interleukin-18 isoform a [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
beta-trefoil_IL18 | cd23298 | beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ... |
41-186 | 1.46e-49 | |||
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. : Pssm-ID: 466780 Cd Length: 149 Bit Score: 157.37 E-value: 1.46e-49
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Name | Accession | Description | Interval | E-value | |||
beta-trefoil_IL18 | cd23298 | beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ... |
41-186 | 1.46e-49 | |||
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466780 Cd Length: 149 Bit Score: 157.37 E-value: 1.46e-49
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IL1 | pfam00340 | Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. |
76-182 | 7.11e-25 | |||
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. Pssm-ID: 395269 Cd Length: 119 Bit Score: 93.67 E-value: 7.11e-25
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IL1 | smart00125 | Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ... |
94-165 | 2.70e-04 | |||
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin. Pssm-ID: 128430 Cd Length: 147 Bit Score: 39.67 E-value: 2.70e-04
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Name | Accession | Description | Interval | E-value | |||
beta-trefoil_IL18 | cd23298 | beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ... |
41-186 | 1.46e-49 | |||
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466780 Cd Length: 149 Bit Score: 157.37 E-value: 1.46e-49
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IL1 | pfam00340 | Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. |
76-182 | 7.11e-25 | |||
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. Pssm-ID: 395269 Cd Length: 119 Bit Score: 93.67 E-value: 7.11e-25
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beta-trefoil_IL1 | cd00100 | beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ... |
44-186 | 5.85e-18 | |||
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466776 Cd Length: 145 Bit Score: 76.21 E-value: 5.85e-18
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beta-trefoil_IL1A | cd23295 | beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ... |
83-165 | 6.82e-05 | |||
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466777 Cd Length: 145 Bit Score: 41.17 E-value: 6.82e-05
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IL1 | smart00125 | Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ... |
94-165 | 2.70e-04 | |||
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin. Pssm-ID: 128430 Cd Length: 147 Bit Score: 39.67 E-value: 2.70e-04
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Blast search parameters | ||||
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