Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137; TNFRSF9 (also known as CD137, ILA, 4-1BB) plays a role in the immunobiology of human cancer where it is preferentially expressed on tumor-reactive subset of tumor-infiltrating lymphocytes. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. It transduces signals that lead to the activation of NF-kappaB, mediated by the TRAF adaptor proteins. CD137 contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. CD137 is modulated by SAHA treatment in breast cancer cells, suggesting that the combination of SAHA with this receptor could be a new therapeutic approach for the treatment of tumors.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   23 AVQNSCDNCQPGTFCRKYN-PVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRC 101
Cdd:cd13410   1 SVQDSCSNCPAGTFCGKNKdQTCIPCPPNSFSSTGGQQTCDICRKCEGVFRTKKPCSSTSNAECECVPGFHCLGPGCSMC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6755831  102 EKDCRPGQELTKQGCKTCSLGTFNDQNGtGVCRPWTNCSLDGRSVLKTGTTEKDVVCGP 160
Cdd:cd13410  81 EPDCKQGQELTKEGCKDCSFGTFNDQEG-GVCRPWTNCSLDGKSVLVNGTKERDVVCGP 138

Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137; TNFRSF9 (also known as CD137, ILA, 4-1BB) plays a role in the immunobiology of human cancer where it is preferentially expressed on tumor-reactive subset of tumor-infiltrating lymphocytes. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. It transduces signals that lead to the activation of NF-kappaB, mediated by the TRAF adaptor proteins. CD137 contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. CD137 is modulated by SAHA treatment in breast cancer cells, suggesting that the combination of SAHA with this receptor could be a new therapeutic approach for the treatment of tumors.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   23 AVQNSCDNCQPGTFCRKYN-PVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRC 101
Cdd:cd13410   1 SVQDSCSNCPAGTFCGKNKdQTCIPCPPNSFSSTGGQQTCDICRKCEGVFRTKKPCSSTSNAECECVPGFHCLGPGCSMC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6755831  102 EKDCRPGQELTKQGCKTCSLGTFNDQNGtGVCRPWTNCSLDGRSVLKTGTTEKDVVCGP 160
Cdd:cd13410  81 EPDCKQGQELTKEGCKDCSFGTFNDQEG-GVCRPWTNCSLDGKSVLVNGTKERDVVCGP 138

Tumor necrosis factor receptor / nerve growth factor receptor repeats; Repeats in growth factor receptors that are involved in growth factor binding. TNF/TNFR

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6755831      47 CPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAEC 85
Cdd:smart00208   1 CKEGTYCSDGNHSSCLRCRRCPPGLVVKQPCTATSDTVC 39

Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137; TNFRSF9 (also known as CD137, ILA, 4-1BB) plays a role in the immunobiology of human cancer where it is preferentially expressed on tumor-reactive subset of tumor-infiltrating lymphocytes. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. It transduces signals that lead to the activation of NF-kappaB, mediated by the TRAF adaptor proteins. CD137 contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. CD137 is modulated by SAHA treatment in breast cancer cells, suggesting that the combination of SAHA with this receptor could be a new therapeutic approach for the treatment of tumors.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   23 AVQNSCDNCQPGTFCRKYN-PVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRC 101
Cdd:cd13410   1 SVQDSCSNCPAGTFCGKNKdQTCIPCPPNSFSSTGGQQTCDICRKCEGVFRTKKPCSSTSNAECECVPGFHCLGPGCSMC 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6755831  102 EKDCRPGQELTKQGCKTCSLGTFNDQNGtGVCRPWTNCSLDGRSVLKTGTTEKDVVCGP 160
Cdd:cd13410  81 EPDCKQGQELTKEGCKDCSFGTFNDQEG-GVCRPWTNCSLDGKSVLVNGTKERDVVCGP 138

