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Conserved domains on  [gi|258613887|ref|NP_033340|]
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substance-K receptor [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11610504)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-318 2.03e-173

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


:

Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 484.35  E-value: 2.03e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd16004    1 ALWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd16004   81 ITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd16004  161 QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd16004  241 SFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
 
Name Accession Description Interval E-value
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-318 2.03e-173

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 484.35  E-value: 2.03e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd16004    1 ALWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd16004   81 ITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd16004  161 QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd16004  241 SFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
50-307 1.10e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 209.08  E-value: 1.10e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887   50 GNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYAS-HNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIA 128
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  129 ADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITV--DQGATKCVVAWPNDNGGKmlLLYHLVVFVL 204
Cdd:pfam00001  81 IDRYLAIVHPLRykRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTvpEGNVTVCFIDFPEDLSKP--VSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  205 IYFLPLVVMFAAYSVIGLTLWKRAVPrhqahGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRKF 284
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASK-----QKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 258613887  285 IQQVYLALFWLAMSSTMYNPIIY 307
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
37-307 2.30e-20

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 90.99  E-value: 2.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIwIILAHERMRTVTNYFIINLALADLCmaaFNATFNF-IYASH-NIWYFGSTFCYFQNLFPV 114
Cdd:PHA03087  44 IVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDLL---FVMTLPFqIYYYIlFQWSFGEFACKIVSGLYY 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWpNDNGGK 192
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPvkSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFY-NNKTMN 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:PHA03087 199 WKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKK------------NKKAIKLVLIIVILFVIFWLPFNVSVFV 266
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 273 G-----TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:PHA03087 267 YslhilHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIY 306
 
Name Accession Description Interval E-value
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-318 2.03e-173

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 484.35  E-value: 2.03e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd16004    1 ALWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd16004   81 ITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd16004  161 QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd16004  241 SFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
34-318 2.51e-145

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 413.61  E-value: 2.51e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITV-----DQGATKCVVAWPND 188
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETyyyytGSERTVCFIAWPDG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQaHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15390  161 PNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGEN-TPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHL 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 269 YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15390  240 YFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-318 5.78e-126

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 364.25  E-value: 5.78e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd16003    1 ALWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPndNGGKM 193
Cdd:cd16003   81 ITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWP--GGPDQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd16003  159 HFTYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYH-EQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVT 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd16003  238 GLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-318 1.02e-120

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 350.70  E-value: 1.02e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd16002    1 ALWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd16002   81 IAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd16002  161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYH-EQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQ 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd16002  240 YFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
34-318 2.22e-100

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 299.42  E-value: 2.22e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATK-----CVVAWPnD 188
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDivrslCLEDWP-E 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15202  160 RADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNI 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 269 YFILGTFQEDiYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15202  240 YVLLLSSKPD-YLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
35-318 2.21e-94

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 283.94  E-value: 2.21e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd14992    2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVA----WPND 188
Cdd:cd14992   82 VSVYASSLTLTAIAFDRYFAIIHPLKPRhrQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIfccqIPPV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd14992  162 DNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 269 YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14992  242 FFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
34-318 4.15e-81

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 249.97  E-value: 4.15e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYA-SHNIWYFGSTFCYFQNLF 112
Cdd:cd15392    1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALlILQYWPFGEFMCPVVNYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQ----GATKCVVAWPND 188
Cdd:cd15392   81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSnascGQYICTESWPSD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15392  161 TNRY---IYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENNRDQRMAESKRKLVKMMITVVAIFALCWLPLNI 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 269 YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15392  238 LNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
39-318 1.91e-72

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 227.87  E-value: 1.91e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd14993    6 LYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITV-------DQGATKCVVAWPNDN 189
Cdd:cd14993   86 ASVLTLVAISIDRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEiissepgTITIYICTEDWPSPE 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHG---ANLRHLQAKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd14993  166 LRK---AYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSAnstSSRRILRSKKKVARMLIVVVVLFALSWLPY 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 267 HLYFILGTFQEDI--YYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14993  243 YVLSILLDFGPLSseESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
36-311 3.25e-72

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 226.79  E-value: 3.25e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYrrRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 lllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRA--VPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd00637  161 ---YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRrrIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 272 LGTFQEDIYyrKFIQQVYLALFWLAMSSTMYNPIIYCCLN 311
Cdd:cd00637  238 LDVFGPDPS--PLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
37-318 5.21e-70

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 221.71  E-value: 5.21e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQ------GATKCVVAWPNDNG 190
Cdd:cd15203   84 IFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPieilpyCGYFCTESWPSSSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GkmlLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANL---RHLQAKKKFVKAM-VLVVVTFAICWLPY 266
Cdd:cd15203  164 R---LIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSrrrRSELRRKRRTNRLlIAMVVVFAVCWLPL 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 267 HLYFIL----GTFQEDIYYRKFIqqvYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15203  241 NLFNLLrdfePLPQIDGRHFYLI---FLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
34-318 5.19e-68

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 216.33  E-value: 5.19e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIyasHNI---WYFGSTFCYFQN 110
Cdd:cd15207    1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLV---DNIltgWPFGDVMCKLSP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCF-----YSTITVDQGATKCVVAW 185
Cdd:cd15207   78 LVQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALvlevkEYQFFRGQTVHICVEFW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNDNGGKmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKF--VKAMVLVVVTFAICW 263
Cdd:cd15207  158 PSDEYRK---AYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSASREAQAAVSKKKVrvIKMLIVVVVLFALSW 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 264 LPYHLYFILGTF------QEDIYYrkfiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15207  235 LPLHTVTMLDDFgnlspnQREVLY----VYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
50-307 1.10e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 209.08  E-value: 1.10e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887   50 GNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYAS-HNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIA 128
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  129 ADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITV--DQGATKCVVAWPNDNGGKmlLLYHLVVFVL 204
Cdd:pfam00001  81 IDRYLAIVHPLRykRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTvpEGNVTVCFIDFPEDLSKP--VSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  205 IYFLPLVVMFAAYSVIGLTLWKRAVPrhqahGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRKF 284
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASK-----QKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 258613887  285 IQQVYLALFWLAMSSTMYNPIIY 307
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
39-316 1.09e-63

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 205.44  E-value: 1.09e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFC----YFQnLFPV 114
Cdd:cd15391    6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCpivlYVQ-LVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAmfvSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITV----DQGATKCVVAWPNDNG 190
Cdd:cd15391   85 TA---SVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRygqySEGRVLCGESWPGPDT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15391  162 SRSA--YTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFN 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 271 ILGTFQEDIYY--RKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15391  240 LVQDFSTVFRNmpQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
34-318 2.04e-62

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 201.87  E-value: 2.04e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQC-FYSTITVDQGAT-----KCVVAWPN 187
Cdd:cd15393   81 VLSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVAlALRVEELTDKTNngvkpFCLPVGPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 DNGGKmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15393  161 DDWWK---IYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQ 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 268 LYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15393  238 TYNLLNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
34-317 2.65e-62

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 201.41  E-value: 2.65e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYS-----TITVDQGATKCVVAWP-- 186
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQklvefEYSNERTRSRCLPSFPep 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNGGKMLllyHLVVFVLIYFLPLVVMFAAYSVIGLTLWKR----AVPRHQahgaNLRHLQAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15389  161 SDLFWKYL---DLATFILQYVLPLLIIGVAYTRVAKKLWLRnaigDVTTEQ----YVAQRRKKKKTIKMLMLVVLLFAIC 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 263 WLPYHLYFILGTFQEDIYYrkfiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSG 317
Cdd:cd15389  234 WLPLNCYHVLLSSHPIRSN----SALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
40-316 3.35e-56

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 185.71  E-value: 3.35e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYA-SHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15394    7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAfEPRGWVFGRFMCYFVFLMQPVTVY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCF--YSTITVDQGATKCVVAWpnDNGGKMLLL 196
Cdd:cd15394   87 VSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAhtYYVEFKGLDFSICEEFW--FGQEKQRLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15394  165 YACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFNVIRDID 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 277 EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15394  245 IDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-318 1.59e-54

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 180.45  E-value: 1.59e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALV-LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd14967    1 LLAVFLSLIiLVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgk 192
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRAliMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 mlllYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd14967  159 ----YVLVSSVISFFIPLLIMIVLYARI------------------FRVARRELKAAKTLAIIVGAFLLCWLPFFIIYLV 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEdiyYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14967  217 SAFCP---PDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-311 2.92e-49

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 167.84  E-value: 2.92e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNF-IYASHN-IWYFGSTFCYFQNLFPVT 115
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMdYYVVRQrSWTHGDVLCAVVNYLRTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTIT--VDQGATKCVVAWPNDNgGKM 193
Cdd:cd15204   85 SLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTpyANQGKIFCGQIWPVDQ-QAY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHgANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15204  164 YKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTE-QIRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVR 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 274 TFQEDIYYRkfiQQVYLALFW----LAMSSTMYNPIIYCCLN 311
Cdd:cd15204  243 DFFPTLLSK---EKLNTTIFYiveaLAMSNSMINTVVYVAFN 281
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
37-318 5.60e-49

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 167.00  E-value: 5.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNlFPVTA 116
Cdd:cd14969    4 AVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYG-FAVTF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 M-FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA-VIAVIWLVALALASPQCF-YSTITVDQGATKCVVAW----PNDn 189
Cdd:cd14969   83 LgLVSISTLAALAFERYLVIVRPLKAFRLSKRRALiLIAFIWLYGLFWALPPLFgWSSYVPEGGGTSCSVDWyskdPNS- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 ggkmlLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVP--RHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd14969  162 -----LSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRaaRRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYA 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 268 LYFILGTFQEDIYYRKFIqQVYLALFwlAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14969  237 VVSLYVSFGGESTIPPLL-ATIPALF--AKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-318 2.58e-48

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 165.64  E-value: 2.58e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15208    6 LYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGA-------TKCVVAWPNDNGG 191
Cdd:cd15208   86 VSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPLanktillTVCDERWSDSIYQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMlllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVP-------------RHQAHGANLRHLQAKKKFVKAMVLVVVT 258
Cdd:cd15208  166 KV---YHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPgtssvvqrkwnkpRKSAVAAEEKQLRSRRKTAKMLIVVVIM 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 259 FAICWLPYHLYFILG-TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15208  243 FAICYLPVHLLNILRyVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
40-318 1.01e-47

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 163.62  E-value: 1.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNFIYASH--NIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd14970    7 YSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADEL---FLLGLPFLATSYllGYWPFGEVMCKIVLSVDAYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ-PRLSAPS-TKAVIAVIWLVALALASPQCFYS-TITVDQGATKCVVAWPNDN--GGK 192
Cdd:cd14970   84 FTSIFCLTVMSVDRYLAVVHPVKsLRFRTPRkAKLVSLCVWALSLVLGLPVIIFArTLQEEGGTISCNLQWPDPPdyWGR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYhlvVFVLIYFLPLVVMFAAYSVIGLTLwKRAVPRHQAHGanlRHLQAKKKFVKAMVLVVV-TFAICWLPYHLYFI 271
Cdd:cd14970  164 VFTIY---TFVLGFAVPLLVITVCYSLIIRRL-RSSRNLSTSGA---REKRRARRKVTRLVLVVVaVFVVCWLPFHVFQI 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 272 ---LGTFQEDiyyrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14970  237 vrlLIDPPET----LTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
40-318 2.52e-44

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 154.47  E-value: 2.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15206    7 YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTI--TVDQGATKCVVAWPNDnggKMLL 195
Cdd:cd15206   87 STFTLVAISLERYFAICHPLKSRVWQTLSHAykVIAGIWLLSFLIMSPILVFSNLipMSRPGGHKCREVWPNE---IAEQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWkravprhqahganlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:cd15206  164 AWYVFLDLMLLVIPGLVMSVAYGLISWTLL-----------------EAKKRVIRMLFVIVVEFFICWTPLYVINTWKAF 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 276 QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15206  227 DPPSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
45-318 2.66e-43

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 152.05  E-value: 2.66e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADL----CMAAFNATfnfIYASHNiWYFGSTFCYFQNLFpvtaMFVS 120
Cdd:cd15095   12 LVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLaflvCCVPFTAA---LYATPS-WVFGDFMCKFVNYM----MQVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSM----TAIAADRYMAIVHPF------QPRLsapsTKAVIAVIWLVALALASPQCFYSTITV---DQGATKCVVAWPN 187
Cdd:cd15095   84 VQATcltlTALSVDRYYAIVHPIrslrfrTPRV----AVVVSACIWIVSFLLSIPVAIYYRLEEgywYGPQTYCREVWPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 DNGGKMLLLYhlvVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVL-VVVTFAICWLPY 266
Cdd:cd15095  160 KAFQKAYMIY---TVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLSERALRQKRKVTRMVIvVVVLFAICWLPN 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 267 HLYFILGTFqeDIYYRKFIQQVYLALFWLAMS---STMyNPIIYCCLNHRFRSGF 318
Cdd:cd15095  237 HVLNLWQRF--DPNFPETYATYALKIAALCLSyanSAV-NPFVYAFMGENFRKYF 288
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
34-318 4.18e-43

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 151.96  E-value: 4.18e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15980    1 AVFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATK------------- 180
Cdd:cd15980   81 GISVSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVvlgsqnktspvyw 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 181 CVVAWPNDnggKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKK--FVKAMVLVVVT 258
Cdd:cd15980  161 CREDWPNQ---EMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVVSRKKqkVIKMLLIVALL 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 258613887 259 FAICWLPYHLYFILGTFQE--DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15980  238 FILSWLPLWTLMMLSDYANlsPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
39-318 9.78e-43

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 150.74  E-value: 9.78e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15399    6 AYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYS-----TITVDQGATKCVVAWPN--DNGG 191
Cdd:cd15399   86 VSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFReysviEISPDFKIQACSEKWPNgtLNDG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 kmlLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPrhqaHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15399  166 ---TIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSP----GGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 272 LGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15399  239 ASDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
44-318 1.53e-40

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 144.75  E-value: 1.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  44 VLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd15096   11 FIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCFYSTITVDQGA----TKCVVAWpndNGGKMLLLY 197
Cdd:cd15096   91 LVLMSLDRYLAVVHPITSMSIRTERNTLIAIvgIWIVILVANIPVLFLHGVVSYGFSseaySYCTFLT---EVGTAAQTF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPrhqaHGANLRHLQAKKKFVKAM-VLVVVTFAICWLPYHLYFIL---G 273
Cdd:cd15096  168 FTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSP----GGRRSAESQRGKRRVTRLvVVVVVVFAICWLPIHIILLLkyyG 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRkfIQQVylALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15096  244 VLPETVLYV--VIQI--LSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
38-318 1.86e-40

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 143.96  E-value: 1.86e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15001    4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPqCFYSTITV------DQGATKCVVAWPndn 189
Cdd:cd15001   84 ICSVLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASP-VLFGQGLVryesenGVTVYHCQKAWP--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGltlwkravprhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15001  160 STLYSRLYVVYLAIVIFFIPLIVMTFAYARDT-----------------------RKQVIKMLISVVVLFAVCWGPLLID 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 270 FILGTFQEDIyyRKFIQQVY---LALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15001  217 NLLVSFDVIS--TLHTQALKymrIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
42-318 4.26e-40

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 143.38  E-value: 4.26e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd14971    9 LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPR-LSAPSTK-AVIAVIWLVALALASPQCFYSTITVDQGA--TKCVVAWPNdngGKMLLLY 197
Cdd:cd14971   89 FTLVAMSLDRFLAVVYPLRSLhIRTPRNAlAASGCIWVVSLAVAAPVLALHRLRNYTPGnrTVCSEAWPS---RAHRRAF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTF-Q 276
Cdd:cd14971  166 ALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR----RAKRKVTRLVLVVVVLFAACWGPIHAILLLVALgP 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 277 EDIYYRKFIQQVYLALfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14971  242 FPLTYATYALRIWAHC--LAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
40-318 1.75e-39

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 142.49  E-value: 1.75e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNI-WYFGSTFCYFQNLFPVTAMF 118
Cdd:cd14979    7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYpWAFGDGGCKLYYFLFEACTY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR-LSAPS-TKAVIAVIWLVALALASPQCFYSTI--------TVDQGATKCVVAwPND 188
Cdd:cd14979   87 ATVLTIVALSVERYVAICHPLKAKtLVTKRrVKRFILAIWLVSILCAIPILFLMGIqylngplpGPVPDSAVCTLV-VDR 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLlyhLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavpRHQAHGANLRHL---------QAKKKFVKAMVLVVVTF 259
Cdd:cd14979  166 STFKYVF---QVSTFIFFVLPMFVISILYFRIGVKLRSM---RNIKKGTRAQGTrnvelslsqQARRQVVKMLGAVVIAF 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 260 AICWLPYHL--YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14979  240 FVCWLPFHAqrLMFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
38-318 3.21e-39

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 141.64  E-value: 3.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATK-------CVVAWPND 188
Cdd:cd15927   85 GVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVtaASIWIVSILLAIPEAIFSHVVTFTLTDNqtiqicyPYPQELGP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFvliYFLPLVVMFAAYSVIGLTLWKRA---VPRHQAHGAnlRHLQAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15927  165 NYPKIMVLLRFLVY---YLIPLLIIGVFYVLMARHLIRSTrniGSGQNQAAQ--RQIEARKKVAKTVLAFVVLFAVCWLP 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 266 YHLYFILGTF--QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15927  240 RHVFMLWFHFapNGLVDYNAFWHVLKIVGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
38-318 4.65e-39

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 141.07  E-value: 4.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15205    5 ITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITV------DQGATKCVVAWPNDN 189
Cdd:cd15205   85 VTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTmlGLVWIVSVIVGSPMLFVQQLEVkydflyEKRHVCCLERWYSPT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMlllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKR------AVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICW 263
Cdd:cd15205  165 QQKI---YTTFILVILFLLPLTTMLFLYSRIGYELWIKkrvgdaSVLQTIHGIEMSKISRKKKRAVKMMVTVVLLFAVCW 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 264 LPYHLYFILG--TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15205  242 APFHVVHMMIeySNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
40-315 3.39e-38

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 138.55  E-value: 3.39e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmaAFNATFNF---IYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd14982    7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADL---LFVLTLPFriyYYLNGGWWPFGDFLCRLTGLLFYIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFY-STITVDQGATKCVVAWPndNGGKM 193
Cdd:cd14982   84 MYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGvcAGVWILVLVASVPLLLLrSTIAKENNSTTCFEFLS--EWLAS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqahgaNLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd14982  162 AAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSK--------QSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILY 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 274 T-----FQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd14982  234 LlvrlsFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFR 280
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
39-311 1.61e-37

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 137.12  E-value: 1.61e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLV-AVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd14986    5 AVLGVLFVfTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKmllL 196
Cdd:cd14986   85 FASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLViFVERELGDGVHQCWSSFYTPWQRK---V 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRA-------------VPRHQAHGANLRHL--QAKKKFVKAMVLVVVTFAI 261
Cdd:cd14986  162 YITWLATYVFVIPLIILSYCYGRILRTIWIRSrqktdrpiaptamSCRSVSCVSSRVSLisRAKIKTIKMTLVIILAFIL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 262 CWLPYHLYFILGTFQEDIYYRkfiQQVYLALFWLAMSSTMYNPIIYCCLN 311
Cdd:cd14986  242 CWTPYFIVQLLDVYAGMQQLE---NDAYVVSETLASLNSALNPLIYGFFS 288
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
38-318 2.33e-37

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 136.19  E-value: 2.33e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNF-IYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLL---FVLTLPFwAVYAADGWVFGSFLCKLVSALYTIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKML 194
Cdd:cd14984   82 FYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLtcLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATTWK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavPRHQAHGAnlrhlqakkkfVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd14984  162 TLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRA--RNHKKHRA-----------LRVIFAVVVVFFLCWLPYNIVLLLDT 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 275 FQE-DIYYR--KFIQQVYLALFW---LAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14984  229 LQLlGIISRscELSKSLDYALQVtesLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
40-318 3.28e-37

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 136.27  E-value: 3.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADL-----CMAAFNATFNfiyaSHNIWYFGSTFCYFQNLFPV 114
Cdd:cd14997    7 YGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLlvllvCMPVALVETW----AREPWLLGEFMCKLVPFVEL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVDqgatkcvvawpNDNGGK 192
Cdd:cd14997   83 TVAHASVLTILAISFERYYAICHPLQAKYVCTKRRAlvIIALIWLLALLTSSPVLFITEFKEE-----------DFNDGT 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 ML------------LLYHLVVFVLIYFLPLVVMFAAYSVIGLTL-WKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTF 259
Cdd:cd14997  152 PVavcrtpadtfwkVAYILSTIVVFFVVPLAILSGLYSVICRRLvGHPALESRRADAANRHTLRSRRQVVYMLITVVVLF 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 260 AICWLPY---HLYFILGTfQEDIYyrKFIQQVYLALFWLA-----MSSTMyNPIIYCCLNHRFRSGF 318
Cdd:cd14997  232 FVCLLPFrvvTLWIIFAP-DEDLQ--ALGLEGYLNLLVFCrvmvyLNSAL-NPILYNLMSTKFRSAF 294
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
40-315 4.89e-36

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 132.58  E-value: 4.89e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15088    7 FGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQFT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQP-RLSAPS-TKAVIAVIWLVALALASPQCFYST-ITVDQGATKCVVAWPNDNGGKMLLL 196
Cdd:cd15088   87 STYILTAMSVDRYLAVVHPIRStKYRTRFvAKLVNVGLWAASFLSILPVWVYSSlIYFPDGTTFCYVSLPSPDDLYWFTI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHlvvFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlRHlqakKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15088  167 YH---FILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSS-RT----KRVTKMVILIVVVFIVCWLPFHVVQLVNLAM 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 277 EDIYYrKFIQQVYLAlFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15088  239 NRPTL-AFEVAYFLS-ICLGYANSCLNPFVYILVSENFR 275
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-318 8.01e-36

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 132.16  E-value: 8.01e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIIL--AHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15098   12 CLGVLGNSLVITVLArvKPGKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFYSTITVDQGA---TKCVVAWPNDNGGKmllLY 197
Cdd:cd15098   92 TLVAMSVDRYIAVVHSRTSSSLRTRRNALLGvlVIWVLSLAMASPVAVHQDLVHHWTAsnqTFCWENWPEKQQKP---VY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKraVPRHQAHGANLrhlqAKKKFVKAMVLVVVTFAICWLPYH---LYFILGT 274
Cdd:cd15098  169 VVCTFVFGYLLPLLLITFCYAKVLNHLHK--KLKNMSKKSER----SKKKTAQTVLVVVVVFGISWLPHHiihLWVEFGD 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 275 F---QEDIYYRkfiqqvyLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15098  243 FpltQASFVLR-------ITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
40-318 3.30e-35

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 130.38  E-value: 3.30e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15978    7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITV-----DQGATKCVVAWPNDnggK 192
Cdd:cd15978   87 STFNLVAISLERYSAICKPLKSRVWQTKSHAlkVIAATWCLSFTIMLPYPIYSNLVPftrinNSTGNMCRLLWPND---V 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahgaNLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15978  164 TQQSWYIFLLLILFLIPGIVMMTAYGLISLELYR-----------GIKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAW 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15978  233 RAFDTRSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
34-318 5.09e-35

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 130.71  E-value: 5.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15981    1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQ------------GATKC 181
Cdd:cd15981   81 GMSVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEhhfmvddynnsyPLYSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 182 VVAWPNDnggKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHG---ANLRHLQAKKKFVKAMVLVVVT 258
Cdd:cd15981  161 WEAWPDT---EMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGeeeEGRRVSKRKIKVINMLIIVALF 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 258613887 259 FAICWLPYHLYFILGTFQEDIYYRKFIQQVYLALF--WLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15981  238 FTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYVFPFahWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
35-317 2.51e-34

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 127.95  E-value: 2.51e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFC----YFQN 110
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCrmyqFVHS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTamfvSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYS---TITVDQgATKCVVAW 185
Cdd:cd15012   81 LSYTA----SIGILVVISVERYIAILHPLRCKqlLTAARLRVTIVTVWLTSAVYNTPYFVFSqtvEILVTQ-DGQEEEIC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRhqahganlrhlqAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15012  156 VLDREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIE------------ARRKVVRLLVAVVVSFALCNLP 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 266 YHLYFILGTFQEDIYYRKFIQQVYLAL-FWLAMSSTMYNPIIYCCLNHRFRSG 317
Cdd:cd15012  224 YHARKMWQYWSEPYRCDSNWNALLTPLtFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
40-318 7.46e-34

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 126.76  E-value: 7.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIwIILAHERMR---TVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15002    6 LGVICLLGFAGNLMVI-GILLNNARKgkpSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHAC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDnGGKMLL 195
Cdd:cd15002   85 MAAKSFTIAVLAKACYMYVVNPTkQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPL-AHEFMS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAvprhqAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYH---LYFIL 272
Cdd:cd15002  164 AFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRG-----TKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWvawLWLIH 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYYRKFIQQVYLalfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15002  239 IKSSGSSPPQLFNVLAQL----LAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
42-318 1.01e-33

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 126.68  E-value: 1.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15051    9 VIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQ-PRLSAPSTKAV-IAVIWLVALALA---------SPQcfYSTITVDQGaTKCVVAWPNdng 190
Cdd:cd15051   89 LNLFAISLDRYLAITAPLRyPSRVTPRRVAIaLAAIWVVSLAVSflpihlgwnTPD--GRVQNGDTP-NQCRFELNP--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gkmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRA---VPRHQAHGANLRHLQAKKKFVKAMV---LVVVTFAICWL 264
Cdd:cd15051  163 -----PYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAkriNALTPASTANSSKSAATAREHKATVtlaAVLGAFIICWF 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 265 PYHLYFILGTFQEDiyyrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15051  238 PYFTYFTYRGLCGD----NINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
38-318 1.35e-33

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 126.08  E-value: 1.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYS-TITVDQGA----TKCVVAWPNDng 190
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAyrVIAATWLLSGLIMIPYPVYSvTVPVPVGDrprgHQCRHAWPSA-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWkravprhqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15979  163 -QVRQAWYVLLLLILFFIPGVVMIVAYGLISRELY--------------RGLLAKKRVIRMLVVIVAMFFLCWLPIFSAN 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 271 ILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15979  228 TWRAFDPLSAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
40-315 1.98e-33

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 126.07  E-value: 1.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15928    7 CSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGAT-----KCVVAwpndNGGK 192
Cdd:cd15928   87 SILHITALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQtprgfECTVV----NVSS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAhGANLRHlQAKKKFVKAMVLVVVTFAICWLPYHL---- 268
Cdd:cd15928  163 GLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTA-GASRRD-NNHRQTVRMLAVIVLAFVLCWLPFHVgrvi 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 269 -YFILGTFQEDIYYRKFIQQVYLALFWLamsSTMYNPIIYCCLNHRFR 315
Cdd:cd15928  241 fNHSRASTKHLHYVSQYFNLVSFVLFYL---SAAINPILYNLMSKRYR 285
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
37-315 2.23e-33

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 126.08  E-value: 2.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15395    4 ALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTIT----------VDQGATK--CVVA 184
Cdd:cd15395   84 ITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQVLTdepfknvnvsLDAYKGKyvCLDQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 185 WPNDNggkMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKkfVKAMVL-VVVTFAICW 263
Cdd:cd15395  164 FPSDT---IRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRSSETKR--INIMLIsIVVAFAVCW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 264 LPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15395  239 LPLNIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
35-315 3.55e-33

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 125.08  E-value: 3.55e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALV-LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15074    1 IIIGIYLTVIgILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHP-FQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGG 191
Cdd:cd15074   81 FLFGCCSINTLTAISIYRYLKICHPpYGPKLSRRHVCIVIVAIWLYALFWAVAPLVgWGSYGPEPFGTSCSIDWTGASAS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwKRAVPRHQAHGaNLRHLQAK--KKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15074  161 VGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKV-KSSRKRVAGFD-SRSKRQHKieRKVTKVAVLICAGFLIAWTPYAVV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 270 FILGTFQEdIYYRKFIQQVYLALFwlAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15074  239 SMWSAFGS-PDSVPILASILPALF--AKSSCMYNPIIYLLFSSKFR 281
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
39-318 6.62e-33

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 124.75  E-value: 6.62e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFN-FIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15134    6 IYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFElYTIWQQYPWVFGEVFCKLRAFLSEMSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASPQCFYSTI---TVDQGATKCV----VAWPND 188
Cdd:cd15134   86 YASVLTITAFSVERYLAICHPLRSHTMSKLSRAIriIIAIWIIAFVCALPFAIQTRIvylEYPPTSGEALeesaFCAMLN 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLiYFLPLVVMFAAYSVIGLTLWKRAVPRHQA---HGANlRHLQAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15134  166 EIPPITPVFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRSTLLRRGQrsvSGGR-RSSQSRRTVLRMLVAVVVAFFICWAP 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 266 YH---LYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMyNPIIYCCLNHRFRSGF 318
Cdd:cd15134  244 FHaqrLLTVYAKNMTPPYLFINRILFYISGVLYYVSSTV-NPILYNVMSAKYRQAF 298
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
37-315 1.22e-32

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 124.08  E-value: 1.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15397    4 VVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTIT----------VDQGATK--CVVA 184
Cdd:cd15397   84 VTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTdepyknlshfFAPLADKavCTES 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 185 WPNdngGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKkfVKAM-VLVVVTFAICW 263
Cdd:cd15397  164 WPS---EHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGHSKR--INVMlVSLVAAFALCW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 264 LPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15397  239 LPLNVFNAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
38-318 2.30e-32

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 122.92  E-value: 2.30e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15000    4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQgatkcvvaWPN-------DNG 190
Cdd:cd15000   84 LASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQ--------WKNfletycaENT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFVLIYfLPLVVMFAAYSVIGLTL--WKRAVPRHQAHganlRHLQAKKKFVKAMVLVVVTFAICWLPYH- 267
Cdd:cd15000  156 QVLPIYWHVIITVLVW-LPLGIMLICYSAIFWKLdkYERRVLRREHP----SVVRYKKKAAKTLFIVLITFVVCRIPFTa 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 268 LYFILGTFQEDIYYRKFIQQVYLaLFWLAMSSTMY-----NPIIYCCLNHRFRSGF 318
Cdd:cd15000  231 LIFYRYKLVPNDNTQNSVSGSFH-ILWFASKYLMFlnaavNPLIYGFTNENFRKAF 285
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-313 2.72e-32

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 122.92  E-value: 2.72e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15197   10 LFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQ-CFYSTITVDQGATKCVVAWPNDNGGKmllLYHLVV 201
Cdd:cd15197   90 VLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPMlIIFEKTGLSNGEVQCWILWPEPWYWK---VYMTIV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 202 FVLIYFLPLVVMFAAYSVIGLTLWKR-----AVPRHQAHGANLRHL-------QAKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15197  167 AFLVFFIPATIISICYIIIVRTIWKKskiqvTINKAGLHDGSSRRSssrgiipRAKIKTIKMTFVIVTVFIICWSPYFVF 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 270 FILGTF------QEDIYYRKFIQQvylalfwLAMSSTMYNPIIYCCLNHR 313
Cdd:cd15197  247 DLLDVFgllprsKTKIAAATFIQS-------LAPLNSAINPLIYCLFSTH 289
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
37-318 2.38e-31

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 120.35  E-value: 2.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNI-WYFGSTFCYFQNLFPVT 115
Cdd:cd15357    4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYpFLFGPVGCYFKTALFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASP--------QCFYSTITVDQGATKCVVAW 185
Cdd:cd15357   84 VCFASILSVTTVSVERYVAILHPFRAKLNSTRERAlkIIVVLWVLSVLFSIPntsihgikLQYFPNGTLIPDSATCTVVK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PndnggkmLLLYHLVVFV---LIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHlQAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15357  164 P-------LWIYNLIIQItslLFYVLPMGVISVLYYLMGLKLRGDKSLEADEMNVNIQR-PSRKSVTKMLFVLVLVFAIC 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 263 WLPYHLYFILGTFQEDIYYR-----KFIQQVYLALFWLamsSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15357  236 WAPFHVDRLFFSFVVEWTEPlanvfNLIHVVSGVFFYL---SSAVNPIIYNLLSRRFRTAF 293
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
40-318 2.87e-31

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 120.07  E-value: 2.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAafnATFNFIYAS-HNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15178    7 YVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFA---LTLPFWAVSvVKGWIFGTFMCKLVSLLQEANFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSA-PSTKAVIAVIWLVALALASPQCFYST--ITVDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15178   84 SGILLLACISVDRYLAIVHATRALTQKrHLVKFVCAGVWLLSLLLSLPALLNRDafKPPNSGRTVCYENLGNESADKWRV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWkravprhQAHGanlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:cd15178  164 VLRILRHTLGFLLPLVVMLFCYGFTIKTLL-------QTRS------FQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTL 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 276 ------QEDIYYRKfiqQVYLALFW---LAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15178  231 mrtkliTETCELRN---HVDVALYVtqiLGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
45-316 5.51e-31

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 118.94  E-value: 5.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIilAHERM-RTVTNYFIINLALADLcmaAFNAT--FNFIY-ASHNIWYFGSTFCYFQNLFPVTAMFVS 120
Cdd:cd14974   12 LLGLPGNGLVIWV--AGFKMkRTVNTVWFLNLALADF---LFCLFlpFLIVYiAMGHHWPFGSVLCKLNSFVISLNMFAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFY-STITVDQGATK---CVVAWPNDNGGKML 194
Cdd:cd14974   87 VFLLTAISLDRCLLVLHPVwaQNHRTVRLASVVCVGIWILALVLSVPYFVFrDTVTHHNGRSCnltCVEDYDLRRSRHKA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLyhLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAvprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd14974  167 LT--VIRFLCGFLLPLLIIAICYSVIAVKLRRKR-------------LAKSSKPLRVLLAVVVAFFLCWLPYHVFALLEL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 275 FQEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd14974  232 VAAAGLPEVVLLGLPLATG-LAYFNSCLNPILYVFMGQDFRK 272
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
42-318 1.32e-30

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 118.65  E-value: 1.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15195    9 VLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITV--DQGATKCVVAWPNDNGGKMLLLYH 198
Cdd:cd15195   89 FMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFiFSVLRKmpEQPGFHQCVDFGSAPTKKQERLYY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 LVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHL------QAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15195  169 FFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNRRRSrtnsleRARMRTLRMTALIVLTFIVCWGPYYVLGLW 248
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEdIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15195  249 YWFDK-ESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
38-315 4.16e-30

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 116.71  E-value: 4.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAP--STKAVIAVIWLVALALASPQCFYSTITV--DQGATKCVVAWPNDnggKM 193
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRrrQARVTCALIWVVACLLSLPTFLLRSLQAieNLNKTACIMLYPHE---AW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIgltlWKRAVPRHQAHGANLRhlqAKKKFVKAMVLVVVTFAICWLPYHLY---F 270
Cdd:cd14985  162 HFGLSLELNILGFVLPLLIILTCYFHI----ARSLRKRYERTGKNGR---KRRKSLKIIFALVVAFLVCWLPFHFFkflD 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 271 ILGTFQEDIYYR--KFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd14985  235 FLAQLGAIRPCFweLFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
37-315 6.67e-30

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 116.36  E-value: 6.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQ----NLF 112
Cdd:cd15336    4 GSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYafcgALF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFvsiySMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQG-ATKCvvAWPNDN 189
Cdd:cd15336   84 GITSMI----TLLAISLDRYLVITKPLASirWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGlLTSC--TWDYMT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK--RAVPRHQAHGANLRHLQAKK-----KFVKAMVLVVVTFAIC 262
Cdd:cd15336  158 FTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRStgREVQKLGSQDRKEKAKQYQRmknewKMAKIAFVVILLFVLS 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 263 WLPYHLYFILGTFQEDIYYRKFIQQVyLALFwlAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15336  238 WSPYACVALIAWAGYAHLLTPYMKSV-PAVI--AKASAIYNPIIYAITHPKYR 287
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-316 7.54e-30

