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Conserved domains on  [gi|114326406|ref|NP_031417|]
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acrosomal protein SP-10 isoform 1 precursor [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 182-260 5.04e-40

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467148  Cd Length: 79  Bit Score: 133.19  E-value: 5.04e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406 182 ITINCHTCAYMNDDAKCLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIMCCRNEPLCNK 260
Cdd:cd23628    1 QALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
PTZ00341 super family cl31759
Ring-infected erythrocyte surface antigen; Provisional
 24-162 2.76e-03

Ring-infected erythrocyte surface antigen; Provisional


The actual alignment was detected with superfamily member PTZ00341:

Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 39.00  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406   24 EELLDSVDQQasvqqlssEYLSLANPSDAEALYEtplDEKTLSGHSSSEQESSEHAVAEHSAGEhsSGEQSSEHMSGDHM 103
Cdd:PTZ00341  413 EDLLFDLEKQ--------KYMDMLDGSEDESVED---NEEEHSGDANEEELSVDEHVEEHNADD--SGEQQSDDESGEHQ 479

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406  104 S----------GEHLSEHTSEEHSSGEhTSTEHTsgEQPATEQSSSDQPSEASSGEVSGDEagEQVSSE 162
Cdd:PTZ00341  480 SvneiveeqsvNEHVEEPTVADIVEQE-TVDEHV--EEPAVDENEEQQTADEHVEEPTIAE--EHVEEE 543
 
Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 182-260 5.04e-40

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467148  Cd Length: 79  Bit Score: 133.19  E-value: 5.04e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406 182 ITINCHTCAYMNDDAKCLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIMCCRNEPLCNK 260
Cdd:cd23628    1 QALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 24-162 2.76e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 39.00  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406   24 EELLDSVDQQasvqqlssEYLSLANPSDAEALYEtplDEKTLSGHSSSEQESSEHAVAEHSAGEhsSGEQSSEHMSGDHM 103
Cdd:PTZ00341  413 EDLLFDLEKQ--------KYMDMLDGSEDESVED---NEEEHSGDANEEELSVDEHVEEHNADD--SGEQQSDDESGEHQ 479

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406  104 S----------GEHLSEHTSEEHSSGEhTSTEHTsgEQPATEQSSSDQPSEASSGEVSGDEagEQVSSE 162
Cdd:PTZ00341  480 SvneiveeqsvNEHVEEPTVADIVEQE-TVDEHV--EEPAVDENEEQQTADEHVEEPTIAE--EHVEEE 543
 
Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 182-260 5.04e-40

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467148  Cd Length: 79  Bit Score: 133.19  E-value: 5.04e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406 182 ITINCHTCAYMNDDAKCLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIMCCRNEPLCNK 260
Cdd:cd23628    1 QALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
TFP_LU_ECD_Ly6G5b cd23544
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) ...
 183-260 1.15e-10

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) and similar proteins; Ly6G5b is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467074  Cd Length: 82  Bit Score: 56.64  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406 183 TINCHTCAYMNDDAKCLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGC---ENMCPSMNLFS--HGTRMQIMCCRNEpL 257
Cdd:cd23544    1 ARRCHLCLLEDPSIGCISGSEKCTPSSGEPCMTITIYYEGKVRFLVRGCgqhSSYRCGERKKTyvSGYWYNARCCQYD-Y 79


                 ...
gi 114326406 258 CNK 260
Cdd:cd23544   80 CNS 82
TFP_LU_ECD_PATE3 cd23579
extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and ...
 180-260 2.70e-10

extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and similar proteins; PATE3 (also called acrosomal vesicle protein HEL-127, or PATE-like protein DJ (PATE-DJ)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE3 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467109  Cd Length: 80  Bit Score: 55.52  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406 180 AAITINCHTCAYMNDDAKCLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIMCCrNEPLCN 259
Cdd:cd23579    1 AATALKCITCHLRTVSDRCRRGFGTCTAQKDESCMRLRIYQGDTLQLSYMVCQKFCRDLTYHFNNRTYVHTCC-NKDYCN 79


                 .
gi 114326406 260 K 260
Cdd:cd23579   80 F 80
TFP_LU_ECD_PATE1 cd23577
extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and ...
 183-259 1.61e-09

extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and similar proteins; PATE1 is a novel sperm-associated protein generally expressed in male genital tract and related to sperm development, maturation and fertilization. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467107  Cd Length: 82  Bit Score: 53.23  E-value: 1.61e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406 183 TINCHTCAYMNDDAKCLRGEGVCTTQNSQQCMLKKIFEG-GKLQFMVQGCENMCPSMNLFSHGT-RMQIMCCRNEPLCN 259
Cdd:cd23577    1 IVQCRMCHLQFPGEKCSRGRGICTATTEEACVVGRIFKKdGTPWLTFMGCLKNCANVKKIKWSVyLVNFRCCRGYDLCN 79
TFP_LU_ECD_mPATE6_like cd23581
extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 ...
 181-259 8.20e-07

extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 (PATE6) and similar proteins; The family includes Mus musculus PATE6 and PATE7. PATE6 (also called called prostate and testis expressed 6, or PATE-like protein C) acts as nicotinic acetylcholine receptor (nAChR) regulator. The biological function of PATE7 (also called called prostate and testis expressed 7) remains unclear. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467111  Cd Length: 82  Bit Score: 45.92  E-value: 8.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406 181 AITINCHTCAYMNDdAKCLRGEGVCTTQNSQQCMLKKIF---EGGKLQFMVQGCENMCPSMNLFSHGTRMQIMCCRNEPL 257
Cdd:cd23581    1 ALALQCNQCLSYKD-GECVHGKQTCTAKPGESCMIRRIFsasESVTINSAERGCTKNCTSTEDISGDYTVITTCCSDFDF 79


                 ..
gi 114326406 258 CN 259
Cdd:cd23581   80 CN 81
TFP_LU_ECD_PATE2 cd23578
extracellular domain (ECD) found in prostate and testis expressed protein 2 (PATE2) and ...
 184-259 2.29e-06

extracellular domain (ECD) found in prostate and testis expressed protein 2 (PATE2) and similar proteins; PATE2 (also called PATE-like protein M (PATE-M)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE2 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467108  Cd Length: 82  Bit Score: 44.62  E-value: 2.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406 184 INCHTCAYMNDDaKCLRGEGVCTTQNSQQCMLKKIF----EGGKL-QFMVQGCENMCPSMNLFSHGTRMQIMCCRNEPLC 258
Cdd:cd23578    3 TVCMVCKHFKGG-RCLEGMGSCTKKYGSGCRTRNFYiysnTGGWLyTYSKLDCVTRCKESVMYFHDLKVETFCCKDQDYC 81


                 .
gi 114326406 259 N 259
Cdd:cd23578   82 N 82
TFP_LU_ECD_PATE4 cd23580
extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and ...
 186-259 3.35e-06

extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and similar proteins; PATE4, also called prostate and testis expressed 4, or PATE-like protein B) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE4 may modulate the function of nicotinic acetylcholine receptors and enhance sperm motility. PATE4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467110  Cd Length: 79  Bit Score: 43.93  E-value: 3.35e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114326406 186 CHTCAYMNDdAKCLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIMCCrNEPLCN 259
Cdd:cd23580    6 CNVCIYSKN-SRCMSGQGRCTAKPGGSCSTISYYRGSKHLYSKHMCKYHCKEEQYYKGDLLRYTMCC-EKNLCN 77
TFP_LU_ECD_C9orf57 cd23610
extracellular domain (ECD) found in Homo sapiens uncharacterized protein C9orf57 and similar ...
 198-260 1.70e-05

extracellular domain (ECD) found in Homo sapiens uncharacterized protein C9orf57 and similar proteins; C9orf57 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467130  Cd Length: 83  Bit Score: 42.11  E-value: 1.70e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114326406 198 CLRGEGVCTTQNSQQCMLKKIFEGGKLQFMVQGC---ENMCPSMNLFSHGTRMQIMCCrNEPLCNK 260
Cdd:cd23610   19 CTLGGGTCLAKPGQYCKTERHIKGGIEWFSIKGCtknSEECGSTKEVGYSGRVTTTCC-NSHMCNF 83
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 24-162 2.76e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 39.00  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406   24 EELLDSVDQQasvqqlssEYLSLANPSDAEALYEtplDEKTLSGHSSSEQESSEHAVAEHSAGEhsSGEQSSEHMSGDHM 103
Cdd:PTZ00341  413 EDLLFDLEKQ--------KYMDMLDGSEDESVED---NEEEHSGDANEEELSVDEHVEEHNADD--SGEQQSDDESGEHQ 479

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326406  104 S----------GEHLSEHTSEEHSSGEhTSTEHTsgEQPATEQSSSDQPSEASSGEVSGDEagEQVSSE 162
Cdd:PTZ00341  480 SvneiveeqsvNEHVEEPTVADIVEQE-TVDEHV--EEPAVDENEEQQTADEHVEEPTIAE--EHVEEE 543
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 184-259 5.69e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 35.15  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326406 184 INCHTCAYMNDDAKCLRGEGV--CTTqNSQQCMLKKIFEGGKLQFMVQGC-----ENMCPSMNLFSHGTRMQIMCCrNEP 256
Cdd:cd00117    1 LKCYQCNSSNDPNCCNSSPTLvtCSS-PETFCRKIVGKVGGGETLVIRGCateceCGCTECCSGTGTSGTTCTSCC-DTD 78


                 ...
gi 114326406 257 LCN 259
Cdd:cd00117   79 LCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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