DNA polymerase alpha subunit B isoform 1 [Mus musculus]
Protein Classification
Pol_alpha_B_N and DNA_pol_E_B domain-containing protein( domain architecture ID 13566362)
Pol_alpha_B_N and DNA_pol_E_B domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| DNA_pol_E_B | pfam04042 | DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase ... |
342-549 | 4.53e-71 | |||||
DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure. : Pssm-ID: 461142 Cd Length: 210 Bit Score: 227.58 E-value: 4.53e-71
|
|||||||||
| Pol_alpha_B_N super family | cl37775 | DNA polymerase alpha subunit B N-terminal; This is the eukaryotic DNA polymerase alpha subunit ... |
21-238 | 3.20e-06 | |||||
DNA polymerase alpha subunit B N-terminal; This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation. This domain adopts an OB fold. The actual alignment was detected with superfamily member pfam08418: Pssm-ID: 462470 Cd Length: 240 Bit Score: 48.87 E-value: 3.20e-06
|
|||||||||
| Name | Accession | Description | Interval | E-value | ||||||
| DNA_pol_E_B | pfam04042 | DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase ... |
342-549 | 4.53e-71 | ||||||
DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure. Pssm-ID: 461142 Cd Length: 210 Bit Score: 227.58 E-value: 4.53e-71
|
||||||||||
| POL12 | COG5214 | DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, ... |
206-576 | 5.56e-68 | ||||||
DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]; Pssm-ID: 227539 [Multi-domain] Cd Length: 581 Bit Score: 231.41 E-value: 5.56e-68
|
||||||||||
| Pol_alpha_B_N | pfam08418 | DNA polymerase alpha subunit B N-terminal; This is the eukaryotic DNA polymerase alpha subunit ... |
21-238 | 3.20e-06 | ||||||
DNA polymerase alpha subunit B N-terminal; This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation. This domain adopts an OB fold. Pssm-ID: 462470 Cd Length: 240 Bit Score: 48.87 E-value: 3.20e-06
|
||||||||||
| MPP_DNA_pol_II_small_archeal_C | cd07386 | archeal DNA polymerase II, small subunit, C-terminal metallophosphatase domain; The small ... |
407-560 | 9.21e-04 | ||||||
archeal DNA polymerase II, small subunit, C-terminal metallophosphatase domain; The small subunit of the archeal DNA polymerase II contains a C-terminal metallophosphatase domain. This domain is thought to be functionally active because the active site residues required for phosphoesterase activity in other members of this superfamily are intact. The archeal replicative DNA polymerases are thought to possess intrinsic phosphatase activity that hydrolyzes the pyrophosphate released during nucleotide polymerization. This domain belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277332 Cd Length: 243 Bit Score: 41.13 E-value: 9.21e-04
|
||||||||||
| Prefoldin_2 | cd23163 | prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic ... |
207-243 | 5.11e-03 | ||||||
prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils. Pssm-ID: 467479 Cd Length: 100 Bit Score: 36.73 E-value: 5.11e-03
|
||||||||||
| Name | Accession | Description | Interval | E-value | ||||||
| DNA_pol_E_B | pfam04042 | DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase ... |
342-549 | 4.53e-71 | ||||||
DNA polymerase alpha/epsilon subunit B; This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure. Pssm-ID: 461142 Cd Length: 210 Bit Score: 227.58 E-value: 4.53e-71
|
||||||||||
| POL12 | COG5214 | DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, ... |
206-576 | 5.56e-68 | ||||||
DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]; Pssm-ID: 227539 [Multi-domain] Cd Length: 581 Bit Score: 231.41 E-value: 5.56e-68
|
||||||||||
| Pol_alpha_B_N | pfam08418 | DNA polymerase alpha subunit B N-terminal; This is the eukaryotic DNA polymerase alpha subunit ... |
21-238 | 3.20e-06 | ||||||
DNA polymerase alpha subunit B N-terminal; This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation. This domain adopts an OB fold. Pssm-ID: 462470 Cd Length: 240 Bit Score: 48.87 E-value: 3.20e-06
|
||||||||||
| MPP_DNA_pol_II_small_archeal_C | cd07386 | archeal DNA polymerase II, small subunit, C-terminal metallophosphatase domain; The small ... |
407-560 | 9.21e-04 | ||||||
archeal DNA polymerase II, small subunit, C-terminal metallophosphatase domain; The small subunit of the archeal DNA polymerase II contains a C-terminal metallophosphatase domain. This domain is thought to be functionally active because the active site residues required for phosphoesterase activity in other members of this superfamily are intact. The archeal replicative DNA polymerases are thought to possess intrinsic phosphatase activity that hydrolyzes the pyrophosphate released during nucleotide polymerization. This domain belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277332 Cd Length: 243 Bit Score: 41.13 E-value: 9.21e-04
|
||||||||||
| Prefoldin_2 | cd23163 | prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic ... |
207-243 | 5.11e-03 | ||||||
prefoldin subunit 2; Prefoldin subunit 2 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils. Pssm-ID: 467479 Cd Length: 100 Bit Score: 36.73 E-value: 5.11e-03
|
||||||||||
| Blast search parameters | ||||
|
