Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are composed of the immunoglobulin variable domain (IgV) of the Cluster of Differentiation (CD) 79B (also known as CD79b molecule, immunoglobulin-associated beta (Ig-beta), and B29). The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375   46 IWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCD 125
Cdd:cd16096   1 IWQHPRFAAKKRSSMVKFHCYTNYSGVMTWFRKKGNQRPQELFPEDGRISQTQNGSVYTLTIQNIQYEDNGIYFCQQKCN 80

                        90
                ....*....|....*.
gi 6680375  126 SANHNVTDSCGTELLV 141
Cdd:cd16096  81 STEPDVTDGCGTELLV 96

Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are composed of the immunoglobulin variable domain (IgV) of the Cluster of Differentiation (CD) 79B (also known as CD79b molecule, immunoglobulin-associated beta (Ig-beta), and B29). The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375   46 IWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCD 125
Cdd:cd16096   1 IWQHPRFAAKKRSSMVKFHCYTNYSGVMTWFRKKGNQRPQELFPEDGRISQTQNGSVYTLTIQNIQYEDNGIYFCQQKCN 80

                        90
                ....*....|....*.
gi 6680375  126 SANHNVTDSCGTELLV 141
Cdd:cd16096  81 STEPDVTDGCGTELLV 96

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375     61 VKFHC-----YTNHSGALTWFRKRGSQQPQELV----------SEEGRIVQTQNGSVY--TLTIQNIQYEDNGIYFCkqK 123
Cdd:pfam07686  14 VTLPCtysssMSEASTSVYWYRQPPGKGPTFLIayysngseegVKKGRFSGRGDPSNGdgSLTIQNLTLSDSGTYTC--A 91

                          90
                  ....*....|....*....
gi 6680375    124 CDSANHNVTDScGTELLVL 142
Cdd:pfam07686  92 VIPSGEGVFGK-GTRLTVL 109

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.

                          10        20
                  ....*....|....*....|
gi 6680375    192 DHTYEGLNIDQTATYEDIVT 211
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20

Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are composed of the immunoglobulin variable domain (IgV) of the Cluster of Differentiation (CD) 79B (also known as CD79b molecule, immunoglobulin-associated beta (Ig-beta), and B29). The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375   46 IWQHPRFAAKKRSSMVKFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKCD 125
Cdd:cd16096   1 IWQHPRFAAKKRSSMVKFHCYTNYSGVMTWFRKKGNQRPQELFPEDGRISQTQNGSVYTLTIQNIQYEDNGIYFCQQKCN 80

                        90
                ....*....|....*.
gi 6680375  126 SANHNVTDSCGTELLV 141
Cdd:cd16096  81 STEPDVTDGCGTELLV 96

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375      61 VKFHCYTNHSGA--LTWFRkrgsqQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQKcdsaNHNVTDSCGTE 138
Cdd:smart00410  12 VTLSCEASGSPPpeVTWYK-----QGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAAT----NSSGSASSGTT 82

                   ...
gi 6680375     139 LLV 141
Cdd:smart00410  83 LTV 85

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375   48 QHPRFAAKKRSSMVKFHCY--TNHSgALTWFRKRGSQQPQEL-------------VSEEGRIVQTQNGSVYTLTIQNIQY 112
Cdd:cd05899   3 QSPRYLIKRRGQSVTLRCSqkSGHD-NMYWYRQDPGKGLQLLfysyggglneegdLPGDRFSASRPSLTRSSLTIKSAEP 81

                ....*...
gi 6680375  113 EDNGIYFC 120
Cdd:cd05899  82 EDSAVYLC 89

Immunoglobulin V-Type;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6680375      62 KFHCYTNHSGALTWFRKRGSQQPQELVSEEGRIVQTQNGSV--------------YTLTIQNIQYEDNGIYFCKQ 122
Cdd:smart00406   7 KFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYQESYkgrftiskdtskndVSLTISNLRVEDTGTYYCAV 81

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680375   70 SGALTWFRKRGSQQPQELVSEE--------GRIVQTQNGSVYTLTIQNIQYEDNGIYFCKQ 122
Cdd:cd04980  30 SNYLAWYQQKPGQAPKLLIYYAstlhsgvpSRFSGSGSGTDFTLTISSVEPEDAAVYYCQQ 90

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.

                           10        20
                   ....*....|....*....|
gi 6680375     192 DHTYEGLNIDQTATYEDIVT 211
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNT 20

Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6680375   69 HSGALTWFRKRGSQQPQELVSEEGRIVQTQNGsvytLTIQNIQYEDNGIYFCK 121
Cdd:cd05871  24 PQATVKWLFQRGGDQRKEEVKSEERLIVTDRG----LLLRSLQRSDAGVYTCQ 72

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6680375     45 QIWQHPRFAAKKRSSMVKFHC--YTNHSGALTWFRkrgsqqPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFCK 121
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCeaTGSPPPTITWYK------NGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCV 75

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680375   48 QHPRFAAKKRSSMVKFHCYTNHSGALT---WFRKRgsQQP---------------------QELVSEEGRIVQTQNGSVY 103
Cdd:cd07700   3 QTPGSLLVQTNQTVKMSCEAKTSPKNTriyWLRQR--QAPskdshfeflaswdpskgivygEGVDQEKLIILSDSDSSRY 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6680375  104 TLTIQNIQYEDNGIYFCkqkCDSANHNVTDSCGTELLV 141
Cdd:cd07700  81 ILSLMSVKPEDSGTYFC---MTVGSPELIFGTGTKLSV 115