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 116.78  E-value: 7.54e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  33 LALWATAYLALVLVAVTGNATVIWIIL-AHERMRTVTNYFIINLALADLcmaAFNATFNF--IYASHNI-WYFGSTFCYF 108
Cdd:cd15190   10 YALIPVIYMLVFVLGLSGNGLVLWTVFrSKRKRRRSADTFIANLALADL---TFVVTLPLwaVYTALGYhWPFGSFLCKL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 QNLFPVTAMFVSIYSMTAIAADRYMAIVHPF-QPRL-SAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCV---- 182
Cdd:cd15190   87 SSYLVFVNMYASVFCLTGLSFDRYLAIVRSLaSAKLrSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVIcdmd 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 183 --VAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGltlwkRAVPRHQAHGANlRHLQAKKKFVKAMVLVVVTFA 260
Cdd:cd15190  167 ysGVVSNESEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIG-----RTVARHFSKLRR-KEDKKKRRLLKIIITLVVTFA 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 258613887 261 ICWLPYHL------YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15190  241 LCWLPFHLvktlyaLMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-318 7.92e-30

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 116.02  E-value: 7.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADlcmAAFNATFNFIYASHNI--WYFGSTFCYFQNLFPVTAM 117
Cdd:cd15093    7 YAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIAD---ELFMLGLPFLAASNALrhWPFGSVLCRLVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAV-IWLVALALASPQCFYSTITVDQ-GATKCVVAWPnDNGGKML 194
Cdd:cd15093   84 FTSIFCLTVMSVDRYLAVVHPIKSaRWRRPRVAKVVNLaVWVASLLVILPVVVFAGTRENQdGSSACNMQWP-EPAAAWS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15093  163 AGFIIYTFVLGFLLPLLIICLCYLLI-----VIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEdIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15093  238 FVQ-LPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-318 1.33e-29

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 115.70  E-value: 1.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNI-WYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15133    7 YLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYpFLLGSGGCYFKTFLFETVCL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQC-----FYSTITVDQGATKCVVawpndngg 191
Cdd:cd15133   87 ASILNVTALSVERYIAVVHPLAARTCSTRPRVtrVLGCVWGVSMLCALPNTslhgiKFLGSGVPASAQCTVR-------- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVV---FVLIYFLPLVVMFAAYSVIGLTLWKRA--------VPRHQAHGANLRHLQAKKKFVKAMVLVVVTFA 260
Cdd:cd15133  159 KPQAIYNMIPqhtGHLFFVLPMAVISVLYLLMALRLARERgldatgagSKIGTRTGQLLQHPRTRAQVTKMLFILVVVFA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 261 ICWLPYHLYFILGTFQEDIY--YRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15133  239 ICWAPFHIDRLMWSFISDWTdnLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
45-318 2.97e-29

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 114.54  E-value: 2.97e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIIL-AHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd15097   12 LLGTVGNSLVLAVLLrSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHPFQPR-LSAP-STKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMlllyHLVV 201
Cdd:cd15097   92 LAAVSVDRYLAIRYPLRSReLRTPrNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGWEEARRKAM----DTCT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 202 FVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlrhlQAKKKFVKAMVLVVVTFAICWLPYH---LYFILGTFqed 278
Cdd:cd15097  168 FAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESK----RAKRKVTKMIIIVTALFCLCWLPHHvviLCYLYGDF--- 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 279 iyyrKFIQQVY---LALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15097  241 ----PFNQATYafrLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
40-318 6.30e-29

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 113.86  E-value: 6.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15123    7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATKCVV---AWPNDNGGKML 194
Cdd:cd15123   87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCkaGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTfeaCAPYPVSEKIL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYH-LVVFVLIYFLPLVVMFAAYSVIGLTLWKRA--VPRHQaHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15123  167 QEIHsLLCFLVFYIIPLSIISVYYFLIARTLYKSTfnMPAEE-HSHARKQIESRKRVAKTVLVLVALFAFCWLPNHILYL 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 272 LGTFQEDIYYRKFIQQVYLALF--WLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15123  246 YRSFTYHTSVDSSAFHLIATIFsrVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
37-318 1.12e-28

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 112.95  E-value: 1.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNFIYASHNI--WYFGSTFCYFQNLFPV 114
Cdd:cd15094    4 AVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADEC---FLIGLPFLIVTMILkyWPFGAAMCKIYMVLTS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQ-PRLSAPS-TKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPND---N 189
Cdd:cd15094   81 INQFTSSFTLTVMSADRYLAVCHPIRsMRYRTPFiAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSsavN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYhlvVFVLIYFLPLVVMFAAYSVIGLTLwKRAVPRHQAHganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15094  161 GQKAFTLY---TFLLGFAIPLLLISVFYTLVILRL-RTVGPKNKSK----EKRRSHRKVTRLVLTVISVYIICWLPYWAF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 270 FILGTFQEDIYY-RKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15094  233 QVHLIFLPPGTDmPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
35-318 1.84e-28

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 112.60  E-value: 1.84e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTV--TNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLF 112
Cdd:cd14976    2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQ-GATKCVVAWPNDN 189
Cdd:cd14976   82 TKLNMYSSIFFLTALSVTRYIAVARALKHgwIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSvNHTLCLLRFPKNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGK----MLLLYHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAHGAnlrhlQAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd14976  162 SVTrwynWLGMYQLQKVVLGFFLPLGIITLSYLLL-----LRFLQRKRGGSK-----RRKSRVTKSVFIVVLSFFICWLP 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 266 YH---LYFILGTF----QEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14976  232 NQalsLWSALIKFddvpFSDAFFAFQTYAFPVAIC-LAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
43-318 4.81e-28

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 111.63  E-value: 4.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15048   10 LILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASAL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTI-----TVDQGatKCVVAWPNDnggkmlL 195
Cdd:cd15048   90 TIVLISLDRYLSVTKAvkYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLwtgysIVPTG--DCEVEFFDH------F 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRA---------------VPRHQAHGANLRHLQAKKKFVKAMVLVVVTFA 260
Cdd:cd15048  162 YFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSrrrplrsvpilpasqNPSRARSQREQVKLRRDRKAAKSLAILVLVFL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 261 ICWLPYHLYFILGTFQEDIYYRKFiqqVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15048  242 ICWAPYTILTIIRSFCSGSCVDSY---LYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
39-267 6.36e-28

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 110.87  E-value: 6.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15168    6 VYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNgGKMLLL 196
Cdd:cd15168   86 GSILFLTCISVHRYLGICHPLRSLgkLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEE-LNDYVI 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavPRHQAHGAnlrhlqAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15168  165 YSMVLTGLGFLLPLLIILACYGLIVRALIRK--LGEGVTSA------LRRKSIRLVIIVLALFAVCFLPFH 227
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
35-315 1.15e-27

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 110.31  E-value: 1.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15396    2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVD------------QGATKCV 182
Cdd:cd15396   82 VSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTDEpfrnlsshsdfyKDKVVCI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 183 VAWPNDNGgkmLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAvPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15396  162 EAWPSETE---RLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRN-SKIDRMRENESRLSENKRINTMLISIVVTFAAC 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 263 WLPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15396  238 WLPLNIFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
39-318 1.23e-27

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 109.78  E-value: 1.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLC--MAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd14995    6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMvlVAAGLPNEIESLLGPDSWIYGYAGCLLITYLQYLG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFYSTITV----DQGATKCvvawpndnG 190
Cdd:cd14995   86 INASSLSITAFTIERYIAICHPMKAQFicTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIkhygDDIVVRC--------G 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKM----LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhlqAKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd14995  158 YKVsrhyYLPIYLADFVLFYVIPLLLAIVLYGLIGRILFS-----------------SRKQVTKMLAVVVVLFALLWMPY 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 267 HLYFIlgtfqediyYRKFIQQVYLALFWLAMSSTM------YNPIIYCCLNHRFRSGF 318
Cdd:cd14995  221 RTLVV---------YNSFASPPYLDLWFLLFCRTCiylnsaINPILYNLMSQKFRAAF 269
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
43-307 1.37e-27

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 110.22  E-value: 1.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15384   10 MFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQpRLSAPS-TKAVIAVIWLVALALASPQCFysTITVDQGA-----TKCVV------AWPNDng 190
Cdd:cd15384   90 ITVLISLDRCVAILYPMK-RNQAPErVRRMVTVAWILSPIFSIPQAV--IFHVERGPfvedfHQCVTygfytaEWQEQ-- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gkmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK------RAVPRHQAHGANLRHL--QAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15384  165 -----LYNMLSLVFMFPIPLVIMVTCYVLIFITLSKssrdfqGLEIYTRNRGPNRQRLfhKAKVKSLRMSAVIVTAFILC 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 263 WLPYHLYFILGTFQEdiyYRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15384  240 WTPYYVIMIWFLFFN---PYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
39-315 2.14e-27

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 109.72  E-value: 2.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALV-LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmaAFNATFNF----IYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15337    5 IYIAIVgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDF---GFSAVNGFplktISSFNKKWIWGKVACELYGFAG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVDQG-ATKCVV-----AW 185
Cdd:cd15337   82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAfiMIIIIWLWSLLWSIPPFFGWGRYVPEGfQTSCTFdylsrDL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNdnggkmlLLYHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAH---------GANLRHLQAKKK----FVKAM 252
Cdd:cd15337  162 NN-------RLFILGLFIFGFLCPLLIIIFCYVNI-----IRAVRNHEKEmtqtaksgmGKDTEKNDARKKaeirIAKVA 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 253 VLVVVTFAICWLPYHLYFILGTFQEDIYYRKFIQQVYLAlfwLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15337  230 IILISLFLLSWTPYAVVALLGQFGPAYWITPYVSELPVM---FAKASAIYNPIIYALSHPKFR 289
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
41-317 2.18e-27

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 109.73  E-value: 2.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVS 120
Cdd:cd15083    8 LIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKMllLY 197
Cdd:cd15083   88 INTLAAIAVDRYLVITRPMkaSVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVLEGLLTSCSFDYLSRDDANR--SY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRH-------------QAHGANLRHLQAKKKFVKAMVLVVVTFAICWL 264
Cdd:cd15083  166 VICLLIFGFVLPLLIIIYCYSFI-----FRAVRRHekamkemakrfskSELSSPKARRQAEVKTAKIALLLVLLFCLAWT 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 265 PYHLYFILGTFQediyYRKFIQQVYLAL-FWLAMSSTMYNPIIYCCLNHRFRSG 317
Cdd:cd15083  241 PYAVVALIGQFG----YLEVLTPLATAIpAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
40-318 2.41e-27

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 109.18  E-value: 2.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADlcmAAFNATFNFIYASHNI--WYFGSTFCYFQNLFPVTAM 117
Cdd:cd15973    7 YALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIAD---ELFMLSVPFLAASAALqhWPFGSAMCRTVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ-PRLSAPSTKAVIAV-IWLVALALASP-QCFYSTITVDQGATKCVVAWPNDNGGKML 194
Cdd:cd15973   84 FTSVFCLTVLSVDRYIAVVHPLRaARYRRPTVAKMINIcVWILSLLVISPiIIFADTATRKGQAVACNLIWPHPAWSAAF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYhlvVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPrhQAHGANLRHlQAKKKFVKAMVLVVVTFAICWLPYHLYFILgt 274
Cdd:cd15973  164 VIY---TFLLGFLLPVLAIGLCYILIIGKM--RAVA--LKAGWQQRR-KSEKKITRMVLMVVTVFVICWMPFYVVQLL-- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 fqeDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15973  234 ---NLFLPRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
35-315 3.17e-27

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 109.20  E-value: 3.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFnfIYAS-HNIWYFGSTFCYFQNLFP 113
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIF--IYNSfYEGWALGPLGCQIYAFLG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALASPQCF--YSTITVDQGATKCVVAWPNDNG 190
Cdd:cd15079   80 SLSGIGSIWTNAAIAYDRYNVIVKPLNGnPLTRGKALLLILFIWLYALPWALLPLLfgWGRYVPEGFLTSCSFDYLTRDW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLllYHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAHganLRHlQAKKKFV-------------------KA 251
Cdd:cd15079  160 NTRS--FVATIFVFAYVIPLIIIIYCYSFI-----VKAVFAHEKA---LRE-QAKKMNVvslrsnadankqsaeiriaKV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 252 MVLVVVTFAICWLPYHLYFILGTFQEDIYYRKFIQQVyLALFwlAMSSTMYNPIIYcCLNH-RFR 315
Cdd:cd15079  229 ALTNVFLWFIAWTPYAVVALIGAFGNQSLLTPLVSMI-PALF--AKTAACYNPIVY-AISHpKYR 289
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
40-318 3.73e-27

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 109.05  E-value: 3.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd14977    7 SLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIV--HPFQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKMLLL 196
Cdd:cd14977   87 TVFSLCALSIDRYRAAVnsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVlSTVARESSLDNSSLTVCIMKPSTPFAET 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 Y---HLVVFVLIYF-LPLVVMFAAYSVIGLTLWKravPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd14977  167 YpkaRSWWLFGCYFcLPLAFTAVCYLLMARTLIR---AAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHISNIL 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 273 GTF---QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14977  244 RATlynEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
45-318 4.63e-27

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 108.21  E-value: 4.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFI-YASHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd15067   11 LVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILhEMTGGYWLFGRDWCDVWHSFDVLASTASILN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgkMLLLYHLVV 201
Cdd:cd15067   91 LCVISLDRYWAITDPIsyPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCLFTDDSG--YLIFSSCVS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 202 FvliyFLPLVVMFAAYSVIgltlWKRAVPRHQAhganlrhlqakkkfVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYY 281
Cdd:cd15067  169 F----YIPLVVMLFTYYRI----YRAAAKEQKA--------------AKTLGIVMGVFILCWLPFFVTNILIGFCPSNCV 226
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 258613887 282 RKFiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15067  227 SNP-DILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-318 4.94e-27

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 108.88  E-value: 4.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15125    5 SLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAP--STKAVIAVIWLVALALASPQCFYST---ITVDQGA--TKCVvawPNDNG 190
Cdd:cd15125   85 GVSVFTLTALSADRYKAIVNPMDIQTSSAvlRTCLKAIAIWVVSVLLAVPEAVFSEvahIMPDDNTtfTACI---PYPQT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFVLIYFL-PLVVMFAAYSVIGLTLWKRAvprHQAHGANLRH----LQAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15125  162 DEMHPKIHSVLIFLVYFLiPLAIISIYYYHIAKTLIKSA---HNIPGEYSEHskrqMETRKRLAKIVLVFVGLFAFCWFP 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 266 YHLYFILGTFQediyYRKFIQQ-----VYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15125  239 NHVLYMYRSFN----YNEIDSSlghmiVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
36-307 6.48e-27

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 108.15  E-value: 6.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaafnATFNFIYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd14972    1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL-----AGIAFVFTFLSVLLVSLTPSPATWLLRKG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFV----SIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALA-SPQCFYSTITVDQGAtkCVVAWPnd 188
Cdd:cd14972   76 SLVLsllaSAYSLLAIAVDRYISIVHGltYVNNVTNKRVKVLIALVWVWSVLLAlLPVLGWNCVLCDQES--CSPLGP-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 nggkmLLLYHLVVFVLIYFL-PLVVMFAAYSVIGLTLWKRAVPRHQAH-GANLRHLQAKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd14972  152 -----GLPKSYLVLILVFFFiALVIIVFLYVRIFWCLWRHANAIAARQeAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 267 HLYFILGTFQEdiyyRKFIQQVYLALF-WLAMSSTMYNPIIY 307
Cdd:cd14972  227 LILLVLDVLCP----SVCDIQAVFYYFlVLALLNSAINPIIY 264
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
36-318 6.94e-27

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 107.43  E-value: 6.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFN-FIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15053    3 WALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAvYVEVNGGKWYLGPILCDIYIAMDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNdnggk 192
Cdd:cd15053   83 MCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLltIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPD----- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 mlllYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15053  158 ----FIIYSSISSFYIPCIVMLLLYYRI------------------FRALRREKKATKTLAIVLGVFLFCWLPFFTLNIL 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 273 GTFQedIYYRKFIQQVYLALF----WLA-MSSTMyNPIIYCCLNHRFRSGF 318
Cdd:cd15053  216 NAIC--PKLQNQSCHVGPALFslttWLGyVNSFL-NPIIYTIFNIEFRKAF 263
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
40-318 1.41e-26

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 107.35  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADlcmAAFNATFNFIYASH--NIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15091    7 YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD---ALVTTTMPFQSTVYlmNSWPFGDVLCKIVISIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHP-----FQPRLSApstKAVIAVIWLVALALASPQCFY--STITVDQGATKCVVAWPNDNG 190
Cdd:cd15091   84 FTSIFTLTMMSVDRYIAVCHPvkaldFRTPLKA---KIINICIWLLSSSVGISAIVLggTKVREDVDSTECSLQFPDDDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK-RAVPRHQAHGANLRhlqakkKFVKAMVLVVVTFAICWLPYHLy 269
Cdd:cd15091  161 SWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSvRLLSGSREKDRNLR------RITRLVLVVVAVFVVCWTPIHI- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 270 FILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15091  234 FILVEALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
40-318 1.42e-26

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 107.24  E-value: 1.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15971    7 YFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADE-LFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQP-RLSAPST-KAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGkMLLLY 197
Cdd:cd15971   86 SIFCLTVMSIDRYLAVVHPIKSaKWRKPRTaKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGESSA-WYTGF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqAHGANLRHlQAKKKFVKAMVLVVVTFAICWLPYHLyFILGTFQE 277
Cdd:cd15971  165 IIYTFILGFFVPLTIICLCYLFIIIKVKSSGI----RVGSSKRK-KSEKKVTRMVSIVVAVFVFCWLPFYI-FNVSSVSV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 258613887 278 DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15971  239 SISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
40-318 1.63e-26

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 107.20  E-value: 1.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALAD-LCMaaFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15972    7 YLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADeLFM--LGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGAtkCVVAWPnDNGGKMLLL 196
Cdd:cd15972   85 TSIFCLTVMSVDRYLAVVHPIRSSkwRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGT--CHIAWP-EPAQVWRAG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIgltLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15972  162 FIIYTATLGFFCPLLVICLCYLLI---VVKVRSSGRRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVC 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 277 EDIYYRKFiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15972  239 PLPEEPSL-FGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
40-318 2.11e-26

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 106.53  E-value: 2.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALAD-LCMaaFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15970    7 YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADeLLM--LSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQ-PRLSAPS-TKAVIAVIWLVALALASPQCFYS-TITVDQGATKCVVAWPnDNGGKMLL 195
Cdd:cd15970   85 TSIYCLTVLSIDRYIAVVHPIKaARYRRPTvAKMVNLGVWVFSILVILPIIIFSnTAPNSDGSVACNMQMP-EPSQRWLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravpRHQAHGANLRHLQAKKKFVKAMVLVVVT-FAICWLPYHLYFILGT 274
Cdd:cd15970  164 VFVVYTFLMGFLLPVIAICLCYILIIVKM------RVVALKAGWQQRKRSERKITLMVMMVVTvFVICWMPFYVVQLVSV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDiyYRKFIQQVYLAlfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15970  238 FVGQ--HDATVSQLSVI---LGYANSCANPILYGFLSDNFKRSF 276
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
43-322 2.17e-26

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 107.26  E-value: 2.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15957   10 IVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVAlALAS--PQCFYSTITVDQGATKCvvaWPNDNGGKMLL--L 196
Cdd:cd15957   90 TLCVIAVDRYFAITSPFkyQSLLTKNKARVIILMVWIVS-GLTSflPIQMHWYRATHQEAINC---YAEETCCDFFTnqA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVI------------GLTLWKRAVPRHQAHGANLRHLQAKKKF-------VKAMVLVVV 257
Cdd:cd15957  166 YAIASSIVSFYVPLVIMVFVYSRVfqeakrqlqkidKSEGRFHNQNIDQNGSGGGGGNRRRSKFclkehkaLKTLGIIMG 245
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 258 TFAICWLPYHLYFILGTFQEDIyyrkFIQQVYLALFWLAMSSTMYNPIIYCclnhrfRS-GFRLAF 322
Cdd:cd15957  246 TFTLCWLPFFIVNIVHVIQDNL----IRKEVYILLNWIGYVNSGFNPLIYC------RSpDFRIAF 301
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
34-318 2.90e-26

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 105.82  E-value: 2.90e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQ------PRLSApstkAVIAVIWLVALALASPQCFYSTITVDQGaTKCVVAwpn 187
Cdd:cd15329   81 VLLCTASILNLCAISVDRYLVITRPLTyavkrtPKRMA----LMIAIVWLLSALISIPPLFGWKNKVNDP-GVCQVS--- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 DNggkmlLLYHLVVFVLIYFLPLVVMFAAYSVIgltlWKRAvprhqahganlrhlQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15329  153 QD-----FGYQIYATFGAFYIPLIVMLVLYYKI----YRAA--------------KSERKAIKTLGIIMGAFTLCWLPFF 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 268 LYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15329  210 ILALLRPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
46-315 3.81e-26

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 106.17  E-value: 3.81e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  46 VAVTGNATVI-WIILAHERMRTVTNYFIINLALADLCM-------AAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd14980   13 LALIGNILVIiWHISSKKKKKKVPKLLIINLAIADFLMgiylliiAIADQYYRGRYAQYSEEWLRSPPCLLACFLVSLSS 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALASPQCFYStitVDQGATKCV-----VAWPNDNGG 191
Cdd:cd14980   93 LMSVLMMLLITLDRYICIVYPFSNkRLSYKSAKIILILGWLFSIIFAAIPILYS---INQPGDNRLygyssICMPSNVSN 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYhLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahGANLRHLQAK--KKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd14980  170 PYYRGW-LIAYLLLTFIAWIIICILYILIFISVRKS--------RKSARRSSSKrdKRIAIRLALILITDLICWLPYYIV 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 270 FILGTFQE---DIYYRKFIqqvylALFWLAMSSTMyNPIIYCCLNHRFR 315
Cdd:cd14980  241 IFSGLLTSteiDIHVLQFI-----AILALPLNSAI-NPYLYTLTTPTFK 283
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
43-318 4.52e-26

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 105.10  E-value: 4.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15064   10 IILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQ-PRLSAPSTKAV-IAVIWLVALALASPQCFYSTITVDQGATKCVVawpNDNGGkmlllYHLV 200
Cdd:cd15064   90 HLCVIALDRYWAITDAVEyAHKRTPKRAAVmIALVWTLSICISLPPLFGWRTPDSEDPSECLI---SQDIG-----YTIF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFVLIYFLPLVVMFAAYsvigltlWK--RAVPRHQahganlrhlqakkKFVKAMVLVVVTFAICWLPYHLYFILGTFQED 278
Cdd:cd15064  162 STFGAFYIPLLLMLILY-------WKiyRAAARER-------------KAAKTLGIILGAFIVCWLPFFLVALIVPLCSH 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 279 IYYRKFIQQVYLalfWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15064  222 CWIPLALKSFFL---WLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-318 4.70e-26

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 106.39  E-value: 4.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNI-WYFGSTFCYFQNLFPVTA 116
Cdd:cd15358    5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYpFLLGAGGCYFKTLLFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAwpnDNGGKML 194
Cdd:cd15358   85 CFASILNVTALSVERYIAVVHPLKAKyvVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPCRGPVP---DSATCML 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 L----LYHLVVFV---LIYFLPLVVMFAAYSVIGLTLWK-------RAVPRHQAHGANLRHLQAKK----KFVKAMVLVV 256
Cdd:cd15358  162 VkprwMYNLIIQIttlLFFFLPMGTISVLYLLIGLQLKRekmllvlEAKGSKAGDSYQHRRIQQEKrrrrQVTKMLFVLV 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 257 VTFAICWLPYHLYFILGTF--QEDIYYRKFIQQVYLA---LFWLamsSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15358  242 VVFGICWAPFHTDRLMWSFisQWTGELHLAFQYVHIIsgvFFYL---SSAANPVLYNLMSTRFREMF 305
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
35-318 5.75e-26

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 104.75  E-value: 5.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCvvAWPNDNGgk 192
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKyrTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSC--YYTYDKG-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 mlllYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15061  157 ----YRIYSSMGSFFLPLLLMLFVYLRI------------------FRVIAKERKTAKTLAIVVGCFIVCWLPFFIMYLI 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYYRKFiqqvYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15061  215 EPFCDCQFSEAL----STAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-316 1.05e-25

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 104.88  E-value: 1.05e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFN-FIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15132    8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPFDlYRLWKSRPWIFGEFLCRLYHYISEGCTYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPST--KAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLY 197
Cdd:cd15132   87 TILHITALSIERYLAICFPLRAKVLVTRRrvKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSRECKHTPYAVSSG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLI----YFLPLVVMFAAYSVIGLTLWKRAVPRhQAHGANLRHlQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15132  167 LLGIMIWVtttyFFLPMLCLSFLYGFIGRKLWKSKNDL-RGPNAAARE-RSHRQTVRILAVVVLAFIICWLPFHIGRILF 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 274 TFQED---IYYRKFIQQVYLALFWLAMSstmYNPIIYCCLNHRFRS 316
Cdd:cd15132  245 ANTEDyrtMMFSQYFNIVAMQLFYLSAS---INPILYNLISRKYRA 287
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
45-272 1.24e-25

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 104.49  E-value: 1.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmAAFNATFNFIYA-SHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd14975   12 AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADL--AVLLTLPVWIYFlATGTWDFGLAACKGCVYVCAVSMYASVFL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHPFQprLSAPSTKA----VIAVIWLVALALASPQCFYSTITVDQGATKCVvawPNDNGGKMLLLYHL 199
Cdd:cd14975   90 ITLMSLERFLAVSRPFV--SQGWRAKAlahkVLAIIWLLAVLLATPVIAFRHVEETVENGMCK---YRHYSDGQLVFHLL 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqahgaNLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd14975  165 LETVVGFAVPFTAVVLCYSCLLRRL-------------RRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLL 224
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
36-322 1.69e-25

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 104.84  E-value: 1.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVA-VTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15058    2 GLLLLLALIILAiVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVAlALAS--PQCFYSTITVDQGATKCvVAWPNDNG 190
Cdd:cd15058   82 LCVTASIETLCVIAVDRYIAITRPLryQVLLTKRRARVIVCVVWIVS-ALVSfvPIMNQWWRANDPEANDC-YQDPTCCD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKR---------------------AVPRHQAHGANLRHLQAKK--K 247
Cdd:cd15058  160 FRTNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQlqlidkrrlrfqsecpapqttSPEGKRSSGRRPSRLTVVKehK 239
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 248 FVKAMVLVVVTFAICWLPYHLYFILGTFQEDIyyrkFIQQVYLALFWLAMSSTMYNPIIYCclnhrfRS-GFRLAF 322
Cdd:cd15058  240 ALKTLGIIMGTFTLCWLPFFIANIINVFNRNL----PPGEVFLLLNWLGYINSGLNPIIYC------RSpEFRTAF 305
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
42-316 1.93e-25

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 104.20  E-value: 1.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15131    9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGAT-----KCVVAWPNDNGGkmL 194
Cdd:cd15131   89 LNITALSVERYFAICFPLRAKvvVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNpidtnECKATEYAVRSG--L 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavpRHQAHGANLRHL-QAKKKFVKAMVLVVVTFAICWLPYHL--YFI 271
Cdd:cd15131  167 LTIMVWVSSVFFFLPVFCLTVLYSLIGRKLWRR---RRENIGPNASHRdKNNRQTVKMLAVVVFAFVLCWLPFHVgrYLF 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 272 LGTFQ----EDIYYRKFIQQVYLALFWLamsSTMYNPIIYCCLNHRFRS 316
Cdd:cd15131  244 SKSFEagslEIALISQYCNLVSFVLFYL---SAAINPILYNIMSKKYRV 289
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
34-318 2.05e-25

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 104.26  E-value: 2.05e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFN-FIYASHNIWYFGstfCYFQNLF 112
Cdd:cd14968    1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAiLISLGLPTNFHG---CLFMACL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCF--YSTITVDQGATKCVVAWPND 188
Cdd:cd14968   78 VLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAwgAIAVCWVLSFLVGLTPMFgwNNGAPLESGCGEGGIQCLFE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKM--LLLYHLVVFVLIyflPLVVMFAAYSVIGLTLWK--RAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWL 264
Cdd:cd14968  158 EVIPMdyMVYFNFFACVLV---PLLIMLVIYLRIFRVIRKqlRQIESLLRSRRSRSTLQKEVKAAKSLAIILFLFALCWL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 265 PYHLYFILGTFQEDIYYRKFIqqVYLALFWLAMSSTMyNPIIYCCLNHRFRSGF 318
Cdd:cd14968  235 PLHIINCITLFCPECKVPKIL--TYIAILLSHANSAV-NPIVYAYRIRKFRQTF 285
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
37-318 2.07e-25

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 103.61  E-value: 2.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15066    3 GFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLS--APSTKAVIAVIWlVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKML 194
Cdd:cd15066   83 STASILHLCCISVDRYYAIVQPLEYPSKmtKRRVAIMLANVW-ISPALISFLPIFLGWYTTEEHLQYRKTHPDQCEFVVN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIgltlWKRAVPRHQAhganlrhlqakkkfVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15066  162 KIYALISSSVSFWIPCIVMIFTYYRI----YLEAKREHKA--------------AKTLGIIMGAFILCWLPFFLWYVTTT 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDIYYRKFIqqVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15066  224 LCGDACPYPPI--LVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
34-311 2.38e-25

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 104.08  E-value: 2.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFI-YASHNIWYFGSTFCYFQNLF 112
Cdd:cd15212    1 AAQALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLtLFSRPGWLFGDRLCLANGFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYST---ITVDQGATKCVVAWPNDn 189
Cdd:cd15212   81 NACFGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASapeYYEKLGFYHCLYVLHSG- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFVLIYFLPLVVM-FAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15212  160 PSRLGAAYSSVLIVLCYLLPFALMcFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 269 YFILGTFQEdiyyRKFIQQVYLALFWLAMSSTMYNPIIYCCLN 311
Cdd:cd15212  240 LGLVAAAGG----YQFPPLMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
40-318 2.58e-25

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 103.68  E-value: 2.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15191    7 YSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV-IWLVALALASPQC-FYSTITVDQ-GATKCVVAWPNDNGGKMLLL 196
Cdd:cd15191   87 SIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLlVWVLACLSSLPTFyFRDTYYIEElGVNACIMAFPNEKYAQWSAG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhQAHGANLRHLQakkKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15191  167 LALMKNTLGFLIPLIVIATCYFGIGRHLLKT-----KGFGKNKQRRD---KVLKMVAAVVLAFLICWFPFHVLTFLDALA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 277 E-----DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15191  239 RmgvinNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
40-318 2.59e-25

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 103.73  E-value: 2.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALAD-LCMAA--FNATFNFIyashNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15974    7 YLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADeLFMLGlpFLATQNAI----SYWPFGSFLCRLVMTVDGVN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVI-AVIWLVALALASPQCFYSTITVDQGAtkCVVAWPNDNG--GK 192
Cdd:cd15974   83 QFTSIFCLTVMSIDRYLAVVHPIKStKWRRPRVAKLInATVWTLSFLVVLPVIIFSDVQPDLNT--CNISWPEPVSvwST 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYhlvVFVLIYFLPLVVMFAAYSVIGLTlwkraVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15974  161 AFIIY---TAVLGFFGPLLVICLCYLLIVIK-----VKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIV 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 273 GTF----QEDIyyrkfIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15974  233 NLIvilpEEPA-----FVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
39-318 2.76e-25

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 104.11  E-value: 2.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALV-LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15056    5 TFLSLViLLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQprlsapSTKAVIAVIWLVALALASPQCFYSTITVDQG----ATKCVVAWPNDNGGKM 193
Cdd:cd15056   85 TASIMHLCCIALDRYYAICCQPL------VYKMTPLRVAVMLGGCWVIPTFISFLPIMQGwnhiGIEDLIAFNCASGSTS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLL-----YHLVVFVLIYFLPLVVMFAAYSVIGLT----------LWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVT 258
Cdd:cd15056  159 CVFmvnkpFAIICSTVAFYIPALLMVLAYYRIYVAareqahqirsLQRAGSSNHEADQHRNSRMRTETKAAKTLGIIMGC 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 259 FAICWLPyhlYFILGTFQEDIYYRkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15056  239 FCVCWAP---FFVTNIVDPFIGYR-VPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
43-318 3.41e-25

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 103.05  E-value: 3.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15325   10 FILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCFYSTITVDQGATKCVVawpNDNGGkmlllYHLV 200
Cdd:cd15325   90 SLCIISIDRYIGVSYPLRYPSIMTERRGLLALlcVWVLSLVISIGPLFGWKEPAPEDETICQI---TEEPG-----YALF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIy 280
Cdd:cd15325  162 SALGSFYLPLAIILVMYCRVYVVALK---------------FSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAY- 225
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 281 yrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15325  226 --KPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
42-318 4.37e-25

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 102.68  E-value: 4.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15327    9 IFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQ-PRLSAPSTKAVI-AVIWLVALALASPQCFYSTITVDQGATKCVVawpNDNGGkmlllYHL 199
Cdd:cd15327   89 LSLCVISVDRYVGVKHSLKyPTIMTERKAGVIlVLLWVSSMVISIGPLLGWKEPPPPDESICSI---TEEPG-----YAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDI 279
Cdd:cd15327  161 FSSLFSFYLPLMVILVMYFRVYVVALK---------------FSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFFPAL 225
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 280 yyrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15327  226 ---KPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
37-318 5.34e-25

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 103.06  E-value: 5.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15124    4 PTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITV--DQGATKCVVA---WPNDN 189
Cdd:cd15124   84 VGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLkaALIWILSMLLAIPEAVFSDLHPfyDKSTNKTFVScapYPHSN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 gGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANL-RHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15124  164 -ELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNLPVEGNVHVrRQIESRKRLAKTVLVFVGLFAFCWLPNHI 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 269 YFILGTF---QEDIYYRKFIQQVYLALfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15124  243 IYLYRSYhysEVDTSMLHFVSSICARI--LAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
42-318 5.42e-25

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 102.28  E-value: 5.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15326    9 AFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCFYSTITVDQGATKCVVAWPndnggkmlLLYHL 199
Cdd:cd15326   89 LSLCAISIDRYIGVRHSLQYPTIVTRKRAILALlgVWVLSTVISIGPLLGWKEPAPPDDKVCEITEE--------PFYAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDI 279
Cdd:cd15326  161 FSSLGSFYIPLIVILVMYCRVYIVALK---------------FSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHL 225
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 280 YYRKFIQQVylaLFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15326  226 KPPETLFKI---IFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
45-316 7.69e-25

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 102.51  E-value: 7.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCY---FQNLFPVTAmfvSI 121
Cdd:cd15073   12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQwyaFLNIFFGMA---SI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHP-FQPRLSAPSTKAVIAVIWLVALALAS-PQCFYSTITVDQGATKCVVAWPNDngGKMLLLYHL 199
Cdd:cd15073   89 GLLTVVAVDRYLTICRPdLGRKMTTNTYTVMILLAWTNAFFWAAmPLVGWASYALDPTGATCTINWRKN--DSSFVSYTM 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDI 279
Cdd:cd15073  167 SVIVVNFIVPLAVMFYCYYNVSRFV--KKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPK 244
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 258613887 280 YYRKFIqQVYLALFwlAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15073  245 KIPPWM-AIIPPLF--AKSSTFYNPCIYVIANKKFRR 278
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
40-318 8.36e-25

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 102.38  E-value: 8.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADlCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15090    7 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVI-WLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLy 197
Cdd:cd15090   86 SIFTLCTMSVDRYIAVCHPVKAlDFRTPRNAKIVNVCnWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLL- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWK-RAVPRHQAHGANLRHlqakkkfVKAMVLVVVT-FAICWLPYHLYFILGTF 275
Cdd:cd15090  165 KICVFIFAFIMPVLIITVCYGLMILRLKSvRMLSGSKEKDRNLRR-------ITRMVLVVVAvFIVCWTPIHIYVIIKAL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 276 QeDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15090  238 V-TIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-318 1.27e-24

