEENFGGSD---PLEVVVdtgEPDGLKDPEVLKEI---------DRLQDYLES---LPEVGKVLS--LADLVKEL 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 862 NpqndqccrlkKGTDEVCPPSF--PSRRcETCFQQgswnYNMSGFPEGKDFMEYLSiwinapSDpcplggrapYSTALVy 939
Cdd:COG1033 505 N----------QALNEGDPKYYalPESR-ELLAQL----LLLLSSPPGDDLSRFVD------ED---------YSAARV- 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 940 netsvsasVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVF 1019
Cdd:COG1033 554 --------TVRLKDLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLA 625
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1020 LQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTvvpSETKKDANSR--VLYSLN 1097
Cdd:COG1033 626 FRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYR---EERRKGGDLEeaIRRALR 702
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 6325251 1098 TIGESVIkGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLII 1139
Cdd:COG1033 703 TTGKAIL-FTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV 743
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
519-1140 |
5.09e-26 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 116.13 E-value: 5.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 519 NRWEERLEEylldlKVPEGLRISFNTEI------SLEKELNNNNDIST--VAISYLMMFLYATWALRRKD-GKTRLLLGI 589
Cdd:TIGR00918 357 EAWQRNFSE-----EVQQSLPKNSSQKIlvfsstTLDDILKKFSDVSAirIVSGYLLMLAYACLTMLRWDcAKSQGSVGL 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 590 SGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYdrnCEQKPEYSIDQKIISAIGRMSPSILM 669
Cdd:TIGR00918 432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAF---SETGQNIPFEERTGECLKRTGASVVL 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 670 SLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSL-------------------------------- 717
Cdd:TIGR00918 509 TSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLdlrrredrrldifccffspcsarviqiepqay 588
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 718 ----------------------YEKRSNYKQITGN-------------------------------EETKESF------- 737
Cdd:TIGR00918 589 adgsappvysshmqstvqlrteYDPGTQHYYTTNEprshlsvqpsdplscqspdiagstrdllsqfEDSKAAClslpcar 668
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 738 --LKTFYFKMLT-------QKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFK---DVYSFLNVgppvYM 805
Cdd:TIGR00918 669 wtLATFAEKHYApfllqswAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDaqfRYFSFYNM----YA 744
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 806 VV-KNLDLTKRQNQ-QKICGKFTtcerdSLANVLEQERHRSTITEPLanWLDDYFMFLNPQNDQCCRLKKGTDEvcppsf 883
Cdd:TIGR00918 745 VTqGNFDYPTQQQLlYDLHQSFS-----SVKYVLKEDNGQLPRMWLH--YFRDWLQGLQKAFDEDWRDGRITKE------ 811
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 884 psrrcetCFQQGSWN----------------------------YNMSGFPEGKDFMEYLSIWINA--------------- 920
Cdd:TIGR00918 812 -------NYRNGSDDavlaykllvqtghrdkpvdkeqlttqrlVNADGIINPNAFYIYLSAWVSNdpvayaasqaniyph 884
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 921 -------PSDPCPLGGRAPYSTALVYNEtsvsasvFRTAHHPLRSQKDFIQAYsDGVR-ISSSFPELDMFAY---SPFyI 989
Cdd:TIGR00918 885 ppewlhdKNDYDPENLRIPAAEPLEYAQ-------FPFYLNGLRETSQFVEAI-EHVRaICNNYEGFGLPSYpsgYPF-L 955
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 990 FFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEF 1069
Cdd:TIGR00918 956 FWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEF 1035
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6325251 1070 CVHIVRSFTVvpseTKKDANSRVLYSLNTIGESVIKGiTLTKFIGVCVLAFAQskiFDvFYFRMWFTLIIV 1140
Cdd:TIGR00918 1036 TVHIALGFLT----AIGDRNRRAVLALEHMFAPVLDG-ALSTLLGVLMLAGSE---FD-FIVRYFFAVLAV 1097
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
321-721 |
7.17e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 72.97 E-value: 7.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 321 GKLANLFTKVGQFSVENPYKILITTVFsIFVFSFIIFQYATLETDPINlWVSKNSEKFKEKEYFDDNFGpfyRTEQIFVV 400
Cdd:COG1033 386 PELGRLLAKLARFVLRRPKVILVVALV-LAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFG---GSDPLEVV 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 401 NETGP---VLSYETLHWwfdVENFiTEELQSSENIG----YQDlcfrptedstcVIESFTQYFQGALPNKDSwkrelqec 473
Cdd:COG1033 461 VDTGEpdgLKDPEVLKE---IDRL-QDYLESLPEVGkvlsLAD-----------LVKELNQALNEGDPKYYA-------- 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 474 gkfpvncLPTFQQPL-KTNLLFSDDDILNAHAFV--------VTLLLTNHTQS-ANRWEERLEEYLLDLKVPEGLRISFN 543
Cdd:COG1033 518 -------LPESRELLaQLLLLLSSPPGDDLSRFVdedysaarVTVRLKDLDSEeIKALVEEVRAFLAENFPPDGVEVTLT 590
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 544 TEISLEKELNNNND---ISTVAISYLMMFLYATWALRRkdgktrlllgisgLLIVLASIV-------CAAGFLTLFGLKS 613
Cdd:COG1033 591 GSAVLFAAINESVIesqIRSLLLALLLIFLLLLLAFRS-------------LRLGLISLIpnllpilLTFGLMGLLGIPL 657
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 614 TLIIAEVIPfLILAIGIDNIFLITHEYDRncEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFA 693
Cdd:COG1033 658 NIATAVVAS-IALGIGVDYTIHFLSRYRE--ERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFG 734
|
410 420
....*....|....*....|....*...
