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Conserved domains on  [gi|1020159030|ref|NP_034707|]
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integrin alpha-5 isoform 1 preproprotein [Mus musculus]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 493-925 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 567.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  493 RPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPN-SIGFEVELQLDWQKQKGGVRRALFLTSKQA 571
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  572 TLTQTLLIQNGAREDCREMKIYLRNEseFRDKLSPIHIALNFSL--DPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCG 649
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDCG 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  650 EDNICVPDLQLDVYGE----KKHVYLGDKNALNLTFHAQNLGEGgAYEAELRVTAPLEAEYSGlVRHPGNFSSLSCDYFA 725
Cdd:pfam08441  159 EDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGED-AYEAELYVTLPPGLDYSG-VRREGSEKQLSCTAKK 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  726 VNQSRQLVCDLGNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLNGVSKPEA 805
Cdd:pfam08441  237 ENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPDQ 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  806 VIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQAL-EGQQLLYVTKVTGLS--NCTSNYTPNSQ 882
Cdd:pfam08441  317 VVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELsNGKWLLYLLDVQGQGkgECSPQNEINPL 396

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1020159030  883 GLELDPETS-------PHHLQKREAPGRS--STASGTQVLKCPE-AKCFRLRC 925
Cdd:pfam08441  397 NLTQSLESSkplrtsrVHHVVKRRDVLKSekATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 392-446 1.30e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.94  E-value: 1.30e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1020159030   392 FSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQ-QGVVFIFPGGPGGLSTKPSQVL 446
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGeTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 325-382 6.10e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 61.62  E-value: 6.10e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1020159030   325 MASYFGYAVA-ATDTNGDGLDDLLVGAPLlmertaDGRPQEVGRVYIYLQRPAGIDPTP 382
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPR------ANDAGETGAVYVYFGSSGGGNSIP 53
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 59-117 3.54e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.84  E-value: 3.54e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020159030    59 PGSLFGFSVEFYRP--GRDGVSVLVGAPKANTSQpgvlQGGAVYVCPWGTSPIQCTTIQFD 117
Cdd:smart00191    1 PGSYFGYSVAGVGDvnGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 458-510 2.25e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.25e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1020159030   458 FFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFN 510
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 271-313 7.92e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.21  E-value: 7.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1020159030   271 DDSYLGYSVA-VGEFSGDDTEDFVAGVPKGN--LTYGYVTVLNGSD 313
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANdaGETGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 493-925 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 567.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  493 RPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPN-SIGFEVELQLDWQKQKGGVRRALFLTSKQA 571
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  572 TLTQTLLIQNGAREDCREMKIYLRNEseFRDKLSPIHIALNFSL--DPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCG 649
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDCG 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  650 EDNICVPDLQLDVYGE----KKHVYLGDKNALNLTFHAQNLGEGgAYEAELRVTAPLEAEYSGlVRHPGNFSSLSCDYFA 725
Cdd:pfam08441  159 EDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGED-AYEAELYVTLPPGLDYSG-VRREGSEKQLSCTAKK 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  726 VNQSRQLVCDLGNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLNGVSKPEA 805
Cdd:pfam08441  237 ENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPDQ 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  806 VIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQAL-EGQQLLYVTKVTGLS--NCTSNYTPNSQ 882
Cdd:pfam08441  317 VVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELsNGKWLLYLLDVQGQGkgECSPQNEINPL 396