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 101.24  E-value: 1.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYA-SHNIWYFGSTFC---YFQNL 111
Cdd:cd15052    3 AALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTElFGGVWPLPLVLCllwVTLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 112 FPVTAmfvSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASPQCFYS----TITVDQGAtkCVVAW 185
Cdd:cd15052   83 LFCTA---SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFlkIAIVWLISIGISSPIPVLGiidtTNVLNNGT--CVLFN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNdnggkmlllYHLVVFVLIYFLPLVVMFAAYSvigLTlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15052  158 PN---------FVIYGSIVAFFIPLLIMVVTYA---LT---------------IRLLSNEQKASKVLGIVFAVFVICWCP 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 266 YH-LYFILGTFQEDIYYrkfIQQVYLALF-WLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15052  211 FFiTNILTGLCEECNCR---ISPWLLSVFvWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
35-318 1.46e-24

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 101.81  E-value: 1.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADL---CMAAFNATFnFIYASHniWYFGSTFCYFQNL 111
Cdd:cd15921    2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLllvCTLPLRLTY-YVLNSH--WPFGDIACRIILY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVawPNDN 189
Cdd:cd15921   79 VLYVNMYSSIYFLTALSVFRYLALVWPYLylRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLE--LAHD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHL- 268
Cdd:cd15921  157 AVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALG-------RTRPSRRKACALIIISLGIFLVCFLPYHIv 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 269 ----YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15921  230 rtihLITERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
39-318 1.88e-24

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 101.36  E-value: 1.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAafnATFNF-IYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15181    6 AYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLL---LTFPFsVVESIAGWVFGTFLCKLVGAIHKLNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHP---FQPRlSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGK-- 192
Cdd:cd15181   83 YCSSLLLACISVDRYLAIVHAihsYRHR-RLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFHQYGIHEsn 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 ----MLLLYHLVVFvliyFLPLVVMFAAYSVIGLTLwKRAVPRHQahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15181  162 wwltSRFLYHVVGF----FLPLLIMGYCYATIVVTL-CQSSRRLQ-----------KQKAIRVAILVTLVFCLCWLPYNI 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 269 YF------ILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15181  226 VIfldtldDLKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
42-318 3.12e-24

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 100.26  E-value: 3.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15063    9 FLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCF-------YSTITVDQGATKCVVAWPNDNGgk 192
Cdd:cd15063   89 LNLCAISLDRYLAITRPIRYPslMSTKRAKCLIAGVWVLSFVICFPPLVgwndgkdGIMDYSGSSSLPCTCELTNGRG-- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 mlllYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15063  167 ----YVIYSALGSFYIPMLVMLFFYFRI------------------YRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLV 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIyyrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15063  225 RAFCEDC----IPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
38-315 3.62e-24

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 100.85  E-value: 3.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIwIILAHERMRTV--TNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd15382    5 IVYSVLFLIAAVGNLTVL-LILLRNRRRKRsrVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFysTITVDQ-----GATKCVV--AWPND 188
Cdd:cd15382   84 GLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSF--IFHVEShpcvtWFSQCVTfnFFPSH 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NggkMLLLYHLVVFVLIYFLPLVVMFAAYSVIgltLW------KRAVPRHQAHGANLR-------HLQ-AKKKFVKAMVL 254
Cdd:cd15382  162 D---HELAYNIFNMITMYALPLIIIVFCYSLI---LCeisrksKEKKEDVSEKSSSVRlrrssvgLLErARSRTLKMTIV 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 255 VVVTFAICWLPYH----LYFILGTFQEDIYYRkfIQQvylALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15382  236 IVLVFIICWTPYFimslWYWFDRESASKVDPR--IQK---GLFLFAVSNSCMNPIVYGYFSIDLR 295
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
34-318 3.70e-24

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 100.04  E-value: 3.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFN-FIYASHNIWYFGSTFCYFQNLF 112
Cdd:cd15310    1 AYYALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVvYLEVTGGVWNFSRICCDVFVTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAV---IAVIWLVALALASPQCFYSTITVDqgATKCVVAWPN 187
Cdd:cd15310   81 DVMMCTASILNLCAISIDRYTAVVMPvhYQHGTGQSSCRRVslmITAVWVLAFAVSCPLLFGFNTTGD--PTVCSISNPD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 dnggkmLLLYHLVVfvlIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15310  159 ------FVIYSSVV---SFYLPFGVTLLVYVRIYVVLLR------------------EKKATQMLAIVLGAFIVCWLPFF 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 268 LYFILGTFQEDIYYRKfiqQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15310  212 LTHILNTHCQACHVPP---ELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
39-266 4.40e-24

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 100.00  E-value: 4.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLV-AVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFN--------ATFNFiyashniwYFGSTFCYFQ 109
Cdd:cd15196    5 AVLATILVlALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNvlpqliwdITYRF--------YGGDLLCRLV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 110 NLFPVTAMFVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCvvaWPN 187
Cdd:cd15196   77 KYLQVVGMYASSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPQLFiFSYQEVGSGVYDC---WAT 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258613887 188 DNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhlqAKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd15196  154 FEPPWGLRAYITWFTVAVFVVPLIILAFCYGRICYVVWR-----------------AKIKTVKLTLVVVACYIVCWTPF 215
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
42-318 5.69e-24

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 100.01  E-value: 5.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15314    9 LISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCF--YSTITVDQGATKCVvawpndnGGKMLLLY 197
Cdd:cd15314   89 LNLCFISIDRYYAVCQPLLYRskITVRVVLVMILISWSVSALVGFGIIFleLNIKGIYYNHVACE-------GGCLVFFS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 H---LVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAK-KKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15314  162 KvssVVGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTKSGASSSKMeRKATKTLAIVMGVFLLCWTPFFLCNIID 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFqedIYYrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15314  242 PF---INY-SIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
43-316 6.20e-24

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 99.91  E-value: 6.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15080   10 LILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQpRLSAPSTKAVIAVI--WLVALALASPQCFYSTITVDQG-ATKCVVAWPNDNGGKMLLLYHL 199
Cdd:cd15080   90 SLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAftWVMALACAAPPLVGWSRYIPEGmQCSCGIDYYTLKPEVNNESFVI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLwKRAVPRHQAHGANLRhlqAKKKFVKAMVLVVVTFAICWLPY-HLYFILGTFQED 278
Cdd:cd15080  169 YMFVVHFTIPLIVIFFCYGRLVCTV-KEAAAQQQESATTQK---AEKEVTRMVIIMVIAFLICWVPYaSVAFYIFTHQGS 244
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 279 IYYRKFIqqVYLALFwlAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15080  245 DFGPIFM--TIPAFF--AKSSAVYNPVIYILMNKQFRN 278
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
45-309 6.35e-24

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 99.89  E-value: 6.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADlCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15121   12 ILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALAD-AAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATK-CVVAWPNDNGgkmlLLYHLVV 201
Cdd:cd15121   91 TLMSMDRCLAVAKPFlsQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKlCIPYHPSVGH----EAFQYLF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 202 FVLIYF-LPLVVMFAAYSVIGLTLwkravprhqahgaNLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL---GTFQE 277
Cdd:cd15121  167 ETITGFlLPFTAIVTCYSTIGRRL-------------RSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIqvaGALQN 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 258613887 278 DIYYRKFIQQVYLA---LFWLAMSSTMYNPIIYCC 309
Cdd:cd15121  234 QAGNASVLKAAKLArpnVTALAFLSSSVNPVLYAF 268
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
40-316 7.11e-24

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 99.83  E-value: 7.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15174    7 YWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADL-LFLCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPS----TKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15174   85 CMLLLTCISVDRYIAIVQATKAHNSKNKrllySKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNRFKV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqahganlrhLQAKK----KFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15174  165 AVLALKVTVGFFLPFVVMVICYTLIIHTL-----------------LQAKRfqkhKALKVIIAVVTVFVLSQLPYNSILL 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 272 LGTFQED---IYYRKFIQQVYLAL---FWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15174  228 IKTINAYnitITDCATSQNLDIAGqvtQSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
42-308 8.56e-24

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 99.98  E-value: 8.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15958    9 LIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLV-ALALASPQCFYSTITVDQGATKCVvawpNDNGGKMLLL-- 196
Cdd:cd15958   89 ETLCVIAIDRYLAITSPFryQSLLTRARAKGIVCTVWAIsALVSFLPIMMHWWRDEDDQALKCY----EDPGCCDFVTnr 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 -YHLVVFVLIYFLPLVVMFAAYSVI--------------------GLTLWKRAVPRHQAHGANLRhlqaKKKFVKAMVLV 255
Cdd:cd15958  165 aYAIASSIISFYIPLLIMIFVYLRVyreakkqikkidkcegrfhnTLTGLGRKCKRRPSRILALR----EQKALKTLGII 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 256 VVTFAICWLPYHLYFILGTFQEDIYYRKfiqqVYLALFWLAMSSTMYNPIIYC 308
Cdd:cd15958  241 MGVFTLCWLPFFLVNVVNVFNRELVPDW----LFVFFNWLGYANSAFNPIIYC 289
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
43-325 8.78e-24

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 99.94  E-value: 8.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15084   20 VVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLW 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHP-----FQPRlsapstKAVI--AVIWLVALALASPQCFYSTITVDQG-ATKCVVAWPndNGGKML 194
Cdd:cd15084  100 SLAILAFERYLVICKPmgdfrFQQR------HAVSgcAFTWGWSLLWTSPPLFGWSSYVPEGlRTSCGPNWY--TGGTNN 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHGANLRhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15084  172 NSYILALFVTCFALPLSTIIFSYSNLLLTL--RAVAAQQKESETTQ--RAEKEVTRMVIAMVMAFLICWLPYATFAMVVA 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 275 FQEDIyyrkFIQQVYLAL-FWLAMSSTMYNPIIYCCLNHRFRSGFrLAFRCC 325
Cdd:cd15084  248 TNKDV----VIQPTLASLpSYFSKTATVYNPIIYVFMNKQFRSCL-LELLCC 294
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
35-316 1.21e-23

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 99.63  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIwIILAHERMRTVTNYFIINLALADL--CMAAFNATFNFIYASHNIWYFGST---FCYFQ 109
Cdd:cd14978    2 LYGYVLPVICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDIlvLLSALPLFLLPYIADYSSSFLSYFyayFLPYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 110 NLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCF---YSTITVDQGATKCVVA 184
Cdd:cd14978   81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRArrVILIIIIFSLLLNLPRFFeyeVVECENCNNNSYYYVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 185 WPNDNGGKMLLL--YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGAN--LRHLQAKKKFVKAMVLVVVT-F 259
Cdd:cd14978  161 PTLLRQNETYLLkyYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRrlLSRSQRRERRTTIMLIAVVIvF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 260 AICWLPYHLYFILGTFQEDIYYRKFIQQ-VYLALFwLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd14978  241 LICNLPAGILNILEAIFGESFLSPIYQLlGDISNL-LVVLNSAVNFIIYCLFSSKFRR 297
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
38-318 1.26e-23

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 99.04  E-value: 1.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFYSTITV--DQGATKCVVAWPNDNGGKM 193
Cdd:cd15192   85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTciVIWLLAGVASLPAIIHRDVFFieNTNITVCAFHYPSQNSTLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLyHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganLRHLQAKK----KFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15192  165 VGL-GLMKNLLGFLIPFLIILTCYTLIGKALKK------------AYEIQRNKprndEIFKMIMAVVLFFFFCWIPHQIF 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 270 filgTFQEDIYYRKFIQQVYLA---------LFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15192  232 ----TFLDVLIQLKVIQDCHIAdivdtampfTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
43-318 1.47e-23

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 99.35  E-value: 1.47e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15065    9 IIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKML---LLY 197
Cdd:cd15065   89 NLCAISLDRYIHIKKPLKyeRWMTTRRALVVIASVWILSALISFLPIHLGWHRLSQDEIKGLNHASNPKPSCALdlnPTY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVI-----------------GLTLWKRAVPRHQAHGANLRHLQAKKKFvkAMVLVVVTFA 260
Cdd:cd15065  169 AVVSSLISFYIPCLVMLLIYSRLylyarkhvvniksqklpSESGSKFQVPSLSSKHNNQGVSDHKAAV--TLGIIMGVFL 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 261 ICWLPYHLYFILGTFQEDIyyrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15065  247 ICWLPFFIINIIAAFCKTC----IPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
35-267 1.61e-23

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 99.00  E-value: 1.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWAtAYLALVLVAVTGNATVIWIILAHERMRTVTN-YFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15376    3 LWP-ILGVEFLVAVLGNGLALWLFVTRERRPWHTGvVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGA-TKCvVAWPNDNG 190
Cdd:cd15376   82 TCNLYGSIFFITCISLNRYLGIVHPFftRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVERHNkTEC-LGTAVDSR 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 191 GKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahgaNLRHLQAKKKFVKAMVLVVVT-FAICWLPYH 267
Cdd:cd15376  161 LPTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVLR-----------SPGITTLEKRKVAALVAVVVAlYAVSFVPYH 227
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
43-318 1.97e-23

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 98.18  E-value: 1.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15059   10 VILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPST--KAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgkmlllYHLV 200
Cdd:cd15059   90 NLCAISLDRYWSVTQAVEYNLKRTPRraKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCELSDDPG------YVLF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIy 280
Cdd:cd15059  164 SSIGSFYIPLLIMIIVYARIYRAAKRK-----------------ERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTC- 225
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 281 yrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15059  226 --GVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
40-318 2.14e-23

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 97.89  E-value: 2.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15060    7 LSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPF---QPRlSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgkmlll 196
Cdd:cd15060   87 SILNLCAIALDRYWAIHDPInyaQKR-TLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLTEEKG------ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 yhLVVFVLI--YFLPLVVMFAAYSVIGLTLWKravprhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15060  160 --YVIYSSSgsFFIPLLIMTIVYVKIFIATSK------------------ERRAARTLGIIMGVFVVCWLPFFLMYVILP 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDIYYRkfiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15060  220 FCETCSPS---AKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
34-315 2.76e-23

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 97.82  E-value: 2.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFC----YFQ 109
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCrisaMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 110 NLFPVTAMFVsiysMTAIAADRYMAIVHPfQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPND 188
Cdd:cd15213   81 WFFVLEGVAI----LLIISVDRYLIIVQR-QDKLNPHRAKILIAVSWVLSFCVSFPPLVgWGKYEFPPRAPQCVLGYTES 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGkmlLLYHLVVFVLIYFLPLVVMFAAYSVIGLTlwkravprhqahganLRHLqaKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15213  156 PAD---RIYVVLLLVAVFFIPFLIMLYSYFCILNT---------------VRSF--KTRAFTTILILFIGFSVCWLPYTV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 269 YFILGTFQEdiyYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15213  216 YSLLSVFSR---YSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
36-316 2.80e-23

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 98.28  E-value: 2.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADL---CMAAFNATFnfiYASHNIWYFGSTFCYFQNLF 112
Cdd:cd15158    3 YSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLlcvCTLPLRVVY---YVHKGQWLFGDFLCRISSYA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNG 190
Cdd:cd15158   80 LYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKAriVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFEPPQSNQQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqahgANLRHLQAKKKFVKAMVLVVVTFAICWLPY---- 266
Cdd:cd15158  160 LTKLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTM-------KARKQQSSRKKAIRMIIIVLLAFLVSFMPYhiqr 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 267 --HLYFIlgtFQEDIY--YRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15158  233 tiHLHFL---SRKDSTceEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
45-316 3.27e-23

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 98.00  E-value: 3.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15085   12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALA-SPQCFYSTITVDQGATKCVVAWPNDNGGKMllLYHLVVF 202
Cdd:cd15085   92 TLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWLFCLFWAvAPLFGWSSYGPEGVQTSCSIGWEERSWSNY--SYLILYF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 203 VLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlrHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYR 282
Cdd:cd15085  170 LMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQGGKN--CPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVVNPELSIS 247
                        250       260       270
                 ....*....|....*....|....*....|....
gi 258613887 283 KFIQQVYLalfWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15085  248 PLAATMPT---YFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
40-315 3.64e-23

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 98.00  E-value: 3.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15194    7 YCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVvawpNDNGGKMLLLY 197
Cdd:cd15194   87 SVFLLTCMSLDRYLAIVLPLVSRKfrTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCN----EDAGTPSKVIF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIgltLWKRAVPRHQAHganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLY---FILGT 274
Cdd:cd15194  163 SLVSLIVAFFLPLLSILTCYCTI---IWKLCHHYQKSG----KHQKKLRKSIKIVFIVVAAFVFSWMPFNLFkalAIASG 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 275 FQEDIYYRKF-IQQVYLALFW-LAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15194  236 LQVEVTCLPYtLAQLGMEVSApLAFANSCANPFIYYFFDRYIR 278
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
40-318 3.65e-23

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 97.71  E-value: 3.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADlcmAAFNATFNFIYASH--NIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15089    7 YSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD---ALATSTLPFQSAKYlmETWPFGELLCKAVLSIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAV-IWLVALALASP-QCFYSTITVDQGATKCVVAWPnDNGGKML 194
Cdd:cd15089   84 FTSIFTLTMMSVDRYIAVCHPVKAlDFRTPAKAKLINIcIWVLSSGVGVPiMVMAVTKTPRDGAVVCMLQFP-SPSWYWD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK-RAVPRHQAHGANLRHlqakkkfVKAMVLVVV-TFAICWLPYHLYFIL 272
Cdd:cd15089  163 TVTKICVFIFAFVVPILVITVCYGLMILRLRSvRLLSGSKEKDRNLRR-------ITRMVLVVVaAFIICWTPIHIFVIV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15089  236 WTLVDIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
38-268 3.91e-23

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 98.06  E-value: 3.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15377    5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15377   85 YGSILFLTCISVHRYTGVVHPLKSlgRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYF 164
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRhlqakKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15377  165 IYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLR-----RKSIYLVIIVLTVFAVSYLPFHV 232
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
42-318 4.39e-23

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 97.17  E-value: 4.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15062    9 AFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVawpNDNGGkmlllYHL 199
Cdd:cd15062   89 MSLCVISVDRYIGVRYPLNypTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGV---NEEPG-----YVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDI 279
Cdd:cd15062  161 FSSLGSFYLPLAIILVMYCRVYVVAFK---------------FSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTL 225
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 280 yyrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15062  226 ---KPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
38-316 5.35e-23

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 97.15  E-value: 5.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfnaTFNFIYASHNI-WYFGSTFCYFQNLFPVTA 116
Cdd:cd15177    5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLL---TLPFAAAETLQgWIFGNAMCKLIQGLYAIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA----VIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGK 192
Cdd:cd15177   82 FYSGFLFLTCISVDRYVVIVRATSAHRLRPKTLFysvlTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWkravprhQAHGANlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15177  162 VKGATALTQVVLGFAIPLIVMAVCYAAIGRTLL-------AARGWE------RHRALRVIAALVVAFVLFQLPYSVVLLL 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 273 ------GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15177  229 dtadllATLELSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
51-316 6.46e-23

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 97.13  E-value: 6.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  51 NATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAAD 130
Cdd:cd15373   18 NILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYCSILFLLCISVH 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 131 RYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKmLLLYHLVVFVLIYFL 208
Cdd:cd15373   98 RFLGVCYPVRSLrwLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQ-FVVYSSVMLVLLFCV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 209 PLVVMFAAYSVIGLTLWKRAVprhqahgANLRHLQAKKKFVKAMVLVVVTFAICWLPYH----LYFILGTFQEDIYYRKF 284
Cdd:cd15373  177 PFVVILVCYALMVRKLLKPSA-------GTSTNSRSKKKSVKMIIIVLAVFILCFLPFHvtrtLYYSFRSMDLSCGTLNA 249
                        250       260       270
                 ....*....|....*....|....*....|..
gi 258613887 285 IQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15373  250 INLAYKVTRPLASANSCLDPILYFLAGQSFRS 281
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
35-316 9.91e-23

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 96.80  E-value: 9.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15374    2 LLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCvvawpNDNGGK 192
Cdd:cd15374   82 ANLYCSILFLTCISVHRYVGICHPIRAlrWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLC-----HDTTRP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLL----YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlrhlqAKKKFVKAMVLVVVTFAICWLPYH- 267
Cdd:cd15374  157 EEFDhyvhYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSRQQGPS-----SKKRSLKTIIMVLTVFAICFVPFHi 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 268 ---LYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15374  232 trtLYYVARLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
37-318 1.16e-22

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 96.47  E-value: 1.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALAD-LCMAA--FNATFNFIyashNIWYFGSTFCYFQNLFP 113
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADtLVLLTlpFQGTDIFL----GFWPFGNALCKTVIAID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAV-IWLVALALASPQCFYSTITVDQGATKCVVAWPnDNGG 191
Cdd:cd15092   80 YYNMFTSTFTLTAMSVDRYVAICHPIKAlDVRTPHKAKVVNVcIWALASVVGVPVMVMGSAQVEDEEIECLVEIP-TPQD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK-RAVPRHQAHGANLRHlqakkkfVKAMVLVVVT-FAICWLPYHLY 269
Cdd:cd15092  159 YWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGvRLLSGSKEKDRNLRR-------ITRLVLVVVAvFVGCWTPIQIF 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 270 FILGTFQEDIyyrKFIQQVYLALFWLAMS--STMYNPIIYCCLNHRFRSGF 318
Cdd:cd15092  232 VLAQGLGVQP---SSETAVAILRFCTALGyvNSSLNPVLYAFLDENFKACF 279
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
40-315 1.20e-22

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 96.34  E-value: 1.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIilAHERM-RTVTNYFIINLALADLCMAAFnATFNFIY-ASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15117    7 YSSAFVLGTLGNGLVIWV--TGFRMtRTVTTVCFLNLAVADFAFCLF-LPFSVVYtALGFHWPFGWFLCKLYSTLVVFNL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAVIAV-IWLVALALASPQCFYSTITVDQGATKCVVAWPNDNG----- 190
Cdd:cd15117   84 FASVFLLTLISLDRCVSVLWPVWARnHRTPARAALVAVgAWLLALALSGPHLVFRDTRKENGCTHCYLNFDPWNEtaedp 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 -------GKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahganlRHLQAKKKFvKAMVLVVVTFAICW 263
Cdd:cd15117  164 vlwletvVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWRE------------GWVHSSRPF-RVLTAVVAAFFLCW 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 264 LPYHLYFILGTF----QEDIYYRKFIQQVYLAlFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15117  231 FPFHLVSLLELVvilnQKEDLNPLLILLLPLS-SSLACVNSCLNPLLYVFVGRDFR 285
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
40-315 1.33e-22

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 96.36  E-value: 1.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmaAFNATFNFIYAS---HNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15193    7 YLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL---VFVLTLPFWAAStalGGQWLFGEGLCKLSSFIIAVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIV--HPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDqgaTKCVvawpNDNGGKML 194
Cdd:cd15193   84 RCSSILFLTGMSVDRYLAVVklLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINE---SVCV----EDSSSRFF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWkravpRHQAHGAnlRHLQAKKKFVKAMVLVVVTFAICWLPY------HL 268
Cdd:cd15193  157 QGISLATLFLTFVLPLIVILFCYCSILVRLR-----RHFHGAK--RTGRRRRNSLRIVFAIVTAFVLSWLPFntlkavRL 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 269 YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15193  230 LLELGGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
40-318 1.61e-22

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 96.36  E-value: 1.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALV---LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15317    4 YIVLVlamLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASpqCFYSTITVDQGaTKCVVAWPNDNGGKML 194
Cdd:cd15317   84 CTTSIFHLCFIAIDRYYAVCDPlrYPSKITVQVAWRFIAIGWLVPGIYTF--GLIYTGANDEG-LEEYSSEISCVGGCQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFV--LIYFLPLVVMFAAYSVIgLTLWKRAVPRHQAHGANLRHLQAKK---------KFVKAMVLVVVTFAICW 263
Cdd:cd15317  161 LFNKIWVLLdfLTFFIPCLIMIGLYAKI-FLVARRQARKIQNMEDKFRSSEENSskasasrerKAAKTLAIVMGIFLFCW 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 264 LPYHLYFILgtfqedIYYRKFIQQ--VYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15317  240 LPYFIDTIV------DEYSNFITPaiVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
42-318 2.05e-22

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 95.96  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMR-TVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGStFCYFQNLFPVTAMFVS 120
Cdd:cd15057    9 LLVLLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSFDIMCSTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALAL-----------ASPQCFYSTITVDQgaTKCVVawpn 187
Cdd:cd15057   88 ILNLCVISVDRYWAISSPFryERRMTRRRAFIMIAVAWTLSALIsfipvqlgwhrADDTSEALALYADP--CQCDS---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 dnggKMLLLYHLVVFVLIYFLPLVVMFAAYSVI---------GLTLWKRAVPRHQAHGANLR-HLQAKKKFVKAMVLVVV 257
Cdd:cd15057  162 ----SLNRTYAISSSLISFYIPVAIMIVTYTRIyriarrqirRIAALERAAQESTNPDSSLRsSLRRETKALKTLSIIMG 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 258 TFAICWLPYHLYFILGTF--QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYcCLNHRFRSGF 318
Cdd:cd15057  238 VFVCCWLPFFILNCVLPFcdLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIY-AFNADFRKAF 299
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
41-315 2.09e-22

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 95.61  E-value: 2.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTG-----NATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd15075    3 LSIIMAVFSIasvvlNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHP-----FQPRLSApstkAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDN 189
Cdd:cd15075   83 FGIAALCTVAVIAVDRLFVVCKPlgtltFQTRHAL----AGIASSWLWSLIWNTPPLFgWGSYQLEGVMTSCAPDWYSRD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAvprhqAHGANLRHLQAKKKF-VKAMVLV-VVTFAICWLPYH 267
Cdd:cd15075  159 PVNV--SYILCYFSFCFAIPFAIILVSYGYLLWTLRQVA-----KLGVAEGGSTAKAEVqVARMVVVmVMAFLLCWLPYA 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 268 LYFILGTFQEDIYYRKFIQQVYLalfWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15075  232 AFALTVVSKPDVYINPLIATVPM---YLAKSSTVYNPIIYIFMNKQFR 276
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
45-307 2.84e-22

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 95.25  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERmRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15118   12 TLGIVENLLILWVVGFRLR-RTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFY-STITVDQGATKCVVAWPNDNGGKMLLLYH--- 198
Cdd:cd15118   91 AAISLDRCLLVVKPVwaQNHRNVAAAKKICGVIWAMALINTIPYFVFrDVIERKDGRKLCYYNFALFSPSPDNNHPIckq 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 ------LVVFVLIYFLPLVVMFAAYSVIGLTLwkravpRHqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15118  171 rqeglaISKLLLAFLIPLVIIAVSYAVVSLII------RH-------RCRRRPGRFVRLVVSVVVSFALCWAPYHIFSII 237
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYY-RKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15118  238 EVMAHNQHSlRPLVIQGLPFATTLAFLNSVLNPVLY 273
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
42-318 4.17e-22

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 94.93  E-value: 4.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15055    9 SISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATK-----CVVAwpndnggkML 194
Cdd:cd15055   89 FNLVLIAIDRYVAVCDPLLypTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNscygeCVVV--------VN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK--RAVPRHQAHGANLR--HLQAKKKFVKA---MVLVVVTFAICWLPYH 267
Cdd:cd15055  161 FIWGVVDLVLTFILPCTVMIVLYMRIFVVARSqaRAIRSHTAQVSLEGssKKVSKKSERKAaktLGIVVGVFLLCWLPYY 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 268 LYFILGTfqediyYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15055  241 IVSLVDP------YISTPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
40-315 4.94e-22

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 94.42  E-value: 4.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIIlAHERMRTVTNYFIINLALADLCMAAFnATFNFIYASHNI-WYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15119    7 YIVAFVLGVPGNAIVIWVT-GFKWKKTVNTLWFLNLAIADFVFVLF-LPLHITYVALDFhWPFGVWLCKINSFVAVLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHP-FQPRL-SAPSTKAVIAVIWLVALALASPQCFY-STITVDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15119   85 ASVLFLTVISLDRYISLAHPvWSHRYrTLKSALILCGIVWLSAAAISGPALYFrDTMELSINVTICFNNFHKHDGDLIVM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVV---FVLIYFLPLVVMFAAYSVIGLTLWKRAvprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15119  165 RHTILVwvrFFFGFLFPLLTMVVCYSLLAIKVKRRT-------------LLISSKFFWTISAVIVAFFVCWTPYHIFSIL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 273 G-TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15119  232 ElSIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
34-318 5.71e-22

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 94.22  E-value: 5.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15321    7 AAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQ--GATKCVV---AWp 186
Cdd:cd15321   87 VLFCTSSIVHLCAISLDRYWSVSRAieYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEqgGLPQCKLneeAW- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 ndnggkmlllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd15321  166 ----------YILSSSIGSFFAPCLIMILVYLRIYLIAKNR-----------------EKRFTFVLAVVIGVFVLCWFPF 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 267 HLYFILGTFQEDIYYrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15321  219 FFSYSLGAICPELCK--VPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
34-318 6.07e-22

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 94.61  E-value: 6.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGStfCYFQNLFP 113
Cdd:cd15069    1 ATYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHS--CLFLACFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALA-SPqcFYSTITVDQGATKCVVAW---PN 187
Cdd:cd15069   79 LVLTQSSIFSLLAVAVDRYLAIKVPlrYKSLVTGKRARGVIAVLWVLAFGIGlTP--FLGWNKAMSATNNSTNPAdhgTN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 DNGGKMLLLYHLVVFV--LIYF-------LPLVVMFAAYSVIGLTLWKRaVPRHQAHGANLRHLQAKKKFVKAMVLVVVT 258
Cdd:cd15069  157 HSCCLISCLFENVVPMsyMVYFnffgcvlPPLLIMLVIYIKIFLVACRQ-LQRTELMDHSRTTLQREIHAAKSLAIIVGI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 259 FAICWLPYHLYFILGTFQEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15069  236 FALCWLPVHILNCITLFQPEFSKSKPKWAMNVAIL-LSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-315 8.31e-22

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 94.04  E-value: 8.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNA-TVIWIILAHERMRTVTNYfIINLALADLcmaAFNATFNFIYASH--NIWYFGSTFCYFQNLFP 113
Cdd:cd14999    3 GTVLSLMCVVGVAGNVyTLVVMCLSMRPRASMYVY-ILNLALADL---LYLLTIPFYVSTYflKKWYFGDVGCRLLFSLD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALASPQCFYSTIT----VDQGATKCVVAWPND 188
Cdd:cd14999   79 FLTMHASIFTLTVMSTERYLAVVKPLDTvKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVtvedKSGGSKRICLPTWSE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLrhlqAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd14999  159 ESYK---VYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRL----PKQKVLKMIFTIVLVFWACFLPFWI 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 269 YFILGTF-QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd14999  232 WQLLYLYsPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
35-315 8.51e-22

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 94.53  E-value: 8.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15403    2 LLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPfQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd15403   82 FFVLEGVAILLIISVDRFLIIVQR-QDKLNPHRAKVMIAISWVLSFCISFPSVVgWTLVEVPARAPQCVLGYTESPADRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 lllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRH---------QAHGANLRHLQA----------KKKFVKAMVL 254
Cdd:cd15403  161 ---YAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHnhadslclsQVSKLGLMGLQRphqmnvdmsfKTRAFTTILI 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 255 VVVTFAICWLPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15403  238 LFVGFSLCWLPHTVFSLLSVFSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFR 298
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
45-315 1.33e-21

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 93.42  E-value: 1.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM-------AAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15137   12 IIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMgvylliiASVDLYYRGVYIKHDEEWRSSWLCTFAGFLATLSS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALA----------------SPQCFYSTITVDQGAtk 180
Cdd:cd15137   92 EVSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLLAvlpllpwdyfgnfygrSGVCLPLHITDERPA-- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 181 cvvAWpndnggkmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqahGANLRHLQAKKKFVKAMVLVVVTFA 260
Cdd:cd15137  170 ---GW----------EYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRK------AAASRKSKRDMAVAKRFFLIVLTDF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 261 ICWLPYHLYFILGTFQEDIYyrkfiQQVY--LALFWLAMSSTMyNPIIYCCLNHRFR 315
Cdd:cd15137  231 LCWIPIIVIGILALSGVPIP-----GEVYawVAVFVLPINSAL-NPILYTLSTPKFR 281
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
42-317 1.36e-21

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 93.36  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFC----YFQNLFPvtam 117
Cdd:cd15008    8 VLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCklvrYFQYLTP---- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQC-FYSTitvdQGATKCVVAWPNDNGGKMLLL 196
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALfFYGS----NWGPHCNFFLPDSWDGAAYAI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIyflPLVVMFAAYSVIGLTLWkravpRHQAHGANLRHL-----QAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15008  160 IHLLVGFLV---PSILIILFYQKVIKYIW-----RIGTDGRTVRRTmnivpRTKVKTIKMFLMLNSMFLLSWLPFYVVQL 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 272 LGTFQEDiyYRKfIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSG 317
Cdd:cd15008  232 WHPRESD--YRQ-SSLVFLAVTWISFSSSASKPTLYSVYNANFRRG 274
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
40-316 1.45e-21

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 93.20  E-value: 1.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15182    7 YYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDL-LFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQC-FYSTITVDQGATKCvvawpNDNGGKMLLL 196
Cdd:cd15182   85 SILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVsvAVWVISILASLPELiLSTVMKSDEDGSLC-----EYSSIKWKLG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLvVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15182  160 YYY-QQNLFFLIPLGIIVYCYVRILQTLMR-------------TRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLK 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 277 ED-IYYRKFIQQVYLALFW---LAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15182  226 DLtIPICECSKQLDYAFYIcrnIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
40-315 2.55e-21

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 92.45  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfNATFNFIYASHNiWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15180    7 YSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLV-TLPFWAVQAVHG-WIFGTGLCKLAGAVFKINFYC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFYSTITVD--QGATKCVVAWP-NDNGGKML 194
Cdd:cd15180   85 GIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSclIVWLFCLLLSIPDFIFLEATKDprQNKTECVHNFPqSDTYWWLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 L--LYHLVVFvliyFLPLVVMFAAYSVIGLTLWKRAvprhqahganlrHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15180  165 LrlLYHIVGF----LLPLAVMVYCYTSILLRLLRSS------------QGFQKQRAIRVIVAVVVVFFLCWTPYNIALLV 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 273 GTFQE-DIYYRKFIQQVYLalfWLAMSST--------MYNPIIYCCLNHRFR 315
Cdd:cd15180  229 DTLIDlSVLDRNCGTESRL---DIALSVTsslgyfhcCLNPLLYAFVGVKFR 277
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
45-315 2.89e-21

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 92.58  E-value: 2.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15078   12 FLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHpfQPRLSAPSTKAVIAVIWLVALALA-SPQCFYSTITVDQGATKCVVAW----PNDNGgkmlllYHL 199
Cdd:cd15078   92 TVLAYERYIRVVH--AKVVNFSWSWRAITYIWLYSLAWTgAPLLGWNRYTLEVHGLGCSFDWkskdPNDTS------FVL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQedi 279
Cdd:cd15078  164 LFFLGCLVVPLGIMAYCYGHILYEIRMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSG--- 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 258613887 280 yYRKFIQ-QVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15078  241 -YSKLVTpTIAIIPSLFAKSSTAYNPVIYIFMIRKFR 276
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
26-315 4.47e-21

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 92.17  E-value: 4.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  26 FSMPGWQLALWATAYLALVLVAVTG-----NATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWY 100
Cdd:cd15082    1 FSGPLKSIAPWNFTVLAALMFVVTSlslaeNFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 101 FGSTFCYFQNlFPVTAM-FVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQG 177
Cdd:cd15082   81 LGVWACVLEG-FAVTFFgIVALWSLAVLAFERFFVICRPLgNIRLQGKHAALGLLFVWTFSFIWTIPPVLgWSSYTVSKI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 178 ATKCVVAWPNDNGGKMllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHGANLRhlQAKKKFVKAMVLVVV 257
Cdd:cd15082  160 GTTCEPNWYSGNMHDH--TYIITFFTTCFILPLGVIFVSYGKLLQKL--RKVSNTQGRLGNAR--KPERQVTRMVVVMIV 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 258 TFAICWLPYHLYFILGTFQEDIYYRKFIQQVyLALFwlAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15082  234 AFMVCWTPYAAFSILVTAHPTIHLDPRLAAI-PAFF--SKTAAVYNPIIYVFMNKQFR 288
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
34-268 4.91e-21

