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Conserved domains on  [gi|31543047|ref|NP_032491|]
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importin subunit alpha-5 isoform 1 [Mus musculus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-516 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 580.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047  33 LQLRKQKREEQLFKRRNVATAEEETEEEVMSdggfHEAQINNMemapggviTSDMTDMIFSNSPEQQLSATQKFRKLLSK 112
Cdd:COG5064  34 VELRKQKREELLNKRRNLADVSEEAESSFIP----MEQQFYSE--------LPQLTQQLFSDDIEQQLQAVYKFRKLLSK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 113 EPNPPIDEVINTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWA 192
Cdd:COG5064 102 ETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 193 LGNIAGDSTMCRDYVLNCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL 271
Cdd:COG5064 181 LGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 272 ADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPK 351
Cdd:COG5064 261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPK 340

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 352 ESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGS--AEQIKYLVELGCIKPLC 429
Cdd:COG5064 341 ENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLC 420

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 430 DLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE 509
Cdd:COG5064 421 DLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDA 500


                ....*..
gi 31543047 510 DSSIAPQ 516
Cdd:COG5064 501 VDELAPE 507
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-516 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 580.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047  33 LQLRKQKREEQLFKRRNVATAEEETEEEVMSdggfHEAQINNMemapggviTSDMTDMIFSNSPEQQLSATQKFRKLLSK 112
Cdd:COG5064  34 VELRKQKREELLNKRRNLADVSEEAESSFIP----MEQQFYSE--------LPQLTQQLFSDDIEQQLQAVYKFRKLLSK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 113 EPNPPIDEVINTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWA 192
Cdd:COG5064 102 ETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 193 LGNIAGDSTMCRDYVLNCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL 271
Cdd:COG5064 181 LGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 272 ADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPK 351
Cdd:COG5064 261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPK 340

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 352 ESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGS--AEQIKYLVELGCIKPLC 429
Cdd:COG5064 341 ENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLC 420

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 430 DLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE 509
Cdd:COG5064 421 DLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDA 500


                ....*..
gi 31543047 510 DSSIAPQ 516
Cdd:COG5064 501 VDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 471-516 5.73e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 80.33  E-value: 5.73e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 31543047   471 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 516
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 158-197 1.78e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.20  E-value: 1.78e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31543047    158 NSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 197
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
33-516 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 580.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047  33 LQLRKQKREEQLFKRRNVATAEEETEEEVMSdggfHEAQINNMemapggviTSDMTDMIFSNSPEQQLSATQKFRKLLSK 112
Cdd:COG5064  34 VELRKQKREELLNKRRNLADVSEEAESSFIP----MEQQFYSE--------LPQLTQQLFSDDIEQQLQAVYKFRKLLSK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 113 EPNPPIDEVINTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWA 192
Cdd:COG5064 102 ETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 193 LGNIAGDSTMCRDYVLNCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVL 271
Cdd:COG5064 181 LGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 272 ADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPK 351
Cdd:COG5064 261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPK 340

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 352 ESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGS--AEQIKYLVELGCIKPLC 429
Cdd:COG5064 341 ENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLC 420

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 430 DLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE 509
Cdd:COG5064 421 DLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDA 500


                ....*..
gi 31543047 510 DSSIAPQ 516
Cdd:COG5064 501 VDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 471-516 5.73e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 80.33  E-value: 5.73e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 31543047   471 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 516
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-104 4.19e-18

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 78.73  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047    10 RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVataeeeteeevmsdgGFHEAQINNMEMaPGGVITSDMTD 89
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNV---------------GAPSSSSSSAES-QLLESLPEMVQ 64

