NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|239915978|ref|NP_034010|]
View 

homeobox protein CDX-1 [Mus musculus]

Protein Classification

Caudal_act and homeodomain domain-containing protein( domain architecture ID 11031543)

Caudal_act and homeodomain domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-211 1.11e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 98.34  E-value: 1.11e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 239915978  156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Caudal_act super family cl22486
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-140 4.73e-14

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


The actual alignment was detected with superfamily member pfam04731:

Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 67.47  E-value: 4.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239915978   13 VYPGPARPSSLGLGPPTYAPPGPAPappqypDFAGYTHVEPAPAPPPTW---AAPFPAPKDDWAAaYGPGPTASAASPAP 89
Cdd:pfam04731   1 MYPGSVRHPGLNLPAQNFVAPPQYS------DYMGYHHVPGMDPHGQSLgawGSPYGPPREDWNA-YGPGPSSTVGTAPM 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 239915978   90 LAFGP------PPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSV 140
Cdd:pfam04731  74 NDASPgqiaysPPDYSSLHPPGPSSGLSLPPPLNSSLEQLSPSRQRRSPYEWMRKTV 130
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-211 1.11e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 98.34  E-value: 1.11e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 239915978  156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 156-210 2.06e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.00  E-value: 2.06e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 239915978   156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKER 210
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 156-211 3.39e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 3.39e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 239915978 156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-140 4.73e-14

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 67.47  E-value: 4.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239915978   13 VYPGPARPSSLGLGPPTYAPPGPAPappqypDFAGYTHVEPAPAPPPTW---AAPFPAPKDDWAAaYGPGPTASAASPAP 89
Cdd:pfam04731   1 MYPGSVRHPGLNLPAQNFVAPPQYS------DYMGYHHVPGMDPHGQSLgawGSPYGPPREDWNA-YGPGPSSTVGTAPM 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 239915978   90 LAFGP------PPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSV 140
Cdd:pfam04731  74 NDASPgqiaysPPDYSSLHPPGPSSGLSLPPPLNSSLEQLSPSRQRRSPYEWMRKTV 130
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
158-216 6.28e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 59.37  E-value: 6.28e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 239915978 158 RVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKK 216
Cdd:COG5576   55 RRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGK 113
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-211 1.11e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 98.34  E-value: 1.11e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 239915978  156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 156-210 2.06e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.00  E-value: 2.06e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 239915978   156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKER 210
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 156-211 3.39e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.22  E-value: 3.39e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 239915978 156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-140 4.73e-14

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 67.47  E-value: 4.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239915978   13 VYPGPARPSSLGLGPPTYAPPGPAPappqypDFAGYTHVEPAPAPPPTW---AAPFPAPKDDWAAaYGPGPTASAASPAP 89
Cdd:pfam04731   1 MYPGSVRHPGLNLPAQNFVAPPQYS------DYMGYHHVPGMDPHGQSLgawGSPYGPPREDWNA-YGPGPSSTVGTAPM 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 239915978   90 LAFGP------PPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSV 140
Cdd:pfam04731  74 NDASPgqiaysPPDYSSLHPPGPSSGLSLPPPLNSSLEQLSPSRQRRSPYEWMRKTV 130
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
158-216 6.28e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 59.37  E-value: 6.28e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 239915978 158 RVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKK 216
Cdd:COG5576   55 RRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH