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Conserved domains on  [gi|83423526|ref|NP_035885|]
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zinc finger protein 271 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-489 1.79e-19

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 91.30  E-value: 1.79e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 102 KPYECEECGKAFRMSSALVLHQRIHTGEKPYPCSW--CIKSFSRSSDLIKHQRVHTGEKPYKC-DECGKAFSQSSDLMIH 178
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 179 QRIHTGEKPYQCSHCSKSFSQHSGMVKHLRIHT---GEKPYMCNHCYKHFSQSSDLI-------------------KHQR 236
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 237 IHTGEKPYKCDVCGKAFSQSSDRILHQRIHTGEKPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLI 316
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 317 LHQRIHTGE-------KPYPCNQCTKSFSRLSDLINHQR--IHTGEKPYPCSQ----CSKMFSRRSDLVKHYRIHTGEKP 383
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 384 YEC--DKCGKTFSQSSN-----LILHQRIHTGEKPYPC--NSCSKSFSRGSDLIKHQRVHTGEKPYTCN--LCSKSFSQS 452
Cdd:COG5048 352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 83423526 453 SDLTKHQRVHSgEKPYHCSSCNKAFRQSSDLILHHRV 489
Cdd:COG5048 432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-562 3.86e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|..
gi 83423526   541 HQRIHTGEKPYPCAQCGKSFSQ 562
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-489 1.79e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 91.30  E-value: 1.79e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 102 KPYECEECGKAFRMSSALVLHQRIHTGEKPYPCSW--CIKSFSRSSDLIKHQRVHTGEKPYKC-DECGKAFSQSSDLMIH 178
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 179 QRIHTGEKPYQCSHCSKSFSQHSGMVKHLRIHT---GEKPYMCNHCYKHFSQSSDLI-------------------KHQR 236
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 237 IHTGEKPYKCDVCGKAFSQSSDRILHQRIHTGEKPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLI 316
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 317 LHQRIHTGE-------KPYPCNQCTKSFSRLSDLINHQR--IHTGEKPYPCSQ----CSKMFSRRSDLVKHYRIHTGEKP 383
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 384 YEC--DKCGKTFSQSSN-----LILHQRIHTGEKPYPC--NSCSKSFSRGSDLIKHQRVHTGEKPYTCN--LCSKSFSQS 452
Cdd:COG5048 352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 83423526 453 SDLTKHQRVHSgEKPYHCSSCNKAFRQSSDLILHHRV 489
Cdd:COG5048 432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 83423526   230 DLIKHQRIHTGEKPYKCDVCGKAFSQ 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-562 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|..
gi 83423526   541 HQRIHTGEKPYPCAQCGKSFSQ 562
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 130-182 9.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 9.27e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 83423526 130 KPYpCSWCIKSFSRSSDLIKHQRvhtgEKPYKCDECGKAFSQSSDLMIH-QRIH 182
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-489 1.79e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 91.30  E-value: 1.79e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 102 KPYECEECGKAFRMSSALVLHQRIHTGEKPYPCSW--CIKSFSRSSDLIKHQRVHTGEKPYKC-DECGKAFSQSSDLMIH 178
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 179 QRIHTGEKPYQCSHCSKSFSQHSGMVKHLRIHT---GEKPYMCNHCYKHFSQSSDLI-------------------KHQR 236
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 237 IHTGEKPYKCDVCGKAFSQSSDRILHQRIHTGEKPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLI 316
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 317 LHQRIHTGE-------KPYPCNQCTKSFSRLSDLINHQR--IHTGEKPYPCSQ----CSKMFSRRSDLVKHYRIHTGEKP 383
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 384 YEC--DKCGKTFSQSSN-----LILHQRIHTGEKPYPC--NSCSKSFSRGSDLIKHQRVHTGEKPYTCN--LCSKSFSQS 452
Cdd:COG5048 352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 83423526 453 SDLTKHQRVHSgEKPYHCSSCNKAFRQSSDLILHHRV 489
Cdd:COG5048 432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-569 4.96e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 83.98  E-value: 4.96e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 158 KPYKCDECGKAFSQSSDLMIHQRIHTGEKPYQCSH--CSKSFSQHSGMVKHLRIHTGEKPYMCNHCYKHFSQSSDLIKHQ 235
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 236 RIHTGE-KPYKCDVCGKAFSQ--SSDRILHQRIHTGEKPYPcaQCNKSFSQ----NSDLIKHRRIHTGEKPYKCsecgka 308
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSrdPQLPDLLSISNLRNNPLP--GNNSSSVNtpqsNSLHPPLPANSLSKDPSSN------ 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 309 fnqsSVLILHQRIHTGEKPYPCNQCTKSFSRLSDLINHQRIHTGEKPYPCSQCSKMF------SRRSDLVKHYRIHTGEK 382
Cdd:COG5048 184 ----LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 383 PYECDKCGKTFSQSSNLILHQRIHTG-EKPYPCNSCSKSFSRGSDLIKHQR--VHTGE--KPYTC--NLCSKSFSQSSDL 455
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDAL 339