                          90
                  ....*....|....*
gi 31543047    90 MIFSNSPEQQLSATQ 104
Cdd:pfam01749  65 GVNSDDPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 158-197 2.13e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 58.62  E-value: 2.13e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 31543047   158 NSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 197
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 158-197 1.78e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.20  E-value: 1.78e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31543047    158 NSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 197
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT COG1413
HEAT repeat [General function prediction only];
168-323 5.26e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.94  E-value: 5.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 168 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTmcrdyvlncniLPPLLQLFSKQNRLTmTRNAVWALSNLcrgKSPpp 247
Cdd:COG1413  15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA-----------VPALLEALKDPDPEV-RAAAAEALGRI---GDP-- 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31543047 248 efAKVSPCLNVLSWllfvSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 323
Cdd:COG1413  78 --EAVPALIAALKD----EDPEVRRAAAEALGRLGD------PAAVPA-----LLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 200-241 1.46e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 1.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 31543047   200 STMCRDYVLNCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 241
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPD-EEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 369-409 2.16e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 31543047   369 NRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATS 409
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 285-325 2.18e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 31543047   285 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT 325
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 412-452 5.17e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.29  E-value: 5.17e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 31543047   412 SAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILR 452
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 285-324 8.76e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 8.76e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 31543047    285 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 324
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 143-196 4.41e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 43.89  E-value: 4.41e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31543047   143 LQFESAWVLTNIASGNSLQTRNVIQAgAVPIFIELLSSEFEDVQEQAVWALGNI 196
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 128-237 8.84e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.25  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047   128 VARFVEFLKRKENCTLQFESAWVLTNIASgnslqtrnviqAGAVPIFIELLSSEFEDVQEQAVWALGNIaGDSTMcrdyv 207
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 31543047   208 lncniLPPLLQLFSKQNRLTMTRNAVWALS 237
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 412-450 1.54e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.54e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31543047    412 SAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENI 450
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 369-409 2.88e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.26  E-value: 2.88e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31543047    369 NRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATS 409
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
185-323 2.90e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.15  E-value: 2.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 185 VQEQAVWALGNIAGDSTmcrdyvlncniLPPLLQLFSKQNRLTMtRNAVWALSNLCRGKSPPPefakvspclnvLSWLLF 264
Cdd:COG1413   1 VRRAAARALGRLGDPAA-----------VPALIAALADEDPDVR-AAAARALGRLGDPRAVPA-----------LLEALK 57

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31543047 265 VSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 323
Cdd:COG1413  58 DPDPEVRAAAAEALGRIGD------PEAVPA-----LIAALKDEDPEVRRAAAEALGRL 105
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 200-241 3.86e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.18  E-value: 3.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 31543047    200 STMCRDYVLNCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 241
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
230-404 5.94e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 5.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 230 RNAVWALSNLcrgkspppefaKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHND 309
Cdd:COG1413   3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD------PRAVPA-----LLEALKDPD 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31543047 310 YKVVSPALRAVGNIvtGDDIQTQVILNcsalqsllhLLSSPKESIKKEACWTISNITagnraqiqtviDANMFPALISIL 389
Cdd:COG1413  61 PEVRAAAAEALGRI--GDPEAVPALIA---------ALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                       170
                ....*....|....*
gi 31543047 390 QTAEFRTRKEAAWAI 404
Cdd:COG1413 119 KDPDWEVRRAAARAL 133
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-156 1.22e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 1.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 31543047   114 PNPPIDEVINtPGVVARFVEFLKrKENCTLQFESAWVLTNIAS 156
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 244-283 1.38e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 1.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 31543047   244 SPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSD 283
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 353-406 8.69e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 34.65  E-value: 8.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31543047   353 SIKKEACWTISNITAGNRAQIQTVIDANMfPALISILQTAEFRTRKEAAWAITN 406
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVPELL-PALLPLLNDDSDLVREAAAWALGR 54
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 185-239 9.69e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 34.65  E-value: 9.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31543047   185 VQEQAVWALGNIAGDSTM-CRDYVLncNILPPLLQLfSKQNRLTMTRNAVWALSNL 239
Cdd:pfam13513   3 VREAAALALGSLAEGGPDlLAPAVP--ELLPALLPL-LNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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