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Conserved domains on  [gi|18401727|ref|NP_029426|]
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SAND family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 181-302 2.31e-31

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465953  Cd Length: 125  Bit Score: 118.08  E-value: 2.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   181 KHFFILSNSGKPIYSRYGDEHKLAGFS--ATLQAIISFVENGGDRVNLVKAGNHQVVFLVKGPIYLVCISCTDETYEYLR 258
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDEDESLLFSlfGPLNGSISFMQTQDDTLTSITCENTKVVFLEKGPLLLVAISRSGESEQQLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 18401727   259 GQLDLLYGQMILILTKS-IDRCFEKNAKFDMTPLLGGTDAVFSSL 302
Cdd:pfam19036  81 RQLDVVYNQILSLLGLPqLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 341-434 1.09e-20

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465954  Cd Length: 98  Bit Score: 86.90  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   341 GVLFSLLMCRHKVVSLAGAQKASLHPDDLLLLSNFVMSSESFRTSESFSPICLPRYNAqAFLHAYVHFFDD-DTYVILLT 419
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPFKSLELWIPICLPKFNP-GVLHRYISFLGDiNLCLLLLS 80

                          90
                  ....*....|....*
gi 18401727   420 TRSDAFHHLKDCRVR 434
Cdd:pfam19037  81 GDKPAFFELSLLDDR 95
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 493-594 3.84e-17

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 76.91  E-value: 3.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   493 GLWHFMYRSIYLDQYISS--EFSPPVTSHRQQKSLYRAYQKLYASMHvKGLGPHKTQYRRDENYTLLCWVTPDFELYAAF 570
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPslPTDPPYTTEQRRRRLRSFYQLLHSTLH-SPSGPLKLLYKVSDYESLLAWFTDCFELYVLF 79

                          90       100
                  ....*....|....*....|....
gi 18401727   571 DPLADKAMAIKICNQVCQRVKDVE 594
Cdd:pfam19038  80 SPLVPKHALRSSANKLLKWIKKEE 103
PHA03169 super family cl27451
hypothetical protein; Provisional
 22-158 3.41e-03

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.34  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   22 PSSDPETNSERVQSQLESMNLSQPSEVSDGSHTE------FSGGGDDNDDEVASANGNEGGvsNGGLLREGVAGTSGGEV 95
Cdd:PHA03169 103 PTPSPSGSAEELASGLSPENTSGSSPESPASHSPppsppsHPGPHEPAPPESHNPSPNQQP--SSFLQPSHEDSPEEPEP 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18401727   96 lLRAENPVEMEAGEEPPSPTSSGYDGERGSSGGATSTYKADDGSEDEIREANVDGDTASQHEA 158
Cdd:PHA03169 181 -PTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPER 242
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 181-302 2.31e-31

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 118.08  E-value: 2.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   181 KHFFILSNSGKPIYSRYGDEHKLAGFS--ATLQAIISFVENGGDRVNLVKAGNHQVVFLVKGPIYLVCISCTDETYEYLR 258
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDEDESLLFSlfGPLNGSISFMQTQDDTLTSITCENTKVVFLEKGPLLLVAISRSGESEQQLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 18401727   259 GQLDLLYGQMILILTKS-IDRCFEKNAKFDMTPLLGGTDAVFSSL 302
Cdd:pfam19036  81 RQLDVVYNQILSLLGLPqLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 341-434 1.09e-20

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 86.90  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   341 GVLFSLLMCRHKVVSLAGAQKASLHPDDLLLLSNFVMSSESFRTSESFSPICLPRYNAqAFLHAYVHFFDD-DTYVILLT 419
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPFKSLELWIPICLPKFNP-GVLHRYISFLGDiNLCLLLLS 80

                          90
                  ....*....|....*
gi 18401727   420 TRSDAFHHLKDCRVR 434
Cdd:pfam19037  81 GDKPAFFELSLLDDR 95
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 493-594 3.84e-17

