|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
103-513 |
2.12e-148 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 439.65 E-value: 2.12e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 180 VKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfedsppdl 259
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVT------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 260 qpqgspfqlnseeqnnpqiaqNSVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSrs 339
Cdd:cd03586 106 ---------------------DYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPPE-- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 340 AVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGERKSMSVER 419
Cdd:cd03586 163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 420 TFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEvnvg 498
Cdd:cd03586 243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEEL---- 318
|
410
....*....|....*
gi 6753636 499 sPHPLRLRLMGVRMS 513
Cdd:cd03586 319 -LDGRPIRLLGVRLS 332
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
107-521 |
7.04e-103 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 322.07 E-value: 7.04e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 107 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 182
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 183 ILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfeDSPpdlQPQ 262
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVT-------------------------------------------------DNK---LCI 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 263 GSpfqlnseeqnnpqiaqnsvvfgtsAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRsaVM 342
Cdd:PRK02406 109 GS------------------------ATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 343 DFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyQQRALLSLLfsetswHYF------LHialglgstDLAR-------- 408
Cdd:PRK02406 163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELI------RHFgkfgrrLY--------ERARgiderpvk 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 409 -DGERKSMSVERTFSEISKTEEQyslCQE----LCAELAHDLQKEG--LKGRTVTIKLKNVNFEVKTRaSTVPAAISTAE 481
Cdd:PRK02406 228 pDRERKSVGVERTFAEDLYDLEA---CLAelprLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKAD 303
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 6753636 482 EIFAIAKELLRTEVNVGsphplrLRLMGVRMSTFSSEDDR 521
Cdd:PRK02406 304 LIELLAQALLRRLGGRG------VRLLGVGVTLLEPQLER 337
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
101-513 |
9.40e-100 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 313.62 E-value: 9.40e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 177
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 178 KEVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmgnylkidtprqeanelteyersispllfedspp 257
Cdd:COG0389 82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 258 dlqpqgspfqlnseeqnnpqiaqnsvvfgTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPS 337
Cdd:COG0389 115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 338 RsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ-RALLSLLFSEtSWHYFLHIALGLGSTDLARDGERKSMS 416
Cdd:COG0389 166 E--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 417 VERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEV 495
Cdd:COG0389 243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLERIY 322
|
410
....*....|....*...
gi 6753636 496 NVGSPhplrLRLMGVRMS 513
Cdd:COG0389 323 RPGRP----VRLLGVRLS 336
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
105-324 |
2.71e-46 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 162.36 E-value: 2.71e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 181
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 182 EILAEY-DPNFMAMSLDEAYLnitqhlqerqdwpedkrryfikmgnylkidtprqeanELTEYERsisplLFEDSppdlq 260
Cdd:pfam00817 81 EILRRFsTPKVEQASIDEAFL-------------------------------------DLTGLEK-----LFGAE----- 113
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6753636 261 pqgspfqlnseeqnnpqiaqnsvvfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 324
Cdd:pfam00817 114 -----------------------------EALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
620-645 |
1.60e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 42.21 E-value: 1.60e-05
10 20
....*....|....*....|....*.
gi 6753636 620 FICPVCFREqegVSLEAFNEHVDECL 645
Cdd:smart00734 2 VQCPVCFRE---VPENLINSHLDSCL 24
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
761-787 |
5.03e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 40.67 E-value: 5.03e-05
10 20
....*....|....*....|....*..
gi 6753636 761 ALVCPVCNLEQetsDLTLFNIHVDICL 787
Cdd:smart00734 1 LVQCPVCFREV---PENLINSHLDSCL 24
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
103-513 |
2.12e-148 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 439.65 E-value: 2.12e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 180 VKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfedsppdl 259
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVT------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 260 qpqgspfqlnseeqnnpqiaqNSVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSrs 339
Cdd:cd03586 106 ---------------------DYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPPE-- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 340 AVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGERKSMSVER 419
Cdd:cd03586 163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 420 TFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEvnvg 498
Cdd:cd03586 243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEEL---- 318
|
410
....*....|....*
gi 6753636 499 sPHPLRLRLMGVRMS 513
Cdd:cd03586 319 -LDGRPIRLLGVRLS 332
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
107-521 |
7.04e-103 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 322.07 E-value: 7.04e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 107 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 182
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 183 ILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfeDSPpdlQPQ 262
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVT-------------------------------------------------DNK---LCI 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 263 GSpfqlnseeqnnpqiaqnsvvfgtsAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRsaVM 342
Cdd:PRK02406 109 GS------------------------ATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 343 DFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyQQRALLSLLfsetswHYF------LHialglgstDLAR-------- 408
Cdd:PRK02406 163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELI------RHFgkfgrrLY--------ERARgiderpvk 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 409 -DGERKSMSVERTFSEISKTEEQyslCQE----LCAELAHDLQKEG--LKGRTVTIKLKNVNFEVKTRaSTVPAAISTAE 481
Cdd:PRK02406 228 pDRERKSVGVERTFAEDLYDLEA---CLAelprLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKAD 303
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 6753636 482 EIFAIAKELLRTEVNVGsphplrLRLMGVRMSTFSSEDDR 521
Cdd:PRK02406 304 LIELLAQALLRRLGGRG------VRLLGVGVTLLEPQLER 337
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
101-513 |
9.40e-100 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 313.62 E-value: 9.40e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 177
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 178 KEVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmgnylkidtprqeanelteyersispllfedspp 257
Cdd:COG0389 82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 258 dlqpqgspfqlnseeqnnpqiaqnsvvfgTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPS 337
Cdd:COG0389 115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 338 RsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ-RALLSLLFSEtSWHYFLHIALGLGSTDLARDGERKSMS 416
Cdd:COG0389 166 E--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 417 VERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEV 495
Cdd:COG0389 243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLERIY 322
|
410
....*....|....*...
