|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
737-1062 |
5.66e-85 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). :
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 277.70 E-value: 5.66e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 737 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 814
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 815 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 889
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 890 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 967
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 968 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1047
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 6671654 1048 PQVETLAMWTPTIPF 1062
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
362-533 |
1.40e-48 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931. :
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 170.18 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 362 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 440
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 441 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 518
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 6671654 519 TKQAKTYMRHYFENS 533
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
661-766 |
2.91e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein. The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 41.51 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 661 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 729
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 6671654 730 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 766
Cdd:pfam17776 82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
737-1062 |
5.66e-85 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 277.70 E-value: 5.66e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 737 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 814
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 815 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 889
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 890 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 967
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 968 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1047
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 6671654 1048 PQVETLAMWTPTIPF 1062
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
362-533 |
1.40e-48 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 170.18 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 362 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 440
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 441 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 518
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 6671654 519 TKQAKTYMRHYFENS 533
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
924-1075 |
9.00e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 90.23 E-value: 9.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 924 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALaKSLLRLSLYNNC 1003
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6671654 1004 ICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1075
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
992-1018 |
1.61e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.70 E-value: 1.61e-04
10 20
....*....|....*....|....*..
gi 6671654 992 KSLLRLSLYNNCICDKGAKSLAQVLPD 1018
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
661-766 |
2.91e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 41.51 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 661 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 729
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 6671654 730 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 766
Cdd:pfam17776 82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
965-1032 |
6.86e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.96 E-value: 6.86e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6671654 965 LETLNLSQNNITDVGacklAEALPALaKSLLRLSLYNNCICDKGAKSLAqvlpDMVSLRVMDVQFNKF 1032
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGL-SNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
737-1062 |
5.66e-85 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 277.70 E-value: 5.66e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 737 LTRYLKRLKLGTLRAGRLLELLHCaheTQQPGIWEHVAHQlpGHLSFLGTRLTPP--DVYVLGRALETASqdfslDLRQT 814
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 815 GVEPSGLGNLVGLSCVTSFRASLS-DTMALWESLQQ---QGEAQLLQAAEEKfTIEPFKAKSPKDV-EDLDRLVQTQRLR 889
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 890 N--PSEDAAKDLPAIRDLKKLEFALGPIlGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 967
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 968 LNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLqKC 1047
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 6671654 1048 PQVETLAMWTPTIPF 1062
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
362-533 |
1.40e-48 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 170.18 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 362 QVVAVLGKAGQGKSHWARTVSHTWACGQLLQY-DFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPD 440
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 441 RVLLILDAFEELEAQDGLLHGpcgslspePCSLRGLLAGIFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 518
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 6671654 519 TKQAKTYMRHYFENS 533
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
924-1075 |
9.00e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 90.23 E-value: 9.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 924 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALaKSLLRLSLYNNC 1003
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6671654 1004 ICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1075
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
916-1053 |
3.53e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 85.61 E-value: 3.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 916 LGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALpALAKSLL 995
