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Conserved domains on  [gi|7106359|ref|NP_034946|]
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MORC family CW-type zinc finger protein 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 16-133 1.96e-64

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


:

Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 212.27  E-value: 1.96e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359   16 FIHANSTTHSFLFGALAELLDNARDAGAVRLDVFSVDNETLQGGFMLCFLDDGCGMSPDEASDVIYFGTSKKRLSTLKFI 95
Cdd:cd16931   1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7106359   96 GQYGNGLKSGSMRIGKDCILFTKKEETMTCLFFSQTFC 133
Cdd:cd16931  81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 481-526 4.60e-12

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 61.17  E-value: 4.60e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 7106359    481 FILQCDLCLKWRVLPSSSNyqEKGLPDLWICASNPNNLENSCNQIE 526
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 235-436 6.48e-11

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 61.02  E-value: 6.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    235 SFRAYTAVLY--FEPRMKIFIQAKRVQTKHLCYSLYKPRKYQYttssfkgkfKTEVQKAEEAVkraellfkevqakvnqp 312
Cdd:pfam17942   2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIADDLKYPEKITY---------KPQVGGGKEVV----------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    313 drialsstqdalqkalqdVDTKhkslrqkqralrkartlslfFGVNTEDQH--QAGMFIYSNNRLIKMYEKVGPQLKMKs 390
Cdd:pfam17942  56 ------------------VITT--------------------IGFLKEAPHinVHGFNVYHKNRLIKPFWRVGNQAGSK- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 7106359    391 llGAGIIGIvnipLET--MEPSHNKQEFLNVQEYNHLLKVMGQYLIQY 436
Cdd:pfam17942  97 --GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 16-133 1.96e-64

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 212.27  E-value: 1.96e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359   16 FIHANSTTHSFLFGALAELLDNARDAGAVRLDVFSVDNETLQGGFMLCFLDDGCGMSPDEASDVIYFGTSKKRLSTLKFI 95
Cdd:cd16931   1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7106359   96 GQYGNGLKSGSMRIGKDCILFTKKEETMTCLFFSQTFC 133
Cdd:cd16931  81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 27-159 4.11e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 113.20  E-value: 4.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359     27 LFGALAELLDNARDAGAVRLDVFSVDNEtlQGGFMLCFLDDGCGMSPDEASDVIYFGTS-KKRLSTLKFIGQYGNGLKSG 105
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNR--GGGTEIVIEDDGHGMSPEELINALRLATSaKEAKRGSTDLGRYGIGLKLA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7106359    106 SMRIGKDCILFTKKEETMTCLFFSQTFCEKEGlTEVVVPIPSWLTRTRESITDD 159
Cdd:pfam13589  79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPAPIENFDELDKD 131
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 481-526 4.60e-12

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 61.17  E-value: 4.60e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 7106359    481 FILQCDLCLKWRVLPSSSNyqEKGLPDLWICASNPNNLENSCNQIE 526
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 235-436 6.48e-11

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 61.02  E-value: 6.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    235 SFRAYTAVLY--FEPRMKIFIQAKRVQTKHLCYSLYKPRKYQYttssfkgkfKTEVQKAEEAVkraellfkevqakvnqp 312
Cdd:pfam17942   2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIADDLKYPEKITY---------KPQVGGGKEVV----------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    313 drialsstqdalqkalqdVDTKhkslrqkqralrkartlslfFGVNTEDQH--QAGMFIYSNNRLIKMYEKVGPQLKMKs 390
Cdd:pfam17942  56 ------------------VITT--------------------IGFLKEAPHinVHGFNVYHKNRLIKPFWRVGNQAGSK- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 7106359    391 llGAGIIGIvnipLET--MEPSHNKQEFLNVQEYNHLLKVMGQYLIQY 436
Cdd:pfam17942  97 --GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 30-97 4.26e-05

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 46.48  E-value: 4.26e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7106359     30 ALAELLDNARDAGAVRLDVFSVDnetlqGGF-MLCFLDDGCGMSPDE-ASDVIYFGTSK-------KRLSTLKFIGQ 97
Cdd:TIGR00585  26 VVKELVENSLDAGATRIDVEIEE-----GGLkLIEVSDNGSGIDKEDlPLACERHATSKiqsfedlERIETLGFRGE 97
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
33-76 4.80e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.88  E-value: 4.80e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 7106359   33 ELLDNARDAGAVRLDVfsvdnETLQGGFML-CFLDDGCGMSPDEA 76
Cdd:COG0323  30 ELVENAIDAGATRIEV-----EIEEGGKSLiRVTDNGCGMSPEDL 69
mutL PRK00095
DNA mismatch repair endonuclease MutL;
33-76 8.59e-04

