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Conserved domains on  [gi|7549750|ref|NP_035930|]
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cadherin-20 isoform 1 precursor [Mus musculus]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 733-792 9.59e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.33  E-value: 9.59e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-490 3.21e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 3.21e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  394 YFVEVPEDVTIGTTIQIISAKDPDVTNNS-IRYSIDRGSDPGrFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 7549750  473 SQVGSVAVTIKVLDVNDN 490
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-270 5.26e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 5.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  169 PYIATVPEMSPVGTSVIQVTATDADDptyGNSARVVYSILQGQP--YFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKD 246
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 7549750  247 MGGQlgGLAGTTTVNITLSDVNDN 270
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-385 2.10e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSN 357
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST----GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 7549750  358 PHLEmrflnlgPFQDTTTVHISVEDVDE 385
Cdd:cd11304  77 GGGP-------PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.63e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750      85 SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEFIIKIQDINDNEP 163
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-599 2.15e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  498 YEAFICENAKAGQLIQTVSAVDQDDPHNGQhFYYSLAPEAANNPnFTVrdnQDNTARILTRRSGFRQQeQSVFYLPILIA 577
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                        90       100
                ....*....|....*....|..
gi 7549750  578 DSGQPVLSSTGTLTIQVCSCND 599
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 733-792 9.59e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.33  E-value: 9.59e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-490 3.21e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 3.21e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  394 YFVEVPEDVTIGTTIQIISAKDPDVTNNS-IRYSIDRGSDPGrFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 7549750  473 SQVGSVAVTIKVLDVNDN 490
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-270 5.26e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 5.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  169 PYIATVPEMSPVGTSVIQVTATDADDptyGNSARVVYSILQGQP--YFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKD 246
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 7549750  247 MGGQlgGLAGTTTVNITLSDVNDN 270
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-385 2.10e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSN 357
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST----GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 7549750  358 PHLEmrflnlgPFQDTTTVHISVEDVDE 385
Cdd:cd11304  77 GGGP-------PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-272 7.67e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 7.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     188 TATDADDptyGNSARVVYSILQG--QPYFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDMGGQlgGLAGTTTVNITLS 265
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 7549750     266 DVNDNPP 272
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
170-264 1.49e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    170 YIATVPEMSPVGTSVIQVTATDADDPTygnSARVVYSILQGQPY--FSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDM 247
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*..
gi 7549750    248 GGQlgGLAGTTTVNITL 264
Cdd:pfam00028  77 GGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
394-485 2.28e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 2.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    394 YFVEVPEDVTIGTTIQIISAKDPDVTNNS-IRYSIDRGsDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGrIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 7549750    473 SQVGSVAVTIKVL 485
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-492 9.00e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 9.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     412 SAKDPDVTNNS-IRYSIDRGSDPGrFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVAVTIKVLDVNDN 490
Cdd:smart00112   1 SATDADSGENGkVTYSILSGNDDG-LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 7549750     491 AP 492
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.63e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750      85 SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEFIIKIQDINDNEP 163
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-599 2.15e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  498 YEAFICENAKAGQLIQTVSAVDQDDPHNGQhFYYSLAPEAANNPnFTVrdnQDNTARILTRRSGFRQQeQSVFYLPILIA 577
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                        90       100
                ....*....|....*....|..
gi 7549750  578 DSGQPVLSSTGTLTIQVCSCND 599
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 80-161 4.20e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 4.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750   80 VGKLH-SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRtGRPMEPESEFIIKIQD 157
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITVLD 94


                ....
gi 7549750  158 INDN 161
Cdd:cd11304  95 VNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-387 6.64e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 6.64e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     298 AKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSNphlemrfLNLGPFQDTTTVH 377
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 7549750     378 ISVEDV-DEPP 387
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
279-381 1.79e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    279 YQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSNp 358
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 7549750    359 hlemrfLNLGPFQDTTTVHISVE 381
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
498-595 6.50e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 6.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    498 YEAFICENAKAGQLIQTVSAVDQDDPHNGQHFYYSLAPEAANnpNFTV-RDNQD-NTARILTRrsgfrqQEQSVFYLPIL 575
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIdPDTGDiSTTKPLDR------ESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 7549750    576 IADSGQPVLSSTGTLTIQVC 595
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
73-156 2.41e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 2.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     73 TGTDPLYVGKlhSDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEF 151
Cdd:pfam00028  11 VGTEVLTVTA--TDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATV 87


                  ....*
gi 7549750    152 IIKIQ 156
Cdd:pfam00028  88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 516-599 9.42e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 9.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     516 SAVDQDDPHNGQhFYYSLAPEAANNPnFTVRDNQDntarILTRRSGFRQQEQSVFYLPILIADSGQPVLSSTGTLTIQVC 595
Cdd:smart00112   1 SATDADSGENGK-VTYSILSGNDDGL-FSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 7549750     596 SCND 599
Cdd:smart00112  75 DVND 78
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 733-792 9.59e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.33  E-value: 9.59e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-490 3.21e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 3.21e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  394 YFVEVPEDVTIGTTIQIISAKDPDVTNNS-IRYSIDRGSDPGrFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 7549750  473 SQVGSVAVTIKVLDVNDN 490
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-270 5.26e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 5.26e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  169 PYIATVPEMSPVGTSVIQVTATDADDptyGNSARVVYSILQGQP--YFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKD 246
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 7549750  247 MGGQlgGLAGTTTVNITLSDVNDN 270
Cdd:cd11304  77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-385 2.10e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 2.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSN 357
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST----GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 7549750  358 PHLEmrflnlgPFQDTTTVHISVEDVDE 385
Cdd:cd11304  77 GGGP-------PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-272 7.67e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 7.67e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     188 TATDADDptyGNSARVVYSILQG--QPYFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDMGGQlgGLAGTTTVNITLS 265
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 7549750     266 DVNDNPP 272
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
170-264 1.49e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    170 YIATVPEMSPVGTSVIQVTATDADDPTygnSARVVYSILQGQPY--FSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDM 247
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*..
gi 7549750    248 GGQlgGLAGTTTVNITL 264
Cdd:pfam00028  77 GGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
394-485 2.28e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 2.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    394 YFVEVPEDVTIGTTIQIISAKDPDVTNNS-IRYSIDRGsDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGrIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 7549750    473 SQVGSVAVTIKVL 485
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-492 9.00e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 9.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     412 SAKDPDVTNNS-IRYSIDRGSDPGrFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVAVTIKVLDVNDN 490
Cdd:smart00112   1 SATDADSGENGkVTYSILSGNDDG-LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 7549750     491 AP 492
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.63e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750      85 SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEFIIKIQDINDNEP 163
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-599 2.15e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.12  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750  498 YEAFICENAKAGQLIQTVSAVDQDDPHNGQhFYYSLAPEAANNPnFTVrdnQDNTARILTRRSGFRQQeQSVFYLPILIA 577
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                        90       100
                ....*....|....*....|..
gi 7549750  578 DSGQPVLSSTGTLTIQVCSCND 599
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 80-161 4.20e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 4.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750   80 VGKLH-SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRtGRPMEPESEFIIKIQD 157
Cdd:cd11304  16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITVLD 94


                ....
gi 7549750  158 INDN 161
Cdd:cd11304  95 VNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-387 6.64e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 6.64e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     298 AKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSNphlemrfLNLGPFQDTTTVH 377
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 7549750     378 ISVEDV-DEPP 387
Cdd:smart00112  71 ITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
279-381 1.79e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    279 YQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDINTDQnfqvGIITVKKPLSFESKKSYTLKVEGSNp 358
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 7549750    359 hlemrfLNLGPFQDTTTVHISVE 381
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
498-595 6.50e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 6.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750    498 YEAFICENAKAGQLIQTVSAVDQDDPHNGQHFYYSLAPEAANnpNFTV-RDNQD-NTARILTRrsgfrqQEQSVFYLPIL 575
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIdPDTGDiSTTKPLDR------ESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 7549750    576 IADSGQPVLSSTGTLTIQVC 595
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
73-156 2.41e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 2.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     73 TGTDPLYVGKlhSDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEF 151
Cdd:pfam00028  11 VGTEVLTVTA--TDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATV 87


                  ....*
gi 7549750    152 IIKIQ 156
Cdd:pfam00028  88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 516-599 9.42e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 9.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750     516 SAVDQDDPHNGQhFYYSLAPEAANNPnFTVRDNQDntarILTRRSGFRQQEQSVFYLPILIADSGQPVLSSTGTLTIQVC 595
Cdd:smart00112   1 SATDADSGENGK-VTYSILSGNDDGL-FSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 7549750     596 SCND 599
Cdd:smart00112  75 DVND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 68-161 3.98e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.10  E-value: 3.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7549750   68 VLEEYTGtdPLYVGKLHSDMDRGDGSIkYILSGEGAGI---VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRP 144
Cdd:cd00031   6 AVEGRSR--GSFRVSIPTDLIASSGEI-IKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                        90
                ....*....|....*..
gi 7549750  145 MEPeSEFIIKIQDINDN 161
Cdd:cd00031  83 QTS-SVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 433-490 9.27e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.25  E-value: 9.27e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 7549750  433 PGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVAVTIKVLDVNDN 490
Cdd:cd00031  41 LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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