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Conserved domains on  [gi|70980543|ref|NP_035504|]
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alpha-N-acetylneuraminide alpha-2,8-sialyltransferase [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 72-343 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467717  Cd Length: 272  Bit Score: 569.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGC 151
Cdd:cd23989   1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 152 GRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPS 231
Cdd:cd23989  81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 232 LRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYY 311
Cdd:cd23989 161 LRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 70980543 312 DNVLPFSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23989 241 DNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 72-343 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 569.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGC 151
Cdd:cd23989   1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 152 GRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPS 231
Cdd:cd23989  81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 232 LRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYY 311
Cdd:cd23989 161 LRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 70980543 312 DNVLPFSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23989 241 DNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 93-338 5.18e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 303.76  E-value: 5.18e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543    93 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 171
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543   172 EYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLKDVGANQT 246
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543   247 ---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDNVLP----FS 318
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 70980543   319 GYHAMPEEFLQLWYLHKIGA 338
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 72-343 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 569.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGC 151
Cdd:cd23989   1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 152 GRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPS 231
Cdd:cd23989  81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 232 LRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYY 311
Cdd:cd23989 161 LRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                       250       260       270
                ....*....|....*....|....*....|..
gi 70980543 312 DNVLPFSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23989 241 DNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 72-343 5.17e-167

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 466.35  E-value: 5.17e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSG 150
Cdd:cd23971   1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSnKPLKTCAVVGNGGILKNSS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 151 CGRQIDEANFVMRCNLPPLSseYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEP 230
Cdd:cd23971  81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 231 SLRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHY 310
Cdd:cd23971 159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                       250       260       270
                ....*....|....*....|....*....|...
gi 70980543 311 YDNVLPFSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23971 239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 77-343 6.28e-117

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 339.81  E-value: 6.28e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  77 FRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQI 155
Cdd:cd23991   6 FRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRgYPYKQCAVVGNGGILKNSSCGAEI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 156 DEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVY 235
Cdd:cd23991  86 DQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVY 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 236 YTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVL 315
Cdd:cd23991 166 YTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQL 245

                       250       260
                ....*....|....*....|....*...
gi 70980543 316 PFSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23991 246 PKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 72-343 1.20e-109

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 321.13  E-value: 1.20e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  72 TSASLFRRQMEDCCDPAHLFAmTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSG 150
Cdd:cd23963   1 TALDKFRKELERLLNTRKLFL-TQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFsHKRYKTCAVVGNSGILLGSG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 151 CGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGT 228
Cdd:cd23963  80 CGKEIDSHDFVIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSST 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 229 EPSLRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIhAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISH 308
Cdd:cd23963 159 NLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPY 237

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 70980543 309 HYYDNVLP--FSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23963 238 HYYDDLSPstKNKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 93-338 5.18e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 303.76  E-value: 5.18e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543    93 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 171
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543   172 EYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLKDVGANQT 246
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543   247 ---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDNVLP----FS 318
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 70980543   319 GYHAMPEEFLQLWYLHKIGA 338
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 72-341 1.84e-97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 290.20  E-value: 1.84e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  72 TSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSG 150
Cdd:cd23990   1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYsRSQFKKCAVVGNGGILKNSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 151 CGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEP 230
Cdd:cd23990  81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 231 SLRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHY 310
Cdd:cd23990 161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                       250       260       270
                ....*....|....*....|....*....|.
gi 70980543 311 YDNVLPFSGYHAMPEEFLQLWYLHKIGALRM 341
Cdd:cd23990 241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 70-343 2.13e-75

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 234.21  E-value: 2.13e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  70 NQTSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYD-GELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILK 147
Cdd:cd23970   2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQnKHYNTCAVVGNSGILT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 148 MSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMK 225
Cdd:cd23970  82 NSQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFH 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 226 TGTEPSLRVYYTLKDVGANQTVLFANP-NFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGD 304
Cdd:cd23970 161 TSATVTRTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGT 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 70980543 305 PISHHYYDN-----VLPFSGYHAMPEEFLQLWYLHKIGALRMQL 343
Cdd:cd23970 241 PLPYHYYDKkgtkfTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 78-342 3.30e-69

