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Conserved domains on  [gi|51491912|ref|NP_035690|]
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dynein light chain Tctex-type protein 2 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 79-189 9.83e-59

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


:

Pssm-ID: 412008  Cd Length: 112  Bit Score: 179.45  E-value: 9.83e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  79 NSYRMEPLKKFQAHLVETKIQQILKDSLKDVKYDDKA-PHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIA 157
Cdd:cd21460   1 NTYRLEPLKKFQPHLVRKKAEEILKEKLKDIKYDADRcRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 51491912 158 SRWIWDVAWDNWVEAKHETESYVVLALVFALY 189
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 79-189 9.83e-59

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 179.45  E-value: 9.83e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  79 NSYRMEPLKKFQAHLVETKIQQILKDSLKDVKYDDKA-PHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIA 157
Cdd:cd21460   1 NTYRLEPLKKFQPHLVRKKAEEILKEKLKDIKYDADRcRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 51491912 158 SRWIWDVAWDNWVEAKHETESYVVLALVFALY 189
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 94-186 9.79e-31

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 107.61  E-value: 9.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912    94 VETKIQQILKDSLK-DVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNWVE 171
Cdd:pfam03645   2 VKEIIKEVLEEVLGgGETYDhEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYAS 81

                          90
                  ....*....|....*
gi 51491912   172 AKHETESYVVLALVF 186
Cdd:pfam03645  82 YKFENKSLFAVVTVF 96
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 79-189 9.83e-59

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 179.45  E-value: 9.83e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  79 NSYRMEPLKKFQAHLVETKIQQILKDSLKDVKYDDKA-PHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIA 157
Cdd:cd21460   1 NTYRLEPLKKFQPHLVRKKAEEILKEKLKDIKYDADRcRSLSLSLAADILAAVKELGFDRYKYVVRVFLGEKTGQSVKIA 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 51491912 158 SRWIWDVAWDNWVEAKHETESYVVLALVFALY 189
Cdd:cd21460  81 SRAVWDTEKDNWVSATFENESLFAVALVFALY 112
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 89-188 5.66e-32

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 111.05  E-value: 5.66e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  89 FQAHLVETKIQQILKDSLKDVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWD 167
Cdd:cd21451   1 FNPEKVKKIIKEVLEERLENVTYDpEECAQLCKELSEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                        90       100
                ....*....|....*....|.
gi 51491912 168 NWVEAKHETESYVVLALVFAL 188
Cdd:cd21451  81 NFASATFENESLFAVATVFGV 101
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 94-186 9.79e-31

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 107.61  E-value: 9.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912    94 VETKIQQILKDSLK-DVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNWVE 171
Cdd:pfam03645   2 VKEIIKEVLEEVLGgGETYDhEKVPQWTKEISEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYAS 81

                          90
                  ....*....|....*
gi 51491912   172 AKHETESYVVLALVF 186
Cdd:pfam03645  82 YKFENKSLFAVVTVF 96
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 88-189 2.46e-27

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


Pssm-ID: 412007  Cd Length: 104  Bit Score: 99.09  E-value: 2.46e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  88 KFQAHLVETKIQQILKDSLKDVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAW 166
Cdd:cd21459   1 KFRPSKVKEIIHEVLKEKLAGKTYDpEEAPQWTKEIADEIKDKLKELGFPRYKIVVQVVIGEQRGQGVRVGSRCLWDADT 80

                        90       100
                ....*....|....*....|...
gi 51491912 167 DNWVEAKHETESYVVLALVFALY 189
Cdd:cd21459  81 DNYASEVFINDSLFCVATVFGVY 103
DLC-like_TCTEX1D4 cd21461
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) ...
 81-191 1.31e-19

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins; Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.


