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Conserved domains on  [gi|6325426|ref|NP_015494|]
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mediator complex subunit NUT2 [Saccharomyces cerevisiae S288C]

Protein Classification

mediator of RNA polymerase II transcription subunit 10( domain architecture ID 10560945)

mediator of RNA polymerase II transcription subunit 10 is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med10 pfam09748
Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits ...
 19-142 3.01e-49

Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.


:

Pssm-ID: 462879  Cd Length: 119  Bit Score: 154.20  E-value: 3.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325426     19 QDQVASIIESFVELGVSIYDFPGTpEATKGMITNLQRNVDRLYKLNVRSNDPQSslskVDIPLEVVQYIEDGRNPDIYTR 98
Cdd:pfam09748   1 EQQLEDVIQSLYELGVQVSDFQGT-ESQEVLNQKINTLVSSLQELDKLKSDLQD----IQVPLEVIQYIDDGRNPDIYTR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6325426     99 EFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVED 142
Cdd:pfam09748  76 EFVELVRRKNQYVKGKMEAFKKFRDVLAEELEEAFPELREDVRR 119
 
Name Accession Description Interval E-value
Med10 pfam09748
Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits ...
 19-142 3.01e-49

Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.


Pssm-ID: 462879  Cd Length: 119  Bit Score: 154.20  E-value: 3.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325426     19 QDQVASIIESFVELGVSIYDFPGTpEATKGMITNLQRNVDRLYKLNVRSNDPQSslskVDIPLEVVQYIEDGRNPDIYTR 98
Cdd:pfam09748   1 EQQLEDVIQSLYELGVQVSDFQGT-ESQEVLNQKINTLVSSLQELDKLKSDLQD----IQVPLEVIQYIDDGRNPDIYTR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6325426     99 EFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVED 142
Cdd:pfam09748  76 EFVELVRRKNQYVKGKMEAFKKFRDVLAEELEEAFPELREDVRR 119
 
Name Accession Description Interval E-value
Med10 pfam09748
Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits ...
 19-142 3.01e-49

Transcription factor subunit Med10 of Mediator complex; Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription. Med10 is part of the middle region of Mediator.


Pssm-ID: 462879  Cd Length: 119  Bit Score: 154.20  E-value: 3.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325426     19 QDQVASIIESFVELGVSIYDFPGTpEATKGMITNLQRNVDRLYKLNVRSNDPQSslskVDIPLEVVQYIEDGRNPDIYTR 98
Cdd:pfam09748   1 EQQLEDVIQSLYELGVQVSDFQGT-ESQEVLNQKINTLVSSLQELDKLKSDLQD----IQVPLEVIQYIDDGRNPDIYTR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6325426     99 EFVEAIRRSNQYQRGKMHGLKQLRDSLADKIVDEFPELKEPVED 142
Cdd:pfam09748  76 EFVELVRRKNQYVKGKMEAFKKFRDVLAEELEEAFPELREDVRR 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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