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 91.70  E-value: 4.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADL---CMAAFNATFnFIYASHniWYFGSTFCYFQN 110
Cdd:cd15157    1 VIYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLmfvSTLPFRADY-YLMGSH--WVFGDIACRIMS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFVSIYSMTAIAADRYMAIVHPFQpRLSAPSTKA---VIAVIWLVALALASPqCFYSTITVDQGATKCVVawPN 187
Cdd:cd15157   78 YSLYVNMYCSIYFLTVLSIVRFLAIVHPFK-LWKVTSIKYariLCAVIWIFVMAASSP-LLSKGTSKYNSQTKCLD--LH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 DNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlrhlqakKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15157  154 PSKIDKLLILNYIVLVVGFILPFCTLSICYILIIKALLKPRVPQSKLRVSH-------KKALLTIIITLILFLLCFLPYH 226

                 .
gi 258613887 268 L 268
Cdd:cd15157  227 I 227
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
45-316 5.59e-21

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 91.37  E-value: 5.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIilAHERM-RTVTNYFIINLALADL--CMAAFNATFNFIYASHniWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15115   12 LLGVPGNGLVIWV--AGLKMkRTVNTIWFLNLAVADLlcCLSLPFSIAHLLLNGH--WPYGRFLCKLLPSIIVLNMFASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCvvawpndnGGKMLLLYHL 199
Cdd:cd15115   88 FTLTAISLDRFLLVIKPVwaQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRC--------GYDFLVAITI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqahGANLRHLQAKKKFvKAMVLVVVTFAICWLPYHLYFILGTFQEDI 279
Cdd:cd15115  160 TRAVFGFLLPLLIIAACYSFIAFRM-----------QRGRFAKSQSKTF-RVIIAVVVAFFVCWAPYHIIGILSLYGDPP 227
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 258613887 280 YYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15115  228 LSKVLMSWDHLSIA-LAYANSCLNPVLYVFMGKDFKK 263
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
38-269 5.83e-21

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 91.68  E-value: 5.83e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIY-ASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15967    5 PVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADL-LYLLTLPFLVVYyLKGRKWIFGQVFCKITRFCFNLN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTitVDQGATKCVVAWPNDNGgKML 194
Cdd:cd15967   84 LYGSIGFLTCISVYRYLAIVHPMRVmgRITTTHSVVISALVWLLVVIQSLPDLFFSK--TNSNGTKCFDTTFNDYL-ESY 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAvprhqahgaNLRHLqAKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15967  161 LTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNN---------NVDKG-LKQRCLKLVIILIVLFSVCYIPYHVF 225
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
36-324 7.40e-21

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 91.17  E-value: 7.40e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd15307    3 WALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASP-QCFYSTitvDQGAT----KCVVAWPnd 188
Cdd:cd15307   83 FCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTlkIVFVWLLSIAMSLPlSLMYSK---DHASVlvngTCQIPDP-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 nggkmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravpRHQAHGANLRHLQakkKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15307  158 -------VYKLVGSIVCFYIPLGVMLLTYCLTVRLLAR----QRSRHGRIIRLEQ---KATKVLGVVFFTFVILWSPFFV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 269 YFILGTFQEDIYYRkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRC 324
Cdd:cd15307  224 LNLLPTVCAECEER-ISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
37-318 8.01e-21

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 91.51  E-value: 8.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLAL-VLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd15959    3 AGALLSLaILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLV--ALALASPQCFYSTITVDQGATKCVVAwPNDNGG 191
Cdd:cd15959   83 CVTASIETLCAIAVDRYLAITNPLRyeALVTKRRARTAVCLVWAIsaAISFLPIMNQWWRDGADEEAQRCYDN-PRCCDF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRA--------------VPRHQAHGANLRH---LQAKK--KFVKAM 252
Cdd:cd15959  162 VTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVrlirkdkvrfppeeSPPAESRPACGRRpsrLLAIKehKALKTL 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 253 VLVVVTFAICWLPYHLYFILGTFQediyyRKFI-QQVYLALFWLAMSSTMYNPIIYcCLNHRFRSGF 318
Cdd:cd15959  242 GIIMGTFTLCWLPFFVANIIKVFC-----RSLVpDPAFLFLNWLGYANSAFNPIIY-CRSPDFRSAF 302
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
41-318 8.97e-21

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 91.28  E-value: 8.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTV-TNYFIINLALADLCM--------AAFNATFNfiyashniWYFGSTFCYFQNL 111
Cdd:cd15383    8 FVLFVLSACSNLAVLWSATRNRRRKLShVRILILHLAAADLLVtfvvmpldAAWNVTVQ--------WYAGDLACRLLMF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGA--TKCVV--AWP 186
Cdd:cd15383   80 LKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFlFHTVTATPPVnfTQCAThgSFP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNGGKmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGAN--LRH-----LQAKKKFVKAMVLVVVTF 259
Cdd:cd15383  160 AHWQET---LYNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEvaLRSssdniPKARMRTLKMTIVIVSSF 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 258613887 260 AICWLPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15383  237 IVCWTPYYLLGLWYWFSPEMLEQTVPESLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
41-316 1.12e-20

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 90.66  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVS 120
Cdd:cd15077    8 LFLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSMTAIAADRYMAIVHPFQpRLSAPSTKAVIAVI--WLVALALASPQCFYSTITVDQG-ATKCVVAWPNDNGGKMLLLY 197
Cdd:cd15077   88 LWSLAVVAFERFLVICKPLG-NFTFRGTHAIIGCIatWVFGLAASLPPLFGWSRYIPEGlQCSCGPDWYTTNNKWNNESY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHGANLRhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQE 277
Cdd:cd15077  167 VMFLFCFCFGVPLSIIVFSYGRLLLTL--RAVAKQQEQSASTQ--KAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNR 242
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 278 DiyyRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15077  243 G---EPFDLRLASIPSVFSKASTVYNPVIYVFMNKQFRS 278
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
46-315 1.18e-20

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 90.98  E-value: 1.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  46 VAVTGNATVIWIIlAHERMRTVTNYFIINLALADLCMAAFnATFNFIYASHNI-WYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15116   13 LGVLGNGLVIFIT-GFKMKKTVNTVWFLNLAVADFLFTFF-LPFSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTSVFLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQ----------------CFYSTITVDQGATKcvvaWP 186
Cdd:cd15116   91 TVISIDRCISVVFPVwsQNHRSVRLASLVSLAVWVVAFFLSSPSfifrdtapsqnnnkiiCFNNFSLSGDNSSP----EV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwKRAvprhqahganlRHLQAKKKFvKAMVLVVVTFAICWLPY 266
Cdd:cd15116  167 NQLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKL-KRN-----------RLAKSSKPF-KIIAAVIVTFFLCWAPY 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 267 HLYFILGTFQEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15116  234 HILNLLEMEATRSPASVFKIGLPITSS-LAFINSCLNPILYVFMGQDFK 281
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
45-316 1.70e-20

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 90.20  E-value: 1.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAA---FNATFnfiYASHNIWYFGSTFCYFqNLFPV-TAMFVS 120
Cdd:cd14991   12 VLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLIclpFRIDY---YLRGEHWIFGEAWCRV-NLFMLsVNRSAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSMTAIAADRYMAIVHPFQpRLSAPSTKAVIAV---IWLVALALASPQCFYSTITVDQGATKCvVAWPNDNGGKMLLLY 197
Cdd:cd14991   88 IAFLTAVALDRYFKVVHPHH-RVNRMSVKAAAGVaglLWALVLLLTLPLLLSTLLTVNSNKSSC-HSFSSYTKPSLSIRW 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGanlrhlqakKKFVKAMVLVVVTFAICWLP-------YHLYF 270
Cdd:cd14991  166 HNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGKQARV---------QRAIRLVFLVVIVFVLCFLPsiiagllALVFK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 271 ILGTFQEdiyYRKFIQQVYLALFWLAMSStMYNPIIYCCLNHRFRS 316
Cdd:cd14991  237 NLGSCRC---LNSVAQLFHISLAFTYLNS-ALDPVIYCFSSPWFRN 278
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
42-318 1.91e-20

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 89.65  E-value: 1.91e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15330    9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQ------PRLSApstkAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAwpNDNGgkml 194
Cdd:cd15330   89 LHLCAIALDRYWAITDPIDyvnkrtPRRAA----VLISLTWLIGFSISIPPMLgWRTPEDRSDPDACTIS--KDPG---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 llYHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15330  159 --YTIYSTFGAFYIPLILMLVLYGRI-----FKAAAR-------------ERKTVKTLGIIMGTFILCWLPFFIVALVLP 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDIYYRKfiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15330  219 FCESTCHMP--ELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
37-307 2.30e-20

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 90.99  E-value: 2.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIwIILAHERMRTVTNYFIINLALADLCmaaFNATFNF-IYASH-NIWYFGSTFCYFQNLFPV 114
Cdd:PHA03087  44 IVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDLL---FVMTLPFqIYYYIlFQWSFGEFACKIVSGLYY 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWpNDNGGK 192
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPvkSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFY-NNKTMN 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:PHA03087 199 WKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKK------------NKKAIKLVLIIVILFVIFWLPFNVSVFV 266
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 273 G-----TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:PHA03087 267 YslhilHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIY 306
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
39-318 2.62e-20

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 89.44  E-value: 2.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmaAFNATFNFI-YASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15173    6 MYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADL---LFLCTLPFWaYSAAHEWIFGTVMCKITNGLYTINL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIV-----HPFQPRLSAPStKAVIAVIWLVALALASPQCFYSTiTVDQGATKCVVAWPNDNGGK 192
Cdd:cd15173   83 YSSMLILTCITVDRFIVIVqatkaHNCHAKKMRWG-KVVCTLVWVISLLLSLPQFIYSE-VRNLSSKICSMVYPPDAIEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFvliYFLPLVVMFAAYSVIGLTLwkravprhqAHGANLRhlqaKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15173  161 VVNIIQMTVG---FFLPLLAMIICYSVIIKTL---------LHAKGFQ----KHKSLKIIFVVVAVFILTQLPYNIMKLI 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15173  225 RTLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
40-315 3.19e-20

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 89.39  E-value: 3.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIIlAHERMRTVTNYFIINLALAD-LCMAAFNATFNFIyASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15114    7 YAVVFLVGVPGNALVAWVT-GFEAKRSVNAVWFLNLAVADlLCCLSLPILAVPI-AQDGHWPFGAAACKLLPSLILLNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATK--CVVAWPNDNGGKML 194
Cdd:cd15114   85 ASVLLLTAISADRCLLVLRPVwcQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKtvCVVDYGGSTGVEWA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLyhLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqahganlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15114  165 VA--IIRFLLGFLGPLVVIASCHGVLLVRTWSRRR-------------QKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIA 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 F---QEDIYYRKFIQQVYLALFWLAMSSTmyNPIIYCCLNHRFR 315
Cdd:cd15114  230 AsapNSRLLANALKADPLTVSLAYINSCL--NPIIYVVAGRGFR 271
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
43-318 4.78e-20

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 88.56  E-value: 4.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15331   10 LILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAI--VHPFQPRlSAPSTKAVIAVIWLVALALASPQCF------YSTITVDQGatKCVVAwpNDNGgkml 194
Cdd:cd15331   90 HLVAIALDRYWAVtnIDYIRRR-TAKRILIMIAVVWFVSLIISIAPLFgwkdedDLDRVLKTG--VCLIS--QDYG---- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 llYHLVVFVLIYFLPLVVMFAAYSVIGLTlwkravprhqahganlrhlqAKKKFVKAMVLVVVT--FAICWLPYHLYFIL 272
Cdd:cd15331  161 --YTIFSTVGAFYVPLLLMIIIYWKIYQA--------------------AKRERKAARTLAIITgaFVVCWLPFFLVALV 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 273 GTFQEDIYYRKFIQQVYLalfWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15331  219 MPFCGAWQISRFLESFFL---WLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
40-318 5.36e-20

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 88.95  E-value: 5.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15312    7 MAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFystITVDQGATKCVVAWPNDNGGKMLL-- 195
Cdd:cd15312   87 SIFHLCFIAVDRYYAVCDPlhYRTKITTPVIKVFLVISWSVPCLFAFGVVF---SEVNLEGIEDYVALVSCTGSCVLIfn 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 -LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAH----GANLRHLQAKK--KFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15312  164 kLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKVINNRPsvtkGDSKNKLSKKKerKAAKTLSIVMGVFLLCWLPFFV 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 269 YFILGTFqedIYYRKFIqQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15312  244 ATLIDPF---LNFSTPV-DLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
34-268 5.65e-20

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 88.61  E-value: 5.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15161    1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQP-RLSAP-STKAVIAVIWLVALALASPQCFYSTITVDQGATKCvvawpndngg 191
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKSmKIRKPlYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVC---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 kmLLLYH-------LVVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHganlrhlqAKKKFVKAMVLVVVTFAICWL 264
Cdd:cd15161  151 --LQLYRekasrgaLVSLAVAFTIPFVTTVTCYLLIIRSL--RTGKREEKP--------LKDKAIKMIILVLTIFLICFV 218

                 ....
gi 258613887 265 PYHL 268
Cdd:cd15161  219 PYHI 222
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
43-315 6.20e-20

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 88.36  E-value: 6.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYfqnlfpVTAMFVSIY 122
Cdd:cd15404   10 ILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCR------VSAMFFWLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIA------ADRYMAIVHPfQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKMll 195
Cdd:cd15404   84 VMEGVAilliisIDRFLIIVQK-QDKLNPYRAKVLIAVSWAVSFCVAFPLAVgSPDLQIPSRAPQCVFGYTTNPGYQA-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 lYHLVVFVLIYFLPLVVMFaaYSVIGLTLWKRAVprhqahganlrhlqAKKKFVKAMVLVVVtFAICWLPYHLYFILGTF 275
Cdd:cd15404  161 -YVILIMLIFFFIPFMVML--YSFMGILNTVRSF--------------KTRAFTTILILFIV-FTVCWAPFTTYSLVATF 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 276 QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15404  223 NSHFYHKHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
39-268 6.81e-20

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 88.68  E-value: 6.81e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFI-YASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15968    6 CYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADL-LYALSLPLLIYnYAMRDRWLFGDFMCRLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMlL 195
Cdd:cd15968   85 YGSILFLTCISVHRYLGICHPMRPwhKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFPHY-V 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15968  164 PYGMALTVSGFLLPFSIILWCYCLVVRTLCR------TLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHI 230
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
40-311 6.98e-20

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 88.66  E-value: 6.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd14987    7 YIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFY-STITVD-QGATKCVVAWPNDNGGKMLL 195
Cdd:cd14987   87 SIFFLTCMSVDRYLSVTLFGNTssRRKKIVRRIICVLVWLLAFVASLPDTYFlKTVTSPsNNETYCRSFYPEESFKEWLI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqahganlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:cd14987  167 GMELVSIVLGFVIPFPIIAVFYFLLARAISASSD-------------QERKSSRKIIFSYVVVFLVCWLPYHTVVLLDIL 233
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 258613887 276 QEdIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLN 311
Cdd:cd14987  234 SF-LHLIPFSCQLENFLY-AALHVTQCFSLVHCCVN 267
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
40-315 7.09e-20

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 88.39  E-value: 7.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMaAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15183    7 YSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVF-LFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLY 197
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITsiITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIRWKRFQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQE 277
Cdd:cd15183  166 ALKLNLLGLILPLLVMIICYTGIINILLRRPNEK-------------KAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQD 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 278 DIYYRKFIQ--QVYLALF---WLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15183  233 VLFTPSCEQsqQLDLALQvteVIAYTHCCVNPVIYVFVGERFR 275
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
35-318 8.45e-20

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 88.46  E-value: 8.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHniwyFGSTF--CYFQNLF 112
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG----FCAAChgCLFIACF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALA-SPQCFYSTITVDQGATKCVVAWPNdn 189
Cdd:cd15068   78 VLVLTQSSIFSLLAIAIDRYIAIRIPlrYNGLVTGTRAKGIIAICWVLSFAIGlTPMLGWNNCGQPKEGKNHSQGCGE-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 gGKMLLLYHLVVFV--LIYF-------LPLVVMFAAYSVIGLTlwkravPRHQAHGANLR---------HLQAKKKFVKA 251
Cdd:cd15068  156 -GQVACLFEDVVPMnyMVYFnffacvlVPLLLMLGVYLRIFLA------ARRQLKQMESQplpgerarsTLQKEVHAAKS 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 252 MVLVVVTFAICWLPYHLYFILGTFQEDIyYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15068  229 LAIIVGLFALCWLPLHIINCFTFFCPDC-SHAPLWLMYLAIV-LSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
38-316 9.07e-20

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 88.29  E-value: 9.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADL-LFVLTLPFWAVDAAAN-WYFGNFLCKAVHVIYTVNL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPF---QPRlSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKML 194
Cdd:cd15179   83 YSSVLILAFISLDRYLAIVHATnsqRPR-KLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELWV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprHQAHGanlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15179  162 VAFRFQHILVGLVLPGLVILTCYCIIISKL-------SHSKG------HQKRKALKTTVILILAFFACWLPYYIGISIDT 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 275 F------QEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15179  229 FmlleiiKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 276
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
40-318 1.04e-19

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 88.21  E-value: 1.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15375    7 YSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKmLLLY 197
Cdd:cd15375   87 SILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVAcaVVWVISLAEVSPMTFLITTKEKNNRTICLDFTSSDNLNT-IWWY 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqAHGANLRhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQE 277
Cdd:cd15375  166 NWILTVLGFLLPLVIVTLCYTRIIYTL---------AKGPHTG-SASKQKARRLIILILLVFYVCFLPFHILRVVRIETR 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 278 DIY----YRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15375  236 LPPvsccLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
40-316 1.11e-19

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 87.90  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15398    7 YTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASP-QCFYSTI----TVDQGATK----CVVAWPNDNg 190
Cdd:cd15398   87 STLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPlPVFHKIVdlseTFNLESLKnkylCIESWPSDS- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gkMLLLYHLVVFVLIYFLPLVVMFAaysvigltlwkravprhqAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15398  166 --YRIAFTISLLFVQYILPLVCLTV------------------SHTSVCRSVKRSRSVFYRLTIVILAFAVSWMPLHLFH 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 271 ILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15398  226 LVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIKS 271
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
35-315 1.15e-19

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 88.01  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHE-RMRTVTNYFIINLALADLCMA------AFNATFNFIyashniWYFGSTFCY 107
Cdd:cd15925    2 LVALAYGLVCAIGLLGNLAVMYLLRNCArRAPPPIDVFVFNLALADFGFAltlpfwAVESALDFH------WPFGGAMCK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 108 FQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAW 185
Cdd:cd15925   76 MVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPgtHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNDnggKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15925  156 PSN---YWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFL--------QQHKVNQNNRQRQSVIARSVRLVVASFFLCWFP 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 266 YH---LYFILGTFQ----EDIYYrkFIQQ-VYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15925  225 NHvvtFWGVLVKFRavpwNSTFY--FIHTyVFPVTTCLAHSNSCLNPVLYCLMRREFR 280
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
40-318 1.20e-19

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 87.87  E-value: 1.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADlcmAAFNATFNFIYASH--NIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15087    7 YSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIAD---DLFTLVLPINIAEHllQQWPFGELLCKLILSIDHYNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPST----KAVIAVIWLVALALASPQCFYSTITV-DQGATKCVVAWPNDNGG- 191
Cdd:cd15087   84 FSSIYFLTVMSVDRYLVVLATVRSRRMPYRTyraaKIVSLCVWLLVTIIVLPFTVFAGVYSnELGRKSCVLSFPSPESLw 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 -KMLLLYHLvvfVLIYFLPLVVMFAAYSVIGLTLwkravpRHQAHGANLRHLQAKKKFVKAMVLVVVTFAI-CWLPYHLY 269
Cdd:cd15087  164 fKASRIYTL---VLGFAIPVSTICILYTMMLYKL------RNMRLNSNAKALDKAKKKVTLMVLVVLAVCLfCWTPFHLS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 270 FILGtFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15087  235 TVVA-LTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
39-318 1.24e-19

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 87.89  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNF-IYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15172    6 IYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADIL---FVLTLPFwAVYEAHQWIFGNFSCKLLRGIYAINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVH---PFQPRLSA-PSTKAVIAVIWLVALALASPQCFYSTI--TVDQGATKCVVAWPNDNGG 191
Cdd:cd15172   83 YSGMLLLACISVDRYIAIVQatkSFRLRSRTlAYSKLICAAVWLLAILISLPTFIFSEVydFGLEEQYVCEPKYPKNSTA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLI-YFLPLVVMFAAYSVIGLTLwkravprHQAHGANlRHlqakkKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15172  163 IMWKLLVLSLQVSLgFFIPLLVMIFCYSFIIKTL-------LQAQNSQ-RH-----KAVRVVVAVVLVFLVCQVPYNIVL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 271 ILGTFQ----------EDIYYRKFIQQVylalfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15172  230 LIEAINlgeqqscsseKAVAYAKTITEC------LAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
40-272 1.54e-19

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 87.39  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAaFNATFNfIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15165    7 YIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLL-LSLPFK-MHSSKKQWPLGRTLCSFLESLYFVNMYG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQ-PRLSAPSTKAVI-AVIWLVALALASPqcFYSTITVDQGATKCVVAWPNDNGGKMLLly 197
Cdd:cd15165   85 SILIIVCISVDRYIAIRHPFLaKRLRSPRKAAIVcLTIWVFVWAGSIP--IYSFHDKPTNNTRCFHGFSNKTWSKKVI-- 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 198 hLVVFVLIYFLPLVVM-FAAYSVIgltlwkRAVPRHQAHGANLRHlqaKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15165  161 -VVVEEFGFLIPMAVMvFCSVQII------RTLLDMRRPEQPKVK---QNKSVKIVLSNLVVFLVCFTPYHLGIFL 226
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
38-318 1.69e-19

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 87.56  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMR---TVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15338    5 SVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQ-PRLSAPSTK-AVIAVIWLVALALASPQCFYS-TITVDQGATKCVVAWPNDNGG 191
Cdd:cd15338   85 NSQITSTYILTVMTLDRYLATVHPIRsTKIRTPRVAvAVICLVWILSLLSITPVWMYAgLMPLPDGSVGCALLLPNPETD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 kmLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQaHGANLRhlqaKKKFVKAMVLVVVTFAICWLPyhlYFI 271
Cdd:cd15338  165 --TYWFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQ-RSLRVR----TKKVTRMAVAICLAFFICWAP---FYI 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 272 LGTFQEDIyYRKFIQQVYLALFWLAM--SSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15338  235 LQLAHLSI-DRPSLAFLYAYNVAISMgyANSCINPFLYIMLSETFKRQF 282
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
35-318 2.01e-19

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 87.28  E-value: 2.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15155    2 LYGAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDL-LFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGK 192
Cdd:cd15155   81 TNIYGSMLFLTCISVDRFLAIVYPFRSRTirTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravPRHQAHGANlrhlqAKKKFVKAMVLVVVTFAICWLPYH----L 268
Cdd:cd15155  161 YLSKITIFIEVVGFIIPLLLNLTCSSLVLRTLRK---PATLSQIGT-----NKEKVLKMILVHVAIFVVCFVPYNsilfL 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 269 YFILGTFQ-EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15155  233 YALVRSQAiANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
40-315 2.54e-19

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 87.12  E-value: 2.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15162    7 YTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMYC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPqcFYS---TITVDQ-GATKCVVAWPNDNGGKM 193
Cdd:cd15162   87 SILLLTCISIDRYLAIVHPMGHRRLRARRYALGTclAIWLLALLVTLP--LYLvkqTIFLPAlDITTCHDVLPEQLLVGD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15162  165 WFYYFLSLAIVGFLIPFILTASCYVATIRTL---------AALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAH 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15162  236 YSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-318 2.87e-19

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 87.21  E-value: 2.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTV---TNYFIINLALADLCMAAFN---ATFNFIYAsHNIWYFGSTFCYFQNLFP 113
Cdd:cd15355    7 YLALFVVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLLILLLAmpvELYNFIWV-HHPWAFGDAACRGYYFLR 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNG 190
Cdd:cd15355   86 DACTYATALNVASLSVERYLAICHPFKAKslMSRSRTKKFISAIWLASALLAIPMLFtMGEQNRSGTHPGGLICTPIVDT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFvLIYFLPLVVMFAAYSVIGLTLwkrAVPRHQAHGANLR-----------------HLQAKKKFVKAMV 253
Cdd:cd15355  166 STLKVVIQVNAF-LSFLFPMLVISVLNTLIANQL---TVMVNQAEQENQVctiggqrtvlsvsmepgRVQSLRHGVLVLR 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258613887 254 LVVVTFAICWLPYH----LYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15355  242 AVVIAFVVCWLPYHvrrlMFCYVSDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-315 5.21e-19

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 85.98  E-value: 5.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMA------AFNATFNFIyashniWYFGSTFCYFQNLFPVTA 116
Cdd:cd15189   10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVsglpfwAMNILNQFN------WPFGELLCRVVNGVIKVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFYSTITV--DQGATKCVVAWPNDNggk 192
Cdd:cd15189   84 LYTSIYLLVMISQDRYLALVKTMAARRlrRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACVLLYPHEA--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 mLLLYHLVVF-VLIYFLPL-VVMFAAYSVIGLTLWKRAVPRHQAhganlrhlQAKKKFVKAMVLVVVTFAICWLPYH--- 267
Cdd:cd15189  161 -WHFAHIVLLnIVGFLLPLlVITFCNYNILQALRTREESTRCED--------RNDSKATALVLAVTLLFLVCWGPYHfft 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 268 ---LYFILGTFQEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15189  232 fldFLFDVGVLDECFWEHFIDIGLQLAVF-LAFSNSCLNPVLYVFVGRYFR 281
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
46-315 6.43e-19

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 86.02  E-value: 6.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  46 VAVTGNATVIWIILAHERmRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMT 125
Cdd:cd15339   13 TGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFACSAIMT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 126 AIAADRYMAIVHPFqpRLSAPSTKA----VIAVIWLVALALASPQCFYS-TITVDQGATKCVVawpNDNGGKMLLLYHLV 200
Cdd:cd15339   92 AMSLDRYIALVHPF--RLTSLRTRSktirINLLVWAASFILVLPVWVYAkVIKFRDGLESCAF---NLTSPDDVLWYTLY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVT-FAICWLPYHLYFILgTFQEDI 279
Cdd:cd15339  167 QTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGvFLVSAAPYHVIQLV-NLSVSQ 245
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 258613887 280 YYRKFIQQVYLALfWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15339  246 PTLAFYVSYYLSI-CLSYASSSINPFLYILLSGNFR 280
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
34-307 6.44e-19

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 85.62  E-value: 6.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERmRTVTNYFIINLALADLcmaAFNATFNFIYASH---NIWYFGSTFCYFQN 110
Cdd:cd15371    1 KLIPAVYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDL---LFCITLPFKIVYHlngNNWVFGETMCRIIT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFY--STITVDQGATKCVVAWP 186
Cdd:cd15371   77 ITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLicALVWTIVFLYMLPFFILkqTYYLKELNITTCHDVLP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNGGKMLLLYHLVVFVLIYFL-PLVVMFAAYSVIGLTLwkravprhqaHGANLRHLQakkkFVKAMVLVVVTFAICWLP 265
Cdd:cd15371  157 ECEQNSNFQFYYFISMAVFGFLiPLVITIFCYISIIRTL----------NAYEHKWFW----YVKITALVLIIFTICFAP 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 266 YHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15371  223 SNVILIIHHFNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLY 264
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
31-324 7.11e-19

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 85.77  E-value: 7.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  31 WQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQN 110
Cdd:cd15299    1 WQVVLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVDQGATkcvvawPND 188
Cdd:cd15299   81 SIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAgvMIGLAWVISFVLWAPAILFWQYFVGKRTV------PPD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVF---VLIYFLPLVVMfaaySVIGLTLWKRAVprhqahganlrhlqAKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15299  155 ECFIQFLSEPIITFgtaIAAFYLPVTIM----TILYWRIYKETI--------------KEKKAAQTLSAILLAFIITWTP 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 266 YHLYFILGTFQEDIyyrkfIQQVYLAL-FWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRC 324
Cdd:cd15299  217 YNIMVLVNTFCDSC-----IPKTYWNLgYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
40-315 1.25e-18

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 84.88  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15185    7 YSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDL-LFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVI--WLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLY 197
Cdd:cd15185   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIitWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDSWKRFH 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqahganLRHLQAKK-KFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15185  166 ALRMNIFGLALPLLIMVICYTGIIKTL--------------LRCPSKKKyKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQ 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 277 -----EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15185  232 siffeTDCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFR 275
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
38-316 1.31e-18

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 84.87  E-value: 1.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTG-NATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15076    4 AAFMGFVFIVGTPlNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQG-ATKCVVAWPNDNGGKML 194
Cdd:cd15076   84 GLVTGWSLAFLAFERYIVICKPFGNfRFGSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGlQCSCGPDWYTVGTKYRS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHGANlrhLQAKKKFVKAMVLVVV-TFAICWLPYHLYFILG 273
Cdd:cd15076  164 EYYTWFLFIFCFIVPLSIIIFSYSQLLGAL--RAVAAQQQESAS---TQKAEREVSRMVVVMVgSFCLCYVPYAALAMYM 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 274 TFQEDiyYRKFIQQVYLALFWlAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15076  239 VNNRD--HGLDLRLVTIPAFF-SKSSCVYNPIIYCFMNKQFRA 278
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
42-266 1.37e-18

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 85.24  E-value: 1.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15386    9 AILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFAST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPrLSAPSTKA--VIAVIWLVALALASPQCF-YSTITVDQGA--TKCVVAWPNDNGGKMLLL 196
Cdd:cd15386   89 YMLIMMTVDRYIAVCHPLRT-LQQPSRQAylMIGATWLLSCILSLPQVFiFSLREVDQGSgvLDCWADFGFPWGAKAYIT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVfvlIYFLPLVVMFAAYSVIGLTL-----WKRAVPRHQAHGANLRHL-----------QAKKKFVKAMVLVVVTFA 260
Cdd:cd15386  168 WTTLS---IFVLPVAILIVCYSLICYEIcknlkGKTQTSRSEGGGWRTQGMpsrvssvrtisRAKIRTVKMTFVIVLAYI 244

                 ....*.
gi 258613887 261 ICWLPY 266
Cdd:cd15386  245 ACWAPF 250
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
43-315 1.46e-18

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 84.91  E-value: 1.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15316   10 GAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALaSPQCFYSTITvDQGATKCVVAWpNDNGGKMLLLYHLV 200
Cdd:cd15316   90 HLCFISVDRYIAVTDPlvYPTKFTVSVSGICISVSWIFSLTY-SFSVFYTGVN-DDGLEELVNAL-NCVGGCQIILNQNW 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFV--LIYFLPLVVMFAAYSVIGLtlwkraVPRHQA--------------HGANLRHLQAKKKFVKAMVLVVVTFAICWL 264
Cdd:cd15316  167 VLVdfLLFFIPTFAMIILYGKIFL------VAKQQArkiemtsskaesssESYKDRVARRERKAAKTLGITVIAFLVSWL 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 265 PYHLYFILGTFQediyyrKFIQQ--VYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15316  241 PYLIDVLIDAFM------NFITPpyIYEICCWCAYYNSAMNPLIYALFYPWFR 287
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
40-268 1.48e-18

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 84.71  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADL--CMAAFNATFNFIYASHniWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15159    7 YSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDIlfTLALPGRIAYYALGFD--WPFGDWLCRLTALLFYINT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ-PRL-SAPSTKAVIAVIWLVALALASPQCFySTITVDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15159   85 YAGVNFMTCLSVDRYIAVVHPLRrHRLrKVKVVRYICVFVWVLVFLQTLPLLF-MPMTKEMGGRITCMEYPNFEKIKRLP 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWkRAVPRHQAHGANLRHlqakKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15159  164 LILLGACVIGFGVPVGIILFCYSQITLKLC-RTAKENPLTEKSGHH----KKACNVILLVLLVFVVCFSPYHL 231
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
40-315 1.54e-18

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 84.95  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVT-NYFIINLALADLcmaAFNATFNFiYASHNI----WYFGSTFCYFQNLFPV 114
Cdd:cd15926    7 YSVVCALGLVGNLLVLYLMKSKQGWKKSSiNLFVTSLAVTDF---QFVLTLPF-WAVENAldftWLFGKAMCKIVSYVTA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGK 192
Cdd:cd15926   83 MNMYASVFFLTAMSVARYHSVASALksKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRGNA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 M--LLLYHLVVFVLIYFLPLVVMFAAYsviglTLWKRAVPRHQAHGANLRHlqaKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15926  163 QfwLGLYHAQKVLLGFLIPLGIISLCY-----LLLVRFITDKNITGSSTKR---RSKVTKSVTIVVLSFFLCWLPNQALT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 271 ILGTFQE----DIYYRKFIQQVYL--ALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15926  235 TWGILIKlnvvHFSYEYFTTQVYIfpITVCLAHSNSCLNPILYCLMRREFR 285
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
40-316 2.04e-18

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 84.36  E-value: 2.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15160    7 YSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFYSTITVDQG-ATKCVVAWPNDnggKMLLL 196
Cdd:cd15160   87 SIGFLCCIAVDRYLAVVHPLRFRGlrTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPnHTLCYEKYPME---GWQAS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVprHQAHGANlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15160  164 YNYARFLVGFLIPLSLILFFYRRV-----LRAV--RQSPSLE---REEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 277 EDIYYRK--FIQQVYLAL-FWLAMSS--TMYNPIIYCCLNHRFRS 316
Cdd:cd15160  234 ELVQNGLcgFEKRVFTAYqISLCLTSlnCVADPILYIFVTEDVRQ 278
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
45-318 3.01e-18

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 83.63  E-value: 3.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15050   12 LITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITvdQGATKCVVAWPNDNGGKMLLLYHLVVF 202
Cdd:cd15050   92 FILCIDRYRSVQQPLKYLKYRTKTRAslMISGAWLLSFLWVIPILGWHHFA--RGGERVVLEDKCETDFHDVTWFKVLTA 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 203 VLIYFLPLVVMFAAYSVIgltlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYr 282
Cdd:cd15050  170 ILNFYIPSLLMLWFYAKI------------------FKAVNRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNCCN- 230
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 258613887 283 kfiQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15050  231 ---ENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
40-311 3.17e-18

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 83.64  E-value: 3.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMaAFNATFNFIYASHNiWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15176    7 YTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKITSALYTMNFSC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVH-PFQPRLSAPSTKAVIAViWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYH 198
Cdd:cd15176   85 GMQFLACISVDRYVAITKaTSRQFTGKHCWIVCLCV-WLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTSAKATIQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 LVVFVLIYFLPLVVMFAAYSVIGLTLWKraVPRHQahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLyfilgtfqed 278
Cdd:cd15176  164 ILEVLLGFVLPFLVMVFCYSRVARALSR--TPNVK-----------KSRALKVLLAVVGVFIVTQLPYNV---------- 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 258613887 279 IYYRKFIQQVYLALFWLAMSSTMYNPI--------IYCCLN 311
Cdd:cd15176  221 VKFYRAIDVIYLLITDCSMSKTLDIAIqvtesialFHSCLN 261
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
43-318 4.34e-18

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 83.06  E-value: 4.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15323   10 LIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVawpNDNggkmlLLYHL 199
Cdd:cd15323   90 HLCAISLDRYWSVTQAVEYNLkrTPRRVKAIIVTVWLISAVISFPPLIsMYRDPEGDVYPQCKL---NDE-----TWYIL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYsvigLTLWKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHL-YFILGTFQED 278
Cdd:cd15323  162 SSCIGSFFAPCLIMILVY----IRIYRVAKAR-------------EKRFTFVLAVVMGVFVVCWFPFFFsYSLYGICREA 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 279 IyyrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15323  225 C---EVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
38-315 5.13e-18

