NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|83523740|ref|NP_034530|]
View 

histocompatibility 60a precursor [Mus musculus]

Protein Classification

MHC_I domain-containing protein( domain architecture ID 194)

major histocompatibility complex class I (MHC_I) domain-containing protein similar to Homo sapiens endothelial protein C receptor and retinoic acid early transcript 1L protein

CATH:  3.30.500.10
Gene Ontology:  GO:0006955

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MHC_I super family cl08246
Class I Histocompatibility antigen, domains alpha 1 and 2;
61-178 5.98e-05

Class I Histocompatibility antigen, domains alpha 1 and 2;


The actual alignment was detected with superfamily member pfam14586:

Pssm-ID: 471794  Cd Length: 174  Bit Score: 42.44  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523740    61 GDKKHEENATKMCADLSQNLREISEEMWKLQS----------GNDTLNVTTQSQYNQGKFIDGFWAINTDEQHSIYFYPL 130
Cdd:pfam14586  46 GDPGETANATEVGECLTQPVNDLCQKLRDKVSntkvdthktnGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTE 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 83523740   131 NMTWRESHSDNSSAMEQWknkNLEKDMRNFLITYFSHCLNKSSSHFRE 178
Cdd:pfam14586 126 NMSWRSANDESGVIMNKW---NDDGDLVQRLKYFIPECRQKIDEFLKQ 170
 
Name Accession Description Interval E-value
MHC_I_2 pfam14586
Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are ...
 61-178 5.98e-05

Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.


Pssm-ID: 291265  Cd Length: 174  Bit Score: 42.44  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523740    61 GDKKHEENATKMCADLSQNLREISEEMWKLQS----------GNDTLNVTTQSQYNQGKFIDGFWAINTDEQHSIYFYPL 130
Cdd:pfam14586  46 GDPGETANATEVGECLTQPVNDLCQKLRDKVSntkvdthktnGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTE 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 83523740   131 NMTWRESHSDNSSAMEQWknkNLEKDMRNFLITYFSHCLNKSSSHFRE 178
Cdd:pfam14586 126 NMSWRSANDESGVIMNKW---NDDGDLVQRLKYFIPECRQKIDEFLKQ 170
 
Name Accession Description Interval E-value
MHC_I_2 pfam14586
Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are ...
 61-178 5.98e-05

Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.


Pssm-ID: 291265  Cd Length: 174  Bit Score: 42.44  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83523740    61 GDKKHEENATKMCADLSQNLREISEEMWKLQS----------GNDTLNVTTQSQYNQGKFIDGFWAINTDEQHSIYFYPL 130
Cdd:pfam14586  46 GDPGETANATEVGECLTQPVNDLCQKLRDKVSntkvdthktnGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTE 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 83523740   131 NMTWRESHSDNSSAMEQWknkNLEKDMRNFLITYFSHCLNKSSSHFRE 178
Cdd:pfam14586 126 NMSWRSANDESGVIMNKW---NDDGDLVQRLKYFIPECRQKIDEFLKQ 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH