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Conserved domains on  [gi|7110653|ref|NP_032392|]
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interleukin-2 precursor [Mus musculus]

Protein Classification

IL2 domain-containing protein( domain architecture ID 10640642)

IL2 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IL2 smart00189
Interleukin-2 family; Interleukin-2 is a cytokine produced by T-helper cells in response to ...
1-168 1.89e-77

Interleukin-2 family; Interleukin-2 is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. This protein is required for T-cell proliferation and other activities crucial to the regulation of the immune response.


:

Pssm-ID: 128486  Cd Length: 154  Bit Score: 227.45  E-value: 1.89e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653       1 MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTaeaqqqqqqqqqqqQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYL 80
Cdd:smart00189   1 MYKIQLLSCIALTLALLTNSAPTSSSTKSTQ--------------QHLEQLLLDLQLLLEGVENPENLKLPRMLTFKFYL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653      81 PKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFC 160
Cdd:smart00189  67 PKQATELKHLQCLEEELKPLEEVLDLAQSKNFQLEHIKDFISNINVTVLKLKGSETRFTCQYDDESVTIVEFLNRWIAFC 146

                   ....*...
gi 7110653     161 QSIISTSP 168
Cdd:smart00189 147 QSIISTLT 154
 
Name Accession Description Interval E-value
IL2 smart00189
Interleukin-2 family; Interleukin-2 is a cytokine produced by T-helper cells in response to ...
1-168 1.89e-77

Interleukin-2 family; Interleukin-2 is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. This protein is required for T-cell proliferation and other activities crucial to the regulation of the immune response.


Pssm-ID: 128486  Cd Length: 154  Bit Score: 227.45  E-value: 1.89e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653       1 MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTaeaqqqqqqqqqqqQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYL 80
Cdd:smart00189   1 MYKIQLLSCIALTLALLTNSAPTSSSTKSTQ--------------QHLEQLLLDLQLLLEGVENPENLKLPRMLTFKFYL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653      81 PKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFC 160
Cdd:smart00189  67 PKQATELKHLQCLEEELKPLEEVLDLAQSKNFQLEHIKDFISNINVTVLKLKGSETRFTCQYDDESVTIVEFLNRWIAFC 146

                   ....*...
gi 7110653     161 QSIISTSP 168
Cdd:smart00189 147 QSIISTLT 154
IL2 pfam00715
Interleukin 2;
7-165 6.46e-72

Interleukin 2;


Pssm-ID: 425834  Cd Length: 145  Bit Score: 213.05  E-value: 6.46e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653      7 ASCVTLTLVLLVNSAPTSSSTSSSTaeaqqqqqqqqqqqQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATE 86
Cdd:pfam00715   1 LSCIALTLALVANSAPTSSSTKETQ--------------QQLEQLLLDLQLLLEGVNNYKNPKLSRMLTFKFYMPKKATE 66
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7110653     87 LKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIIS 165
Cdd:pfam00715  67 LKHLQCLEEELKPLEEVLNLAQSKNFHLIDTKEFISNINVTVLKLKGSETTFTCEYDDETATIVEFLNKWITFCQSIIS 145
 
Name Accession Description Interval E-value
IL2 smart00189
Interleukin-2 family; Interleukin-2 is a cytokine produced by T-helper cells in response to ...
1-168 1.89e-77

Interleukin-2 family; Interleukin-2 is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. This protein is required for T-cell proliferation and other activities crucial to the regulation of the immune response.


Pssm-ID: 128486  Cd Length: 154  Bit Score: 227.45  E-value: 1.89e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653       1 MYSMQLASCVTLTLVLLVNSAPTSSSTSSSTaeaqqqqqqqqqqqQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYL 80
Cdd:smart00189   1 MYKIQLLSCIALTLALLTNSAPTSSSTKSTQ--------------QHLEQLLLDLQLLLEGVENPENLKLPRMLTFKFYL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653      81 PKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFC 160
Cdd:smart00189  67 PKQATELKHLQCLEEELKPLEEVLDLAQSKNFQLEHIKDFISNINVTVLKLKGSETRFTCQYDDESVTIVEFLNRWIAFC 146

                   ....*...
gi 7110653     161 QSIISTSP 168
Cdd:smart00189 147 QSIISTLT 154
IL2 pfam00715
Interleukin 2;
7-165 6.46e-72

Interleukin 2;


Pssm-ID: 425834  Cd Length: 145  Bit Score: 213.05  E-value: 6.46e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110653      7 ASCVTLTLVLLVNSAPTSSSTSSSTaeaqqqqqqqqqqqQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATE 86
Cdd:pfam00715   1 LSCIALTLALVANSAPTSSSTKETQ--------------QQLEQLLLDLQLLLEGVNNYKNPKLSRMLTFKFYMPKKATE 66
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7110653     87 LKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIIS 165
Cdd:pfam00715  67 LKHLQCLEEELKPLEEVLNLAQSKNFHLIDTKEFISNINVTVLKLKGSETTFTCEYDDETATIVEFLNKWITFCQSIIS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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