gi 6753636 496 NVGSPhplrLRLMGVRMS 513
Cdd:COG0389 323 RPGRP----VRLLGVRLS 336
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
16-537 |
2.59e-82 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 275.36 E-value: 2.59e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 16 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDK 87
Cdd:PTZ00205 42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 88 FAMELERNRNLNnTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 167
Cdd:PTZ00205 122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 168 PNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQErqdwpedkrryfikmgnylkidtprqeanelteyersi 247
Cdd:PTZ00205 201 PDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIER-------------------------------------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 248 spllFEdsppdlqpqgspfqlnseeqnnpqiaqnsvvfGT-SAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKN 326
Cdd:PTZ00205 243 ----FE--------------------------------GTkTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNIN 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 327 KPNGQYQI-LPSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGL---- 401
Cdd:PTZ00205 287 KPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASIGImqwp 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 402 --------GSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTV 473
Cdd:PTZ00205 367 daataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQYTKSL 446
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6753636 474 PAAISTAEEIFAIAKELLRtevnvgsPHPLR---LRLMGVRMSTFSSEDDRkHQQRsiigflQAGNQ 537
Cdd:PTZ00205 447 IQYSDDSATLRRAVDGLLL-------PHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
98-528 |
1.38e-67 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 228.45 E-value: 1.38e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 98 LNNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK14133 1 MDRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITQhlqerqdwpedkrryfikmgnylkIDtprqeanelteyersispllfed 254
Cdd:PRK14133 81 EVSKNIFKILYEVTPIVEPVSIDEAYLDITN------------------------IK----------------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 255 sppdlqpqgspfqlnseeqNNPqiaqnsvvfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 334
Cdd:PRK14133 114 -------------------EEP-------------IKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKII 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 335 lpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ-QRALLSLLFSETSWHYFLHIAlGLGSTDLARDGERK 413
Cdd:PRK14133 162 --TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEVSRERK 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 414 SMSVERTFS-EISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLR 492
Cdd:PRK14133 239 SIGKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEILE 318
|
410 420 430
....*....|....*....|....*....|....*.
gi 6753636 493 tEVNVGSPhplrLRLMGVRMSTFSSEddrKHQQRSI 528
Cdd:PRK14133 319 -HINIKEP----IRLIGLSVSNLSEN---KIEQLSF 346
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
101-520 |
4.71e-67 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 229.43 E-value: 4.71e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 178
Cdd:PRK02794 37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 179 EVKEILAEYDPNFMAMSLDEAYLnitqhlqerqdwpedkrryfikmgnylkidtprqeanELTEYERsisplLFEDSPpd 258
Cdd:PRK02794 117 EVRAMMQALTPLVEPLSIDEAFL-------------------------------------DLSGTER-----LHGAPP-- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 259 lqpqgspfqlnseeqnnpqiaqnSVVFgtsaeevvkeIRF--RIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQILp 336
Cdd:PRK02794 153 -----------------------AVVL----------ARFarRVEREIGITVSVGLSYNKFLAKIASDLDKPRG-FSVI- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 337 SRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLFSETSWHYflHIALGLGSTDLARDGERKS 414
Cdd:PRK02794 198 GRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSPDREAKS 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 415 MSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRT 493
Cdd:PRK02794 276 VSAETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLEK 355
|
410 420
....*....|....*....|....*..
gi 6753636 494 EvnvgsPHPLRLRLMGVRMSTFSSEDD 520
Cdd:PRK02794 356 E-----TDGTAFRLIGIGVSDLSPADE 377
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
101-517 |
1.33e-60 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 212.49 E-value: 1.33e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 176
Cdd:PRK03348 6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 177 SKEVKEILAEYDPNFMAMSLDEAYLNitqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfedsP 256
Cdd:PRK03348 86 SRRVFDTLRELSPVVEQLSFDEAFVE-----------------------------------------------------P 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 257 PDLQpqgspfqlnseeqnnpqiaqnsvvfGTSAEEVVK---EIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQ 333
Cdd:PRK03348 113 AELA-------------------------GASAEEVEAfaeRLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRV 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 334 ILPSRSavMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLfSETSWHYFLHIALGLGSTDLARDGE 411
Cdd:PRK03348 168 VPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAAlsEAEVANLL-GATVGPALHRLARGIDDRPVAERAE 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 412 RKSMSVERTFSEISKTEEQYSLCQELCAELAHD-LQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKEL 490
Cdd:PRK03348 245 AKQISAESTFAVDLTTRAQLREAIERIAEHAHRrLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVLAATARRL 324
|
410 420
....*....|....*....|....*..