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 218.05  E-value: 3.30e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543  78 RRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPL-KKCAVVGNGGILKMSGCGRQID 156
Cdd:cd23969   7 RKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHfRTCAVVGNSGILLNSGCGQEID 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 157 EANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLLWS--RKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRV 234
Cdd:cd23969  87 SHDFVIRCNLAPVE-GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFVSKGGEE---HV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 235 YYTLKDV---GANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYY 311
Cdd:cd23969 163 QWTNEIIlkhKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYY 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 70980543 312 DNvLPFS---GYHAMPEEFLQLWYLHKIGALRMQ 342
Cdd:cd23969 243 DN-RKYLttaRPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 113-341 1.30e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 185.91  E-value: 1.30e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 113 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSII 191
Cdd:cd23987  42 TMNISQNLYELLPRTSPLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVV 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 192 RQRFENLL---WsRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDV---GANQTVLFANPNFLRNIGKFWKSR 265
Cdd:cd23987 121 QRAFEDLVnetW-KEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDLIlkhHINVRTAYPSLRLLHAVRGYWLTN 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 266 GIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV----LPFSGYHAMPEEFLQLWYLHKIGALRM 341
Cdd:cd23987 197 KVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLkygyTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 113-341 3.28e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 177.07  E-value: 3.28e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 113 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSII 191
Cdd:cd23988  42 TLNISQNLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV-EFAADVGTKSDFITMNPSVV 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 192 RQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDVGANQ-TVLFANPNF--LRNIGKFWKSRG 266
Cdd:cd23988 121 QRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVKGGEK---HVEWVNALILKNKlKVRTAYPSLrlIHAVRGYWLTNK 197

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 70980543 267 IHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV----LPFSGYHAMPEEFLQLWYLHKIGALRM 341
Cdd:cd23988 198 VNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLkyryFSNAGPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 137-327 2.02e-27

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 106.68  E-value: 2.02e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 137 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYnhsY 216
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLEEEVV---L 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 217 IYMPAFsmktgTEPSLRVYYTLKDVGANQT-VLFANPNF-------LRNIGKFWKSRGIHAkrlSTGLFLVSAALGLCEE 288
Cdd:cd19952  77 ILSRAA-----AADFKRLKRRKKRHDNAVLlLTDPAPDLlsyvrkrLEKLGLKSFFGGNAP---SSGLLAVLLALQLCDS 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 70980543 289 VSIYGFWPFSVNMQGDPisHHYYDNVLP--FSGYHAMPEEF 327
Cdd:cd19952 149 VDLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 136-340 1.26e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 104.26  E-value: 1.26e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLpPLSSEYTRDVGSKTQLVTANP--SIIRQRFENLLWSRKKFVDNM-KIY 212
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFPesLHNSLLKHVPQDKDTKYLFIPfKIR 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 213 nhSYIYMPAFS----MKTGTEPSLRVYYTLKDVGANQTVLFANPNFLRNIGKFW-KSRGIHakRLSTGLFLVSAALGLCE 287
Cdd:cd23964 163 --DYDYLDAVLsgkpVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWlNSSTSY--RPTTGALMLLTALHTCD 238

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 70980543 288 EVSIYGF---WPFSVnmqgdpishHYYDN----VLPFSGYHAMPEEfLQLW-YLHKIGALR 340
Cdd:cd23964 239 QVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNE-RKLWrKLHEEGIIN 289
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 136-341 2.53e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 81.34  E-value: 2.53e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRKK 204
Cdd:cd23974  86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngppqSKETRYI 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 205 FVDNmkiYNHSYIYMPAFSMKT----GTEPSLR-VYYTLKDVGANQTVLFaNPNFLRNI-GKFWKSRGIHAK-----RLS 273
Cdd:cd23974 165 FLPD---HDRDYLLVKAALTHTpidrGRDKSKRpSKYFGKDVTAEKFKIY-HPDFIRYLrNRFLWSPILNTKqrdiyRPS 240

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 70980543 274 TGLFLVSAALGLCEEVSIYGFwpfsvnMQGD--PISHHYYDNV---LPFSGYHAMPEEfLQLWY-LHKIGALRM 341
Cdd:cd23974 241 TGAVMLLAALHTCDQVSAYGF------MTPDygKYSDHYYDKTyhkVVFYANHDLRLE-MQLWQkLHKAGLIKL 307
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 136-341 2.06e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 78.09  E-value: 2.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPsiirQRFENLLWSRKKFVDNMKIYNHS 215
Cdd:cd23966  79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTTHHFMYP----ESAVDLDPGVHLVLVPFKVLDLQ 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 216 YIyMPAFSMKTGTepslRVYYTLKD-VGANQT-VLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVSIYG 293
Cdd:cd23966 154 WL-ISALTTGEIT----RTYTPVKRfIKADKDkVLVINPAFIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFG 226