Cdd:COG5238 248 IGDEGVIALAEALKNNTTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLH 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 6671654 996 RLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETL 1053
Cdd:COG5238 324 TLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
935-1070 |
3.17e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 76.37 E-value: 3.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 935 QHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALpALAKSLLRLSLYNNCICDKGAKSLAQ 1014
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 1015 VLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPF----GVQEHLQQ 1070
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
869-1053 |
1.16e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 64.95 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 869 KAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFAlgpILGPQAFPTLAKILPAFSSLQHLDldsLSENKIG 948
Cdd:COG4886 76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESL---DLSGNQLTDLPEELANLTNLKELD---LSNNQLT 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 949 DkgvskLSATFPQLKALETLNLSQNNITDvgackLAEALPALaKSLLRLSLYNNCIcdkgaKSLAQVLPDMVSLRVMDVQ 1028
Cdd:COG4886 150 D-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNL-TNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLS 213
|
170 180
....*....|....*....|....*
gi 6671654 1029 FNKFTAagaqqLASSLQKCPQVETL 1053
Cdd:COG4886 214 GNQLTD-----LPEPLANLTNLETL 233
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
850-1053 |
9.29e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 62.11 E-value: 9.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 850 QGEAQLLQAAEEKfTIEPFKAKSPkdVEDLDRLVQTQRLrnPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILP 929
Cdd:COG5238 68 QGDPGLNPVALEK-AAEAFPTQLL--VVDWEGAEEVSPV--ALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRIN 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 930 AFSSL--------QHLDLDSLSENKIGDKGVSKlsatFPQLKALETLNLSQNNITDVGACKLAEALPAlAKSLLRLSLYN 1001
Cdd:COG5238 143 LIQVLkdplggnaVHLLGLAARLGLLAAISMAK----ALQNNSVETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKR 217
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6671654 1002 NCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETL 1053
Cdd:COG5238 218 NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETL 269
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
897-1045 |
1.61e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.94 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 897 KDLPA-IRDLKKLEFaLgpILGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNNI 975
Cdd:COG4886 172 TDLPEeLGNLTNLKE-L--DLSNNQITDLPEPLGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6671654 976 TDvgacklaeaLPALA--KSLLRLSLYNNCICDkgakslaqvLPD---MVSLRVMDVQFNKFTAAGAQQLASSLQ 1045
Cdd:COG4886 241 TD---------LPELGnlTNLEELDLSNNQLTD---------LPPlanLTNLKTLDLSNNQLTDLKLKELELLLG 297
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
360-943 |
4.69e-06 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 50.96 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 360 ETQVVAVLGKAGQGKS----HWARTVshtWACGQLLQYDFVFYVPCHCLDRPGDtyhLRDLLCPPSLQPLAMDDEVLDYI 435
Cdd:COG5635 179 KKKRLLILGEPGSGKTtllrYLALEL---AERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKRGGEPEDALERL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 436 VRQpDRVLLILDAFEELeaqdgllhgpcgslsPEPCSLRGLLAGI--FQRKlLRGCTLLLTARPRGRLAQSLSKADaIFE 513
Cdd:COG5635 253 LRN-GRLLLLLDGLDEV---------------PDEADRDEVLNQLrrFLER-YPKARVIITSRPEGYDSSELEGFE-VLE 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 514 VPSFSTKQAKTYMRHYFENsgTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKalleqgTEAQLPCTLTGLY---V 590
Cdd:COG5635 315 LAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALLLR------ERGELPDTRAELYeqfV 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 591 SLL----------GPAAQNSPPGALVELAKLAWELgrrHQStlQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFL 660
Cdd:COG5635 387 ELLlerwdeqrglTIYRELSREELRELLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALLDELLLRTGL 461
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 661 LQC---------------FLGAVWLAqcneikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHC-----LGA 720
Cdd:COG5635 462 LVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKelidaLLA 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 721 LVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRAL 800
Cdd:COG5635 534 RDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLL 613
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 801 ETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLD 880
Cdd:COG5635 614 LLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLL 693
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6671654 881 RLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLS 943
Cdd:COG5635 694 LLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESS 756
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
992-1018 |
1.61e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.70 E-value: 1.61e-04
10 20
....*....|....*....|....*..
gi 6671654 992 KSLLRLSLYNNCICDKGAKSLAQVLPD 1018
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
661-766 |
2.91e-04 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 41.51 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6671654 661 LQCFLGAVWLAQCNEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAVAAv 729
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81
|
90 100 110
....*....|....*....|....*....|....*..
gi 6671654 730 adRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQ 766
Cdd:pfam17776 82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
933-1005 |
3.97e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.85 E-value: 3.97e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6671654 933 SLQHLDLdslSENKIGDkgVSKLSAtfpqLKALETLNLSQNNITDVGAckLAEALPALaKSLLRLSLYNNCIC 1005
Cdd:cd21340 121 SLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDLEE--LLDLLSSW-PSLRELDLTGNPVC 181
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
965-1032 |
6.86e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.96 E-value: 6.86e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6671654 965 LETLNLSQNNITDVGacklAEALPALaKSLLRLSLYNNCICDKGAKSLAqvlpDMVSLRVMDVQFNKF 1032
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGL-SNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
|