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 83.26  E-value: 5.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTnYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15372    5 SLYTLVFLVGLPANGLALWVLATQVKRLPST-IFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFY--STITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd15372   84 YCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCmcTAIWLIAAALTLPLTLQrqSYPLERLNITLCHDVLPLDEQDTY 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15372  164 LFYYFACLAVLGFLLPLVVILFCYGSVLHTL--------------LRSGQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLH 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15372  230 YSDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
43-318 5.28e-18

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 82.68  E-value: 5.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15322   10 LMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPqcfySTITVDQGATKCVVAWPNDNGGKMLLLYHLV 200
Cdd:cd15322   90 HLCAISLDRYWSITQAIEYNLkrTPRRIKCIIFIVWVISAVISFP----PLITIEKKSGQPEGPICKINDEKWYIISSCI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VfvlIYFLPLVVMFAAYsvigLTLWKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIY 280
Cdd:cd15322  166 G---SFFAPCLIMVLVY----IRIYQIAKNR-------------EKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCSV 225
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 281 YRKFIQqvylALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15322  226 PETLFK----FFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
43-318 5.30e-18

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 83.19  E-value: 5.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMR-TVTNYFIINLALADL---CMAAFNATFNFIYASHNIwyfGSTFCYFQNLFPVTAMF 118
Cdd:cd15104    9 LSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFlvgLAIPGLATDELLSDGENT---QKVLCLLRMCFVITSCA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVawpndnGGKMLLL 196
Cdd:cd15104   86 ASVLSLAAIAFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSF------FAAFHPR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLT--LWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVT---FAICWLPYHLYFI 271
Cdd:cd15104  160 VLLVLSCMVFFPALLLFVFCYCDILKIarVHSRAIYKVEHALARQIHPRRTLSDFKAARTVAVLigcFLLSWLPFQITGL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 272 LGTF-QEDIYYRkfIQQVYLALfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15104  240 VQALcDECKLYD--VLEDYLWL--LGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
46-318 5.44e-18

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 83.30  E-value: 5.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  46 VAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMT 125
Cdd:cd15199   13 LGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 126 AIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTItvdQGATKCVVAWPNDNGGKMLLLYHlVVFV 203
Cdd:cd15199   93 AVALDRYFRVVHPRGKKnsLSLQAAPYISFLVWLLLVGLTIPTLLASQP---KNFTECNSFSPKDDEDFSDTWQE-AVFF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 204 LIYFLPLVVMFAAYSVIGLTLWKRavprhqahganLRHLQAKKKFVKAMVL---VVVTFAICWLPYHLYFIL-GTFQ--E 277
Cdd:cd15199  169 LQFLLPFGLIVFCTVRIIRRLKKR-----------LRDVGKQPKLQRAMALvtsVVVVFGFCFLPCFLARVLmLIFQnkE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 258613887 278 DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15199  238 SCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
43-311 1.20e-17

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 82.55  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYAS-HNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15198   10 ILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELlGDRWMAGDVACRLLKLLQASARGASA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPRLSApstKAVIAVIWLVALALASPQCFYSTITVDQGATKcvvAWPNDNGGKMLLL----Y 197
Cdd:cd15198   90 NLVVLLALDRHQAIRAPLGQPLRA---WKLAALGWLLALLLALPQAYVFRVDFPDDPAS---AWPGHTLCRGIFAplprW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVF-----VLIYFLPLVVMFAAYSVIGLTLWKRA-------VPRHQAHGANLRHL------QAKKKFVKAMVLVVVTF 259
Cdd:cd15198  164 HLQVYatyeaVVGFVAPVVILGVCYGRLLLKWWERAnqapgakKPWKKPSKSHLRATapsalpRAKVKTLKMTLVIALLF 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 260 AICWLPYHLYFILGTFQEDIYYRKfiqQVYLALFWLAMSSTMYNPIIYCCLN 311
Cdd:cd15198  244 VGCSLPYFIAELAAAFGSGDWEPE---KVAAALGVMAVANSATNPFVFLFFN 292
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
38-275 1.33e-17

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 82.16  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLAL-VLVAVTGNATVIWIILA--HERMRTVTNYFIINLALAD---LCMAAFNATFnfiyASHNIWYFGSTFCYFQNL 111
Cdd:cd15122    4 TIFLLLaALLGLPGNGFIIWSILWkmKARGRSVTCILILNLAVADgavLLLTPFFITF----LTRKTWPFGQAVCKAVYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPS-TKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAwpNDN 189
Cdd:cd15122   80 LCCLSMYASIFIIGLMSLDRCLAVTRPYlAQSLRKKAlVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICE--PCH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFVLIYF-LPLVVMFAAYSVIGLTLwkravprhqaHGANLRHLQAKKKFVKAmvlVVVTFAICWLPYHL 268
Cdd:cd15122  158 ASRGHAIFHYTFETLVAFvLPFGVILFSYSVILVRL----------KGARFRRRARVEKLIAA---IVVAFALLWVPYHV 224

                 ....*..
gi 258613887 269 YFILGTF 275
Cdd:cd15122  225 VNLLQVV 231
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
38-318 1.45e-17

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 82.07  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALV-LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFnATFNFIYASH-NIWYFGSTFCYFQNLFPVT 115
Cdd:cd15922    4 PVFLSLVfLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPA-APLLIAYFSLgSHWPFGQFLCQLKVFLLST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHpFQPRLSA---PSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGk 192
Cdd:cd15922   83 HMYGSIYFLMLISIHRYVTVVH-YNWKSLWkkkSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSL- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKravprhqAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15922  161 LYFVWNFVLLILGFLLPFGVSLTCYALLGASIAK-------MNSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTV 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 273 GTFQEDIYYRK-----FIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15922  234 GVVVKLFYPESctllhKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
44-318 1.47e-17

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 81.88  E-value: 1.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  44 VLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd15401   11 IVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgkmlllYHLVV 201
Cdd:cd15401   91 ITAIAINRYCYICHSlrYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSS------YTITV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 202 FVLIYFLPLVVMFAAYsvigLTLWKRAVP-RHQAHGANLRHLQAK--KKFVkAMVLVVVTFAICWLPYHLYFILGTFQED 278
Cdd:cd15401  165 VVVHFIVPLSIVTFCY----LRIWVLVIQvKHRVRQDSKQKLKANdiRNFL-TMFVVFVLFAVCWGPLNFIGLAVAINPL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 279 IYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15401  240 KVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
37-315 1.71e-17

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 81.87  E-value: 1.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15402    4 ACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgkml 194
Cdd:cd15402   84 VIGSIFNITGIAINRYCYICHSlkYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSA---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 llYHLVVFVLIYFLPLVVMFAAYsvigLTLWKRAVP-RHQAHGANLRHLQAK--KKFVkAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15402  160 --YTIAVVFFHFILPIIIVTFCY----LRIWILVIQvRRRVKPDNKPKLKPHdfRNFV-TMFVVFVLFAVCWAPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 272 LGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15402  233 AVAVDPETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFR 276
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
43-318 1.94e-17

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 81.17  E-value: 1.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd17790   10 LSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVDQG---ATKCVVAWpndnggkmlLLY 197
Cdd:cd17790   90 NLLIISFDRYFSITRPLTYRAKRTPRRAaiMIGLAWLISFVLWAPAILFWQYLVGERtvlAGQCYIQF---------LSQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVF---VLIYFLPLVVMFAAYsvigltlWKRavprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd17790  161 PIITFgtaIAAFYLPVTIMIILY-------WRI-----------YRETIKEKKAARTLSAILLAFILTWTPYNIMVLVST 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDIYYRKFIQQVYlalfWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd17790  223 FCKDCVPKTLWELGY----WLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
37-315 2.30e-17

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 81.36  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15209    4 ACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQ-PRL-SAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNggkml 194
Cdd:cd15209   84 VIGSIFNITAIAINRYCYICHSLQyDRLySLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVST----- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 lLYHLVVFVLIYFLPLVVMFAAYsvigLTLWKRAVPRHQAHGANLR---HLQAKKKFVkAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15209  159 -VYTITVVVIHFLLPLLIVSFCY----LRIWVLVLQVRQRVKPDQRpklKPADVRNFL-TMFVVFVLFAVCWAPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 272 LGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15209  233 AVAINPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
44-315 3.68e-17

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 80.67  E-value: 3.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  44 VLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd15318   11 MLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASpqCFYSTITVDQGATKCVVAWPNDNGGKMLL--LYHL 199
Cdd:cd15318   91 LCFISIDRHCAICDPllYPSKFTIRVACIFIAAGWLVPTVYTS--VFLYTKAVEEGLAELLTSVPCVGSCQLLYnkLWGW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLiYFLPLVVMFAAYSVIGLTLWKRAvpRHQAHGANLRHLQAK--KKFVKAMVLVVVTFAICWLPyhlyFILGTFQE 277
Cdd:cd15318  169 LNFPV-FFIPCLIMIGLYVKIFIVAKRQA--RAIASLLSDTNGASKreRKAAKTLGIAVGVYLLCWLP----FTIDTMVD 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 278 DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15318  242 SLLNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFR 279
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
40-308 5.88e-17

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 80.16  E-value: 5.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd14964    5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVD-QGATKCVVAWPNDNggkmlll 196
Cdd:cd14964   85 SIWTTLVLTYHRYFALCGPLKYTRLSSPGKTrvIILGCWGVSLLLSIPPLVGKGAIPRyNTLTGSCYLICTTI------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYF-LPLVVMFAAYSVIGLTLwkRAVPRHQAHGANLRHLQAKKKFVKAMVLvVVTFAICWLPYHLYFILGTF 275
Cdd:cd14964  158 YLTWGFLLVSFlLPLVAFLVIFSRIVLRL--RRRVRAIRSAASLNTDKNLKATKSLLIL-VITFLLCWLPFSIVFILHAL 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 258613887 276 QEDIYYRKfiqQVYLALFWLAMSSTMYNPIIYC 308
Cdd:cd14964  235 VAAGQGLN---LLSILANLLAVLASTLNPFIYC 264
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
34-269 6.65e-17

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 80.21  E-value: 6.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIiLAHERMRTVTNYFIINLALADLCmaaFNATFNFiYASH----NIWYFGSTFCYFQ 109
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLI---FTLILPF-MAVHvlmdNHWAFGTVLCKVL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 110 NLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQ-CFYSTITVDQGATKCVV--- 183
Cdd:cd15120   76 NSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWAsaIVLGVWISAILLSIPYlAFRETRLDEKGKTICQNnya 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 184 ---AWPNDNGGKMLLLYHLVVFV----LIYFLPLVVMFAAYSVIGLTLWKRAVPRhqahganlrhlqAKKKFvKAMVLVV 256
Cdd:cd15120  156 lstNWESAEVQASRQWIHVAMFVfrflLGFLLPFLIITFCYVRMALKMKERGLAR------------SSKPF-KVMFTAV 222
                        250
                 ....*....|...
gi 258613887 257 VTFAICWLPYHLY 269
Cdd:cd15120  223 VSFFVCWLPYHLH 235
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
43-318 9.44e-17

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 79.14  E-value: 9.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15324   10 IILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIV 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPqcfySTITVDQGATKCVVawpNDNggkmlLLYHLV 200
Cdd:cd15324   90 HLCAISLDRYWSVTKAVSYNLkrTPKRIKRMIAVVWVISAVISFP----PLLMTKHDEWECLL---NDE-----TWYILS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFVLIYFLPLVVMFAAYSVIgltlWKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIY 280
Cdd:cd15324  158 SCTVSFFAPGLIMILVYCKI----YRVAKMR-------------EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRC 220
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 281 YrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15324  221 G--IPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
40-316 1.01e-16

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 79.41  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15184    7 YSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDL-LFLLTLPFWAHYAANE-WVFGNAMCKLLTGLYHIGFFS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLY 197
Cdd:cd15184   85 GIFFIILLTIDRYLAIVHAVFALKARTVTFGVVtsVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYQFWKNFQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQE 277
Cdd:cd15184  165 TLKMNILGLVLPLLVMIICYSGILKTLLRC------------RNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQE 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 278 -----DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15184  233 ffglnNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
45-315 1.85e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 78.74  E-value: 1.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15400   12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGgkmlllYHLVVF 202
Cdd:cd15400   92 TGIAINRYCYICHSFayDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASSS------YTIAVV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 203 VLIYFLPLVVMFAAYSVIGLTLWKraVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYR 282
Cdd:cd15400  166 VIHFIVPITVVSFCYLRIWVLVIQ--VRRKVKSESKPRLKPSDFRNFLTMFVVFVIFAICWAPLNLIGLAVAINPQEMAP 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 258613887 283 KFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15400  244 KVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-303 2.09e-16

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 78.79  E-value: 2.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15977   10 IFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPR-LSAPSTKAV-IAVIWLVALALASPQCF-YSTITVD-QGATKCVVAWPNDNGGKMLLLYH 198
Cdd:cd15977   90 SLCALSIDRYRAVASWSRIRgIGIPVWKAVeVTLIWAVAIIVAVPEAIaFDMVEIDyRGQTLLVCMLPMEQTSSFMRFYQ 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 LV----VFVLIYFLPLVVMFAAYSVIGLTLWKRavpRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIlgt 274
Cdd:cd15977  170 DVkdwwLFGFYFCLPLACTGVFYTLMSCEMLSI---KNGMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSRI--- 243
                        250       260
                 ....*....|....*....|....*....
gi 258613887 275 FQEDIYYRKFIQQVYLALFWLAMSSTMYN 303
Cdd:cd15977  244 LKKTIYDVKDPQRCELLSFLLVMDYTGIN 272
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
44-275 2.12e-16

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 78.41  E-value: 2.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  44 VLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM-------AAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15136   11 FLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMgiylgllAIVDAKTLGEYYNYAIDWQTGAGCKTAGFLAVFS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCF----YSTITVdqgatkCVvawPNDNG 190
Cdd:cd15136   91 SELSVFTLTVITLERWYAITHAMHlnKRLSLRQAAIIMLGGWIFALIMALLPLVgvssYSKTSI------CL---PFETE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYhlVVFVLIY-FLPLVVMFAAYSVIGLTLwkravprhqaHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15136  162 TPVSKAY--VIFLLLFnGLAFLIICGCYIKIYLSV----------RGSGRAANSNDTRIAKRMALLVFTDFLCWAPIAFF 229

                 ....*.
gi 258613887 270 FILGTF 275
Cdd:cd15136  230 GLTAAF 235
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
38-316 2.19e-16

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 78.69  E-value: 2.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMaafnaTFNFIYASHNI-----WYFGSTFCYFQNLF 112
Cdd:cd15380    5 TFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVF-----VLGLPFWAENIrnqfnWPFGNFLCRVISGV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITV--DQGATKCVVAWPND 188
Cdd:cd15380   80 IKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVicLLIWVFGGLLSIPTFLFRSVKHvpDLNISACILLFPHE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 nggKMLLLYHLVVFVLIYFLPL--VVMFAAYSVIGLtlwkravprhQAHGANLRHLQAKKKFVKAMVL---VVVTFAICW 263
Cdd:cd15380  160 ---AWHFARRVELNIVGFLLPLaaIVFFNFHIIASL----------RERTEESRKRCGGLKDTKATRLiltLVLMFLVCW 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 264 LPYHLYFILG-TFQ----EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15380  227 TPYHFFAFLDfLFQveviQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRT 284
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
37-324 2.65e-16

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 78.41  E-value: 2.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHN-IWYFGSTFCYFQNLFPVT 115
Cdd:cd15305    4 ALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASPQCFY-----STITVDqgaTKCVVAWPNd 188
Cdd:cd15305   84 FSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMmkIAAVWTISIGISMPIPVIglqddEKVFVN---GTCVLNDEN- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 nggkMLLLYHLVVFvliyFLPLVVMFAAYSvigLTLwkRAVPRHQAhganlrhLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15305  160 ----FVLIGSFVAF----FIPLIIMVITYC---LTI--QVLQRQQA-------INNERRASKVLGIVFFLFLIMWCPFFI 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 269 YFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRC 324
Cdd:cd15305  220 TNILSVLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
34-318 2.75e-16

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 78.13  E-value: 2.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASP-----QCFYSTITVDQGAtkCVVAWP 186
Cdd:cd15049   81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAilMIALAWVISFVLWAPailgwQYFVGERTVPDGQ--CYIQFL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDnggkmlllyHLVVFVLI---YFLPLVVMFAAYSVIgltlWKRAVprhqahganlrhlqAKKKFVKAMVLVVVTFAICW 263
Cdd:cd15049  159 DD---------PAITFGTAiaaFYLPVLVMTILYWRI----YRETA--------------RERKAARTLSAILLAFIITW 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 264 LPYHLYFILGTFqediyYRKFIQQVYLAL-FWLA-MSSTMyNPIIYCCLNHRFRSGF 318
Cdd:cd15049  212 TPYNILVLVSTF-----CAKCIPDTLWSFgYWLCyINSTI-NPFCYALCNKTFRKTF 262
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
43-319 4.46e-16

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 77.30  E-value: 4.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15334   10 LALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQ-PRLSAPSTKAV-IAVIWLVALALASPQCFYSTITVDQgATKCVVawpndnggkmllLYHLV 200
Cdd:cd15334   90 HLSAIALDRYRAITDAVEyARKRTPKHAGImIAVVWIISIFISMPPLFWRHQTTSR-EDECII------------KHDHI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 VFVL-----IYFLPLVVMFAAYSVIgltlwKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:cd15334  157 VFTIystfgAFYIPLALILILYYKI-----YRAATR-------------ERKAATTLGLILGAFVICWLPFFVKEVIVNT 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 276 QEDIYYRKFIQQVylaLFWLAMSSTMYNPIIYCCLNHRFRSGFR 319
Cdd:cd15334  219 CDSCYISEEMSNF---LTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
43-318 5.52e-16

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 77.00  E-value: 5.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15309   10 LIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKAV---IAVIWLVALALASPQCFYSTITvdqGATKCVVAWPndnggkMLLLYHL 199
Cdd:cd15309   90 NLCAISIDRYTAVAMPMLYNTRYSSKRRVtvmISVVWVLSFAISCPLLFGLNNT---DQNECIIANP------AFVVYSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVfvlIYFLPLVVMFAAYSVIGLTlwkravprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEdi 279
Cdd:cd15309  161 IV---SFYVPFIVTLLVYVQIYIV------------------LQKEKKATQMLAIVLGVFIICWLPFFITHILNMHCD-- 217
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 280 yyRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15309  218 --CNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
38-315 6.29e-16

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 77.11  E-value: 6.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNFIYAS-HNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15175    5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADIL---FLLTLPFWAASaAKKWVFGEEMCKAVYCLYKMS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIV-----HPFQPRLSAPStKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAwpNDNGG 191
Cdd:cd15175   82 FFSGMLLLMCISIDRYFAIVqaasaHRHRSRAVFIS-KVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIF--TNNKQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhqahganlrhLQA----KKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15175  159 TLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTL-----------------LQArnfeKNKAIKVIIAVVVVFVVFQLPYN 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 268 LYFILGTFQE------DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15175  222 SVMLVSTLSSfkgnttDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFR 275
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
43-318 8.81e-16

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 76.79  E-value: 8.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15295   10 LALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPST-KAVI--AVIWLVALALASPQCFYSTiTVDQGATKCVVAWPNDNggkmlllYHL 199
Cdd:cd15295   90 NIVLISYDRYQSVSNAVSYRNQQTATlRIVTqmVAVWVLAFLVHGPAILVSD-SWKTEDGECEPEFFSNW-------YIL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSV-IGLTLWKRavprhqahganLRhlqaKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQED 278
Cdd:cd15295  162 AITSVLEFLVPVILVAYFNTqIYWSLWKR-----------LR----DRKLAKSLAIILGTFAICWAPYSLFTIIRAACEK 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 279 IYYRKFiqqvYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15295  227 HRGSPW----YNFAFWLQWFNSFINPFLYPLCHKRFRKAF 262
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
35-307 1.02e-15

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 76.81  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15156    2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDL-LFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFY--STITVDQGATKCVVAWPNDNG 190
Cdd:cd15156   81 TNMYGSILFLTCISVDRFLAIVYPFRSKTlrTKRNAKIVCAAVWLTVLAGSLPASFFqsTNNQLNNNSETCFENFSSKTW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMllLYHLVVFVLI--YFLPLVVMFAAYSVIGLTLWKRAVPRhqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15156  161 KTY--LSKIVIFIEIvgFFIPLILNVTCSTMVLKTLRRPNTLS--------RSKLNKKKVLKMIFVHLFIFCFCFIPYNV 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 269 YFILGTFQEDIYYRK-----FIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15156  231 NLVLYSLVRTQTFKNcsvvaAVRTMYPITLCIAVSNCCFDPIVY 274
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
40-315 1.11e-15

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 76.73  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLV-AVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNI-WYFGSTFCYFQNLFPVTAM 117
Cdd:cd15381    6 YLWIIFVlGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADL-LLVCCLPFWAINISNGFnWPFGEFLCKSVNAVIYMNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ-PRLSAPS-TKAVIAVIWLVALALASPQCFYSTITVDQG--ATKCVVAWPNDNGGKM 193
Cdd:cd15381   85 YSSIYFLMMVSIDRYLALVKTMSsGRMRRPAcAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEynITACVLDYPSEGWHVA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIyflPLVVMFAAYSVIGLTLWKRAVPRhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15381  165 LNILLNVVGFLI---PLSIITFCSTQIIQVLRNNKMQK-------FKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLD 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 274 TFQ-----EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15381  235 TLHklgliSGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
39-315 1.13e-15

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 76.34  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFnATFNFIY-ASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15368    6 VYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACF-LPFQIVYhIQRNHWIFGKPLCNVVTVLFYANM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVI--WLVALALASPqCFYSTITV---DQGATKC--VVAWPNDNG 190
Cdd:cd15368   85 YSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIgmWLLVLTALSP-LERTDLTYyvkELNITTCfdVLKWTMLPN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkraVPRHQAHGAnlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15368  164 IAAWAAFLFTLFILLFLIPFIITVYCYVLIILKL----VQTSERYGR-----EQKRRAIYLALIVLLVFITCFAPNNFIL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 271 ILGTFQEdIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15368  235 LAHMVSR-LFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFR 278
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
40-323 1.16e-15

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 77.75  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIwIILAHERMRTVTNYFIINLALADLCmaaFNATFNF-IYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:PHA02638 105 YIIIFILGLFGNAAII-MILFCKKIKTITDIYIFNLAISDLI---FVIDFPFiIYNEFDQWIFGDFMCKVISASYYIGFF 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF--------YSTITVDQGAT--KCVVAWP 186
Cdd:PHA02638 181 SNMFLITLMSIDRYFAILYPisFQKYRTFNIGIILCIISWILSLIITSPAYFifeasniiFSAQDSNETISnyQCTLIED 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNGGKMLL--LYHLVVFVLIYFLPLVVMFAAYSVIGLtlwkravprhqahgaNLRHLQ--AKKKFVKAMVLVVVTFAIC 262
Cdd:PHA02638 261 NEKNNISFLgrILQFEINILGMFIPIIIFAFCYIKIIL---------------KLKQLKksKKTKSIIIVSIIIICSLIC 325
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 263 WLPYHLYFILGT----------FQEDIYyrKFIQQVYLALFWLAMSST--MYNPIIYCCLNHRFRSGFRLAFR 323
Cdd:PHA02638 326 WIPLNIVILFATmysfkgfnsiISEHIC--GFIKLGYAMMLAEAISLThcCINPLIYTLIGENFRMHLLMIFR 396
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
30-318 1.20e-15

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 75.99  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  30 GWQLALwaTAYLALVLVAVT-GNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYF 108
Cdd:cd15333    2 GLKISL--AVLLALITLATTlSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 QNLFPVTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWP 186
Cdd:cd15333   80 WLSSDITCCTASILHLCVIALDRYWAITDAveYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NdnggkmlLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd15333  160 H-------ILYTVYSTVGAFYIPTLLLIALYGRIYVEARAR-----------------ERKATKTLGIILGAFIVCWLPF 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 267 HLYFILGTFQEDIYYRKFIQQVYLAlfWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15333  216 FIISLVLPICKDACWFHLAIFDFFT--WLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
43-318 1.33e-15

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 76.03  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFnFIYASH--NIWYFGSTFCYFQNLFPVTAMFVS 120
Cdd:cd15308   10 LILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPL-YVYSEFqgGVWTLSPVLCDALMTMDVMLCTAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 121 IYSMTAIAADRYMAIVHPFQPRLSAPSTK--AVIAVIWLVALALASPQCFYSTITVDQGATKCVVawpNDNGgkmlllYH 198
Cdd:cd15308   89 IFNLCAISVDRFIAVSVPLNYNRRQGSVRqlLLISATWILSFAVASPVIFGLNNVPNRDPAVCKL---EDNN------YV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 LVVFVLIYFLPLVVMFAAYSvigltlwkravprhqahgANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQED 278
Cdd:cd15308  160 VYSSVCSFFIPCPVMLVLYC------------------AMFRGLGRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCES 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 258613887 279 IYyrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15308  222 CS---IPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
29-316 1.51e-15

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 76.48  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  29 PGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYF 108
Cdd:cd15081    8 PRWVYNLTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 QNLFPVTAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKC---VV 183
Cdd:cd15081   88 EGFTVSVCGITGLWSLTIISWERWVVVCKPFgNIKFDGKLAIVGIIFSWVWSAVWCAPPIFgWSRYWPHGLKTSCgpdVF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 184 AWPNDNGGKMlllYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkRAVPRHQAHGANLRhlQAKKKFVKAMVLVVVTFAICW 263
Cdd:cd15081  168 SGSSDPGVQS---YMIVLMITCCIIPLAIIILCYLQVWLAI--RAVAQQQKESESTQ--KAEKEVSRMVVVMIFAYCFCW 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 264 LPYHLYFILGTFQEDIYYRKFIQQVYLalfWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15081  241 GPYTFFACFAAANPGYAFHPLAAALPA---YFAKSATIYNPIIYVFMNRQFRN 290
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
41-318 2.08e-15

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 75.38  E-value: 2.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCyfqNLFPVTAMF-- 118
Cdd:cd15210    8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLC---RVFPLLRYGlv 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 -VSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF--YSTITVDQGATKCVVAwPNDNGGKm 193
Cdd:cd15210   85 aVSLLTLVLITLNRYILIAHPslYPRIYTRRGLALMIAGTWIFSFGSFLPLWLgiWGRFGLDPKVCSCSIL-RDKKGRS- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 lllYHLVVFVLIYFLPLVVMFAAYSvigltlwkravprhqahganlrhlQAKKKFVKAMVLVV-VTFAICWLPYHLYfil 272
Cdd:cd15210  163 ---PKTFLFVFGFVLPCLVIIICYA------------------------RREDRRLTRMMLVIfLCFLVCYLPITLV--- 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 273 gtfqeDIYYRKFIQQV-YLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15210  213 -----NVFDDEVAPPVlHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
35-315 3.34e-15

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 75.22  E-value: 3.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPV 114
Cdd:cd15187    2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDL-LFVFSLPFQAYYLLDQ-WVFGNAMCKIVSGAYY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVH---PFQPRLSAPSTKAVIAViWLVALALASPQCFYSTITVDQGATKCVVAWPnDNGG 191
Cdd:cd15187   80 IGFYSSMFFITLMSIDRYLAIVHavyALKVRTASHGTILSLAL-WLVAILASVPLLVFYQVASEDGRLQCIPFYP-GQGN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravpRHQAHGAnlrHLQAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15187  158 SWKVFTNFEVNILGLLIPFSILIFCYHNI----------LRNLRRC---HNQNKTKAIKLVFIVVIVFFLFWTPFNVVLF 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 272 LGTFQE--DIYYRKFIQQVYLALFWLAMSSTMY---NPIIYCCLNHRFR 315
Cdd:cd15187  225 LDSLHSlhIIDGCQNSQRLTLALHLTETISFTHcclNPVIYAFVGEKFK 273
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
38-315 3.51e-15

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 75.14  E-value: 3.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmaAFNATFNF--IYASHNIWYFGSTFCYFQNLFPVT 115
Cdd:cd15378    5 TMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDL---AFLCTLPMlvYSYSNGQWLFGDFLCKSNRYLLHA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFYSTITVDQGATKCvVAWPNDNGGKM 193
Cdd:cd15378   82 NLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAIslAIWVLVTLELLPILTFIGPNLKDNVTKC-KDYASSGDATN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAvpRHQAHGANLrhlqakKKFVKAMVLVVVTFAICWLPYH------ 267
Cdd:cd15378  161 SLIYSLFLTVTGFLIPLCVMCFFYYKIALFLKNRN--RQLANATSF------EKPLTLVILAVVIFSVLFTPYHvmrnvr 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 268 LYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15378  233 IASRLDSIGVSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-318 5.31e-15

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 74.89  E-value: 5.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15976   12 VLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPFQPR-LSAPSTKAV-IAVIWLVALALASPQCF-YSTITVD-QGATKCVVAWPNDNGGKMLLLYHLV 200
Cdd:cd15976   92 CALSIDRYRAVASWSRIKgIGVPKWTAVeIVLIWVVSIILAVPEAIgFDMITMDyKGELLRICLLHPIQKTAFMQFYKTA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 201 ----VFVLIYFLPLVVMFAAYSVIGLTLWKRavpRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILgtfQ 276
Cdd:cd15976  172 kdwwLFSFYFCLPLACTAVFYTLMTCEMLRK---KNGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRIL---K 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 277 EDIYYRKFIQQVYLALFWLAMS---------STMYNPIIYCCLNHRFRSGF 318
Cdd:cd15976  246 LTIYDEKDPNRCELLSFFLVLDyiginmaslNSCINPIALYLVSKRFKNCF 296
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
39-307 5.38e-15

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 74.41  E-value: 5.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd16001    6 TYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKmLLL 196
Cdd:cd16001   86 GSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIgsAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFGN-YFP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLTLWkravprhQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL-----YFI 271
Cdd:cd16001  165 YGMVLTVTGFLIPFLIILLCYCLMIKSLI-------RSEEAAGVGKAARAKSIRTILLVCGLFALCFVPFHItrtiyLFV 237
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 258613887 272 LGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd16001  238 RVYLVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLY 273
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
40-315 7.46e-15

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 74.05  E-value: 7.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAH-ERMRTVTNYFIINLALADLCmaaFNATFNF--IYASHNiWYFGSTFCYFQNLFPVTA 116
Cdd:cd15188    7 YTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLL---FLVTLPFwaMYVAWH-WVFGSFLCKFVSTLYTIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQ-CFYSTITVDQGATKCVVawpnDNGGKM 193
Cdd:cd15188   83 FYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSllVLVAVWVLSIALSVPDmVFVQTHHTNNGVWVCHA----DYGGHH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 L---LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPrhqahganlrhlqAKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15188  159 TiwkLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPP-------------GQGRALRFVAALVVVFFVLWFPYNLTL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 271 ILGTFQEDIYYR--KFIQQVYLALF---WLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15188  226 FLHSLQDLHVIGncERSRHLDYALQvteSLAFVHCCLNPLLYAFVSKRFR 275
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
40-276 9.86e-15

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 73.70  E-value: 9.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAaFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15166    7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFI-LSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCF-YSTITVDQGATKCVvawpndnggKMLLL 196
Cdd:cd15166   86 ALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACvgVWIMTLASTFPLLFlYEDPDKASNFTTCL---------KMLDI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHL--------VVFVLIYFLPLVVMFAAYSVIgltlwkravPRHQAHGANLR-HLQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15166  157 IHLkevnvlnfTRLIFFFLIPLFIMIGCYLVI---------IHNLVHGRTSKlKPKVKEKSIRIIITLIVQVLVCFVPFH 227

                 ....*....
gi 258613887 268 LYFILGTFQ 276
Cdd:cd15166  228 ICFAFLMLQ 236
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
40-318 1.17e-14

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 73.62  E-value: 1.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERM-RTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15086    6 FLGFILTFGFLNNLLVLVLFCKYKVlRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSApSTKAVIAVI--WLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15086   86 VSLISLAVLSYERYCTLLRPTEADVSD-YRKAWLGVGgsWLYSLLWTLPPLLgWSSYGPEGPGTTCSVQWTSRSANSISY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIyfLPLVVMFAAYSVIGLTLwkravprHQAHGANLRHLQAKKKFVKAMVLV-VVTFAICWLPYHLYFILGT 274
Cdd:cd15086  165 IICLFIFCLL--LPFLVMVYCYGRLLYAI-------KQVGKINKSTARKREQHVLLMVVTmVICYLLCWLPYGVMALLAT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDIYYRKFIQQVYLAlfwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15086  236 FGKPGLVTPVASIVPSI---LAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
45-266 1.21e-14

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 73.70  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSM 124
Cdd:cd15385   12 AVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTYML 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPFQP-RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFV 203
Cdd:cd15385   92 VMMTADRYIAICHPLKTlQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIENGSGVYDCWANFIVPWGIKAYITWITI 171
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 204 LIYFLPLVVMFAAYSVIGLTLWKRA---VPRHQAHGANLRHL------------QAKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd15385  172 SIFVVPVIILLTCYGFICYNIWRNIkckTRRGLSDNALKNILlavcvssvktisRAKIRTVKMTFVIVLAYIVCWAPF 249
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
38-315 1.44e-14

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 73.37  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHN---IWYFGSTFCYFQNLFPV 114
Cdd:cd15006    4 TVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPhccWWIYTLLFCKVIKFLHK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGkml 194
Cdd:cd15006   84 VFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSLGH--- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKR-------AVPRHQAHGANLRHLQAKKKFVKAMVL-VVVTFAICWLPY 266
Cdd:cd15006  161 LVYVIIYNITTVILPVAVVFLFMILIRRALSASqkkkviiAALRTPQNTISIPYVSQREAELHAMLLsMVLVFILCSVPY 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 267 HLYFILGTFQEDIYYRKFIQqvyLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15006  241 ATLVIYRTILNISDISVFLL---LTAIWLPKVSLLANPLLFLTVNKSVR 286
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
40-308 2.68e-14

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 72.51  E-value: 2.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15365    7 YIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNFYT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQ---PRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDnggKMLLL 196
Cdd:cd15365   87 STALLTCIALDRYLAVVHPLKfmhLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHESSSHTLCYDKFPLE---DWQAR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAHGAnlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15365  164 LNLFRICLGYLLPLLIILFCYWKI-----YQAVRSNQATED-----QEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIV 233
                        250       260       270
                 ....*....|....*....|....*....|....
gi 258613887 277 EDIYYRKFIQQVYLALFWLAMSS--TMYNPIIYC 308
Cdd:cd15365  234 EPCDCRNAKWLYTLYKITVALTSlnCIADPFLYC 267
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
37-318 2.94e-14

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 71.97  E-value: 2.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15298    4 ATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATkcvvawPNDNGGKML 194
Cdd:cd15298   84 SNASVMNLLIISFDRYFCVTKPltYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV------PDNQCFIQF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVF---VLIYFLPLVVMFAAYSVIGLtlwkravprhqahgANLRhlqaKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15298  158 LSNPAVTFgtaIAAFYLPVVIMTVLYIHISL--------------ASAR----ERKVTRTIFAILLAFILTWTPYNVMVL 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 272 LGTFQEDIyyrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15298  220 VNTFCQSC----IPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
34-318 3.04e-14

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 72.88  E-value: 3.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNI-WYFGSTFCYFQNLF 112
Cdd:cd15005    1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAW---- 185
Cdd:cd15005   81 AVLFCFHSAFTLFCIAVTRYMAIAHHrfYAKRMTFWTCLAVICMAWTLSVAMAFPPVFdVGTYTFIREEDQCTFEHrsyk 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNDNGGKMLLLY------HLVVFVLIYFL-------PLVV-----------------MFAAYSVIGL--------TLWKR 227
Cdd:cd15005  161 ANDTLGFMLVLAvviaatHLVYLKLLIFLrhhrkmkPAQLvpaisqnwtfhgpgatgQAAANWTAGFgrgptpptLLGIR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 228 AVPRHQAHGANLR-HLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDiyyrKFIQQVYLAL-FWLAMSSTMYNPI 305
Cdd:cd15005  241 QAFHSGARRLLVLdEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRG----YAVPQGFLTAaVWMTFAQAGVNPI 316
                        330
                 ....*....|...
gi 258613887 306 IYCCLNHRFRSGF 318
Cdd:cd15005  317 VCFFFNRELRKCL 329
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
40-272 3.18e-14