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1020159030  883 GLELDPETS-------PHHLQKREAPGRS--STASGTQVLKCPE-AKCFRLRC 925
Cdd:pfam08441  397 NLTQSLESSkplrtsrVHHVVKRRDVLKSekATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 392-446 1.30e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.94  E-value: 1.30e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1020159030   392 FSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQ-QGVVFIFPGGPGGLSTKPSQVL 446
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGeTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 325-382 6.10e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 61.62  E-value: 6.10e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1020159030   325 MASYFGYAVA-ATDTNGDGLDDLLVGAPLlmertaDGRPQEVGRVYIYLQRPAGIDPTP 382
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPR------ANDAGETGAVYVYFGSSGGGNSIP 53
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 329-371 1.23e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.23e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1020159030  329 FGYAVAATDTNGDGLDDLLVGAPLlmertadGRPQEVGRVYIY 371
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPG-------EGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 395-431 1.75e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.97  E-value: 1.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1020159030  395 FGSSLTpLGDLDQDGYNDVAIGAPFGGEAQQGVVFIF 431
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 59-117 3.54e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.84  E-value: 3.54e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020159030    59 PGSLFGFSVEFYRP--GRDGVSVLVGAPKANTSQpgvlQGGAVYVCPWGTSPIQCTTIQFD 117
Cdd:smart00191    1 PGSYFGYSVAGVGDvnGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 458-510 2.25e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.25e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1020159030   458 FFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFN 510
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 271-313 7.92e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.21  E-value: 7.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1020159030   271 DDSYLGYSVA-VGEFSGDDTEDFVAGVPKGN--LTYGYVTVLNGSD 313
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANdaGETGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 493-925 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 567.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  493 RPIISASASLTIFPSMFNPEERSCSLEGNPVSCINLSFCLNASGKHVPN-SIGFEVELQLDWQKQKGGVRRALFLTSKQA 571
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  572 TLTQTLLIQNGAREDCREMKIYLRNEseFRDKLSPIHIALNFSL--DPKAPMDSHGLRPVLHYQSKSRIEDKAQILLDCG 649
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDCG 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  650 EDNICVPDLQLDVYGE----KKHVYLGDKNALNLTFHAQNLGEGgAYEAELRVTAPLEAEYSGlVRHPGNFSSLSCDYFA 725
Cdd:pfam08441  159 EDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGED-AYEAELYVTLPPGLDYSG-VRREGSEKQLSCTAKK 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  726 VNQSRQLVCDLGNPMKAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLNGVSKPEA 805
Cdd:pfam08441  237 ENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPDQ 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  806 VIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQAL-EGQQLLYVTKVTGLS--NCTSNYTPNSQ 882
Cdd:pfam08441  317 VVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELsNGKWLLYLLDVQGQGkgECSPQNEINPL 396

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1020159030  883 GLELDPETS-------PHHLQKREAPGRS--STASGTQVLKCPE-AKCFRLRC 925
Cdd:pfam08441  397 NLTQSLESSkplrtsrVHHVVKRRDVLKSekATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 392-446 1.30e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.94  E-value: 1.30e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1020159030   392 FSRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQ-QGVVFIFPGGPGGLSTKPSQVL 446
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGeTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 325-382 6.10e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 61.62  E-value: 6.10e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1020159030   325 MASYFGYAVA-ATDTNGDGLDDLLVGAPLlmertaDGRPQEVGRVYIYLQRPAGIDPTP 382
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPR------ANDAGETGAVYVYFGSSGGGNSIP 53
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 329-371 1.23e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.23e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1020159030  329 FGYAVAATDTNGDGLDDLLVGAPLlmertadGRPQEVGRVYIY 371
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPG-------EGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 395-431 1.75e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.97  E-value: 1.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1020159030  395 FGSSLTpLGDLDQDGYNDVAIGAPFGGEAQQGVVFIF 431
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 59-117 3.54e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.84  E-value: 3.54e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1020159030    59 PGSLFGFSVEFYRP--GRDGVSVLVGAPKANTSQpgvlQGGAVYVCPWGTSPIQCTTIQFD 117
Cdd:smart00191    1 PGSYFGYSVAGVGDvnGDGYPDLLVGAPRANDAG----ETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 337-415 3.19e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 45.29  E-value: 3.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159030  337 DTNGDGLDDLLVGAPllmertadgrpqevGRVYIYLQRPAGidptpTLTLTGQDEFSRFGSSLTP-LGDLDQDGYNDVAI 415
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDG-----TFTFITSVSLGGGGGGLSVaVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 458-510 2.25e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.25e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1020159030   458 FFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFN 510
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 271-313 7.92e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.21  E-value: 7.92e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1020159030   271 DDSYLGYSVA-VGEFSGDDTEDFVAGVPKGN--LTYGYVTVLNGSD 313
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANdaGETGAVYVYFGSS 46
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 404-479 2.07e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.59  E-value: 2.07e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1020159030  404 DLDQDGYNDVAIgapfggeAQQGVVFIFPGGPGGLSTKPSQVLQPLWAAGRTPDFFgsalrggrDLDGNGYPDLIV 479
Cdd:pfam13517    1 DLDGDGKLDLVV-------ANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVG--------DLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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