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 43.28  E-value: 8.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 7106359    33 ELLDNARDAGAVRLDVfsvdnETLQGGfmlcfL------DDGCGMSPDEA 76
Cdd:PRK00095  29 ELVENALDAGATRIDI-----EIEEGG-----LklirvrDNGCGISKEDL 68
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 16-133 1.96e-64

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 212.27  E-value: 1.96e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359   16 FIHANSTTHSFLFGALAELLDNARDAGAVRLDVFSVDNETLQGGFMLCFLDDGCGMSPDEASDVIYFGTSKKRLSTLKFI 95
Cdd:cd16931   1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7106359   96 GQYGNGLKSGSMRIGKDCILFTKKEETMTCLFFSQTFC 133
Cdd:cd16931  81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 27-159 4.11e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 113.20  E-value: 4.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359     27 LFGALAELLDNARDAGAVRLDVFSVDNEtlQGGFMLCFLDDGCGMSPDEASDVIYFGTS-KKRLSTLKFIGQYGNGLKSG 105
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNR--GGGTEIVIEDDGHGMSPEELINALRLATSaKEAKRGSTDLGRYGIGLKLA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7106359    106 SMRIGKDCILFTKKEETMTCLFFSQTFCEKEGlTEVVVPIPSWLTRTRESITDD 159
Cdd:pfam13589  79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPAPIENFDELDKD 131
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 481-526 4.60e-12

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 61.17  E-value: 4.60e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 7106359    481 FILQCDLCLKWRVLPSSSNyqEKGLPDLWICASNPNNLENSCNQIE 526
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEID--PYELPEPWYCSMNPDPKYNSCDAPE 44
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 235-436 6.48e-11

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 61.02  E-value: 6.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    235 SFRAYTAVLY--FEPRMKIFIQAKRVQTKHLCYSLYKPRKYQYttssfkgkfKTEVQKAEEAVkraellfkevqakvnqp 312
Cdd:pfam17942   2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIADDLKYPEKITY---------KPQVGGGKEVV----------------- 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    313 drialsstqdalqkalqdVDTKhkslrqkqralrkartlslfFGVNTEDQH--QAGMFIYSNNRLIKMYEKVGPQLKMKs 390
Cdd:pfam17942  56 ------------------VITT--------------------IGFLKEAPHinVHGFNVYHKNRLIKPFWRVGNQAGSK- 96

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 7106359    391 llGAGIIGIvnipLET--MEPSHNKQEFLNVQEYNHLLKVMGQYLIQY 436
Cdd:pfam17942  97 --GRGVIGV----LEAnfIEPTHDKQDFERTSLYQRLEARLKQMLKEY 138
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 30-97 4.26e-05

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 46.48  E-value: 4.26e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7106359     30 ALAELLDNARDAGAVRLDVFSVDnetlqGGF-MLCFLDDGCGMSPDE-ASDVIYFGTSK-------KRLSTLKFIGQ 97
Cdd:TIGR00585  26 VVKELVENSLDAGATRIDVEIEE-----GGLkLIEVSDNGSGIDKEDlPLACERHATSKiqsfedlERIETLGFRGE 97
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 33-96 2.08e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 43.19  E-value: 2.08e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7106359   33 ELLDNARDAGAVRLDVFsVDNETLQggfMLCFLDDGCGMSPDEASDVIY-FGTSK-------KRLSTLKFIG 96
Cdd:cd16926  20 ELVENSIDAGATRIDVE-IEEGGLK---LIRVTDNGSGISREDLELAFErHATSKissfedlFSITTLGFRG 87
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
33-76 4.80e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.88  E-value: 4.80e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 7106359   33 ELLDNARDAGAVRLDVfsvdnETLQGGFML-CFLDDGCGMSPDEA 76
Cdd:COG0323  30 ELVENAIDAGATRIEV-----EIEEGGKSLiRVTDNGCGMSPEDL 69
mutL PRK00095
DNA mismatch repair endonuclease MutL;
33-76 8.59e-04

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 43.28  E-value: 8.59e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 7106359    33 ELLDNARDAGAVRLDVfsvdnETLQGGfmlcfL------DDGCGMSPDEA 76
Cdd:PRK00095  29 ELVENALDAGATRIDI-----EIEEGG-----LklirvrDNGCGISKEDL 68
PRK14083 PRK14083
HSP90 family protein; Provisional
 31-104 2.31e-03

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 41.85  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7106359    31 LAELLDNARDA------------GAVRLDVFSVDNETLQggfmlcFLDDGCGMSPDEASD---VIyfGTSKKR-----LS 90
Cdd:PRK14083  28 VRELLQNAVDAitarraldptapGRIRIELTDAGGGTLI------VEDNGIGLTEEEVHEflaTI--GRSSKRdenlgFA 99

                         90
                 ....*....|....
gi 7106359    91 TLKFIGQYGNGLKS 104
Cdd:PRK14083 100 RNDFLGQFGIGLLS 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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