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 72.10  E-value: 3.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFnatFNF-IYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15923    7 YIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLIS---LPFkMHSYRRESAGLQKLCNFVLSLYYINMY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAVI-AVIWlVALALASPQCFYSTITVDQgaTKCVvawpnDNGGKMLLL 196
Cdd:cd15923   84 VSIFTITAISVDRYVAIRYPLRAReLRSPRKAAVVcAVIW-VLVVTISIPYFLLDSSNEK--TMCF-----QRTKQTESL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFVLIYF-LPLVVMFAAYSVIGLTLWKRavprhqahganLRHLQAKKKFVKAMVLVVV---TFAICWLPYHLYFIL 272
Cdd:cd15923  156 KVFLLLEIFGFlLPLIIMTFCSARVIHTLQKR-----------LDDVGSRSETKQCIRVIMAnliVFIVCFLPVHVGFFV 224
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
39-265 4.01e-14

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 71.72  E-value: 4.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVL-----VAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfNATFNF-IYASHNIWYFGSTFCYFqNLF 112
Cdd:cd15200    1 AFLAPVLgiefvLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLII-NLPFRIdYYLRNEVWRFGATACQV-NLF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTA-MFVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPqcfYSTITVDQGATKCVVAWPNDN 189
Cdd:cd15200   79 MLSMnRTASIVFLTAIALNRYLKVVHPHHqlSKASVGCAAKVAAGLWILILLLNIH---LLLLDHVQSNSTCLSYDHGTD 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 190 gGKMLLLYHLVVFVLIYFLPL-VVMFAAYSvIGLTLWKRAVPRhqahganlrhlQAK-KKFVKAMVLVVVTFAICWLP 265
Cdd:cd15200  156 -PSASDRWHRILFFLEFFLPLgIILFCIFS-IILTLKQRKLAK-----------QAGpQRAVKVLAVIVLVYTVCFLP 220
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
38-316 4.13e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 71.75  E-value: 4.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15366    5 TLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ-PRLSAPSTKAVI-AVIWLVALALASPQCFYSTITVDQ-GATKCVVAWPNDNGGKML 194
Cdd:cd15366   85 YISIAFLCCISVDRYLAVAHPLRfAKVRRVKTAVAVsAVVWAIEIGANSAPLFHDELFRDRyNHTFCFEKYPMEDWVAWM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHlvvfVLIYFL-PLVVMFAAYSVIgLTLWKRAVPRHQAHGANLRHLqakkkfvkAMVLVVVTFaICWLPYHLYFILG 273
Cdd:cd15366  165 NLYR----VFVGFLfPWVLMLFSYRGI-LRAVRGNVSTEQQEKAKIKRL--------ALSLIAIVL-LCFAPYHVLLLSR 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 274 TFqedIYYRK-----FIQQVYLALFW-LAMSS--TMYNPIIYCCLNHRFRS 316
Cdd:cd15366  231 SV---VYLGKpcdcgFEERVFTAYHVsLALTSlnCVADPILYCLVNEGARS 278
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
36-324 4.31e-14

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 71.79  E-value: 4.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLV-AVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFN---ATFNFIYasHNIWYFGSTFCYFQNL 111
Cdd:cd15306    2 WAALLILMVIIpTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVmpiALLTILF--EAMWPLPLVLCPIWLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDN 189
Cdd:cd15306   80 LDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFikITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKER 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFvliyFLPLVVMFAAYSVIGLTLWKRAVPRHQahganlrhlqakkKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15306  160 FGDFILFGSLAAF----FTPLAIMIVTYFLTIHALRKQTITNEQ-------------RASKVLGIVFFLFLLMWCPFFIT 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 270 FILGTFQeDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRC 324
Cdd:cd15306  223 NITSVLC-DSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-318 4.94e-14

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 71.90  E-value: 4.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTN---YFIINLALADLCMAAFNAT---FNFIYAsHNIWYFGSTFCYF 108
Cdd:cd15130    2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPvelYNFIWV-HHPWAFGDAGCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 QNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCFYSTI---TVDQGATKCVV 183
Cdd:cd15130   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIPMLFTMGLqneSDDGTHPGGLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 184 AWPNDNGGKMLLLYHLVVFVlIYFLPLVVMFAAYSVIGLTLwkravprhqahganlrhLQAKKKFVKAMVLVVVTFAICW 263
Cdd:cd15130  161 CTPIVDTATLKVVIQVNTFM-SFLFPMLVTSILNTVIANKL-----------------VQALRRGVLVLRAVVIAFVVCW 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 258613887 264 LPYHLYFILGTFQEDIYYRKFIQQVYLALFW----LAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15130  223 LPYHVRRLMFCYISDEQWTTFLFDFYHYFYMltnaLFYVSSAINPILYNLVSANFRQVF 281
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
35-315 5.01e-14

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 71.68  E-value: 5.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV 114
Cdd:cd15152    2 IYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADL-LQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGK-- 192
Cdd:cd15152   81 VNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDTNPTCCFADLPLRNVGLtt 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 ---MLLLYHLVVFVLiyflPLVVmfaaysvIGLTLWKRAVPRHQAHGAnLRHLQAKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15152  161 sviMLTIAELTGFVT----PLLI-------VLYCSWKTVMSLREKTPV-LQDLGEKKKALKMILTCAVVFLICFAPYHIS 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258613887 270 FIL-----GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15152  229 FPLdflvkSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFK 279
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
42-318 6.10e-14

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 71.15  E-value: 6.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15297    9 SLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASP-----QCFYSTITVDQGatKCVVAWPNDNggkml 194
Cdd:cd15297   89 MNLLIISFDRYFCVTKPltYPVKRTTKMAGMMIAAAWVLSFILWAPailfwQFIVGGRTVPEG--ECYIQFFSNA----- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 llyhLVVF---VLIYFLPLVVMFAAYSVIgltlwKRAVPRhqahganlrhlqaKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15297  162 ----AVTFgtaIAAFYLPVIIMTVLYWQI-----SRASSR-------------EKKVTRTILAILLAFIITWTPYNVMVL 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 272 LGTFQEDIyyrkFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15297  220 INTFCASC----IPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
40-318 7.14e-14

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 71.34  E-value: 7.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd14988    7 YLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVH--PFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTItVDQGATKCVVAWPNDNGGKMLLLY 197
Cdd:cd14988   87 SIFFLTCLSVDRYLTLTSssPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQL-LDGVEPMCLFLAPFETYDEWALAV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHganlrhlqakkkfVKAMVLVVVTFAICWLPYHLYFILGTFqE 277
Cdd:cd14988  166 SLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRH-------------CLLIYAYILVFVVCWLPYHVTLLLLTL-H 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 278 DIYYRKFIQQVYLALFW------LAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14988  232 GSHISLHCNLVHFLYFFydvidcFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
40-268 8.03e-14

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 71.06  E-value: 8.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15379    7 YSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTNLHG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQP---RLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDnGGKMLLL 196
Cdd:cd15379   87 SILFLTCISVQRYLGICHPLASwhkKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPA-RSTAYFP 165
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 258613887 197 YHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRhlqaKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15379  166 YGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEK----RGKAARMIIVVAAVFLISFLPFHY 233
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
38-315 9.81e-14

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 70.98  E-value: 9.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcmaAFNATFNFIYASH---NIWYFGSTFCYFQNLFPV 114
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADL---LFVIWFPLKIAYHingNNWIYGEALCKVLIGFFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPF-QPRLSAPSTKAVIAVIWLVALALASPQCFYS-TITV-DQGATKCVVAWPNDNGG 191
Cdd:cd15370   82 GNMYCSILFMTCLSVQRYWVIVNPMsHSRKKANIAIGISLAIWLLILLVTIPLYLVKqTVFIpALDITTCHDVLPEQLLV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwkravprhQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15370  162 GDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRAL--------KSSINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLV 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 272 LGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15370  234 VHYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
43-322 1.20e-13

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 71.19  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRT-VTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGStFCYFQNLFPVTAMFVSI 121
Cdd:cd15320   11 LILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALAL-----------ASPQCFYstitvDQGATKcvVAWPND 188
Cdd:cd15320   90 LNLCVISVDRYWAISSPFryERKMTPKVAFIMISVAWTLSVLIsfipvqlnwhkAKPTSFL-----DLNASL--RDLTMD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKML-LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKR-----AVPRHQAHGANLRH--------------------L 242
Cdd:cd15320  163 NCDSSLnRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQirrisALERAAVHAKNCQNstgnrgsgdcqqpessfkmsF 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 243 QAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRKF-IQQVYLALF-WLAMSSTMYNPIIYCclnhrFRSGFRL 320
Cdd:cd15320  243 KRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTSTEPFcISSTTFDVFvWFGWANSSLNPIIYA-----FNADFRK 317

                 ..
gi 258613887 321 AF 322
Cdd:cd15320  318 AF 319
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
66-273 1.55e-13

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 70.37  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  66 TVTNYFIINLALADLCMAAFnATFNFIYASHN-IWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLS 144
Cdd:cd15170   34 TPIDILLLNLTVSDLIFLLF-LPFKMAEAASGmIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 145 APSTKAVIA--VIWLVALALAS----PQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVV-MFAAY 217
Cdd:cd15170  113 RRPLYAVIAsvFFWVLAFSHCSivyiVEYHIDSENTSVTNNSRCYDNFTPEQLKILLPVRLELFLVLFCIPFLItCFCYI 192
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 258613887 218 SVIGLTLwkravprhqahgaNLRHLQAKKKFvKAMVLVVVT---FAICWLPYHLYFILG 273
Cdd:cd15170  193 NFIRILS-------------SLPHISRQRKQ-RAIGLAVATllnFIVCFAPYNISHVVG 237
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
34-315 1.65e-13

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 70.19  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFgsTFCYFQNLFP 113
Cdd:cd15070    1 VTYISIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHF--YSCLFMSCLL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCF---YSTITVDQGATKCVVAWPND 188
Cdd:cd15070   79 VVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALglCWLVSFLVGLTPMFgwnRKPSLESVNTTPLQCQFTSV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLIyflPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15070  159 MRMDYMVYFSFFTWILI---PLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLALVLFLFAVCWLPLSI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 269 YFILgtfqedIYYRKFIQQVYLAL-FWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15070  236 INCV------VYFNPKVPKIALYLgILLSHANSMMNPIVYACKIKKFK 277
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
37-267 1.73e-13

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 70.11  E-value: 1.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMaAFNATFNFIY-ASHNIWYFGSTFC-YFQNLFPV 114
Cdd:cd15148    4 AVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLL-IICLPFRILYhVNNNQWTLGPLLCkVVGNLFYM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TaMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPqcFYSTITVDQGATKCVVAWPNDNG-G 191
Cdd:cd15148   83 N-MYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVAcgVLWAVALVGFVP--MIVLTEKNEESTKCFQYKDRKNAkG 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVmfaAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVkamvlVVVTFAICWLPYH 267
Cdd:cd15148  160 KAIFNFLIVAMFWLVFLLLIL---SYGKIAKKLLRISRDKPDFPNAAKYNRTARKSFF-----VLFIFTVCFVPYH 227
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
41-318 3.22e-13

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 69.19  E-value: 3.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNI-WYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15304    8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLFSTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVI--WLVALALASPQCFYS----TITVDQGAtkCVVAWPNdnggkm 193
Cdd:cd15304   88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIavWTISVGISMPIPVFGlqddSKVFKEGS--CLLADEN------ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 lllYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15304  160 ---FVLIGSFVAFFIPLTIMVITYFLTIKSLQQS--------------ISNEQKASKVLGIVFFLFVVMWCPFFITNVMA 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15304  223 VICKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
50-307 4.01e-13

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 68.92  E-value: 4.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  50 GNATVIWIILAHERMRTVTNYFIINLALAD-LCMAA--FNATFnfiYASHNIWYFGSTFCYFQnLFpVTAM--FVSIYSM 124
Cdd:cd15201   17 GNGLALWIFCFHLKSWKSSTVYLFNLAVADfLLIIClpFRTDY---YLRGKHWKFGDIPCRIV-LF-MLAMnrAGSIFFL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 125 TAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATKCvVAWPNDNGGKMLLLYHLVVF 202
Cdd:cd15201   92 TAVAVDRYFRVVHPHHRINSISVRKAAIiaCGLWLLTIAMTVYLLTKKHLFPRGNATQC-ESFNICTGTDSSSNWHEAMF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 203 VLIYFLPL-VVMFAAYSVIgLTLWKRAVPRHqahganlrhlqAK-KKFVKAMVLVVVTFAICWLP-----YHLYFILGTF 275
Cdd:cd15201  171 LLEFFLPLaIILYCSVRII-WQLRGRQLDRH-----------AKiKRAVQFIMVVAIVFIICFLPsnvtrIAIWILKHTS 238
                        250       260       270
                 ....*....|....*....|....*....|...
gi 258613887 276 QEDI-YYRKFIQQVYLALFWLAMSStMYNPIIY 307
Cdd:cd15201  239 NEDCqYYRSVDLAFYITISFTYFNS-MLDPVVY 270
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
36-307 4.13e-13

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 68.68  E-value: 4.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALV-LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYAShniWYFGSTFCYFQNL 111
Cdd:cd15054    2 WVAAFLCLIiLLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVvmpPAMLNALYGR---WVLARDFCPIWYA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVAlALAS--------------PQCFYSTITVD 175
Cdd:cd15054   79 FDVMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRAlaLILAAWTLA-ALASflpielgwhelgheRTLPNLTSGTV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 176 QGATKCVVAWPndnggkmlllYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprhqahganlrhLQAKKKFVKAMV-- 253
Cdd:cd15054  158 EGQCRLLVSLP----------YALVASCLTFFLPSGAICFTYCRI---------------------LLAARKALKASLtl 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 254 -LVVVTFAICWLPYHLYFILGTFQEDIYyrkfiQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15054  207 gILLGMFFVTWLPFFVANVVQAVCDCVS-----PGLFDVLTWLGYCNSTMNPIIY 256
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
37-315 6.28e-13

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 68.04  E-value: 6.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15214    3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGgkm 193
Cdd:cd15214   83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALvyIWLHSLIGCLPPLFgWSSLEFDRFKWMCVAAWHKEAG--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 lllYHLVVFVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAhganlrhlqakKKFVKAMVlVVVTFAICWLPYhlyfILG 273
Cdd:cd15214  160 ---YTAFWQVWCALLPFVVMLVCYGFI-----FRVARANQC-----------KAFITILV-VLGAFVTTWGPY----MVV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 274 TFQEDIYYRKFIQQVYLALF-WLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15214  216 ISTEALWGKNSVSPQLETLAtWLSFTSAVCHPLIYGLWNKTVR 258
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
40-307 6.54e-13

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 68.28  E-value: 6.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILaHERMRTVTNYFIINLALADLCMAAfnaTFNF-IYASHNI--WYFGSTFCYFQNLFPVTA 116
Cdd:cd15969    7 YLIIFIGSILLNGLAVWIFF-HIRNKTSFIFYLKNIVIADLLMTL---TFPFkIIQDSGLgpWNFNFFLCRYTSVLFYAS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPF-QPRL-SAPSTKAVIAVIWLVALALASPqcfySTITVDQGATKCVVAWPNDNGGKML 194
Cdd:cd15969   83 MYTSIVFLGLISLDRYLKVVKPFgDSRMySITFTKVLSACVWLIMAFLSLP----NIILTNGQPTEDNIHDCSKLKSPLG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVF---VLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQakkkfvkAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15969  159 VKWHTAVSyinICIFVAVLVILIVCYISISRYIYKSSKQFISSSSRTRKHNQ-------SIRVVVAVFFVCFLPYHLCRI 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 258613887 272 LGTF-QEDIYYRKFIQQVYL----ALFWLAMSSTMYNPIIY 307
Cdd:cd15969  232 PFTFsQLDKILDCTIKTILYyckeATLFLSACNVCLDPIIY 272
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
38-268 7.29e-13

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 68.06  E-value: 7.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLV-AVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfnaTFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15164    4 LIIYIPILFfGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLF---SLPFVLYFLKHSWPDDELCLVLQSIYFIN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAVI-AVIWLVALALASpqcfYSTITVDQGATKCVvawpnDNGGKML 194
Cdd:cd15164   81 RYMSIYIITAIAVDRYIAIKYPLKAKsLRSPRKAALTcGLLWVLVIISVS----LRLAWEEQEENFCF-----GKTSTRP 151
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258613887 195 LLYHLVVFVLIYFLPLVVM-FAAYSVIgltlwkRAVPRHQAhganlRHLQAKKKFVKAMVLV---VVTFAICWLPYHL 268
Cdd:cd15164  152 SKRTLIFSLLGFFIPLIILsFCSIQVI------RSLKKKKK-----TNPHEEKLIQKAIYIVsanLIVFIVCFLPLHI 218
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
37-318 1.13e-12

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 67.36  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15300    4 AAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASP-----QCFYSTITVdqgatkcvvawPNDN 189
Cdd:cd15300   84 SNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAgiMIGLAWLISFILWAPpilcwQYFVGKRTV-----------PERE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVF---VLIYFLPLVVMFAAYSVIgltlwkravprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPY 266
Cdd:cd15300  153 CQIQFLSEPTITFgtaIAAFYIPVSVMTILYCRI------------------YKETIKERKAAQTLSAILLAFIITWTPY 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 267 HLYFILGTFQEDIYYRKFIQQVYlalfWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15300  215 NIMVLVSTFCSDCIPLTLWHLGY----WLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
39-318 1.45e-12

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 67.48  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15154    6 GYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHY-WPFGNFLCQFSGSIFQMNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR-LSAPS-TKAVIAVIWLVALALASP--------QCFYSTITVdqgaTKCVVAWpND 188
Cdd:cd15154   85 GSCLFLMCINVDRYLAIVHPLRFRhLRRPKvARLLCLAVWALILGGSVPaaivhsssDCLLHGEKV----YRCFESF-SD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGanlrhlqakkKFVKAMVLVVVTFAICWLPYH- 267
Cdd:cd15154  160 NDWKGLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRR----------KTVRLLLVNLVIFLICFVPYNt 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 268 ---LYFIL--GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15154  230 tlaVYGLLraNLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
43-318 1.57e-12

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 67.08  E-value: 1.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYA-SHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15302   10 LSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVlNGDYWPLGWVLCDLWLSVDYTVCLVSI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPRLSAPSTKAV--IAVIWLVALALASPQCF----YSTITVDQGATKCVVAWPNDNggkmll 195
Cdd:cd15302   90 YTVLLITIDRYCSVKIPAKYRNWRTPRKVLliIAITWIIPALLFFISIFgwqyFTGQGRSLPEGECYVQFMTDP------ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprHQAhgANlrhlQAKKKFvKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:cd15302  164 YFNMGMYIGYYWTTLIVMLILYAGI-----------YRA--AN----RARKAL-RTITFILGAFVICWTPYHILATIYGF 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 276 QEDiyYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15302  226 CEA--PPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
35-315 1.62e-12

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 67.47  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIiLAHERMRTVTN---YFIINLALADLCmaaFNATFNF---IYASHNIWYFGSTFCYF 108
Cdd:cd15147    2 LFPIVYSIIFVLGLIANCYVLWV-FARLYPSKKLNeikIFMVNLTIADLL---FLITLPFwivYYHNEGNWILPKFLCNV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 QNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFY-STITVDQGA---TKCV 182
Cdd:cd15147   78 AGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIisVAIWVIIVASASYFLFMdSTNTVKIDSgnfTRCF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 183 VAWPNDNGgKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHganlrhlqAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15147  158 EGYEKDNS-KPVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQRNAG--------VKRRALWMVCTVLAVFVIC 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 263 WLPYH---LYFILGTFQ----EDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15147  229 FVPHHvvqGPWTLAVLQqwryWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
41-315 1.75e-12

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 67.09  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTnyFIINLALADLCMAAFNATFNFIYAS--HNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15220    7 VLLDLTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGILSSSpfFLGVVFGEAECRVYIFLSVCLVS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF----YSTITvDQGATKCVVAWpndnGGK 192
Cdd:cd15220   85 ASILTISAISVERYYYIVHPmrYEVKMTIGLVAAVLVGVWVKALLLGLLPVLgwpsYGGPA-PIAARHCSLHW----SHS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLIYF-LPLVVMFAAYSVIGLTLwkravprhqahganlrhlqAKKKFVKAMVLVVVTFAICWLPY---HL 268
Cdd:cd15220  160 GHRGVFVVLFALVCFlLPLLLILVVYCGVFKVF-------------------GGGKAALTLAAIVGQFLCCWLPYfafHL 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 269 YFILGTfqediyYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15220  221 YSALAA------SPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
40-311 3.54e-12

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 66.01  E-value: 3.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNFiYASHNI--WYFGSTFCYFQNLFPVTAM 117
Cdd:cd15186    7 YSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLL---FVATLPF-WTHYLIneWGLHNAMCKLTTAFFFIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV--IWLVALALASPQCFYStitvDQGATKCVVAWPNDNGGKMLL 195
Cdd:cd15186   83 FGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISlgVWAAAILVAVPQFMFT----KMKENECLGDYPEVLQEIWPV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVprhqahganlrhlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:cd15186  159 LRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKN-------------HKKARAIKLILLVVIVFFLFWTPYNVMIFLETL 225
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 258613887 276 QediYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLN 311
Cdd:cd15186  226 K---LYDFFPSCDMKKDLRLALSVTETIAFSHCCLN 258
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
43-318 4.68e-12

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 65.58  E-value: 4.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15296   10 LVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKAVI---AVIWLVALALASPqcfySTITVDQGATKCVVAWPNDNGGKMLLLYHL 199
Cdd:cd15296   90 NIVLISYDRFLSVTRAVSYRAQKGMTRQAVlkmVLVWVLAFLLYGP----AIISWEYIAGGSIIPEGECYAEFFYNWYFL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLI-YFLPLVVMFAAYSVIGLTLWKRavpRHQahganlrhLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL-----G 273
Cdd:cd15296  166 MTASTLeFFTPFISVTYFNLSIYLNIQKR---RFR--------LSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIraachG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQEDIYYRKFiqqvylalFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15296  235 HCVPDYWYETS--------FWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
33-318 6.13e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 65.33  E-value: 6.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  33 LALWATAYLALVLVAVTgNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLF 112
Cdd:cd15335    1 MLIVLTLALITILTTVL-NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNdng 190
Cdd:cd15335   80 DMTCCTCSILHLCVIALDRYWAITDAieYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDH--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gkmlLLYHLVVFVLIYFLPLVVMFAAYSVIgltlwkravprhqAHGANlrhlqAKKKFVKAMVLVVVTFAICWLPyhlyF 270
Cdd:cd15335  157 ----VIYTIYSTFGAFYIPLTLILILYYRI-------------YHAAS-----RERKAARILGLILGAFILSWLP----F 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 271 ILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15335  211 FIKELIVGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
35-318 1.25e-11

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 64.50  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVT---NYFIINLALADLCMAAFNAT---FNFIYAsHNIWYFGSTFCYF 108
Cdd:cd15356    2 LFTAVYALIWALGAAGNALTIHLVLKKRSLRGLQgtvHYHLVSLALSDLLILLISVPielYNFVWF-HYPWVFGDLVCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 QNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALASPQCF-----YSTITVD----QG 177
Cdd:cd15356   81 YYFVRDICSYATVLNIASLSAERYLAICQPLRAKrlLSKRRTKWLLALIWASSLGFALPMAFimgqkYELETADgepePS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 178 ATKCVVAWPNDNGGKMLLLYHLVVFVliyfLPLVVMFAAYSVIgltlwkravprhqahgANLRHLQAKKKFVKAMVLVVV 257
Cdd:cd15356  161 SRVCTVLVSRATLKVFIQVNAFVSFV----LPLALIAFLNGVT----------------VSHLRIQSLQHSVQVLRAIVI 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 258 TFAICWLPYH-----LYFILGTFQEDIYYrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15356  221 AYVICWLPYHarrlmFCYVPDDAWTDSLY-NFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-266 1.31e-11

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 64.84  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVL-VAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15387    5 TVLALILfLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQpRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGGKMLLL 196
Cdd:cd15387   85 FASTYMLLLMSIDRCLAICQPLR-SLHRRSDRVYVLFSWLLSLVFSIPQVHiFSLREVGNGVYDCWADFIQPWGPKAYIT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YhlvVFVLIYFLPLVVMFAAYSVIGLTLWKRaVPRHQAHGANLRHL-------------------QAKKKFVKAMVLVVV 257
Cdd:cd15387  164 W---ITLSVYIIPVLILSVCYGLISFKIWQN-VKLKTRRETKTPLSsaasggaalarvssvklisKAKIRTVKMTFVIVL 239

                 ....*....
gi 258613887 258 TFAICWLPY 266
Cdd:cd15387  240 AYIVCWTPF 248
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
34-318 1.70e-11

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 64.48  E-value: 1.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15071    1 AAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVLI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMfvSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVI--WLVALALA-SPQCFYSTITVDQGATKCVVAWPN--- 187
Cdd:cd15071   81 LTQS--SILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAgcWILSFLVGlTPMFGWNNLNAVERAWAANSSMGElvi 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 188 ----DNGGKMLLLYHLVVFVLIyFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLR-HLQAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15071  159 kcqfETVISMEYMVYFNFFVWV-LPPLLLMLLIYLEVFYLIRKQLNKKVSSSSSDPQkYYGKELKIAKSLALILFLFALS 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 263 WLPYHLYFILGTFQEDIYYRKFIqqVYLALFWLAMSSTMyNPIIYCCLNHRFRSGF 318
Cdd:cd15071  238 WLPLHILNCITLFCPSCKKPMIL--TYIAIFLTHGNSAM-NPIVYAFRIKKFRTTF 290
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
40-318 2.91e-11

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 63.67  E-value: 2.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLF--PVT-- 115
Cdd:cd14996    7 YSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFgtLVIhv 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVH-----------------PFQPRLSAPS-TKAVIAVIWLVALALASP-QCFYSTITVDQ 176
Cdd:cd14996   87 SMCVSILILSWIAISRYATLMKhdsatqkqscyekifygHFLKRFRQPKfARYLCIYIWGVVLCIIIPvVVYYSVREADE 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 177 GATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTlwKRAVPRHQAHGANLRHLQAKKKFVKAMVLVV 256
Cdd:cd14996  167 DGESLCYNRQVELGAKGSQIAGLIATTFFFLFFLVVLLSYYSFVNHL--RRIQKNTCISEKDLIYRSVKRNILIIQALLV 244
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 257 VtfaiCWLPYHLY---FILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd14996  245 V----CFLPYHIFkpvFYVLHQREDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
42-220 3.61e-11

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 62.94  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSI 121
Cdd:cd15215    8 IFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNGgkmlllYH 198
Cdd:cd15215   88 NTIVVVSVDRYLAIIHPlsYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYgWGQAAFDERNALCSVIWGSSYS------YT 161
                        170       180
                 ....*....|....*....|..
gi 258613887 199 LVVFVLIYFLPLVVMFAAYSVI 220
Cdd:cd15215  162 ILSVVSSFVLPVIIMLACYSMV 183
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
41-318 9.07e-11

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 61.89  E-value: 9.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHE---RMRT---VTNYFIINLALADLCMAAFNATFNFIYA-SHNIWYFGSTFCYFQNLFP 113
Cdd:cd15328    2 LVLTLLAMLVVATFLWNLLVLVtilRVRTfhrVPHNLVASMAVSDVLVAALVMPLSLVHElSGRRWQLGRSLCQVWISFD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPS--TKAVIAVIWLVALALA-SPQCFYSTITVDQGATKCVVAWPNDng 190
Cdd:cd15328   82 VLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRriSNVMIALTWALSAVISlAPLLFGWGETYSEDSEECQVSQEPS-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gkmlllYHLVVFVLIYFLPLVVMFAAYsvigltlWKRavprhqahganLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYF 270
Cdd:cd15328  160 ------YTVFSTFGAFYLPLCVVLFVY-------WKI-----------YKAAQKEKRAALMVGILIGVFVLCWIPFFLTE 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 271 ILGTFQEdiyyrKFIQQVYLALF-WLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15328  216 LISPLCS-----CDIPPIWKSIFlWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
43-315 9.27e-11

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 61.76  E-value: 9.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIY 122
Cdd:cd15301   10 LSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQcfystitvdqgatkcVVAWPNDNGG--------- 191
Cdd:cd15301   90 NLLIISFDRYFSVTRPltYRARRTTKKAAVMIASAWIISLLLWPPW---------------IYSWPYIEGKrtvpagtcy 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 -KMLLLYHLVVF---VLIYFLPLVVMFAAYSVIgltlWKRAVPRHQahganlrhlQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15301  155 iQFLETNPYVTFgtaLAAFYVPVTIMCILYWRI----WRETKKRQK---------KQESKAAKTLSAILLAFIVTWTPYN 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 268 LYFILGTFQEDIYYrkfIQQVYLALFW-LAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15301  222 VLVLIKAFFPCSDT---IPTELWDFSYyLCYINSTINPLCYALCNAAFR 267
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
38-317 1.09e-10

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 61.61  E-value: 1.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALAD--LCMAAFNATFNFIYAShniWYFGSTFCY---FQNLF 112
Cdd:cd15072    5 SILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADmgISLNALVAASSSLLRR---WPYGSEGCQahgFQGFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 pvTAMfVSIYSMTAIAADRYMAIVHPFQPRLSAPSTkaVIAVIWLVALALAS-PQCFYSTITVDQGATKCVVAWPNDNGG 191
Cdd:cd15072   82 --TAL-ASICSSAAIAWDRYHHYCTRSKLQWSTAIS--LVLFVWLFSAFWAAmPLLGWGEYDYEPLGTCCTLDYSKGDRN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIyfLPLVVMFAAYSVIGLTLWKRAVPRHQAhganlrhlqakkkfvkamVLVVVTFAICWLPYHLYFI 271
Cdd:cd15072  157 YVSYLFTMAFFNFI--LPLFILLTSYSSIEQKLKKEGHLRFNT------------------GLPLLTLLICWGPYAILAL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 258613887 272 LGTFQEDIYYRKFIQQVyLALfwLAMSSTMYNPIIYCCLNHRFRSG 317
Cdd:cd15072  217 YAAITDVTSISPKLRMV-PAL--LAKTSPTINAILYALGNENYRGG 259
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
51-311 1.45e-10

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 61.44  E-value: 1.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  51 NATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYashnIWYFGSTFCYFQNLFPVTAMFV-SIYSMTAIAA 129
Cdd:cd15963   18 NAIVVAVIFYTPAFRAPMFLLIGSLATADL-LAGLGLILHFAF----VYCIQSAPVNLVTVGLLAPSFTaSVSSLLAITI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 130 DRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALAS-PQCFYSTItvdQGATKCVVAWPndnggkmLLLYHLVVFVLIY 206
Cdd:cd15963   93 DRYLSLYNAltYYSERTVTRTYIMLILTWGASLCLGLlPVVGWNCL---KDPSTCSVVKP-------LTKNHLVILSISF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 207 FLPLVVMFAAYSVIGLTLWKRAVPRH-QAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYrkfi 285
Cdd:cd15963  163 FMVFALMLQLYAQICRIVCRHAHQIAlQRHFLPTSHYVTTRKGIATLAVILGTFASCWLPFAVYCLLGDYTYPALY---- 238
                        250       260
                 ....*....|....*....|....*.
gi 258613887 286 qqVYLALFwLAMSSTMYNPIIYCCLN 311
Cdd:cd15963  239 --TYATLL-PATYNSMINPIIYAFRN 261
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
51-307 1.50e-10

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 61.34  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  51 NATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYashnIWYFGSTFCYFQNL-FPVTAMFVSIYSMTAIAA 129
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADL-LAGLGLILHFVF----RYCVYSEALSLVSVgLLVAAFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 130 DRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALAL-ASPQCFYSTItvdQGATKCVVAWPndnggkmLLLYHLVVFVLIY 206
Cdd:cd15100   93 DRYLSLYNAltYYSERTLTFTYVMLALLWTLALGLgLLPVLGWNCL---REGSSCSVVRP-------LTKNHLAVLAVAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 207 FLPLVVMFAAYSVIGltlwkRAVPRH------QAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIY 280
Cdd:cd15100  163 LLVFALMLQLYAQIC-----RIVLRHahqialQRHFLAPSHYVATRKGVSTLALILGTFAACWIPFAVYCLLGDGSSPAL 237
                        250       260
                 ....*....|....*....|....*..
gi 258613887 281 YrkfiqqVYLALFWLAMSStMYNPIIY 307
Cdd:cd15100  238 Y------TYATLLPATYNS-MINPIIY 257
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
39-268 1.77e-10

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 61.33  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVT-GNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15388    5 AVLAIIFACALlSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ------PRLSAPstkavIAVIWLVALALASPQCF-YSTITVDQGATKCVVAWPNDNG 190
Cdd:cd15388   85 FASSYMIVAMTFDRHQAICRPMVtfqkgrARWNGP-----VCVAWAISLILSLPQVFiFSKVEVAPGVYECWACFIEPWG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 GKMLLLYHLVVfvlIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQ--------------AKKKFVKAMVLVV 256
Cdd:cd15388  160 LKAYVTWITLV---VFVLPTLIITVCQVLIFKEIHINIYLKSQIIVAVVKKKQllssrassvaevskAMIKTVKMTLVIV 236
                        250
                 ....*....|..
gi 258613887 257 VTFAICWLPYHL 268
Cdd:cd15388  237 LVYVLCWAPFFL 248
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-272 1.83e-10

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 61.38  E-value: 1.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFG--STFCYFQNLFPV---TAMFV 119
Cdd:cd15128   12 IVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGdqPFGQFLCKLVPFiqkASVGI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAV-IAVIWLVALALASPQCF-YSTITVD---QGATKCVVAWPNdnggKM 193
Cdd:cd15128   92 TVLNLCALSVDRYRAVASWSRIQgIGIPMWTAVeIVMIWMLSAVLAVPEAIgFDMVRFNykgVTLRTCLLRPET----SF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLV----VFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAhgANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15128  168 MKFYIDVkdwwLFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMLRI--ALNEHLKQRREVAKTVFCLVVIFALCWLPLHLS 245

                 ...
gi 258613887 270 FIL 272
Cdd:cd15128  246 RIL 248
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
40-315 4.05e-10

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 60.15  E-value: 4.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILaHERMRTVTNYFIINLALADLCMAAfnaTFNFIYASH---NIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15924    7 YTVIFFAGILLNGLAMWIFF-HIPSKSSFIIYLKNTVVADLLMIL---TFPFKILSDaglGPWQLRTFVCRVTSVLFYFT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPqcfySTITVDQGATKCVVAWPNDNGGKML 194
Cdd:cd15924   83 MYTSIVFLGLISIDRYLKIVRPFKTSFpkSVSFAKILSVVVWALMFLLSLP----NMILTNQQPREKNVKKCSFLKSELG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVV---FVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGAnlrhlqAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15924  159 LKWHEIVnyiCQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSS------RRKKSNVKIFIIVAVFFVCFVPYHFARI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 272 LGTFQE-----DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15924  233 PYTLSQtrdvfDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFR 281
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
35-315 6.31e-10

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 59.42  E-value: 6.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNiWYFGSTFCYFQNLFPV 114
Cdd:cd15153    2 LYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHT-WPFGRFLCLLCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKM 193
Cdd:cd15153   81 LNMYASICFLTCISIQRCFFLLHPFKARdWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLplvvmfAAYSVIGLTLWKRAVPRHQAhGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL- 272
Cdd:cd15153  161 AAIAMMTVAELFGFV------IPLFIIAWCTWKTENSLRQR-NKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFy 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 273 ----GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15153  234 lmvsESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
41-316 6.44e-10

