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Conserved domains on  [gi|6325274|ref|NP_015342|]
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guanine nucleotide exchange factor DSS4 [Saccharomyces cerevisiae S288C]

Protein Classification

bifunctional GNAT family N-acetyltransferase/guanine nucleotide exchange factor MSS4 family protein( domain architecture ID 10083295)

bifunctional GNAT family N-acetyltransferase/guanine nucleotide exchange factor MSS4 family protein which contains an N-terminal domain which may may catalyze the transfer of an acetyl group from acetyl-CoA to a substrate, and a C-terminal domain which may positively regulate Rab GTPase function by promoting the exchange of GDP on the RAB GTPase with GT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RabGEF cd00246
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely ...
 2-136 4.35e-43

Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;


:

Pssm-ID: 238150  Cd Length: 103  Bit Score: 137.69  E-value: 4.35e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325274    2 SKATCSFegCHSAVITINDDNIINLPEQVHSEFKLLENRTMRDATPSESNFLVVpDVWDFDNVGVSREIPssilgdlsdk 81
Cdd:cd00246   1 KAVLCQR--CGSRVLTIQPGTVLFLPRQLFLPSMRKKPGSNPDGDLLEDHWLVV-DMFTFENVGFSKDVG---------- 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6325274   82 sdfvfeygnsswkikkCLKYLICADCDKGPIGIICKVqdqTKNEERVLHLLSLRS 136
Cdd:cd00246  68 ----------------NLKYLVCADCEKGPIGYHCLD---DKNSEYVALERVSHE 103
 
Name Accession Description Interval E-value
RabGEF cd00246
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely ...
 2-136 4.35e-43

Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;


Pssm-ID: 238150  Cd Length: 103  Bit Score: 137.69  E-value: 4.35e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325274    2 SKATCSFegCHSAVITINDDNIINLPEQVHSEFKLLENRTMRDATPSESNFLVVpDVWDFDNVGVSREIPssilgdlsdk 81
Cdd:cd00246   1 KAVLCQR--CGSRVLTIQPGTVLFLPRQLFLPSMRKKPGSNPDGDLLEDHWLVV-DMFTFENVGFSKDVG---------- 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6325274   82 sdfvfeygnsswkikkCLKYLICADCDKGPIGIICKVqdqTKNEERVLHLLSLRS 136
Cdd:cd00246  68 ----------------NLKYLVCADCEKGPIGYHCLD---DKNSEYVALERVSHE 103
Mss4 pfam04421
Mss4 protein;
12-138 5.90e-25

Mss4 protein;


Pssm-ID: 461301  Cd Length: 94  Bit Score: 91.16  E-value: 5.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325274     12 HSAVITINDDNIINLPEQVhsefKLLENRTMRDATPS---ESNFLVVPDVWDFDNVGVSREIPSSilgdlsdksdfvfey 88
Cdd:pfam04421   1 GSVVLNPGTATFVEKELFL----PLMRKKSAGDEDPNgetLSDFWLVEDMYTFENVGFSKTVDNV--------------- 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 6325274     89 gnsswkikkclKYLICADCDKGPIGIICkvqdqtKNEERVLHLLSLRSLQ 138
Cdd:pfam04421  62 -----------KYLICADCEKGPIGWHD------LSDKKSFYLALERVVH 94
 
Name Accession Description Interval E-value
RabGEF cd00246
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely ...
 2-136 4.35e-43

Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;


Pssm-ID: 238150  Cd Length: 103  Bit Score: 137.69  E-value: 4.35e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325274    2 SKATCSFegCHSAVITINDDNIINLPEQVHSEFKLLENRTMRDATPSESNFLVVpDVWDFDNVGVSREIPssilgdlsdk 81
Cdd:cd00246   1 KAVLCQR--CGSRVLTIQPGTVLFLPRQLFLPSMRKKPGSNPDGDLLEDHWLVV-DMFTFENVGFSKDVG---------- 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6325274   82 sdfvfeygnsswkikkCLKYLICADCDKGPIGIICKVqdqTKNEERVLHLLSLRS 136
Cdd:cd00246  68 ----------------NLKYLVCADCEKGPIGYHCLD---DKNSEYVALERVSHE 103
Mss4 pfam04421
Mss4 protein;
12-138 5.90e-25

Mss4 protein;


Pssm-ID: 461301  Cd Length: 94  Bit Score: 91.16  E-value: 5.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325274     12 HSAVITINDDNIINLPEQVhsefKLLENRTMRDATPS---ESNFLVVPDVWDFDNVGVSREIPSSilgdlsdksdfvfey 88
Cdd:pfam04421   1 GSVVLNPGTATFVEKELFL----PLMRKKSAGDEDPNgetLSDFWLVEDMYTFENVGFSKTVDNV--------------- 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 6325274     89 gnsswkikkclKYLICADCDKGPIGIICkvqdqtKNEERVLHLLSLRSLQ 138
Cdd:pfam04421  62 -----------KYLICADCEKGPIGWHD------LSDKKSFYLALERVVH 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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