Pssm-ID: 412009  Cd Length: 114  Bit Score: 79.70  E-value: 1.31e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  81 YRMEPLK--KFQAhlveTKIQQILK---DS-LKDVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQA 153
Cdd:cd21461   1 YKTGPDPgcRFDA----SRVQQILEatlDSyLGGARYSpATCGQLSQGLSELVRSKVKDLSPPRYKLVCQVVLGQCGNQG 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 51491912 154 INIASRWIWDVAWDNWVEAKHETESYVVLALVFALYCE 191
Cdd:cd21461  77 LRVASRCLWDPERDNFASASFQNASLFAVATVHGVYFE 114
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 98-187 1.19e-13

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 63.51  E-value: 1.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  98 IQQILKDSLKDVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNWVEAKHET 176
Cdd:cd21449   6 IKEVLESILDDKEYDpLKLKEIAKKISEEIKEKLKELSPSRYKYIVHVTISENNGQGIRADSGCLWDPDTDGFVSEVYEN 85

                        90
                ....*....|.
gi 51491912 177 ESYVVLALVFA 187
Cdd:cd21449  86 DNIICTVTVFG 96
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 94-188 4.18e-12

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 59.51  E-value: 4.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  94 VETKIQQILKDSLKDVKYD-DKAPHLSLELADRILAAVKEFAyHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNWVEA 172
Cdd:cd21455   3 VESIVKEAIEAVLGDKTYShSKVNQWSNSIVEEILKRLAKLN-KPFKYIVTCVIMQKTGAGLHTASSCYWDPTTDGSVTV 81

                        90
                ....*....|....*.
gi 51491912 173 KHETESYVVLALVFAL 188
Cdd:cd21455  82 RWENKTMYCIVTVFGL 97
DLC-like_TCTEX1D1 cd21458
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) ...
 95-191 4.19e-12

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) and similar proteins; Tctex1 domain-containing protein 1 (TCTEX1D1) is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. The model corresponds to the (dynein light chain) DLC-like domain of TCTEX1D1.


Pssm-ID: 412006  Cd Length: 104  Bit Score: 59.61  E-value: 4.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  95 ETKIQQILKDS----LKDVKYD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNW 169
Cdd:cd21458   3 VASVKNILKDVlesyLQEERYEpELCRQMTKTISEVIKARVKDLMLPRYKIIVLVHIGQLNDQGLRVGSRCLWDPANDTF 82

                        90       100
                ....*....|....*....|..
gi 51491912 170 VEAKHETESYVVLALVFALYCE 191
Cdd:cd21458  83 SSYEFRNSSLFAVATVYGVYFE 104
DLC-like_DYNLT1-like cd21448
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 96-184 3.33e-05

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) subfamily and similar proteins; The dynein light chain Tctex-type 1 (DYNLT1) subfamily includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The family also includes Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1), Saccharomyces cerevisiae topoisomerase I damage affected protein 2 (TDA2) and similar proteins. SpDlc1 belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. TDA2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast. It works independently of the dynein motor complex and microtubules.


Pssm-ID: 411996  Cd Length: 98  Bit Score: 41.28  E-value: 3.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  96 TKIQQILKDSLKDVKYDDKAPHLSLE-----LADRILAAVKEFAYHRYKFIIQVLFIQKTGQAINIASRWIWDVAWDNWV 170
Cdd:cd21448   1 RKLVTIIQEAIDSALDDNEYDHAKTEswsnlIIKLVLSELEKLSKSPFKYIANCTILSINNFGLHTATGAFWDSKKDGSF 80

                        90
                ....*....|....*.
gi 51491912 171 EAKHE--TESYVVLAL 184
Cdd:cd21448  81 TYKWEnkNMCQCITIL 96
DLC-like_SpDlc1-like cd21456
dynein light chain (DLC)-like domain found in Schizosaccharomyces pombe dynein light chain ...
 93-186 1.70e-03

dynein light chain (DLC)-like domain found in Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1) and similar proteins; Schizosaccharomyces pombe dynein light chain 1 (SpDlc1) belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. The model corresponds to the dynein light chain (DLC)-like domain found in SpDlc1 and similar proteins.


Pssm-ID: 412004  Cd Length: 110  Bit Score: 36.57  E-value: 1.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51491912  93 LVETKIQQI----LKDSLKDVK-YD-DKAPHLSLELADRILAAVKEFAYHRYKFIIQVLFIQKTG-----QAINIASRWI 161
Cdd:cd21456   2 IPTSKLKQIaseaCTSALGSVEsYDhDKTSTWNSEIINTILKALIKETSPSYKFIVNSTIVQHLPpshgrRGMHSATGAF 81

                        90       100
                ....*....|....*....|....*..
gi 51491912 162 WDVAWDNWVEAKHETESY--VVLALVF 186
Cdd:cd21456  82 WNNEKDGMWTYKWSGGKGvdVVVSITW 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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