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 59.04  E-value: 6.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHN---IWYFGSTFCYFQNlfpvtaM 117
Cdd:cd15163    8 TLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAGnclTCSFVHIFSYFVN------M 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLVALALAspqcfYSTITVDQGATKCVvawpndnggkmlL 195
Cdd:cd15163   82 YCSILFLTCICVDRYLAIVQVEASRrwRNPNYAKGICVFIWLFAIVVT-----FSILTTAIKFASCC------------L 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYHLVVFVLIYFLPLVVMFAAYSVIgltLWKRAVPrhqahgaNLRHlQAKKKFVKAMVL---VVVTFAICWLPYHLYFIL 272
Cdd:cd15163  145 SKLFALTVFEFFLPLLIITFFTIRI---MCALSRP-------GLMH-QSRERRMRAVQLlitVLIIFMICFTPFHVRQVA 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 273 GTFQEDIYYRKFIQQVYLALFWLAMSSTMyNPIIYCCLNHRFRS 316
Cdd:cd15163  214 VAFNPDIPHHTSLIVYHVTVTLSSLNSCM-DPIVYCFVTNNFQS 256
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-318 7.05e-10

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 59.47  E-value: 7.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNY-FIINLALADLCMAAFnATFNFIyASHNIWYFGSTFCYFQNLFPVTAMFV-SIY 122
Cdd:cd15099   12 PVTFLENILVLLTILSSTALRRRPSYlFIGSLALADMLASVI-FTISFL-DFHVFHQRDSRNLFLFKLGGVTMAFTaSVG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 123 SMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALAS-PQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHL 199
Cdd:cd15099   90 SLLLTALDRYLCIYQPSNYKLLVTRTRAKVAilLMWCVTIIISFlPLMGWRCKTWDSPCSRLFPYIDRHYLASWTGLQLV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFA---AYSVIGLTLWKRAVPRHQAHGANLRhlqakkkFVKAMVLVVVTFAICWLP---YHLYFILG 273
Cdd:cd15099  170 LLFLIIYAYPYILWKAhrhEANMGGPKLGRQQVKGQARMRMDIR-------LAKTLSLILLVLAICWLPvlaFMLVDVRV 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 274 TFQediyyrKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15099  243 TLT------NKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
51-311 1.00e-09

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 58.79  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  51 NATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYashNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAAD 130
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADL-LAGCGLILNFVF---QYVIQSETISLITVGFLVASFTASVSSLLAITVD 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 131 RYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGAtkCVVAWPndnggkmLLLYHLVVFVLIYFL 208
Cdd:cd15962   94 RYLSLYNAltYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGWNCLEERAS--CSIVRP-------LTKSNVTLLSASFFF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 209 PLVVMFAAYSVIGLTLWKRAvprHQ----AHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRkf 284
Cdd:cd15962  165 IFILMLHLYIKICKIVCRHA---HQialqQHFLTASHYVATKKGVSTLAIILGTFGASWLPFAIYCVVGDHEYPAVYT-- 239
                        250       260
                 ....*....|....*....|....*..
gi 258613887 285 iqqvyLALFWLAMSSTMYNPIIYCCLN 311
Cdd:cd15962  240 -----YATLLPATYNSMINPIIYAYRN 261
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
35-308 1.94e-09

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 57.85  E-value: 1.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYA-SHNIWYFGSTFCYFQNLFP 113
Cdd:cd15367    2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADL-LYIFSLPFWLQYVlQHDNWTYSELLCKICGILL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFqpRLSAPST-KA---VIAVIWLVALALASPQCFYSTITVDQGATK-CVVAWPND 188
Cdd:cd15367   81 YENIYISIGFLCCISVDRYLAVVHPF--RFHAFRTmKAatlVSTVIWLKELMTCVFFFLHGEISKDKENHSvCFEHYPIK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLiyfLPLVVMFAAYSVIgltlwKRAVprHQAHGANlrhlQAKKKFVKAMVLV-VVTFAICWLPYH 267
Cdd:cd15367  159 AWEHNINYYRFYAGFL---FPIFLLSFSYCRI-----LRAV--RKSHGTQ----KSQKIQIKRLVLStVVIFLVCFGPYH 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 258613887 268 LYFILGT-FQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYC 308
Cdd:cd15367  225 ILLLVRSvFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYC 266
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
40-268 2.27e-09

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 57.89  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfnaTFNFIYASHNiWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15920    7 YSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVL---CLPFRVAYQN-TAGPLSFCKIVGAFFYLNMYA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFySTITVDQGATKCvvaWPNDNGGKMLLLY 197
Cdd:cd15920   83 SILFLSLISLDRYLKIIKPLQQFKihTVPWSSAASGGVWLLLLACMIPFLF-ESRNEGPCDNKC---FHFRSKGLTAGGI 158
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 198 HLVVFVLIYFLPLVVMFaAYSVIGLTLWKraVPRHQAHGANLRhlqAKKKFVKAMVLVVVTFAICWLPYHL 268
Cdd:cd15920  159 NLTAVVIFYILSLLFLY-FYAKISHKLYK--VSLGNAQQQIKK---ASKRAIIKTFIVLAIFIVCFVPYHI 223
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
45-265 5.47e-09

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 56.87  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAH--ERMRTVTNYFIINLALADLCMAAFNATFNFI-YASHNIWYFGSTFCYFqnlFPVTAMFVSI 121
Cdd:cd14981   12 VFGVLGNLLALIVLARSskSHKWSVFYRLVAGLAITDLLGILLTSPVVLAvYASNFEWDGGQPLCDY---FGFMMSFFGL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSM---TAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALALAS---------------PQCFYSTItvdqgatkc 181
Cdd:cd14981   89 SSLlivCAMAVERFLAITHPFfyNSHVKKRRARLMLGAVWAFALLIASlpllglgsyvlqypgTWCFLDFY--------- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 182 vvawpndnGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVL---VVVT 258
Cdd:cd14981  160 --------SKNTGDAAYAYLYSILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVVLllaITVV 231

                 ....*..
gi 258613887 259 FAICWLP 265
Cdd:cd14981  232 FSVCWLP 238
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
40-318 5.75e-09

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 56.88  E-value: 5.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVL------VAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfnATFNFIYAS---HNIWYFGSTFCYFQN 110
Cdd:cd15217    1 YVKLVLlgliicVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSA--VCFPFVLVSirnGSAWTYSVLSCKIVA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF-YSTITVDQGATKCVVAW-- 185
Cdd:cd15217   79 FMAVLFCFHAAFMLFCISVTRYMAIAHHrfYSKRMTFWTCIAVICMVWTLSVAMAFPPVFdVGTYKFIREEDQCIFEHry 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 --PNDNGGKMLLLYHLVVFVLIYFLPLVV-------MFAAYSVIGLTL-WKRAVP------------------------- 230
Cdd:cd15217  159 fkANDTLGFMLMLAVLIVATHIVYGKLLLfeyrhrkMKPVQMVPAISQnWTFHGPgatgqaaanwiagfgrgpmpptllg 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 231 -RHQAHGANLR-----HLQAKKKFVKAMVLVVVTFAICWLPYHLyfilgtfqeDIYYRKFIQQV-----YLAL-FWLAMS 298
Cdd:cd15217  239 iRQNAHTANRRllgmeEFKAEKRLGRMFYVITLSFLVLWSPYIV---------ACYWRVFVKACsiphrYLSTaVWMSFA 309
                        330       340
                 ....*....|....*....|
gi 258613887 299 STMYNPIIYCCLNHRFRSGF 318
Cdd:cd15217  310 QAGVNPIVCFLLNKDLKKCL 329
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
42-272 5.89e-09

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 56.79  E-value: 5.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYF-----GSTFCYFQNLFPVTA 116
Cdd:cd15975    9 IIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKAS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAV-IAVIWLVALALASPQCF-YSTITV---DQGATKCVVAWPNdng 190
Cdd:cd15975   89 VGITVLNLCALSVDRYRAVASWSRVQgIGIPLITAIeIFSIWVLSFILAIPEAIgFVMVPFeynGEQYRTCMLNATT--- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gKMLLLYHLV----VFVLIYFLPLVVMFAAYSVIGLTLWKRavprhqaHGANLR-----HLQAKKKFVKAMVLVVVTFAI 261
Cdd:cd15975  166 -KFMNFYVDAkdwwLFGFYFCVPLACTAIFYTLMTCEMLNR-------RKGSLRialseHLKQRREVAKTVFCLVVIFAL 237
                        250
                 ....*....|.
gi 258613887 262 CWLPYHLYFIL 272
Cdd:cd15975  238 CWFPLHLSRIL 248
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
43-318 8.56e-09

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 56.50  E-value: 8.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRT-VTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGsTFCYFQNLFPVTAMFVSI 121
Cdd:cd15319   10 LILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVALALAspqCFYSTITVDqgatkcvVAWPNDNGGKMLLL----- 196
Cdd:cd15319   89 LNLCVISVDRYWAISSPF--RYERKMTQRVALVMISVAWTLS---VLISFIPVQ-------LNWHKDSGDDWVGLhnssi 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 ---------------YHLVVFVLIYFLPLVVMFAAYSVI---------GLTLWKRAVPRHQ---------AHGANLR-HL 242
Cdd:cd15319  157 srqveencdsslnrtYAISSSLISFYIPVAIMIVTYTRIyriaqiqirRISSLERAAEHAQscrsnridcHHHTSLRtSI 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 243 QAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQE------DIYYRKFIQQVYLALFWLAMSSTMYNPIIYcCLNHRFRS 316
Cdd:cd15319  237 KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDrppadpDAGLPCVSETTFDVFVWFGWANSSLNPIIY-AFNADFRK 315

                 ..
gi 258613887 317 GF 318
Cdd:cd15319  316 VF 317
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
31-307 1.20e-08

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 55.67  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  31 WQLALWATAylalvLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYashnIWYFGSTFCYFQN 110
Cdd:cd15960    3 WDIALCVTG-----TVMACENAIVIAILFYTPSLRAPMFILIGSLALADL-LAGLGLIANFVA----IYVMNSEAVTLCS 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMF-VSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALAL-ASPQCFYSTItvDQGATKCVVAWP 186
Cdd:cd15960   73 AGLLLAAFsASVCSLLAITVDRYLSLYNAltYHTERTLTFTYGLLALLWLTCIGIgLLPAMGWNCL--RAPASCSVLRPV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYsvigltlwkravpRH------QAHGANLRHLQAKKKFVKAMVLVVVTFA 260
Cdd:cd15960  151 TKNNAAVLAVSFLLLFALMMQLYLQICRIAF-------------RHaqqiavQHQFVNFCLASSTRKGVSTLSLILATFA 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 261 ICWLPYHLYFILGtfqeDIYYrKFIQQVYLALfwLAMSSTMYNPIIY 307
Cdd:cd15960  218 FCWVPFAVYSMVA----DSSY-PMIYTYYLVL--PAACNSVINPIIY 257
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
41-323 1.81e-08

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 54.95  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWiiLAHERM-RTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd14973    8 VLLSLCGLVGNGLVLW--LLGFRIkRNPFSVYILNLAAADF-LFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPF-----QP-RLSApstkAVIAVIWLVALaLASPQCFYStitvdqgatkCVVAWPNDNGgkM 193
Cdd:cd14973   85 GLSLLAAISTERCLSVLFPIwyrchRPkHLSA----VVCALLWALSL-LLSVLESYF----------CGFLFWKFNE--S 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 LLLYHLVVFVLIYFLPLVVMFaaysVIGLTLWKRAVPRHQAHganlrhlQAKKKFVKAMVLVVVtFAICWLPYHLYFILG 273
Cdd:cd14973  148 ACRTFNFLSALLFLLLFLVMC----VSSLTLLIRVQCSSQRR-------PPTRLYVVILLTVLV-FLLCGLPLGIYWFLL 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 274 TFQEDiyYRKFIQQVYLALFWLAMSSTmyNPIIYCCL----NHRFRSGFRLAFR 323
Cdd:cd14973  216 LWFSN--YLFHTFHPISDLLSCVNSSA--NPIIYFFVgslrGRRLREPLRVVLQ 265
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
40-315 2.09e-08

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 54.79  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILaHERMRTVTNYFIINLALADLCMAaFNATFNFIYASH-NIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15151    7 YTVLFLVGLILNSVAAWIFF-HIPSTSTFIVYLKNTLVADLIMT-LMLPFKILSDSGlGPWQLRAFVCRFSAVVFYITMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPqcfySTITVDQGATKCVVAWPNDNGGKMLLL 196
Cdd:cd15151   85 ISIILLGLISFDRYLKIVRPFGKSWvqRVRFAKILSGAVWLVMFLLSVP----NMILSNKPATPISVKKCASLKSPLGLK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 197 YHLVVFV---LIYFLPLVVMFAAYSVIGLTLWkravprhQAHGANLRHLQAKKKFVKAMVLVVVT-FAICWLPYHLYFIL 272
Cdd:cd15151  161 WHEVVNYicqFIFWGVFALMVLFYTIISKKVY-------ESYKKSRSKDNKASKKTKAKVFIIVAvFFVCFAPFHFVRVP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 273 GTF-----------QEDIYYRKFIQqvylalFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15151  234 YTLsqtgkitdcqlQNLLYIAKEIT------LWLAATNVCLDPLIYIFLCKSFR 281
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
45-318 5.74e-08

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 53.71  E-value: 5.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM-------AAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15360   12 ILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMgiyllliASVDIRTKSQYYNYAIDWQTGAGCAAAGFFTVFAS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ--PRLSAPSTKAVIAVIWLVALALASPQCFYSTitvdqGATKCVVAWPNDNGGKMLL 195
Cdd:cd15360   92 ELSVYTLTVITLERWHTITYAMQldRKVRLRHAAVIMVGGWIFAFTVALLPIFGIS-----SYMKVSICLPMDIESPLSQ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYhlVVFVLIY-FLPLVVMFAAYSVIGLTLwkravprhqaHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15360  167 AY--IIFILVLnVLAFLIICACYIKIYLTV----------RNPNFVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISAS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 275 FQEDIYYRKfIQQVYLALFWLAMSSTmyNPIIYCCLNHRFRSGF 318
Cdd:cd15360  235 LKVPLITVS-KSKILLVLFYPINSCA--NPFLYAIFTKTFRRDF 275
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
46-315 1.07e-07

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 52.91  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  46 VAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAA--FNATFNFiyasHNIWYFGSTFCYFQNLFPVTAMFVSIYS 123
Cdd:cd14989   13 IGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVAdsLIEVFNL----NEKYYDIAVLCTFMSLFLQINMYSSIFF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAI--VHPFQPRLSAPSTKAVIAVIWLVALaLASPQCFysTITVDQGATKCVVAWPNDNGGKMLLLyhlvv 201
Cdd:cd14989   89 LTWMSFDRYIALakVMKSSPLRTMQHARLSCGLIWMASI-SATLLPF--TAVQAQHTGEVHFCFADVREIQWLEV----- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 202 fVLIYFLPLVVMFAAYSVIgltlwKRAVPRHQAHganlRHLQAKKKFVKAMVLVVV-TFAICWLPYHLYFILGTFQEDIY 280
Cdd:cd14989  161 -TLGFIIPFSIIGLCYSLI-----VRVLVRAQKH----RRLRPRRQKALRMILVVVlVFFICWLPENVFISIQLLQGTQE 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 258613887 281 YRKFIQQVYLALFWL--------AMSSTMYNPIIYCCLNHRFR 315
Cdd:cd14989  231 PSESYDESFRHNHPLtghivnlaAFSNSCLNPLIYSFLGETFR 273
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
38-271 1.13e-07

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 52.85  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAA---FNATFNFiyaSHNIWYFGSTFCYFqnlfpV 114
Cdd:cd15369    5 SVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLllpFKIAYHF---SGNDWLFGEAMCRV-----V 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TA-----MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFY-STITV-DQGATKCVVAW 185
Cdd:cd15369   77 TAafycnMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFtcAAIWLLSIAGVVPLLLSeQTIQIpDLGITTCHDVL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHganlrhlqaKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15369  157 NEQLLMGYYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSK---------KTRALFMAVAVFCVFVICFGP 227

                 ....*.
gi 258613887 266 YHLYFI 271
Cdd:cd15369  228 TNVLLL 233
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
40-307 1.27e-07

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 52.47  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHN-IWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15364    7 YSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCEL-LYLGTLPLWTIYVSNNhKWPWGSLACKITGYIFFCNIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNggkMLLLY 197
Cdd:cd15364   86 ISILLLCCISIDRFVAVVYALESRgRRRQRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHTCFETLQMDT---QVAGF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPL-VVMFAAYSVIGLTLWKRAVPRHQahganlrhlQAKKKFVKamVLVVVTFAICWLPYHLYFILGTFQ 276
Cdd:cd15364  163 YYARFCIGFAIPLaILIFTNYRIFRSIQTSTSLTPHQ---------KAKVKYLA--IAVIVIFLICFAPYHLVLLVRAIA 231
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 258613887 277 EDIY------YRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15364  232 FSLYpngmcgFEERIYTPSVIFLCLSTVNSVADPIIY 268
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
40-138 1.27e-07

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 52.40  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMaAFNAT----FNFIYASHNIWYFGstfCYFQNLFPVT 115
Cdd:cd15412    7 FLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCY-SSNVTpkmlVNFLSEKKTISFAG---CFTQCYFFIA 82
                         90       100
                 ....*....|....*....|...
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15412   83 LVITEYYMLAVMAYDRYMAICNP 105
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
51-318 1.37e-07

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 52.34  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  51 NATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYAshniWYFGSTFCYFQNLFPVTAMF-VSIYSMTAIAA 129
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADL-LAGIGLILNFIFA----YLLQSEAAKLVTVGLIVASFsASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 130 DRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQgATKCVVAWPNDNGGKMLLLYHLVVFVLIYF 207
Cdd:cd15961   93 DRYLSLYYAltYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADE-STCSVVRPLTKNNAAILSVSFLLMFALMLQ 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 208 LPL----VVMFAAYSVIgltlwkravprHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRk 283
Cdd:cd15961  172 LYIqickIVMRHAHQIA-----------LQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYT- 239
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 258613887 284 fiqqvyLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15961  240 ------YATLLPATYNSIINPVIYAFRNQEIQKAL 268
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
40-322 1.91e-07

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 52.21  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYfIINLALADLcMAAFNATFnFIYASHNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:PHA02834  35 YILLFIFGLIGNVLVIAVLIVKRFMFVVDVY-LFNIAMSDL-MLVFSFPF-IIHNDLNEWIFGEFMCKLVLGVYFVGFFS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAV-IWLVALALASPQCFYSTITVDQGATKCVVawpnDNGGKMLLLYH 198
Cdd:PHA02834 112 NMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVaAWVCSVILSMPAMVLYYVDNTDNLKQCIF----NDYHENFSWSA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 LVVFVLIYF---LPLVVMFAAYSVIGLTLwkravprhqahgANLRHlQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTF 275
Cdd:PHA02834 188 FFNFEINIFgivIPLIILIYCYSKILYTL------------KNCKN-KNKTRSIKIILTVVTFTVVFWVPFNIVLFINSL 254
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 276 QE----DI---YYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRSGFRLAF 322
Cdd:PHA02834 255 QSvgliDIgcyHFKKIVYSIDIAEL-ISFVHCCVNPIIYAFVGKNFKKVFKNMF 307
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
45-315 2.84e-07

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 51.44  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM-------AAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAM 117
Cdd:cd15964   12 LLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMgiyllliASVDLHTRSEYYNHAIDWQTGPGCNTAGFFTVFAS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQP--RLSAPSTKAVIAVIWLVALALAspqcFYSTITVDQGAtKCVVAWPNDNGGKMLL 195
Cdd:cd15964   92 ELSVYTLTVITLERWYAITFAMRLdrKIRLRHASAIMLGGWVFCFLLA----LLPLVGVSSYA-KVSICLPMDTETPLAQ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 196 LYhlVVFVLIY-FLPLVVMFAAYSVIGLTLwkravprhqaHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIlgt 274
Cdd:cd15964  167 AY--IVFVLMLnIIAFVIICACYIKIYITV----------RNPQYKSGDKDTKIAKRMAVLIFTDFICMAPISFYAL--- 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 275 fqEDIYYRKFI----QQVYLALFWLAMSSTmyNPIIYCCLNHRFR 315
Cdd:cd15964  232 --SAILNKPLItvsnSKILLVLFYPLNSCA--NPFLYAIFTKAFR 272
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
120-315 3.04e-07

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 51.32  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHPFQPR-LSAPS-TKAVIAVIWLVALALASPQCFYSTITVDQGATKCVvawpndngGKMLLLY 197
Cdd:cd15129   89 SIWITVLLTVDRYVALCHPLRYRaVSYPErTRRIIAAVFVAALATGIPFYWWSDMWRDSHPPTTL--------DKVLKWT 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVfvlIYFLPLVVMFAAYSVIGLTLWKRAvprhqahGANLRHLQAKKkfVKAMVLVVVT-FAICWLP------YHLYf 270
Cdd:cd15129  161 HCFI---IYFIPCTIFLVTNSVIIHKLRRRK-------GRSGPQRRSGK--TTAILLAITTvFAVLWAPrtvviiYHLY- 227
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 271 iLGTFQEDiyyrkfiQQVYLAL---FWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15129  228 -VSSVNRD-------WRVHLALdlaNMLAMLNTAVNFFLYCFVSKRFR 267
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
40-318 3.49e-07

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 51.34  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHER----MRTVTNYfIINLALADLCMAAFNATFNFiYAShnIWY-----FGSTFCYFQN 110
Cdd:cd15135    7 YSLILVAGILGNSATIKVTQVLQKkgylQKSVTDH-MVSLACSDLLVLLLGMPVEL-YSA--IWDpfatpSGNIACKIYN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFVSIYSMTAIAADRYMAIVHPFQPR-LSAPSTKAVIAVIWLVALALASPQCF-------YSTITVDQGATKCV 182
Cdd:cd15135   83 FLFEACSYATILNVATLSFERYIAICHPFKYKaLSGSRVRLLICFVWLTSALVALPLLFamgtedpLEAFPSYRGTRHHC 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 183 vawpNDNGGKML----LLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWK--RAVPRHQ----AHGANLRHLQ--------- 243
Cdd:cd15135  163 ----QDQKSNLTictsLSSKWTVFQASIFSAFVLYLLVLASVAFMCRRmmRALMGSKkgavAVKGPGGSVQllrkhesae 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 244 ---AKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQ-----EDIYYRKFI--QQVYLALFWLamsSTMYNPIIYCCLNHR 313
Cdd:cd15135  239 gktARKQTILFLGLIVGTLAVCWMPNQIRRIMAAAKpkddwTRSYFRAYIilLPIADTFFYL---SSVLNPLLYNLSSQQ 315

                 ....*
gi 258613887 314 FRSGF 318
Cdd:cd15135  316 FRSVF 320
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
35-283 4.93e-07

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 50.89  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNY-FIINLALADLCMAAFnATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd14983    2 LSLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNViYMINLCLSDLVFILS-LPIKIVEALSSAWTLPAVLCPLYNLAH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVA-------LALASPQCFYSTITVDQGATKCVVA 184
Cdd:cd14983   81 FSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLvcVAIWALVifhvtlvFILETSGGTLDINTPVGNSSTCYEN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 185 WpNDNGGKMLLLYHLVVFVLIYFLPLVV-MFAAYSVIgltlwkRAVPRhqahgaNLRHLQAKKKFVKAMVLVVVTFAICW 263
Cdd:cd14983  161 F-TPEQLALLAPVRLELSLVLFFLPLAItAFCYVRCI------RILVR------SRLHERRKRRAVRVAVSTLLTFVVCF 227
                        250       260
                 ....*....|....*....|.
gi 258613887 264 LPYHLYFILGTFQ-EDIYYRK 283
Cdd:cd14983  228 GPYNISHVVGFVRhESVWWRK 248
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
45-317 5.73e-07

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 50.47  E-value: 5.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERmRTVTNYFIINLALAD---LCmaafnatFNFIYASHNIWYFGSTFCYFQNLFPVTAMF--V 119
Cdd:cd15107   12 LVGLAGNAIVLWLLGFHMH-RNAFSVYILNLAGADflfLC-------TQIVFSLEIVLQFHSIDIHIPLFLLTVTMFayL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSM-TAIAADRYMAIVHPFQPRLSAPS-TKAVI-AVIWLVAL---ALASPQCFYSTITVDQGATKcvvawpndnggkm 193
Cdd:cd15107   84 AGLSMiTAISIERCLSVMWPIWYHCQRPRhTSAVIcTLLWVLSLllsLLEGKGCGFLFSTYDYYWCW------------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 194 lllyhlvVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRhqahganlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG 273
Cdd:cd15107  151 -------TLDLITTAWLIVLFVVLSGSSLALLVRIFCG--------SHRIPVTRLYVTIALTVLVFLIFGLPFGIYWFLL 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 274 TFQEDIYYrKFIQQVYLALFWLAMSSTMYNPIIYCCL----NHRFRSG 317
Cdd:cd15107  216 KWIEEFYI-VPCCGFYEVILFLSCVNSCANPIIYFLVgsirHHRFQRK 262
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-318 6.39e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 50.18  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNL------FP 113
Cdd:cd15103    7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsMI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWlvalalaspqcfystitvdqgaTKCVVAwpndnGG 191
Cdd:cd15103   87 CSSLLASICSLLAIAVDRYITIFYALRYHsiMTVRRAGVIITAIW----------------------VFCTVC-----GI 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYH--LVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQA--HGANLRHLQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15103  140 LFIIYSDsvPVIICLISMFFAMLVLMASLYVHMFLLARSHVKKIAalPGQRSTRQRANMKGAVTLTILLGVFIFCWAPFF 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 268 LYFILGTF-QEDIYYRKFIQ--QVYLALFwlaMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15103  220 LHLTLMIScPSNPYCACYMShfNVYLILI---MCNSVIDPLIYAFRSQELRKTF 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
40-140 6.86e-07

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 50.38  E-value: 6.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMA---AFNATFNFIYASHNIWYFG-STFCYFQNLFPVT 115
Cdd:cd15419    7 FLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSsviAPKALANFLSESKTISYNGcAAQFFFFSLFGTT 86
                         90       100
                 ....*....|....*....|....*
gi 258613887 116 AMFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15419   87 EGFL----LAAMAYDRFIAICNPLL 107
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
37-318 7.13e-07

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 50.29  E-value: 7.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVL--VAVTGNATVIWIILAHERMRTVTNY-FIINLALADLCMAAFnatfnFIYASHNIWYF---GSTFCYFQN 110
Cdd:cd15340    2 AIAVLSLTLgtFTVLENLLVLCVILHSRSLRCRPSYhFIGSLAVADLLGSVI-----FVYSFLDFHVFhrkDSPNVFLFK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 111 LFPVTAMFV-SIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALAS-PQCFYSTITVDqgaTKCVVAWP 186
Cdd:cd15340   77 LGGVTASFTaSVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAfcVMWTIAIVIAVlPLLGWNCKKLN---SVCSDIFP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 NDNgGKMLLLYHLVVFVLIYFLPLVVMFaaysviglTLWK--------------RAVPRHQAHGANLRHLQAKK-----K 247
Cdd:cd15340  154 LID-ETYLMFWIGVTSVLLLFIVYAYMY--------ILWKahhhavrmlqrgtqKSIIVYTSEDGKVQTTRPDQtrmdiR 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 248 FVKAMVLVVVTFAICWLPyhlyfILGTFQEDIYYR--KFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15340  225 LAKTLVLILVVLIICWGP-----LLAIMVYDVFGKmnKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
40-316 8.49e-07

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 50.20  E-value: 8.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILaheRMRTVTNY--FIINLALADLCMAAfnaTFNF-IYASHNI--WYFGSTFCYFQNLFPV 114
Cdd:cd15150    7 YTVLFIVGLTMNGLAMRVFF---QIPSKSNFiiFLKNTVISDLLMIL---TFPFkILSDAKLgsWPLRGFVCQVTSVIFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFqpRLSAPST----KAVIAVIWLVALALASPQ-CFYSTITVDQGATKCvvawpNDN 189
Cdd:cd15150   81 FTMYISILFLGLITIDRYQKTTRPF--KTSNPKNllgaKILSTVIWASMFALSLPNmILTNRQPTPKNVKKC-----SLL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 190 GGKMLLLYHLVVFV---LIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKkkfvkaMVLVVVTFAICWLPY 266
Cdd:cd15150  154 KSEFGLVWHEIVNYicqVIFWVNFLIVIVCYTLITKELYKSYKRTRGVGKVSRKKVNVK------VFIIIAVFFICFVPF 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 258613887 267 HLYFILGTFQEDIYYRKFIQQVYL-----ALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15150  228 HFARIPYTLSQTRDVFDCTAKNTLfyvkeSTLWLTSLNACLDPFIYFFLCKSFRN 282
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
36-183 1.04e-06

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 49.85  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVL--VAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15127    1 YAVMCLSVVIfgIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIE 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHP---FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQG------ATKCVV 183
Cdd:cd15127   81 VASLGVTTFTLCALCIDRFRAATNVqmyYEMIENCTSTTAKLAVIWVGALLLALPEVVLRQLSKEDGgsgappAERCVV 159
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
45-163 1.18e-06

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 49.48  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM-------AAFNATFNFIYASHNI-WYFGSTfCYFQNLFPVTA 116
Cdd:cd15359   12 ILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMglyllliASVDSQTKSQYYNHAIdWQTGSG-CSTAGFFTVFA 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVI--WLVALALA 163
Cdd:cd15359   91 SELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLggWVFSLLIA 139
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
37-318 1.38e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 49.17  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNA---TFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15354    4 AEVFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAwetITIYLLNNRHLVIEDAFVRHIDNVFD 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 ---VTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITvdqgatkcvvawpnd 188
Cdd:cd15354   84 sliCISVVASMCSLLAIAVDRYVTIFYAlrYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSEST--------------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 nggkmlllYHLVVFVLIYFLPLVVMFAAYSVIGLtLWKRAVPRHQA-HGANLRHLQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15354  149 --------YVIICLITMFFAMLFLMVSLYIHMFL-LARTHVKRIAAlPGYNSVRQRTSMKGAVTLTILLGIFIVCWAPFF 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 268 LYFILG-TFQEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15354  220 LHLILMiSCPQNLYCVCFMSHFNMYLI-LIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
70-318 1.43e-06

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 49.49  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  70 YFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVhpfQPRLSAPSTK 149
Cdd:cd15346   37 YFIGNLALSDL-LAGVAYTANLLLSGATTYKLTPTQWFLREGSMFVALSASVFSLLAIAIERYITML---KMKLHNGSNS 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 150 A----VIAVIWLVALALAS-PQCFYSTITvdqGATKCVVAWPNDNggKMLLLYHLVVFVLIyFLPLVVMFAAYSVIGLTL 224
Cdd:cd15346  113 FrsflLISACWVISLILGGlPIMGWNCIS---ALSSCSTVLPLYH--KHYILFCTTVFTLL-LLSIVILYCRIYSLVRTR 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 225 WKRAVPRHQAHGANlRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILG----TFQEDIYYRKfiqQVYLAlfwLAMSST 300
Cdd:cd15346  187 SRRLTFRKNIRKAS-RSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDvgckVKTCSILFKA---EYFLV---LAVLNS 259
                        250
                 ....*....|....*...
gi 258613887 301 MYNPIIYCCLNHRFRSGF 318
Cdd:cd15346  260 ATNPIIYTLTNKEMRRAF 277
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
43-211 1.48e-06

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 49.65  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  43 LVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFnaTFNFIYAS---HNIWYFGSTFCYFQNLFPVTAMFV 119
Cdd:cd15218   10 IIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAI--CFPFVFTSvknGSTWTYGTLTCKVIAFLGVLSCFH 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCF----YSTI-TVDQGATKCVVAWPNDNGGK 192
Cdd:cd15218   88 TAFMLFCISVTRYLAIAHHrfYTKRLTFWTCLAVICMVWTLSVAMAFPPVLdvgtYSFIrEEDQCTFQHRSFRANDSLGF 167
                        170
                 ....*....|....*....
gi 258613887 193 MLLLYHLVVFVLIYFLPLV 211
Cdd:cd15218  168 MLLLALILLATQLVYLKLI 186
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
35-315 1.83e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 48.99  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRT-VTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15219    1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGG 191
Cdd:cd15219   81 TFLTSNAMLSMAALSIDRWIAVVFPlsYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLYASCTLHLPREEER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYsvigLTLWKraVPRHQahganlrhlQAKKKfvkaMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15219  161 RRFAVFTAFFHAFTFLLSLLVLCVTY----LKVLK--VRRRQ---------RATKK----ISIFIGTFVLCFAPYVITRL 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887 272 LgtfqediyyrKFIQQVYLALFW------LAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15219  222 V----------ELLPFVTINRYWgivskcLTYSKAASDPFVYSLLRQQYR 261
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
40-318 2.17e-06

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 48.62  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM-AAFNA--------TFNFIYAshnIWYF--GSTFcyf 108
Cdd:cd15102    7 FVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAgAAYLAnillsgarTLRLSPA---QWFLreGSMF--- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 109 qnlfpvTAMFVSIYSMTAIAADRYMAIVhpfQPRLSAPSTK----AVIAVIWLVALALASPQCFystitvdqgATKCVVA 184
Cdd:cd15102   81 ------VALSASVFSLLAIAIERHLTMA---KMKPYGASKTsrvlLLIGACWLISLLLGGLPIL---------GWNCLGA 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 185 WpnDNGGKMLLLY--HLVVF-VLIYFLPLVVMFAAYSVIGLTLWKRA--VPRHQAHGANLRHLqakkkfvKAMVLVVVTF 259
Cdd:cd15102  143 L--DACSTVLPLYskHYVLFcVTIFAGILAAIVALYARIYCLVRASGrkATRASASPRSLALL-------KTVLIVLLVF 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 258613887 260 AICWLPYHLYFILgtfqeDIYYRKFIQQVYLALFW---LAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15102  214 IACWGPLFILLLL-----DVACPVKTCPILYKADWflaLAVLNSALNPIIYTLRSRELRRAV 270
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
41-318 2.23e-06

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 48.64  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFgSTFCYF--QNLFPvTAMF 118
Cdd:cd15342    8 LTVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADL-FAGVAYLFLMFHTGPWTAKL-SLYQWFlrQGLLD-TSLT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVH-PFQPRLSAPSTKAVIAVIWLVALALAspqcfystiTVDQGATKCVVAWpnDNGGKMLLLY 197
Cdd:cd15342   85 ASVANLLAIAVERHQTIFTmQLHSKMSNQRVVILIFGIWMVALILG---------LIPAMGWNCLCDL--KRCSTMAPLY 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 ---HLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL-G 273
Cdd:cd15342  154 srsYLVFWALSNLLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRYRETVLGLMKTVVIILGAFVVCWTPGQVVLLLdG 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 258613887 274 TFQED---IYYRKFIqqvylalFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15342  234 LGCEScnvLAYEKYF-------LLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
40-277 2.74e-06

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 48.29  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATFNFiyASHNIWYFGSTfcyfqnLFPVTAMFV 119
Cdd:cd15171    7 CSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLC---FLLTLPF--WAHAAWHGGSL------GNPTCKVLV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 120 SIYS--MTAIAADRYMAIVHP----FQPRLSAPSTK----AVIAVI--WLVALALASPQCFYSTITVDQGATKCVVAWP- 186
Cdd:cd15171   76 ALSSvgLHSEALFNVLLTVQAsrvfFHGRLASSARRvapcGIIASVlaWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPh 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 187 ----NDNGGKMLLLYHLVVFVLIyfLPLVVMfaaysvIGLTLWKRAVPRHQahganlrhlQAKKKFVKAMVLVVVTFAIC 262
Cdd:cd15171  156 flpaEETFWKYFLTLKMNIVVLV--FPLLVF------IICCVQLRKTQRFR---------ERQRDLSKLVFAIMVVFLLM 218
                        250
                 ....*....|....*
gi 258613887 263 WLPYHLYFILGTFQE 277
Cdd:cd15171  219 WAPYNIALFLSAFKE 233
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
37-315 3.84e-06

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 47.90  E-value: 3.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTA 116
Cdd:cd15348    4 AVAFLAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDL-LAGAAYAANILMSGANTLKLTPALWFLREGGVFIT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVH-PFQPRLSAPSTKAVIAVIWLVALALAS-PQCFYSTITVDQGATKCVVAWpndngGKML 194
Cdd:cd15348   83 LTASVFSLLAIAIERHITMVRmKPYPGDKRGRMFLLIGAAWLVSILLGVlPILGWNCLGNLDACSTVLPLY-----AKSY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIyFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGAnLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15348  158 ILFCITVFLAI-LAAIVVLYARIYRIVKANSQRLGALPTRKGR-ARRSQKYLALLKTVTIVLGTFVACWLPLFLLLLLDV 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 258613887 275 FQEDIYYRKFIQQVYLalFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15348  236 SCPAQACPVLLKADYF--LGLAMINSLLNPIIYTLTSRDMR 274
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
36-318 8.11e-06