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 294 F-------WpfsvnmqgdpisHHYYDNVLPFS-----GYHAMPEEFLQLWYLHKIGALRM 341
Cdd:cd23966 227 FgadskgnW------------HHYWEKNRSAGafrktGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 135-313 6.20e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 74.15  E-value: 6.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFEN--LLWSRKKFVDNMKIY 212
Cdd:cd23980  82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNvsMILVPFKTLDLEWVI 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 213 --------NHSYIYMPAfsmktgtepSLRVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALG 284
Cdd:cd23980 161 satttgtiSHTYVPVPR---------KIKV--------KKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILSVIFSLH 221

                       170       180
                ....*....|....*....|....*....
gi 70980543 285 LCEEVSIYGfwpFSVNMQGDpiSHHYYDN 313
Cdd:cd23980 222 VCDEVDLYG---FGADSKGN--WHHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 117-341 1.95e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.93  E-value: 1.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 117 DNSTYSLFPqatPFQLPLK--KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLV-----TANPS 189
Cdd:cd23972  66 DSANAKLFF---PRDTPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFYgftvnTMKNS 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 190 IIrqRFENLLWSRKKFVDNMKiynhsYIYMPAfsmktgtepSLRVYYTLK------------DVGANQTVLFA------- 250
Cdd:cd23972 142 LI--SYWNLGFTRTPQGQDLQ-----YIFIPS---------DIRDYVMLRsailgvpvpeglDKGDRPHKYFGpeasakk 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 251 ----NPNFLRNI-GKFWKSRGI-----HAKRLSTGLFLVSAALGLCEEVSIYGF-----WPFsvnmqgdpiSHHYYDNV- 314
Cdd:cd23972 206 fkllHPDFISYLtDRFLKSKLLnthygHLYMPSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKk 276

                       250       260       270
                ....*....|....*....|....*....|
gi 70980543 315 --LPFSGYHAMPEEfLQLW-YLHKIGALRM 341
Cdd:cd23972 277 kpLVFYANHDMLLE-AALWrRLHKAGILQL 305
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 133-336 2.33e-14

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 71.17  E-value: 2.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQRFENllwsrkkfvdnmkI 211
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYPeSAFRDPEEY-------------D 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 212 YNHSYIYMPAFSMK--------TGTEPSLRVYYTLK-----DVGANQTVLFaNPNFLR----NIGKFWKSRGIHAKRLST 274
Cdd:cd23967  67 SDWLLVLVPFKSMDllwlqaviKGKKPNGKGGFWKKiatsvPKPPKKIRIL-NPYILQeaafDLIGLPMNGKQGKNVPTT 145

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 70980543 275 GLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNVL----PFSGYHAMPEEFLqlwYLHKI 336
Cdd:cd23967 146 GIIAIVMALHYCDEVDIAGF-GYDPSDPNAPL--HYYDSLTmkaiKRSWTHNVTKEKK---YLKKL 205
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 135-313 1.13e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 70.29  E-value: 1.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT----------QLVTANPSIIRQRFE--NLLWsr 202
Cdd:cd23979  81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTthhfmypesaKNLPANVSFVLVPFKtlDLLW-- 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 203 kkFVDNMKIYNHSYIYMPafsmktgTEPSLRVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAA 282
Cdd:cd23979 158 --ITSALSTGQIRFTYAP-------VKQFLRV--------DKDKVQIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFA 218

                       170       180       190
                ....*....|....*....|....*....|.
gi 70980543 283 LGLCEEVSIYGfwpFSVNMQGDpiSHHYYDN 313
Cdd:cd23979 219 LHVCDEVNVYG---FGADSRGN--WHHYWEN 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 136-341 3.60e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 69.40  E-value: 3.60e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLlwsRKKFVDNMKIYNH- 214
Cdd:cd23973  85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFYVHTAHSITSSLMIL---QKRGFKNIPQDKDi 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 215 SYIYMPAfsmktgtepSLRVYYTLKDVGANQTV-----------------------LFANPNFLRNI-GKFWKSRGIHAK 270
Cdd:cd23973 161 KYILFPE---------GPRDYQWLEALLKNKTIpsgayygrrprsyfsgdftedkyLVLHPDFLRYVkNRFLRSKTLKGK 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 271 -----RLSTGLFLVSAALGLCEEVSIYGFwpfsvnMQGD--PISHHYYDNV---LPFSGYHAMPEEfLQLW-YLHKIGAL 339
Cdd:cd23973 232 ywaiyRPTTGAFLLLTALHLCDTVSAYGF------ITEDyrKYPDHYYDKKktkLVFYINHDFRLE-KKLWkRLHDEKII 304


