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Conserved domains on  [gi|6671654|ref|NP_031601|]
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MHC class II transactivator isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
737-1062 5.66e-85

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 277.70  E-value: 5.66e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   737 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 814
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   815 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 889
Cdd:cd00116   71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   890 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 967
Cdd:cd00116  150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   968 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1047
Cdd:cd00116  226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
                        330
                 ....*....|....*
gi 6671654  1048 PQVETLAMWTPTIPF 1062
Cdd:cd00116  305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
362-533 1.40e-48

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 170.18  E-value: 1.40e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     362 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 440
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     441 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 518
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
                          170
                   ....*....|....*
gi 6671654     519 TKQAKTYMRHYFENS 533
Cdd:pfam05729  152 ESDRKQYVRKYFSDE 166
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
661-766 2.91e-04

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 41.51  E-value: 2.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     661 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 729
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 6671654     730 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 766
Cdd:pfam17776   82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
737-1062 5.66e-85

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 277.70  E-value: 5.66e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   737 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 814
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   815 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 889
Cdd:cd00116   71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   890 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 967
Cdd:cd00116  150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   968 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1047
Cdd:cd00116  226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
                        330
                 ....*....|....*
gi 6671654  1048 PQVETLAMWTPTIPF 1062
Cdd:cd00116  305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
362-533 1.40e-48

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 170.18  E-value: 1.40e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     362 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 440
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     441 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 518
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
                          170
                   ....*....|....*
gi 6671654     519 TKQAKTYMRHYFENS 533
Cdd:pfam05729  152 ESDRKQYVRKYFSDE 166
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
924-1075 9.00e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 90.23  E-value: 9.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   924 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALaKSLLRLSLYNNC 1003
Cdd:COG5238  284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6671654  1004 ICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1075
Cdd:COG5238  360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
992-1018 1.61e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 39.70  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*..
gi 6671654      992 KSLLRLSLYNNCICDKGAKSLAQVLPD 1018
Cdd:smart00368    2 PSLRELDLSNNKLGDEGARALAEALKD 28
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
661-766 2.91e-04

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 41.51  E-value: 2.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     661 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 729
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 6671654     730 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 766
Cdd:pfam17776   82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
LRR_8 pfam13855
Leucine rich repeat;
965-1032 6.86e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.86e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6671654     965 LETLNLSQNNITDVGacklAEALPALaKSLLRLSLYNNCICDKGAKSLAqvlpDMVSLRVMDVQFNKF 1032
Cdd:pfam13855    3 LRSLDLSNNRLTSLD----DGAFKGL-SNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
737-1062 5.66e-85

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 277.70  E-value: 5.66e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   737 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 814
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   815 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 889
Cdd:cd00116   71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   890 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 967
Cdd:cd00116  150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   968 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1047
Cdd:cd00116  226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
                        330
                 ....*....|....*
gi 6671654  1048 PQVETLAMWTPTIPF 1062
Cdd:cd00116  305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
362-533 1.40e-48