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 76.91  E-value: 3.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   493 GLWHFMYRSIYLDQYISS--EFSPPVTSHRQQKSLYRAYQKLYASMHvKGLGPHKTQYRRDENYTLLCWVTPDFELYAAF 570
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPslPTDPPYTTEQRRRRLRSFYQLLHSTLH-SPSGPLKLLYKVSDYESLLAWFTDCFELYVLF 79

                          90       100
                  ....*....|....*....|....
gi 18401727   571 DPLADKAMAIKICNQVCQRVKDVE 594
Cdd:pfam19038  80 SPLVPKHALRSSANKLLKWIKKEE 103
PHA03169 PHA03169
hypothetical protein; Provisional
 22-158 3.41e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.34  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   22 PSSDPETNSERVQSQLESMNLSQPSEVSDGSHTE------FSGGGDDNDDEVASANGNEGGvsNGGLLREGVAGTSGGEV 95
Cdd:PHA03169 103 PTPSPSGSAEELASGLSPENTSGSSPESPASHSPppsppsHPGPHEPAPPESHNPSPNQQP--SSFLQPSHEDSPEEPEP 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18401727   96 lLRAENPVEMEAGEEPPSPTSSGYDGERGSSGGATSTYKADDGSEDEIREANVDGDTASQHEA 158
Cdd:PHA03169 181 -PTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPER 242
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 181-302 2.31e-31

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 118.08  E-value: 2.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   181 KHFFILSNSGKPIYSRYGDEHKLAGFS--ATLQAIISFVENGGDRVNLVKAGNHQVVFLVKGPIYLVCISCTDETYEYLR 258
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDEDESLLFSlfGPLNGSISFMQTQDDTLTSITCENTKVVFLEKGPLLLVAISRSGESEQQLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 18401727   259 GQLDLLYGQMILILTKS-IDRCFEKNAKFDMTPLLGGTDAVFSSL 302
Cdd:pfam19036  81 RQLDVVYNQILSLLGLPqLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 341-434 1.09e-20

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 86.90  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   341 GVLFSLLMCRHKVVSLAGAQKASLHPDDLLLLSNFVMSSESFRTSESFSPICLPRYNAqAFLHAYVHFFDD-DTYVILLT 419
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPFKSLELWIPICLPKFNP-GVLHRYISFLGDiNLCLLLLS 80

                          90
                  ....*....|....*
gi 18401727   420 TRSDAFHHLKDCRVR 434
Cdd:pfam19037  81 GDKPAFFELSLLDDR 95
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 493-594 3.84e-17

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 76.91  E-value: 3.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   493 GLWHFMYRSIYLDQYISS--EFSPPVTSHRQQKSLYRAYQKLYASMHvKGLGPHKTQYRRDENYTLLCWVTPDFELYAAF 570
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPslPTDPPYTTEQRRRRLRSFYQLLHSTLH-SPSGPLKLLYKVSDYESLLAWFTDCFELYVLF 79

                          90       100
                  ....*....|....*....|....
gi 18401727   571 DPLADKAMAIKICNQVCQRVKDVE 594
Cdd:pfam19038  80 SPLVPKHALRSSANKLLKWIKKEE 103
PHA03169 PHA03169
hypothetical protein; Provisional
 22-158 3.41e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.34  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401727   22 PSSDPETNSERVQSQLESMNLSQPSEVSDGSHTE------FSGGGDDNDDEVASANGNEGGvsNGGLLREGVAGTSGGEV 95
Cdd:PHA03169 103 PTPSPSGSAEELASGLSPENTSGSSPESPASHSPppsppsHPGPHEPAPPESHNPSPNQQP--SSFLQPSHEDSPEEPEP 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18401727   96 lLRAENPVEMEAGEEPPSPTSSGYDGERGSSGGATSTYKADDGSEDEIREANVDGDTASQHEA 158
Cdd:PHA03169 181 -PTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPER 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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