                ..
gi 70980543 340 RM 341
Cdd:cd23973 305 KL 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 129-316 9.29e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 67.20  E-value: 9.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 129 PFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQL-VTANPS---IIRQRFENLLWSRKK 204
Cdd:cd23976  10 PLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 205 FV------DNMK------IYNHsyiympaFSMKTGTEPSLRVYYTLKdvganQTVLFANPNFLRNIGKfwkSRGIHAKRL 272
Cdd:cd23976  89 VFifwgpsNYMRrdgkglVYNN-------LQLMNQILPKLKVYTITR-----HKMLQFDELFKRETGK---DRKISNTWL 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 70980543 273 STGLFLVSAALGLCEEVSIYGFWP--FSVNMQGDPISHHYYDNVLP 316
Cdd:cd23976 154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 121-326 3.43e-12

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 65.76  E-value: 3.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 121 YSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKT-------QLVTAN-----P 188
Cdd:cd23968  32 YPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTtlrlinsQILSKPefnflT 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 189 SIIRQRFENLLWSRKKFVDNMKI--YNHSYIYMPAFSMKTGTEPSLRVYytlkdvganqtvlFANPNFLRNIgkfWK--- 263
Cdd:cd23968 111 DPLYRNVTLLVWDPSSYNVNLEKwyKKPDFDFFPNYIKYRRRHPEEPFY-------------LIDPRFLWRL---WDilq 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 264 ---SRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPfsvNMQGDPIShHYYDNVL----PFSGYHAMPEE 326
Cdd:cd23968 175 eytPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVP---SVRQTDRC-HYYDVEKdlacTLGAWHPLAAE 240
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 133-315 3.54e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 61.99  E-value: 3.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQL-------VTANPSIIRQRFENLLWSRKKF 205
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPV-RGFEKDVGSKTTIrlfypesAQFDPGIENDPDTLLVLVPFKP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 206 VDNMKIYNhsyiympafsMKTGTEPSLRVYYT----LKDVGANQT-VLfaNPNFLRNIG-KFWKSRGIHAK--RLSTGLF 277
Cdd:cd23982  80 LDFYWLYE----------ILSNEKRVRKGFWKqpprIWDANPKQIrIL--NPYYTYVAAtKLLQVPGQRKKkqKPTTGLL 147

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 70980543 278 LVSAALGLCEEVSIYGF-WPFSVNmQGDPIshHYYDNVL 315
Cdd:cd23982 148 AITLALHLCDEVHIAGFgYPDNGN-SNQPI--HYYNQIT 183
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 135-312 4.34e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 62.19  E-value: 4.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLV----TANPSIIRQR---FEN------LLWS 201
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQgyfFQQsrdtkyVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 202 RKKFVDNMKiynhSYIYMPAFSMKTGTEPSLRVYYTLKDVGANQTVLFANPNflrnigkfWKSRGIHAKRLSTGLFLVSA 281
Cdd:cd23977  81 PERNMDRDG----GGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNET--------GKNRMKSGSFLSTGWFTMIL 148

                       170       180       190
                ....*....|....*....|....*....|...
gi 70980543 282 ALGLCEEVSIYGFWPFSV--NMQGDPISHHYYD 312
Cdd:cd23977 149 ALELCEEILVYGMVSDSYcrNKNHSSVPYHYYE 181
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 135-312 5.59e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 61.49  E-value: 5.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRQRFENLLWSRKKFVDNMKIyn 213
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPRLLRNAILLLAGTRAPTVVV-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 214 hsyIYMPAFSMKTGTEPSLRV------------YYTLKDVGanqtVLFANPNFLRNIGkfwKSRGIHAKRLSTGLFLVSA 281
Cdd:cd23965  79 ---FWGPETKMNKDGAGKYNLlrslskkypdveFYSLTPEK----MDYADELFEKETG---KSRIKSGTWLSTGWFTMLL 148

                       170       180       190
                ....*....|....*....|....*....|...
gi 70980543 282 ALGLCEEVSIYGFWP--FSVNMQGDPISHHYYD 312
Cdd:cd23965 149 ALDVCDEIKVYGMVPenYCREHPNSKVPYHYYE 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 133-333 9.85e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 60.53  E-value: 9.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQ---------------RFE 196
Cdd:cd23984   1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIFSDpshydpnttvvlipfKPH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 197 NLLWSrkkfvdnMKIYNHSYIYMPAFSMKtgtePSLRVYYTLkdvgaNQTVLFaNPNFLR----NIGKFWKSRGIHAKRL 272
Cdd:cd23984  80 DLRWL-------LDLLMGKKVSAKGFWKK----PALNLIYKP-----NQIRIL-NPFILRiaayELLHFPKRFPKEKKPK 142