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), also known as decoy receptor 3 (DcR3); The subfamily TNFRSF6B is also known as decoy receptor 3 (DcR3), M68, or TR6. This protein is a soluble receptor without death domain and cytoplasmic domain, and secreted by cells. It acts as a decoy receptor that competes with death receptors for ligand binding. It is a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases, and cancer. Over-expression of this gene has been noted in several cancers, including pancreatic carcinoma, and gastrointestinal tract tumors. It can neutralize the biological effects of three tumor necrosis factor superfamily (TNFSF) members: TNFSF6 (Fas ligand/FasL/CD95L) and TNFSF14 (LIGHT) which are both involved in apoptosis and inflammation, and TNFSF15 (TNF-like molecule 1A/TL1A), which is a T cell co-stimulator and involved in gut inflammation. DcR3 is a novel inflammatory marker; higher DcR3 levels strongly correlate with inflammation and independently predict cardiovascular and all-cause mortality in chronic kidney disease (CKD) patients on hemodialysis. Increased synovial inflammatory cells infiltration in rheumatoid arthritis and ankylosing spondylitis is also associated with the elevated DcR3 expression. In cartilaginous fish, mRNA expression of DcR3 in the thymus and leydig, which are the representative lymphoid tissues of elasmobranchs, suggests that DcR3 may act as a modulator in the immune system. Interestingly, in banded dogfish (Triakis scyllia), DcR3 mRNA is strongly expressed in the gill, compared with human expression in the normal lung; both are respiratory organs, suggesting potential relevance of DcR3 to respiratory function.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   28 CDNCQPGTF----CRKYNP-VCKSCPPSTFSSIGGQPN-CNICRV-CAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTR 100
Cdd:cd10575  16 CDQCPPGTFvakhCTRDRPtVCGPCPDLHYTQFWNYLEkCRYCNVfCTERQVEKRQCNATHNRVCECKPGYYMEHGFCLR 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6755831  101 cEKDCRPGQELTKQG-------CKTCSLGTFN-DQNGTGVCRPWTNCSLDGRSVLKTGTTEKDVVC 158
Cdd:cd10575  96 -HSSCPPGEGVIKLGtpysdtqCEPCPPGFFSaSSSSTEPCQPHTNCTQGGLETNVPGNDYHDTLC 160

Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6); TNFRSF21 (also known as death receptor 6 (DR6), CD358, BM-018) is highly expressed in differentiating neurons as well as in the adult brain, and is upregulated in injured neurons. DR6 negatively regulates neurondendrocyte, axondendrocyte, and oligodendrocyte survival, hinders axondendrocyte and oligodendrocyte regeneration and its inhibition has a neuro-protective effect in nerve injury. It activates nuclear factor kappa-B (NFkB) and mitogen-activated protein kinase 8 (MAPK8, also called c-Jun N-terminal kinase 1), and induces cell apoptosis by associating with TNFRSF1A-associated via death domain (TRADD), which is known to mediate signal transduction of tumor necrosis factor receptors. TNFRSF21 plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. Its possible ligand is alpha-amyloid precursor protein (APP), hence probably involved in the development of Alzheimer's disease; when released, APP binds in an autocrine/paracrine manner to activate a caspase-dependent self-destruction program that removes unnecessary or connectionless axons. Increasing beta-catenin levels in brain endothelium upregulates TNFRSF21 and TNFRSF19, indicating that these death receptors are downstream target genes of Wnt/beta-catenin signaling, which has been shown to be required for blood-brain barrier development. DR6 is up-regulated in numerous solid tumors as well as in tumor vascular cells, including ovarian cancer and may be a clinically useful diagnostic and predictive serum biomarker for some adult sarcoma subtypes.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   28 CDNCQPGTFCRKYNP-----VCKSCPPSTFSS-IGGQPNCNICRV-CAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTR 100
Cdd:cd10583  15 CDKCPAGTYVSKHCTetslrECSPCPNGTFTRhENGIEQCHRCRKpCPAPMIEKTPCTALTDRECTCPPGTFLSNDTCVP 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6755831  101 cEKDCRPGQELTKQG-------CKTCSLGTFNDQNGTGV-CRPWTNCSLDGRSVLKTGTTEKDVVC 158
Cdd:cd10583  95 -HSVCPVGWGVRKKGtetedvrCKPCPRGTFSDVPSSVLkCKTYTDCLGLGLVVIKPGTKETDNVC 159

Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   28 CDNCQPGT----FCRKYNPVCKSCPPS-TFSSI-GGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGP--QCT 99
Cdd:cd13416  15 CEQCPPGEgvarPCGDNQTVCEPCLDGvTFSDVvSHTEPCQPCTRCPGLMSMRAPCTATHDTVCECAYGYYLDEDsgTCE 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755831  100 RCEKdCRPGQELTKQ-------GCKTCSLGTFNDQNGTGV-CRPWTNCSlDGRSVLKTGTTEKDVVC 158
Cdd:cd13416  95 PCTV-CPPGQGVVQScgpnqdtVCEACPEGTYSDEDSSTDpCLPCTVCE-DGEVELRECTPVSDTVC 159

Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) in teleosts; also known as CD40; TNFRSF5 (commonly known as CD40 and also as CDW40, p50, Bp50) is widely expressed in diverse cell types including B lymphocytes, dendritic cells, platelets, monocytes, endothelial cells, and fibroblasts. It is essential in mediating a wide variety of immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Its natural immunomodulating ligand is CD40L, and a primary defect in the CD40/CD40L system is associated with X-linked hyper-IgM (XHIM) syndrome. It is also involved in tumorigenesis; CD40 expression is significantly higher in gastric carcinomas and it is associated with the lymphatic metastasis of cancer cells and their tumor node metastasis (TNM) classification. Upregulated levels of CD40/CD40L on B cells and T cells may play an important role in the immune pathogenesis of breast cancer. Consequently, the CD40/CD40L system serves as a link between tumorigenesis, atherosclerosis, and the immune system, and offers a potential target for drug therapy for related diseases, such as cancer, atherosclerosis, diabetes mellitus, and immunological rejection. Salmon CD40 and CD40L are widely expressed, particularly in immune tissues, and their importance for the immune response is indicated by their relatively high expression in salmon lymphoid organs and gills.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   71 FRFKKFCSSTHNAECECIEGFHCLGPQCTRC--EKDCRPGQELTKQG-------CKTCSLGTF-NDQNGTGVCRPWTNCS 140
Cdd:cd13422  64 FEISVNKSKTSRSVCKCKPGFHCSSEECLTCvpHTTCGPGQGVKSKGnhirdtvCEECPDGTFsNNSSAEGVCKKWTECE 143

                        90
                ....*....|....*....
gi 6755831  141 lDGRSVLKTGTTEKDVVCG 159
Cdd:cd13422 144 -SGYKVEAAGTNTSDNICV 161

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2; TNFRSF1B (also known as TNFR2, type 2 TNFR, TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b) binds TNF-alpha, but lacks the death domain (DD) that is associated with the cytoplasmic domain of TNFRSF1A (TNFR1). It is inducible and expressed exclusively by oligodendrocytes, astrocytes, T cells, thymocytes, myocytes, endothelial cells, and in human mesenchymal stem cells. TNFRSF1B protects oligodendrocyte progenitor cells (OLGs) against oxidative stress, and induces the up-regulation of cell survival genes. While pro-inflammatory and pathogen-clearing activities of TNF are mediated mainly through activation of TNFRSF1A, a strong activator of NF-kappaB, TNFRSF1B is more responsible for suppression of inflammation. Although the affinities of both receptors for soluble TNF are similar, TNFRSF1B is sometimes more abundantly expressed and thought to associate with TNF, thereby increasing its concentration near TNFRSF1A receptors, and making TNF available to activate TNFRSF1A (a ligand-passing mechanism).

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   24 VQNSCDNCQPG----TFCRK-YNPVCKSCPPSTFSSIGGQ-PNCNICRV-CAGYFRFKKFCSSTHNAECECIEGFHCLGP 96
Cdd:cd10577  12 AQMCCSKCPPGqhvkHSCTKtSDTVCAPCEESTYTQLWNWvPECLSCSSpCSSDQVETQACTRQQNRICSCKPGWYCVLK 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6755831   97 QCTRCE-----KDCRPGQELTKQG-------CKTCSLGTFND-QNGTGVCRPWTNCSldgrSVLKTGTTEKDVVC 158
Cdd:cd10577  92 LQEGCRqcrplKKCGPGFGVARPGtassdveCKPCAPGTFSDtTSSTDTCRPHRICS----SVAIPGNASMDAVC 162

Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR); TNFRSF3 (also known as lymphotoxin beta receptor, LTbetaR, CD18, TNFCR, TNFR3, D12S370, TNFR-RP, TNFR2-RP, LT-BETA-R, TNF-R-III) plays a role in signaling during development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Its ligands include lymphotoxin (LT) alpha/beta membrane form (heterotrimer) and tumor necrosis factor ligand superfamily member 14 (also known as LIGHT). TNFRSF3 agonism by these ligands initiates canonical, as well as non-canonical nuclear factor-kappaB (NF-kappaB) signaling, and preferentially results in the translocation of p52-RELB complexes into the nucleus. While these ligands are often expressed by T and B cells, TNFRSF3 is conspicuous absence on T and B lymphocytes and NK cells, suggesting that signaling may be unidirectional for TNFRSF3. Activity of this receptor has also been linked to carcinogenesis; it helps trigger apoptosis and can also lead to release of the interleukin 8 (IL8). Alternatively spliced transcript variants encoding multiple isoforms have been observed.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   28 CDNCQPGTFC-----RKYNPVCKSCPPSTFSSIGGQ-PNCNICRVCAGYFRFKKF--CSSTHNAECECIEGFHC--LGPQ 97
Cdd:cd10578  49 CSRCPPGTHVsaecsRSQDTVCATCPENSYNEHWNHlSICQLCRPCDPVLGFEEVapCTSDRKTQCRCQPGMFCvhWDNE 128