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 47.06  E-value: 8.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALAD-LCMAA--FNATFNFIYAShniWYFGSTFCYFQNLF 112
Cdd:cd15167    3 FTYFYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADfLLTLAlpVKIAVDLGIAP---WKLKIFHCQVTACL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQ-PRLSAPS-TKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNG 190
Cdd:cd15167   80 IYINMYLSIIFLGFVSIDRYLQLTHSSKlYRIQEPGfAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEFG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 191 gkmlLLYHlvvfVLIYFLPLVVMFAAySVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKaMVLVVVTFAICWLPYHLYF 270
Cdd:cd15167  160 ----RHWH----VLTNFICMAIFLNF-SAIILISNFLVIRKLYRNKDSEEYRNARQALVN-ILLVTAGYVICFVPYHIVR 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 271 ILGTFQE-----DIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15167  230 IPYTLSQsevitDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
34-272 9.04e-06

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 46.67  E-value: 9.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  34 ALWATAYLALVLVavTGNATVIWIILAHERMRTVTNYFIINLALADLCMAafnATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15905    1 IFWLSVPLSSLII--FANLFIILGIACNRKLHNTANYFFLSLLLADLLTG---VALPFIPGMSNESRRGYHSCLFVYVAP 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALASPQCFystitvdqgatkcvvAWPNDNGG 191
Cdd:cd15905   76 NFLFLSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLAllLTWALPLLFACLPAL---------------GWNNWTPG 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KmLLLYHLV-----VFVLIYFLPLVVMFAAYSVIGLTLW------------KRAV----PRHQAHGANLRHlqakkkfVK 250
Cdd:cd15905  141 S-NCSYKQVfpaayIYLEVYGLVLPSILAIAFMSVRVLAvarrqlqdicklLRAVqrdgPSELEQQLNLRY-------AK 212
                        250       260
                 ....*....|....*....|..
gi 258613887 251 AMVLVVVTFAICWLPYHLYFIL 272
Cdd:cd15905  213 CIAGVSLTFLVCWVPYIAYLLM 234
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
35-140 9.69e-06

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 46.68  E-value: 9.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGstfCYFQNL 111
Cdd:cd15227    2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVtvpKSIANSLTNTRSISFLG---CVAQVF 78
                         90       100
                 ....*....|....*....|....*....
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPFQ 140
Cdd:cd15227   79 LFIFFAASELALLTVMAYDRYVAICHPLH 107
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
72-315 1.51e-05

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 46.40  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  72 IINLALADLCMA-------AFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQ-PRL 143
Cdd:cd15965   39 IISLCCADCLMGiylfvigAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRcLTP 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 144 SAPSTKAVIAVIWLVALALA----SPQCFYSTITVDQGAtkCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSV 219
Cdd:cd15965  119 GKCRTITILILIWIIGFIIAfiplSNKEFFRNYYGTNGV--CFPLHSEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGS 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 220 IGLTLWKRAVPRHQAHGanlrHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIyyrKFIQQVYLALFWLAMSS 299
Cdd:cd15965  197 MFYSIHQTAIMATEISN----HIKKEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQVEI---PGTISSWVVIFILPINS 269
                        250
                 ....*....|....*.
gi 258613887 300 TMyNPIIYCCLNHRFR 315
Cdd:cd15965  270 AL-NPILYTLTTRPFK 284
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
12-138 1.76e-05

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 46.20  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  12 ILSGLESNatgvtafsmPGWQLALWATaYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMA---AFNAT 88
Cdd:cd15943    3 ILLGLTDN---------PELQVILFAV-FLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSsaiTPKML 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 258613887  89 FNFIYASHNIWYFGstfCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15943   73 VNFLAENKTISFTG---CAAQMYFFVAFATTECFLLAVMAYDRYVAICNP 119
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
40-138 1.92e-05

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 45.68  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNAT------FNFIYASHNIWYFGstfCYFQNLFP 113
Cdd:cd15918    7 FLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDIC---FTSTtvpkmlVNIQTQSKSISYAG---CLTQMYFF 80
                         90       100
                 ....*....|....*....|....*
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15918   81 LLFGDLDNFLLAVMAYDRYVAICHP 105
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
41-323 2.46e-05

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 45.47  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYfIINLALADLCMAAFNATFNFIYASHniWYFGSTFCYFQNL-FPVTAMF- 118
Cdd:cd15110    8 LIICLLGLVGNGIVLWFLGFRIRRNPFTVY-ILHLAIADFTFLLCIFILSIMYIGP--FNFSHSRDYVAMLiFIILFLFg 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 --VSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI--AVIWLVALALASPQCFYSTITVDQGATKCVvawpndnggkML 194
Cdd:cd15110   85 ynTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIvcGLLWALSVLMTSLEYLMCIDEGFHVRNECR----------AV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 195 LLYHLVVFVLIyFLPLVVMFAAYSVIGLTlwkravprhqahgANLRHLQAKKKFVkAMVLVVVTFAICWLPYHLYFILGT 274
Cdd:cd15110  155 LIFIGILTFLV-FTPLMLISSLILFIKVR-------------CNSQRRHPGKLYI-IIMLTVIFFLIFAMPMRVLLLLNY 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258613887 275 FqediYYRKFIQQV-YLALFWLAMSSTmyNPIIY----CCLNHRFRSGFRLAFR 323
Cdd:cd15110  220 L----HHSSFLFSNpVPFLLSTVNSSI--NPIVYflvgSLRRKRIKKSLKVALQ 267
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
40-318 2.87e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.16  E-value: 2.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWY------FGSTFCYFQNLFP 113
Cdd:cd15350    7 FFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYlnrrgpFETKLDDIMDSLF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWLValalaspqCFYSTITvdqgatkcvvawpndngg 191
Cdd:cd15350   87 CLSLLGSIFSILAIAADRYITIFHALRYHniMTMRRTLVILAIIWTF--------CGGSGIL------------------ 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 kMLLLYH----LVVFVLIYFLPLVVMFAAYsvIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVV--TFAICWLP 265
Cdd:cd15350  141 -MILFFHfvatVICFTVLFFLMLVLILCLY--VHMFLLARSHARKIASLPNHHAQHQRSNMRGAITLTILlgVFVCCWAP 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 258613887 266 YHLYFILGTFQEDIYYrkfiQQVYLALF----WLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15350  218 FVLHLLLMMFCPMNPY----CACYRSLFqvngTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
40-138 3.18e-05

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 45.10  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNAT---FNFIYASHNIWYFGstfCYFQNLFpvTA 116
Cdd:cd15415    7 FLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPrllVNFLVEKKTISYSA---CIAQHFF--FA 81
                         90       100
                 ....*....|....*....|....
gi 258613887 117 MFVSI--YSMTAIAADRYMAIVHP 138
Cdd:cd15415   82 VFVTTegFLLAVMAYDRYVAICNP 105
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
50-319 3.48e-05

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 45.13  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  50 GNATVIWIiLAHERMRTVTNYFIINLALAD----LCMAAFNA--TFNFIYASHNIWYFGSTFCYFqnlfpvtAMFVSIYS 123
Cdd:cd15108   17 GNGLVVWL-LSCRGRRTPFCVYVLHLAVADllflLCMASTLSleTSPLVITHDLAYEVVRRVKYF-------AYTASLSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 124 MTAIAADRYMAIVHPF------QPRLSApstkAVIAVIWLVALALASPQCFYstitvdqgatkCVVAWPNDNGGKMLLLY 197
Cdd:cd15108   89 LTAISTQRCLSVLFPIwykchqPRHLSA----VVCALLWALSLLMNVLASFF-----------CSEFWHPDEWQCFKVDM 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 198 HLVVFVLIYFLPLVVMfaaySVIGLTLWKRAVPRHQahganlrHLQAKKKFVKAMVLVVVtFAICWLPYHLYFILgtfqe 277
Cdd:cd15108  154 VFSFLIMGIFTPVMAL----SSLILFVRVRRSSRQW-------RRRPTRLYVVVLASVLV-FLACALPLGIYWFL----- 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 278 dIYYRKFIQQV-----YLALFWLAMSSTMyNPIIYCCLNHRFRSGFR 319
Cdd:cd15108  217 -LYWLDLPQEVktlfsCLSRLSSSVSSSA-NPVIYFLVGSRGSRRLR 261
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
41-323 4.02e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 45.19  E-value: 4.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERmrtVTNYFIINLALADLCMAAF--NATFNFIYAShNIWYFGSTF--CYFQNLFPVTA 116
Cdd:PHA03235  40 LLIISVGGPLNLIVLVTQLLANR---VHGFSTPTLYMTNLYLANLltVFVLPFIMLS-NQGLLSGSVagCKFASLLYYAS 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQPRLSA-PSTKAVIAVIWLVALALASPQCFYSTI----TVDQGAT---KCVVAWPND 188
Cdd:PHA03235 116 CTVGFATVALIAADRYRVIHQRTRARSSAyRSTYKILGLTWFASLICSGPAPVYTTVvahdDVDPEAPgyeTCVIYFRAD 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 NGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLwKRAVPRHQAhganlRHLQakkkFVKAMVLvvvTFAICWLPYHL 268
Cdd:PHA03235 196 QVKTVLSTFKVLLTLVWGIAPVVMMTWFYTFFYRTL-KRASYKKRS-----RTLT----FVCILLL---SFLCLQTPFVA 262
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258613887 269 YFILGTFQ--------EDIYYRKFIQqvYLALFWLAMsSTMYNPIIYCCLNHRFRSGFRLAFR 323
Cdd:PHA03235 263 IMIFDSYAtliwpsdcEHINLRDAVS--TLSRLVPNL-HCLLNPILYAFLGNDFLKRFRQCFR 322
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
35-138 4.15e-05

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 44.95  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNAT---FNFIYASHNIWYFGstfCYFQNL 111
Cdd:cd15231    2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPkmlVNLLRERKTISYIG---CLAQLF 78
                         90       100
                 ....*....|....*....|....*..
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15231   79 FFVSFVGTECLLLAVMAYDRYVAICNP 105
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
29-138 4.47e-05

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 44.67  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  29 PGWQLALWATaYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGstf 105
Cdd:cd15406    6 PELQLPLFLL-FLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVitpKMLVNFVSEKNIISYPE--- 81
                         90       100       110
                 ....*....|....*....|....*....|...
gi 258613887 106 CYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15406   82 CMTQLFFFCVFAIAECYMLTAMAYDRYVAICNP 114
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
36-166 6.05e-05

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 44.47  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  36 WATAYLALVLVAV--TGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFP 113
Cdd:cd15126    1 YGILLLALVVFAVgiVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYME 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPF---QPRLSAPSTKAVIAVIWLVALALASPQ 166
Cdd:cd15126   81 VTSLGVTTFSLCALGIDRFHAATSPQpkaRPVERCQSILAKLAVIWVGSMTLAVPE 136
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
40-138 7.91e-05

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 43.85  E-value: 7.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMA---AFNATFNFIYASHNIWYFgstFCYFQNLFPVTA 116
Cdd:cd15413    7 FLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYStavTPKMLVNFVVEQNTISFY---ACATQLAFFLTF 83
                         90       100
                 ....*....|....*....|..
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15413   84 IISELFLLSAMAYDRYVAICNP 105
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
39-315 8.62e-05

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 44.07  E-value: 8.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYfIINLALADLCMAAfnaTFNFIYASH---NIWYFGSTFCYFQNLFPVT 115
Cdd:cd15149    6 FYSLVFIVGILLNGVNFWIFFYVPSNKSFIVY-LKNIVFADLLMSL---TFPFKILSDvelGPWQLNVIVCRYSAVIFYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHPFQPRL--SAPSTKAVIAVIWLVALALASPQCFYSTITV-DQGATKCV-------VAW 185
Cdd:cd15149   82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFvqNVGYSKALSVVVWMLMAVLSVPNIILTNQSFhEANYTKCArlkselgIQW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 186 PNDNGGKMLLLYHLVVFVLIYFlplvvmfaaYSVIGLTLWKrAVPRHQAHGANLrhlqaKKKFVKAMVLVVVTFAICWLP 265
Cdd:cd15149  162 HKASNYICVSIFWVVFLLLIIF---------YVAISRKIYK-SNQKFRRNSTNM-----KAKSSRNIFSILFVFFVCFVP 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 258613887 266 YHLYFILGTF-----------QEDIYYRKFIQqvylalFWLAMSSTMYNPIIYCCLNHRFR 315
Cdd:cd15149  227 YHALRIPYTLsqtgadyscqsKTILYYMKEFT------LLLSAANVCLDPIIYFFLCQPFR 281
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
42-163 9.47e-05

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 43.56  E-value: 9.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIwyfGSTFCYFQNLFPVTAMF 118
Cdd:cd15950    9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSivpKMLSIFWLGSAEI---SFEACFTQMFFVHSFTA 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVALALA 163
Cdd:cd15950   86 VESGVLLAMAFDRYVAICHPL--RYSAILTSQVIAQIGLAIVLRA 128
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
45-316 1.09e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 43.67  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNY-FIINLALAD-LCMAAFNATFNFIYASHNIwyfGSTFCYFQNLFPVTAMFV-SI 121
Cdd:cd15341   12 LLCILENVAVLYLILSSPKLRRKPSYlFIGSLALADfLASVVFACSFVDFHVFHGV---DSSAIFLLKLGGVTMSFTaSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPRLSAPSTKAVIA--VIWLVALALAS-PQCFYSTITVDQGATKCVVAWPNDnggkmlLLYH 198
Cdd:cd15341   89 GSLLLMAFDRYVCIYYPSEYKALVTRKRALVAlaVMWVLTALIAYlPLMGWNCCPLNSPCSELFPLIPND------YLLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 199 LVVFVLIYFLPLVVMFaaysviGLTLWKR-----AVPRHQAH-GANLRHLQAKKKFVKAMVLVVVTFAICWLPyhlYFIL 272
Cdd:cd15341  163 WLLLVAILLSGIIYTY------GHVLWKAhkhvvYMEKHQDQqGPGNARMRLDVRLAKTLGLVLAVLLICWSP---VLAL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 258613887 273 GTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15341  234 MMHSLFTSLSDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRS 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
40-140 1.13e-04

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 43.55  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGstfCYFQNLFPVTA 116
Cdd:cd15409    7 FLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSvtpKMLVNFLSKNKMISFSG---CAAQFFFFGFS 83
                         90       100
                 ....*....|....*....|....
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFQ 140
Cdd:cd15409   84 ATTECFLLAAMAYDRYVAICNPLL 107
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
41-140 1.52e-04

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 42.86  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFG-STFCYFQNLFPVTA 116
Cdd:cd15912    8 LLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVvipKMLANLLSGKKTISFAGcFAQSFFYFFLGTTE 87
                         90       100
                 ....*....|....*....|....
gi 258613887 117 MFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15912   88 FFL----LAVMSFDRYVAICNPLH 107
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
45-307 1.53e-04

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 43.20  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYfIINLALAD---LCMAAFNATFNFIYASHNIWYfgSTFCYFQNLFPvtaMFVSI 121
Cdd:cd15106   12 LVGLTGNAVVLWLLGFRMRRNAFSVY-ILNLAAADflfLCCHIIDSLLRLINIFHIISI--PKILTNVMTFP---YFAGL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 YSMTAIAADRYMAIVHPFQPRLSAPS-TKAVIAV-IWLVALALASPQCFYSTITVDQGATkcvvawpndnggkmlLLYHL 199
Cdd:cd15106   86 SMLSAISTERCLSVLWPIWYRCHRPRhLSAVVCVlLWALSLLLSILEWKFCGFLFSGADS---------------HWCQT 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFlpLVVMFAAYSVIGLTLWKRAVprhqahgANLRHLQAKKKFVkAMVLVVVTFAICWLPYHLY-FILGTFQED 278
Cdd:cd15106  151 FDFITTAW--LIFLFVVLCGSSLALLVRIL-------CGSRKMPLTRLYV-TILLTVLVFLLCGLPFGIQwFLLLWIHID 220
                        250       260
                 ....*....|....*....|....*....
gi 258613887 279 IYYrkFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15106  221 LEV--LFCHVYLVSVVLSCLNSSANPIIY 247
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
40-140 1.56e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 42.98  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATF------NFIYASHNIWYFGS-TFCYFQNLF 112
Cdd:cd15235    8 FLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDIC---FTSTTvpkmlaNLLSGSKTISYAGClAQMYFFIAF 84
                         90       100
                 ....*....|....*....|....*...
gi 258613887 113 PVTAMFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15235   85 GNTDSFL----LAVMAYDRYVAICHPLH 108
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
41-140 1.63e-04

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 42.92  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLC--------MAAfnatfNFIYASHNIWYFGstfCYFQNLF 112
Cdd:cd15421    8 LLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMlisttvpkMAT-----NFLSGRKSISFVG---CGTQIFF 79
                         90       100
                 ....*....|....*....|....*...
gi 258613887 113 PVTAMFVSIYSMTAIAADRYMAIVHPFQ 140
Cdd:cd15421   80 FLTLGGAECLLLALMAYDRYVAICHPLR 107
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
40-140 2.31e-04

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 42.63  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNAT---FNFIYASHNIWYFG-STFCYFQNLFPVT 115
Cdd:cd15417    7 FLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPkmlSDFFREQKTISFVGcATQYFVFSGMGLT 86
                         90       100
                 ....*....|....*....|....*
gi 258613887 116 AMFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15417   87 ECFL----LAAMAYDRYVAICNPLL 107
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
40-139 3.03e-04

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 42.31  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNATF------NFIYASHNIWYFGstfCYFQNLFP 113
Cdd:cd15408   20 FLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDIC---YSSTItpktllNLLAERKVISFTG---CLTQLYFY 93
                         90       100
                 ....*....|....*....|....*.
gi 258613887 114 VTAMFVSIYSMTAIAADRYMAIVHPF 139
Cdd:cd15408   94 AVFATTECYLLAAMAYDRYVAICNPL 119
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
115-316 3.49e-04

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 41.81  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPR-LSAPS-TKAVIAVIWLVALALASPQCFYSTItvdqgatkcvvaWPNDNggK 192
Cdd:cd15919   84 SSIHTSIWITVPLTIDRYIAVCHPLKYHtVSYPArTRKVIVSVYITCFLTSIPYYWWPNI------------WIEDY--T 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFV---LIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANlrhlqakkKFVKAMVLVVVTFAICWLPYHLY 269
Cdd:cd15919  150 STSMHHVLIWIhcfTVYLVPCSIFFVLNSIIVYKLRRKSNFRLRGYSTG--------KTTAILFTITSIFAILWAPRIIM 221
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 258613887 270 FILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRS 316
Cdd:cd15919  222 ILYHLYVSPINNSWLVHIVSDIANMLALLNTAINFFLYCFISKRFRT 268
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
40-138 4.36e-04

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 41.63  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGS-TFCYFQNLFPVT 115
Cdd:cd15405    7 FLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVftpKMLMNFVSEKNTISYAGCmTQLFFFCFFVIS 86
                         90       100
                 ....*....|....*....|...
gi 258613887 116 AMFVsiysMTAIAADRYMAIVHP 138
Cdd:cd15405   87 ECYV----LTAMAYDRYVAICNP 105
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-138 4.37e-04

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 41.70  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfnAT-----FNFIYASHNIWYFGstfCYFQNLFPVTAMFV 119
Cdd:cd13954   12 LLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTS--VTvpkmlANLLSGDKTISFSG---CLTQLYFFFSLGGT 86
                         90
                 ....*....|....*....
gi 258613887 120 SIYSMTAIAADRYMAIVHP 138
Cdd:cd13954   87 ECFLLAVMAYDRYVAICHP 105
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
40-140 4.52e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 41.47  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGS-TFCYFQNLFPVT 115
Cdd:cd15232    7 FLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTvvpKLLQNLLTERKTISFGGCmAQLYFFTWSLGS 86
                         90       100
                 ....*....|....*....|....*
gi 258613887 116 AMFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15232   87 ELLL----LTAMAYDRYVAICHPLH 107
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
40-138 4.64e-04

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 41.69  E-value: 4.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNAT---FNFIYASHNIWYFGstfCYFQNLFPVTA 116
Cdd:cd15944   20 FLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPrmlADFLTKHKVISFSG---CATQFAFFVGF 96
                         90       100
                 ....*....|....*....|..
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15944   97 VDAECYVLAAMAYDRYVAICNP 118
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
39-140 4.92e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 41.27  E-value: 4.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNAT---FNFIYASHNIWYFGS-TFCYFQNLFPV 114
Cdd:cd15940    6 LFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPkmlSDLLSEEKTISFNGCvTQLFFLHLFAC 85
                         90       100
                 ....*....|....*....|....*.
gi 258613887 115 TAMFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15940   86 TEIFL----LTIMAYDRYVAICNPLH 107
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-272 5.97e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 41.32  E-value: 5.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV----- 114
Cdd:cd15351    7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVidtmi 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 -TAMFVSIYSMTAIAADRYMAIVHP--FQPRLSAPSTKAVIAVIWLVALALASPQCFYSTitvDQGATKCVVAWpndngg 191
Cdd:cd15351   87 cSSVVSSLSFLGAIAVDRYITIFYAlrYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYYN---SNAVILCLIVF------ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 kmllLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAhganlrhlqAKKKFVKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15351  158 ----FLFMLVLMLVLYIHMFILACRHSQSISSQQRRQCPHQQT---------ASLKGAITLTILLGIFFLCWGPFFLHLT 224

                 .
gi 258613887 272 L 272
Cdd:cd15351  225 L 225
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
29-138 7.57e-04

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 41.11  E-value: 7.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  29 PGWQLALWATaYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMA---AFNATFNFIYASHNIWYFGstf 105
Cdd:cd15410   10 PELQVPLFLV-FLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSsviAPKMLVNFLAEDKAISYSG--- 85
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 258613887 106 C----YFQNLFPVTAMFVsiysMTAIAADRYMAIVHP 138
Cdd:cd15410   86 CmlqfFFFCTFVVTESFL----LAVMAYDRYVAICNP 118
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
42-160 8.50e-04

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 40.56  E-value: 8.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAfnATFN-----FIYASHNIwyfGSTFCYFQNLFPVTA 116
Cdd:cd15222    9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSL--STLPtvlgiFWFNAREI---SFDACLAQMFFIHTF 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVAL 160
Cdd:cd15222   84 SFMESSVLLAMAFDRFVAICNPL--RYASILTNSRIAKIGLAIV 125
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
40-140 9.27e-04

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 40.46  E-value: 9.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIY--ASHNIWYFGStfCYFQNLFPVTAM 117
Cdd:cd15429    7 FLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHflAEHKTISFAS--CVAQLFISLALG 84
                         90       100
                 ....*....|....*....|...
gi 258613887 118 FVSIYSMTAIAADRYMAIVHPFQ 140
Cdd:cd15429   85 GTEFILLAVMAYDRYVAVCHPLR 107
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
51-318 9.80e-04

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 40.57  E-value: 9.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  51 NATVIWIILAHERMRTVTNYFIINLALADLC--MAAFNATFNFIYASHNIWYfgSTFCYFQNLFPvTAMFVSIYSMTAIA 128
Cdd:cd15101   18 NLLVIAAIYKNRRFHFPIYYLLANLAAADFFagLAYFFLMFNTGPNTRRLTV--STWFLRQGLLD-TSLTASVANLLAIA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 129 ADRYMAIVH-PFQPRLSAPSTKAVIAVIWLVALALASpqcfystitVDQGATKCVVAWpnDNGGKMLLLY---HLVVFVL 204
Cdd:cd15101   95 VERHISVMRmQLHSRLSNRRVVVLIVLVWTMAIVMGA---------IPSVGWNCLCAI--DACSNMAPLYsrsYLVFWAI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 205 IYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFIL---GTFQEDI-Y 280
Cdd:cd15101  164 SNLVTFLVMVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLdglCCRQCNVlA 243
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 258613887 281 YRKFiqqvylaLFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15101  244 VEKF-------FLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
40-138 1.21e-03

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 40.38  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGstfCYFQNLFPVTA 116
Cdd:cd15411    7 FLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTitpKALENFLSGRKAISFAG---CFVQMYFFIAL 83
                         90       100
                 ....*....|....*....|..
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15411   84 ATTECFLLGLMAYDRYVAICNP 105
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
42-168 1.27e-03

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 40.02  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILA----HERMRtvtnYFIINLALADLCMA---AFNATFNFIYASHNIWYFGstfCYFQnLFPV 114
Cdd:cd15951    9 IMYAVALLGNFTILFIVKTepslHEPMY----LFLCMLAITDLVLStstLPKMLSIFWFNSREIDFSA---CLTQ-MFFI 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAmFVSIYS--MTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVAL----ALASPQCF 168
Cdd:cd15951   81 HS-FSTMESgiFVAMALDRYVAICNPL--RHSTILTNSVVAKIGLAVVlrggILVSPHPF 137
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
39-138 1.39e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 40.11  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNAT---FNFIYASHNIWYFGstfCYFQNLFPVT 115
Cdd:cd15945   19 VFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPkmlVDLLAKRKSIPFYG---CALQMFFFAA 95
                         90       100
                 ....*....|....*....|...
gi 258613887 116 AMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15945   96 FADAECLLLAVMAYDRYVAICNP 118
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
45-161 1.46e-03

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 39.94  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFnatfnFIYASHNIWYFGS---TF--CYFQNLFPVTAMFV 119
Cdd:cd15953   12 IVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTS-----VVPKALCIFWFNLkeiTFsgCLTQMFFIHTLSIM 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 258613887 120 SIYSMTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVALA 161
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPL--RYATILTNSRIAKLGLVGLI 126
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
42-164 1.60e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 39.96  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  42 ALVLVAVTGNATVIWIILA----HERMRtvtnYFIINLALADLCMAAF---NATFNFIYASHNIWYFGstfCYFQNLF-- 112
Cdd:cd15917    9 AMYLVALLGNITILFVIKIesslHEPMY----LFLAMLAATDLVLSTStvpKMLGIFWFNAREISFDA---CLAQMFFih 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 113 PVTAMFVSIysMTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVALALAS 164
Cdd:cd15917   82 SFTAMESGV--LLAMAFDRYVAICYPL--RYTTILTNTVVGKIGLAILLRAV 129
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
40-318 1.85e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 39.51  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYA--SHNIWYFGSTFCYFQNLFP---V 114
Cdd:cd15353    7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITllNGNDTDAQSFTVNIDNVIDsviC 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHPFQPR--LSAPSTKAVIAVIWlvalalaspqcfystitvdqgaTKCVVAwpndngGK 192
Cdd:cd15353   87 SSLLASICSLLSIAVDRYFTIFYALQYHniMTVRRAGVIITCIW----------------------TACTVS------GV 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 193 MLLLYHLVVFVLI----YFLPLVVMFAAYSVIGLTLWKRAVPRHQA-HGANLRHLQAKKKFVKAMVLVVVTFAICWLPYH 267
Cdd:cd15353  139 LFIIYSDSSVVIIclisMFFTMLALMASLYVHMFLLARLHIKRIAVlPGTGPIRQGANMKGAITLTILLGVFVVCWAPFF 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 268 LYFILG-TFQEDIYYRKFIQQVYLALFwLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15353  219 LHLIFYiSCPRNPYCVCFMSHFNMYLI-LIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
50-307 2.06e-03

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 39.62  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  50 GNATVIWIILAHERMRTVTNYFIINLALADLC--MAAFNATFNFIYASHNIWYfgSTFCYFQNLFPvTAMFVSIYSMTAI 127
Cdd:cd15344   17 ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFagLAYFYLMFNTGPNTRRLTV--STWLLRQGLID-TSLTASVANLLAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 128 AADRYMAIVH-PFQPRLSAPSTKAVIAVIWLVALAL-ASPQCFYSTItvdqgatkCVVawpnDNGGKMLLLY---HLVVF 202
Cdd:cd15344   94 AIERHITVFRmQLHTRMSNRRVVVVIVVIWTMAIVMgAIPSVGWNCI--------CDI----ENCSNMAPLYsdsYLVFW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 203 VLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQED---I 279
Cdd:cd15344  162 AIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQcdvL 241
                        250       260
                 ....*....|....*....|....*...
gi 258613887 280 YYRKFIqqVYLALFWLAMsstmyNPIIY 307
Cdd:cd15344  242 AYEKFF--LLLAEFNSAM-----NPIIY 262
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
38-138 2.47e-03

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 39.27  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  38 TAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCM---AAFNATFNFIYASHNIWYFGstfCYFQNLFPV 114
Cdd:cd15416    5 VLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYsssVTPKMLVNFLVEKTTISYPG---CAAQLCSAA 81
                         90       100
                 ....*....|....*....|....
gi 258613887 115 TAMFVSIYSMTAIAADRYMAIVHP 138
Cdd:cd15416   82 TFGTVECFLLAAMAYDRYVAICNP 105
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
45-161 2.50e-03

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 39.20  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAF---NATFNFIYASHNIWYFGstfCYFQnLFPVTAMFVSI 121
Cdd:cd15221   12 IVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTtvpKMLAIFWFGAGEISFDG---CLTQ-MFFVHFVFVTE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 258613887 122 YS-MTAIAADRYMAIVHPFqpRLSAPSTKAVIAVIWLVALA 161
Cdd:cd15221   88 SAiLLAMAFDRYVAICYPL--RYTTILTHSVIGKIGVAAVA 126
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
45-307 3.16e-03

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 38.96  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  45 LVAVTGNATVIWIILAHERmRTVTNYFIINLALAD---LCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVsi 121
Cdd:cd15105   12 LVGLTGNAIVFWLLGFRLH-RNAFSVYILNLALADflfLLCHIIDSTLLLLKVFYPNIIFLPCFYTIMMVLYITGLSM-- 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 122 ysMTAIAADRYMAIVHPFQPRLSAP--STKAVIAVIWLVALALASPQCFYstitvdqgatkCVVAWPNDNGGKMLLLYHL 199
Cdd:cd15105   89 --LSAISTERCLSVLCPIWYRCRRPehTSTVMCAVIWVLSLLICILNRYF-----------CGFLDTKYENDSVCLASNF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 200 VVFVLIYFLPLVVMFAAYSVIGLTLWkravprhqahGANLRHLqaKKKFVKAMvLVVVTFAICWLPYHLYFILgTFQEDI 279
Cdd:cd15105  156 FTAAYLMFLFVVLCLSSLALLARLFC----------GAGQMKL--TRLYVTIM-LTVLVFLLCGLPFGIYWFL-LFWIKD 221
                        250       260
                 ....*....|....*....|....*...
gi 258613887 280 YYRKFIQQVYLALFWLAMSSTMYNPIIY 307
Cdd:cd15105  222 DFHVLDYGLYLASVVLTAVNSCANPIIY 249
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
45-161 3.38e-03

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 38.73  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887   45 LVAVTG---NATVIWIILAHERMRTVTNYFIINLALAD----LCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFpvtAM 117
Cdd:pfam10328   2 LISLIGlvaNLLVFIAFLKLPSLKNSFGILCLSQAIGNaiicLIFLFYVVPMTLFQNSFLPEWLNSHIIGLIAMG---LY 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 258613887  118 FVSIYSMTAIAADRYMAIVHPF--QPRLSAPSTKAVIAVIWLVALA 161
Cdd:pfam10328  79 EISPLSHLLIALNRFCAVFFPLkyEKIFSIKNTKIIIIFIWIVSII 124
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
37-318 3.96e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 38.72  E-value: 3.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPV-- 114
Cdd:cd15352    4 AEVFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVfd 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 115 ----TAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA--VIAVIWLVALALASPQCFYSTITVdqgatkcvvawpnd 188
Cdd:cd15352   84 smicISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKAlvLIAVIWVVCIVCGIVFIVYSESKT-------------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 189 nggkmlllyhLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVV---TFAICWLP 265
Cdd:cd15352  150 ----------VIVCLITMFFAMLVLMATLYVHMFLFARLHVKRIAALPPAVDGAPQQRSCMKGAVTITIllgVFIVCWAP 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258613887 266 YHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGF 318
Cdd:cd15352  220 FFLHLILIISCPHNPYCLCYTSHFNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
37-165 5.13e-03

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 38.29  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  37 ATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVtA 116
Cdd:cd15211    3 STVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLGYRLFREGLLFL-G 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 258613887 117 MFVSIYSMTAIAADRYMAIVHP---FQPRLSAPSTKAVIAVIWLVALALASP 165
Cdd:cd15211   82 LTVSLLSHSLIALNRYVLITKLpavYQALYQKRNTEWMIALSWALALGLLLP 133
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
39-307 6.35e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 38.23  E-value: 6.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  39 AYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLcMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMF 118
Cdd:cd15349    6 LFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDL-LTGTSYLVNICLSGERTFRLTPALWFLREGLLFTALA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 119 VSIYSMTAIAADRYMAIVHPFQPRLSAPSTK--AVIAVIWLVA-----LALASPQCFYSTitvdqgaTKCVVAWPNDNgg 191
Cdd:cd15349   85 ASTFSLLVTAVERYATMVRPVAENTATKTYRvyGMIVLCWILAfligfLPLLGWNCLCDF-------RSCSSLLPLYS-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887 192 KMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTlwKRAVPRHQAHGANLRHLqakkkfvKAMVLVVVTFAICWLPYHLYFI 271
Cdd:cd15349  156 KSYILFCLVIFFIILLTIIGLYFAIYCLVRAS--GQRVISARSRRRSLRLL-------KTVLMILGAFMVCWGPLFILLL 226
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 258613887 272 LgtfqeDIYYRKFIQQVYLALFW---LAMSSTMYNPIIY 307
Cdd:cd15349  227 V-----DFFCSSRSCKPLFGMEWvlaLAVLNSAINPLIY 260
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
41-140 7.64e-03

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 37.82  E-value: 7.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  41 LALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLC--------MAAfnatfNFIYASHNIWYFGstfC----YF 108
Cdd:cd15225    8 LLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICytsvivpkMLV-----NLLSEDKTISFLG---CatqmFF 79
                         90       100       110
                 ....*....|....*....|....*....|..
gi 258613887 109 QNLFPVTAMFVsiysMTAIAADRYMAIVHPFQ 140
Cdd:cd15225   80 FLFLGGTECFL----LAAMAYDRYVAICNPLR 107
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
35-140 8.77e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 37.64  E-value: 8.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  35 LWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFN---ATFNFIYASHNIWYFGstfCYFQNL 111
Cdd:cd15237    2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTvpqMLVHLLSEHKTISFVG---CAAQMF 78
                         90       100
                 ....*....|....*....|....*....
gi 258613887 112 FPVTAMFVSIYSMTAIAADRYMAIVHPFQ 140
Cdd:cd15237   79 FFLALGVTECVLLAVMAYDRYVAICNPLR 107
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
40-138 9.45e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 37.44  E-value: 9.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFII-NLALADLCMAAFNA---TFNFIYASHNIWYFGSTF-CYFQNLFPV 114
Cdd:cd15935    7 VLACYAAILLGNLLIVVTVHADPHLLQSPMYFFLaNLSLIDMTLGSVAVpkvLADLLTCGRTISFGGCMAqLFFLHFLGG 86
                         90       100
                 ....*....|....*....|....
gi 258613887 115 TAMFVsiysMTAIAADRYMAIVHP 138
Cdd:cd15935   87 SEMLL----LTLMAYDRYVAICHP 106
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
40-138 9.68e-03

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 37.56  E-value: 9.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258613887  40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCmaaFNAT------FNFIYASHNIWYFGstfCYFQNLFp 113
Cdd:cd15234    7 FLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADIC---FSSTtvpkmlVNIQTQSKSISYTG---CLTQMCF- 79
                         90       100
                 ....*....|....*....|....*..
gi 258613887 114 vTAMFVSIYSM--TAIAADRYMAIVHP 138
Cdd:cd15234   80 -FLLFGGLDNFllAVMAYDRYVAICHP 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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