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Conserved domains on  [gi|188528620|ref|NP_032662|]
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metal regulatory transcription factor 1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
92-308 3.34e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620  92 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 167
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 168 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESQGCSKYFTT 241
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188528620 242 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCpsNGCEKTFSTQySLKSH 308
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDL-DLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
92-308 3.34e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620  92 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 167
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 168 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESQGCSKYFTT 241
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188528620 242 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCpsNGCEKTFSTQySLKSH 308
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDL-DLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-270 4.71e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 4.71e-06
                          10        20
                  ....*....|....*....|....*..
gi 188528620  244 DLRKHIRTHTGEKPFRCDHdgCGKAFA 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
92-308 3.34e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620  92 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 167
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 168 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESQGCSKYFTT 241
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 188528620 242 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCpsNGCEKTFSTQySLKSH 308
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDL-DLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-315 7.07e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 7.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 171 CNQEGCGKAFLTSYSLRIHVR--VHTKE--KPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCE-SQGCSKYFTTLSDL 245
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEkLLNSSSKFSPLLNN 369

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 188528620 246 RKH-----IRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNK 315
Cdd:COG5048  370 EPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-270 4.71e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 4.71e-06
                          10        20
                  ....*....|....*....|....*..
gi 188528620  244 DLRKHIRTHTGEKPFRCDHdgCGKAFA 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 230-309 4.65e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 42.79  E-value: 4.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620  230 CESQGCSKYFTTLSDLRKHIRTHTGE------KPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNgCEKTFSTQY 303
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCEN-CLLRFRTHR 80


                  ....*.
gi 188528620  304 SLKSHM 309
Cdd:pfam15909  81 SLFKHL 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-301 4.85e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.85e-05
                          10        20
                  ....*....|....*....|....*...
gi 188528620  274 HLKTHVRTHTGERPFFCPSngCEKTFST 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 196-283 7.42e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 196 EKPFECDVQGCEKAFNTLYRLKAHqRLHTgktfncesqGCSKYFTTLSDLRKHIRTHTGEKPFRCDHdgCGKAFAASHHL 275
Cdd:COG5189  347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL 414


                 ....*...
gi 188528620 276 KTHvRTHT 283
Cdd:COG5189  415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-212 1.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.29e-04
                          10        20
                  ....*....|....*....|....*...
gi 188528620  185 SLRIHVRVHTKEKPFECDVqgCEKAFNT 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-379 1.57e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 226 KTFNCEsqGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGErpffcPSNGCEKTFSTQYSL 305
Cdd:COG5048   32 RPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNN-----PSDLNSKSLPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 306 KSH-MKGHDNKGTAYSALPQHNGSedtNHSLYLSELGLLSTDSELQEN-------SSSTQDQDLSTISPAIIFESMFQNS 377
Cdd:COG5048  105 ASSsSLSSSSSNSNDNNLLSSHSL---PPSSRDPQLPDLLSISNLRNNplpgnnsSSVNTPQSNSLHPPLPANSLSKDPS 181


                 ..
gi 188528620 378 DD 379
Cdd:COG5048  182 SN 183
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 243-327 2.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 243 SDLRKHIRTHTGEKPfRCDHDGCGKAFAASHHLKThvrthTGERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGTAYSA 321
Cdd:COG5189  311 IDVRKLPCTNSSSNG-KLAHGGERNIDTPSRMLKV-----KDGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENP 384


                 ....*..
gi 188528620 322 LPQ-HNG 327
Cdd:COG5189  385 SPEkMNI 391
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 171-249 1.28e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620  171 CNQEGCGKAFLTSYSLRIHVRVHT------KEKPFECDVQGCEKAFNTLYRLKAHQRLH--TGKTFNCESqgCSKYFTTL 242
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHykPNRYFKCEN--CLLRFRTH 79


                  ....*..
gi 188528620  243 SDLRKHI 249
Cdd:pfam15909  80 RSLFKHL 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-243 3.62e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 188528620 166 EYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFTTLS 243
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 258-282 4.54e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.54e-03
                          10        20
                  ....*....|....*....|....*
gi 188528620  258 FRCDHdgCGKAFAASHHLKTHVRTH 282
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 228-252 8.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.51e-03
                          10        20
                  ....*....|....*....|....*
gi 188528620  228 FNCEsqGCSKYFTTLSDLRKHIRTH 252
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-377 8.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 8.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 144 EGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLH 223
Cdd:COG5048   37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528620 224 TGKTFNCESQGC--SKYFTTLSDLRKHIrthtgEKPFRCDHDGCGKAFAASHHLKTHVRT---HTGERPFFCPSNGCEKT 298
Cdd:COG5048  117 SNDNNLLSSHSLppSSRDPQLPDLLSIS-----NLRNNPLPGNNSSSVNTPQSNSLHPPLpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 188528620 299 FSTQYSLKSHmKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQDLSTiSPAIIFESMFQNS 377
Cdd:COG5048  192 VSTSIPSSSE-NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS-SASESPRSSLPTA 268
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 288-312 9.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.03e-03
                          10        20
                  ....*....|....*....|....*
gi 188528620  288 FFCPsnGCEKTFSTQYSLKSHMKGH 312
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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