                        90
                ....*....|....*
gi 6755831   98 CTRCEK--DCRPGQE 110
Cdd:cd10578 129 CEHCEPlsDCPPGTE 143

Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) in teleost; also known as herpes virus entry mediator (HVEM); This subfamily of TNFRSF14 (also known as herpes virus entry mediator or HVEM, ATAR, CD270, HVEA, LIGHTR, TR2) is found in teleosts, many of which are as yet uncharacterized. It regulates T-cell immune responses by activating inflammatory as well as inhibitory signaling pathways. HVEM acts as a receptor for the canonical TNF-related ligand LIGHT (lymphotoxin-like), which exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM. It also acts as a ligand for the immunoglobulin superfamily proteins BTLA (B and T lymphocyte attenuator) and CD160, a feature distinguishing HVEM from other immune regulatory molecules, thus, creating a functionally diverse set of intrinsic and bidirectional signaling pathways. HVEM is highly expressed in the gut epithelium. Genome-wide association studies have shown that HVEM is an inflammatory bowel disease (IBD) risk gene, suggesting that HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense, and the microbiota. Mouse models have revealed that HVEM is involved in colitis pathogenesis, mucosal host defense, and epithelial immunity, thus acting as a mucosal gatekeeper with multiple regulatory functions in the mucosa. HVEM plays a critical role in both tumor progression and resistance to antitumor immune responses, possibly through direct and indirect mechanisms. It is known to be expressed in several human malignancies, including esophageal squamous cell carcinoma, follicular lymphoma, and melanoma. HVEM network may therefore be an attractive target for drug intervention. In Asian seabass, the up-regulation of differentially expressed TNFRSF14 gene has been observed.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   28 CDNCQPGTFCRKY-----NPVCKSCPPSTF-SSIGGQPNCNICRVCAGYF--RFKKFCSSTHNAECECIEGFHCLGPQCT 99
Cdd:cd13405  13 CPMCPPGSRVSRHctedtSTSCVPCPDGTYmDEPNGLEKCFPCTNCDPGFglRVKQGCTYTSDTVCEPLEGFYCIDSTKD 92

                        90
                ....*....|....*
gi 6755831  100 RCE-----KDCRPGQ 109
Cdd:cd13405  93 GCSaaqrhSSCKPGQ 107

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) in teleost; also known as TNFR2; This subfamily of TNFRSF1B (also known as TNFR2, type 2 TNFR, TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b) is found in teleosts. It binds TNF-alpha, but lacks the death domain (DD) that is associated with the cytoplasmic domain of TNFRSF1A (TNFR1). It is inducible and expressed exclusively by oligodendrocytes, astrocytes, T cells, thymocytes, myocytes, endothelial cells, and in human mesenchymal stem cells. TNFRSF1B protects oligodendrocyte progenitor cells (OLGs) against oxidative stress, and induces the up-regulation of cell survival genes. While pro-inflammatory and pathogen-clearing activities of TNF are mediated mainly through activation of TNFRSF1A, a strong activator of NF-kappaB, TNFRSF1B is more responsible for suppression of inflammation. Although the affinities of both receptors for soluble TNF are similar, TNFRSF1B is sometimes more abundantly expressed and thought to associate with TNF, thereby increasing its concentration near TNFRSF1A receptors, and making TNF available to activate TNFRSF1A (a ligand-passing mechanism). Knockout studies in zebrafish embryos have shown that a signaling balance between TNFRSF1A and TNFRSF1B is required for endothelial cell integrity. TNFRSF1A signals apoptosis through caspase-8, whereas TNFRSF1B signals survival via NF-kB in endothelial cells. In goldfish (Carassius aurutus L.), TNFRSF1B expression is substantially higher than that of TNFRSF1 in tissues and various immune cell types. Both receptors are most robustly expressed in monocytes; mRNA levels of TNFRSF1B are lowest in peripheral blood leukocytes.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755831   28 CDNCQPGTFCRKY-----NPVCKSCPPSTFS-SIGGQPNCNICRVCAGY--FRFKKFCSSTHNAECECIEGFHC----LG 95
Cdd:cd15835  21 CSKCRPGTRLKTKcsetsDTVCEPCPSGQYSeNWNYYPNCFSCPKCKERkgLQYAQNCSSTTNAVCVCKPGMYCimgfDH 100

                        90       100
                ....*....|....*....|..
gi 6755831   96 PQCTRCEK--DCRPGQELTKQG 115
Cdd:cd15835 101 PSCSECKKyrTCKPGYGVSVPG 122

TNFR/NGFR cysteine-rich region;

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6755831     47 CPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAEC 85
Cdd:pfam00020   1 CPPGTYTDNWNGLKCLPCTVCPPGQVVVRPCTPTSDTVC 39