gi 6325251 694 IYSTVSVIFNGVLQLTAYVSILSLYEKR 721
Cdd:COG1033 735 LLLALGLLVALLAALLLLPALLLLLDPR 762
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
347-811 |
8.62e-10 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 62.93 E-value: 8.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 347 FSIFVFSFIIF------QYATLETDpINLWVSKNSEKFKEKEYFDDNFGpfYRTEQIFVVNETGPVLSYETLHWWFDVEN 420
Cdd:TIGR00921 6 AIILVFLALLIlsaygaQHLNVESD-TEKQLPKDFESYKWYHVLQREFG--TSTKTLLVVIEGDDVTRKPVLDYMRRLEQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 421 FITEELQSSENIGYQDLcfrptedstcVIESftqYFQGALPNKDSWKRELqecgkfpVNCLPtfqqPLKTNLLFSDDdil 500
Cdd:TIGR00921 83 RLREKPYVTNVRSAADI----------MRQI---PGNFPLPVTMPEVRPL-------MSEYP----RSKEMFLSKDH--- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 501 nAHAFVVTLLLTNHTQS-----ANRWEERLEE----YLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLY 571
Cdd:TIGR00921 136 -TVAIIIVQLKSDADYKqvvpiYNDVERSLERtnppSGKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 572 ATWalRRKdgktrlllgISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPfLILAIGID-NIFLITHEYDRNCEQKpey 650
Cdd:TIGR00921 215 KRW--WRP---------LLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDyGIQTLNRYEEERDIGR--- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 651 SIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGN 730
Cdd:TIGR00921 280 AKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVKKEII 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 731 EETKESFLKTFYFKMLTQ--KRLIIIIFSAWFFTSLVFL---PEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNV-GPPVY 804
Cdd:TIGR00921 360 AIGGKSSEIEEELSKVLSitVRHPVPALVAALIITGLGLygaAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGsHDFAT 439
|
....*..
gi 6325251 805 MVVKNLD 811
Cdd:TIGR00921 440 ILVKADD 446
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
595-717 |
3.29e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 61.01 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 595 VLASIVCAAGFLTLFGLKSTLIIAEVIPfLILAIGIDNIFLITHEYdrnCEQKPEYSIDQKIISAIGRMSPSILMSLLCQ 674
Cdd:TIGR00921 601 IGSGILWAIGLMGLRGIPSFLAMATTIS-IILGLGMDYSIHLAERY---FEERKEHGPKEAITHTMERTGPGILFSGLTT 676
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 6325251 675 TGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSL 717
Cdd:TIGR00921 677 AGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1008-1110 |
1.96e-06 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 52.30 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1008 AIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKD 1087
Cdd:pfam00873 340 AIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVVDDAIVVVENIERVLEENGLK 419
|
90 100
....*....|....*....|...
gi 6325251 1088 ANSRVLYSLNTIGESVIkGITLT 1110
Cdd:pfam00873 420 PLEAAYKSMGEIGGALV-AIALV 441
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1005-1065 |
2.32e-06 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 52.03 E-value: 2.32e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6325251 1005 IGSAIILIFFISSVFLQNIRSSFL------LALVVTMIIvdigalMALLGISLNAVSLVNLIICVGL 1065
Cdd:COG0841 337 LLEAILLVVLVVFLFLRSWRATLIpavaipVSLIGTFAV------MYLLGFSLNILTLFALVLAIGI 397
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
1002-1068 |
7.95e-06 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 50.50 E-value: 7.95e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6325251 1002 LKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVE 1068
Cdd:TIGR00915 341 VHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVD 407
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
1002-1083 |
1.15e-05 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 49.90 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1002 LKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVP 1081
Cdd:PRK15127 341 VKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420
|
..
gi 6325251 1082 SE 1083
Cdd:PRK15127 421 AE 422
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
990-1122 |
1.16e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 49.47 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 990 FFVQYQTLgplTLKLIGSAIILIFFISSVFLQNIRSSF------LLALVVTMiivdigALMALLGISLNAVSLVNLIICV 1063
Cdd:COG4258 633 LFGRYRND---ALWLLLLALLLILLLLLLRLRSLRRALrvllppLLAVLLTL------AILGLLGIPLNLFHLIALLLVL 703
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 6325251 1064 GLGVEFCVhivrsFTVVPSETKKDAnSRVLYSLnTIGesvikgiTLTKFIGVCVLAFAQ 1122
Cdd:COG4258 704 GIGIDYAL-----FFTEGLLDKGEL-ARTLLSI-LLA-------ALTTLLGFGLLAFSS 748
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
1008-1074 |
3.90e-04 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 44.60 E-value: 3.90e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6325251 1008 AIILIFFISsvfLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIV 1074
Cdd:TIGR03480 724 AITVLLLLT---LRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMV 787
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
1008-1074 |
6.32e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 44.07 E-value: 6.32e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6325251 1008 AIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIV 1074
Cdd:PRK09577 346 AGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVDDAIVVV 412
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
1002-1083 |
1.53e-03 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 42.89 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325251 1002 LKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVP 1081
Cdd:PRK10555 341 VKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERIM 420
|
..
gi 6325251 1082 SE 1083
Cdd:PRK10555 421 SE 422
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
1000-1068 |
3.18e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 41.93 E-value: 3.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6325251 1000 LTLKLIGSAIILIFFIssvFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVE 1068
Cdd:NF033617 334 STLLEAVALVILVVFL---FLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
|
|
| |