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 170.18  E-value: 1.40e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     362 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 440
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     441 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 518
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
                          170
                   ....*....|....*
gi 6671654     519 TKQAKTYMRHYFENS 533
Cdd:pfam05729  152 ESDRKQYVRKYFSDE 166
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
924-1075 9.00e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 90.23  E-value: 9.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   924 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALaKSLLRLSLYNNC 1003
Cdd:COG5238  284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6671654  1004 ICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1075
Cdd:COG5238  360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
916-1053 3.53e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 85.61  E-value: 3.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   916 LGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALpALAKSLL 995
Cdd:COG5238  248 IGDEGVIALAEALKNNTTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLH 323
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6671654   996 RLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETL 1053
Cdd:COG5238  324 TLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
935-1070 3.17e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 76.37  E-value: 3.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   935 QHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALpALAKSLLRLSLYNNCICDKGAKSLAQ 1014
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654  1015 VLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPF----GVQEHLQQ 1070
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
869-1053 1.16e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   869 KAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFAlgpILGPQAFPTLAKILPAFSSLQHLDldsLSENKIG 948
Cdd:COG4886   76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESL---DLSGNQLTDLPEELANLTNLKELD---LSNNQLT 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   949 DkgvskLSATFPQLKALETLNLSQNNITDvgackLAEALPALaKSLLRLSLYNNCIcdkgaKSLAQVLPDMVSLRVMDVQ 1028
Cdd:COG4886  150 D-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNL-TNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLS 213
                        170       180
                 ....*....|....*....|....*
gi 6671654  1029 FNKFTAagaqqLASSLQKCPQVETL 1053
Cdd:COG4886  214 GNQLTD-----LPEPLANLTNLETL 233
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
850-1053 9.29e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 9.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   850 QGEAQLLQAAEEKfTIEPFKAKSPkdVEDLDRLVQTQRLrnPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILP 929
Cdd:COG5238   68 QGDPGLNPVALEK-AAEAFPTQLL--VVDWEGAEEVSPV--ALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRIN 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   930 AFSSL--------QHLDLDSLSENKIGDKGVSKlsatFPQLKALETLNLSQNNITDVGACKLAEALPAlAKSLLRLSLYN 1001
Cdd:COG5238  143 LIQVLkdplggnaVHLLGLAARLGLLAAISMAK----ALQNNSVETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKR 217
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6671654  1002 NCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETL 1053
Cdd:COG5238  218 NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETL 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
897-1045 1.61e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   897 KDLPA-IRDLKKLEFaLgpILGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNNI 975
Cdd:COG4886  172 TDLPEeLGNLTNLKE-L--DLSNNQITDLPEPLGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6671654   976 TDvgacklaeaLPALA--KSLLRLSLYNNCICDkgakslaqvLPD---MVSLRVMDVQFNKFTAAGAQQLASSLQ 1045
Cdd:COG4886  241 TD---------LPELGnlTNLEELDLSNNQLTD---------LPPlanLTNLKTLDLSNNQLTDLKLKELELLLG 297
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
360-943 4.69e-06

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 50.96  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   360 ETQVVAVLGKAGQGKS----HWARTVshtWACGQLLQYDFVFYVPCHCLDRPGDtyhLRDLLCPPSLQPLAMDDEVLDYI 435
Cdd:COG5635  179 KKKRLLILGEPGSGKTtllrYLALEL---AERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKRGGEPEDALERL 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   436 VRQpDRVLLILDAFEELeaqdgllhgpcgslsPEPCSLRGLLAGI--FQRKlLRGCTLLLTARPRGRLAQSLSKADaIFE 513
Cdd:COG5635  253 LRN-GRLLLLLDGLDEV---------------PDEADRDEVLNQLrrFLER-YPKARVIITSRPEGYDSSELEGFE-VLE 314
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   514 VPSFSTKQAKTYMRHYFENsgTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKalleqgTEAQLPCTLTGLY---V 590
Cdd:COG5635  315 LAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALLLR------ERGELPDTRAELYeqfV 386
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   591 SLL----------GPAAQNSPPGALVELAKLAWELgrrHQStlQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFL 660
Cdd:COG5635  387 ELLlerwdeqrglTIYRELSREELRELLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALLDELLLRTGL 461
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   661 LQC---------------FLGAVWLAqcneikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHC-----LGA 720
Cdd:COG5635  462 LVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKelidaLLA 533
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   721 LVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRAL 800
Cdd:COG5635  534 RDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLL 613
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654   801 ETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLD 880
Cdd:COG5635  614 LLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLL 693
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6671654   881 RLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLS 943
Cdd:COG5635  694 LLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESS 756
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
992-1018 1.61e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 39.70  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*..
gi 6671654      992 KSLLRLSLYNNCICDKGAKSLAQVLPD 1018
Cdd:smart00368    2 PSLRELDLSNNKLGDEGARALAEALKD 28
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
661-766 2.91e-04

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 41.51  E-value: 2.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654     661 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 729
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 6671654     730 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 766
Cdd:pfam17776   82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
933-1005 3.97e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 3.97e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6671654   933 SLQHLDLdslSENKIGDkgVSKLSAtfpqLKALETLNLSQNNITDVGAckLAEALPALaKSLLRLSLYNNCIC 1005
Cdd:cd21340  121 SLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDLEE--LLDLLSSW-PSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
965-1032 6.86e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.86e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6671654     965 LETLNLSQNNITDVGacklAEALPALaKSLLRLSLYNNCICDKGAKSLAqvlpDMVSLRVMDVQFNKF 1032
Cdd:pfam13855    3 LRSLDLSNNRLTSLD----DGAFKGL-SNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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