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 456 TKHQRVHSGEKPYHC--SSCNKAFRQSSD-----LILHHRVHTGERPYACT--QCPRSFSQKSDLIKHQRIHTGEKPYKC 526
Cdd:COG5048 340 KRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC 419

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 83423526 527 M---CGKAFSQCSAFTLHQRIHTgEKPYPCAQCGKSFSQRSDLVNH 569
Cdd:COG5048 420 KnppCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-578 1.15e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 270 KPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLIL--HQRIHTGEKPYPCNQ--CTKSFSRLSDLIN 345
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 346 HQrIHTGEKPYPCSQCSKMFSRRSDLVKHYRIHT---GEKPYECDKCGKTFSQSSNLI-------------------LHQ 403
Cdd:COG5048 112 SS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 404 RIHTGEKPYPCNSCSKSFSRGSDLIKHQRVHTGEKPYTCNLCSKSFSQSSDLTKHQRVHSGEKPYHCSSCNKAFRQSSDL 483
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 484 ILHHRVHTGER-------PYACTQCPRSFSQKSDLIKHQR--IHTGE--KPYKCM---CGKAFSQCSAFTLHQRIHTGEK 549
Cdd:COG5048 271 QSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPyslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350
                ....*....|....*....|....*....|.
gi 83423526 550 PYPC--AQCGKSFSQRSDLVNHQRVHADQKL 578
Cdd:COG5048 351 PAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 184-253 2.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.21e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83423526 184 GEKPYQCS--HCSKSFSQHSGMvKHLRIHtgekpymcNHCYKHFSQSSDLIKHQRIHTGEKPYKCDVCGKAF 253
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGL-KYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 83423526   230 DLIKHQRIHTGEKPYKCDVCGKAFSQ 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 7.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 83423526   146 DLIKHQRVHTGEKPYKCDECGKAFSQ 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 7.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 83423526   286 DLIKHRRIHTGEKPYKCSECGKAFNQ 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 380-463 7.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 7.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 380 GEKPYECD--KCGKTFSQSSNLILHqRIHtgekpypcNSCSKSFSRGSDLIKHQRVHTGEKPYTCNLCSKSFSQSSDLtK 457
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                ....*.
gi 83423526 458 HQRVHS 463
Cdd:COG5189 416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 83423526   174 DLMIHQRIHTGEKPYQCSHCSKSFSQ 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 240-318 1.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83423526 240 GEKPYKCDV--CGKAFsQSSDRILHQRIHtgekpypcAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLIL 317
Cdd:COG5189 346 DGKPYKCPVegCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 83423526 318 H 318
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 83423526   370 DLVKHYRIHTGEKPYECDKCGKTFSQ 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-423 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 83423526   398 NLILHQRIHTGEKPYPCNSCSKSFSR 423
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 83423526   342 DLINHQRIHTGEKPYPCSQCSKMFSR 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
541-562 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|..
gi 83423526   541 HQRIHTGEKPYPCAQCGKSFSQ 562
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 384-406 5.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.05e-03
                          10        20
                  ....*....|....*....|...
gi 83423526   384 YECDKCGKTFSQSSNLILHQRIH 406
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-339 5.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.77e-03
                          10        20
                  ....*....|....*....|....*
gi 83423526   315 LILHQRIHTGEKPYPCNQCTKSFSR 339
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-451 5.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|....*.
gi 83423526   426 DLIKHQRVHTGEKPYTCNLCSKSFSQ 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 160-182 7.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.20e-03
                          10        20
                  ....*....|....*....|...
gi 83423526   160 YKCDECGKAFSQSSDLMIHQRIH 182
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 130-182 9.27e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 9.27e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 83423526 130 KPYpCSWCIKSFSRSSDLIKHQRvhtgEKPYKCDECGKAFSQSSDLMIH-QRIH 182
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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