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 70980543 273 --STGLFLVSAALGLCEEVSIYGF-WPFSvnmqgDPISH-HYYDN----VLPFSGYHAMPEEFLQLWYL 333
Cdd:cd23984 143 hpTTGIIAITLALHICNEVHIAGFkYDFS-----NLNSTlHYYGNetmsVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 135-314 1.32e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 57.24  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 135 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRK 203
Cdd:cd23981   3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQyekdslfvlagFKWQDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 204 KFVDNMkiynhsyIYMPAFSMKTGTEPSLRVYYTlkdvGANQTVLFANPNFLRN-----IGKFWKSRGIHAKRLST-GLF 277
Cdd:cd23981  82 KWLKYI-------VYKEKVSASDGFWKSVATRVP----REPHEIRILNPYFIQEaafsfIGLPFNNGLMGRGNIPTlGSV 150

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 70980543 278 LVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNV 314
Cdd:cd23981 151 AITMALHNCDEVAVAGF-GYDMNTPNAPL--HYYETI 184
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 133-314 1.49e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 57.44  E-value: 1.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-----SIIRQRFENL--------- 198
Cdd:cd23983   1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYPegapkSEQEYDPTSLfvavlfksv 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 199 ---------------LWSRKKF-----------VDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVganqtvlfanP 252
Cdd:cd23983  80 dfawlkamvkkeplsFWSRLFFwkevadsiplkPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNV----------P 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70980543 253 nflrnigkfwksrgihakrlSTGLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNV 314
Cdd:cd23983 150 --------------------TLGVTAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 134-328 3.35e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 57.15  E-value: 3.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 134 LKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSII---RQRFEN---------LLWS 201
Cdd:cd23986  49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILtnpNHHFIDsslykdvilVAWD 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 202 RKKFVDNMKIYNHSyiymPAFSMKTgtePSLRvyYTLKDvgANQTVLFANPNFlrnIGKFWK------SRGIHAKRLSTG 275
Cdd:cd23986 128 PAPYSANLHKWYKK----PDYNLFT---PYVQ--YRKRN--PNQPFYILHPKF---IWQLWDiiqentQEKIQPNPPSSG 193

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 70980543 276 LFLVSAALGLCEEVSIYGFWPfSVNmQGDPISHH--YYDNVLPFSGYHAMPEEFL 328
Cdd:cd23986 194 FIGILIMMSMCREVHVYEYIP-SVR-QTDLCHYHerYYDAACTLGAYHPLLYEKL 246
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 133-185 3.93e-09

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 56.64  E-value: 3.93e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 133 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT-------QLVT 185
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP-TAGFQQDVGTKTtirlinsQLVT 102
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 136-312 8.86e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 55.25  E-value: 8.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 136 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRqrfenLLWSRKKFVDnmKIYNH 214
Cdd:cd23978   3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSVYR-----VLRRPQEFLN--RTPET 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 215 SYIYM-PAFSMKTGTEPSL-RVYYTLKDVGANQTVLFANPNFLRNIGKFW-----KSRGIHAKRLSTGLFLVSAALGLCE 287
Cdd:cd23978  75 TLIFWgPPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFrgetgRDRKKSHSWLSTGWFTMVIAVELCD 154

                       170       180
                ....*....|....*....|....*...
gi 70980543 288 EVSIYGFWPF---SVNMQGDPISHHYYD 312
Cdd:cd23978 155 NVHVYGMVPPnycSKRPTPKKMPYHYYE 182
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 137-293 1.94e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 42.23  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 137 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQ----------LVTANPSIIRQRFENLLWSRKKFV 206
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTirvvshtsvpLLLKNPDYFFKETNETIYVIWGPF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70980543 207 DNMKIYNHSYIYmPAFSMKTGTEPSLRVYYTlkdvgANQTVLFANPNFLRNIGkfwKSRGIHAKRLSTGLFLVSAALGLC 286
Cdd:cd23975  83 RNMRKDGKGIVY-NMLKKAVESYPQAKIYVT-----TEKRMSYCDTVFKKETG---KDRVQSGSYLSTGWFTLILAMDAC 153


                ....*..
gi 70980543 287 EEVSIYG 293
Cdd:cd23975 154 YGIHVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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