gi 6753636 491 LRTEVNVGSphplrLRLMGVRMSTFSS 517
Cdd:PRK03348 325 LLDPDEIGP-----IRLVGVGFSGLSD 346
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
103-513 |
1.15e-52 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 187.18 E-value: 1.15e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 103 VHVDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 178
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVvpfnSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 179 EVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfedsppd 258
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLT------------------------------------------------------ 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 259 lqpqGSPFQLnseeqnnpqiaqnsvvfgTSAEEVVKEIRFRIEQKT-TLTASAGIAPNTMLAKVCSDKNKPNGQYQILPs 337
Cdd:cd00424 107 ----GSARLL------------------GLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLTILDP- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 338 rSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELY--QQRALLSLLFSETS--WHYFLHialGLGSTDLARDGERK 413
Cdd:cd00424 164 -EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPPRPRK 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 414 SMSVERTFSEISKTEEQ-YSLCQELCAELAHDLQKEGLKGRTVTIKLKNVN------FEVKTRASTVPAAISTaEEIFAI 486
Cdd:cd00424 240 SFSHERVLPRDSRNAEDaRPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GELLHA 318
|
410 420
....*....|....*....|....*..
gi 6753636 487 AKELLRTEVNVgsPHPLRLRLMGVRMS 513
Cdd:cd00424 319 LDKLWRALLDD--KGPRRLRRLGVRLS 343
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
102-567 |
2.73e-52 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 187.93 E-value: 2.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 102 IVHVDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 176
Cdd:PRK01810 7 IFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYREA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 177 SKEVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkiDTPrqeanelteyeRSISPLlfedsp 256
Cdd:PRK01810 87 SRQMFQILSEFTPLVQPVSIDEGYLDIT--------------------------DCY-----------ALGSPL------ 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 257 pdlqpqgspfqlnseeqnnpqiaqnsvvfgtsaeEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQILP 336
Cdd:PRK01810 124 ----------------------------------EIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG-ITVLR 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 337 SRSaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ-QRALLSLLFSETSWHyfLH-IALGL--GSTDLARDGER 412
Cdd:PRK01810 169 KRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGINGVR--LQrRANGIddRPVDPEAIYQF 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 413 KSMSVERTFSEISKTE-EQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELL 491
Cdd:PRK01810 246 KSVGNSTTLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWEKRDIFQAASRLF 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 492 RTEVNvGSPhplrLRLMGV-------------RMSTFSSEDDRKHQQ-RSIIGFLQA--GNQALSSTGDSLDKTDKTEla 555
Cdd:PRK01810 326 KQHWN-GDP----VRLLGVtatdlewkteavkQLDLFSFEEDAKEEPlLAVIDQINDkyGMPLLQRGSQLLRKQEKTF-- 398
|
490
....*....|..
gi 6753636 556 kplEMSHKKSFF 567
Cdd:PRK01810 399 ---GTSFEKDFM 407
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
101-546 |
2.73e-50 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 182.11 E-value: 2.73e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 180
Cdd:PRK03858 5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 181 KEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRyfikmgnylkidtprqeanelteyersispllfedsppdlq 260
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVG-----------GLRR----------------------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 261 pqgspfqlnseeqnnpqiaqnsvVFGTSAeEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRSa 340
Cdd:PRK03858 112 -----------------------ISGTPV-QIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRE- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 341 vMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLFSETSWHyfLHiALGlgstdLARD-------GE 411
Cdd:PRK03858 167 -LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LH-ALA-----HNRDprrvetgRR 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 412 RKSMSVERTFSEISKTEEQY--SLCQeLCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKE 489
Cdd:PRK03858 238 RRSVGAQRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAARD 316
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 6753636 490 LLRtevNVGSPHPLR-LRLMGVRMSTFsseDDRKHQQRSIIGFLQAGNQALSSTGDSL 546
Cdd:PRK03858 317 LVA---AAAPLIAERgLTLVGFAVSNL---DDDGAQQLELPFGLRRPGSALDAALDAV 368
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
98-493 |
2.39e-48 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 176.74 E-value: 2.39e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 98 LNNTIVHVDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLATSNYHARRFGVRAAMpgFI--AKRLCPQLIIVPPNFD 171
Cdd:cd01701 45 LQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSYGIKNGM--WVgqAKKLCPQLVTLPYDFE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 172 KYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQErqdwpedkrryfikmgnylkidtprqeaneltEYErsispll 251
Cdd:cd01701 123 AYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEE--------------------------------TYE------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 252 fedsppdlqpqgspfqlnseeqnnpqiaqnsvvfgtSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQ 331
Cdd:cd01701 164 ------------------------------------LPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDGQ 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 332 YQILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ----RALLSLLFSETSWHyFLHIALGLGSTDLA 407
Cdd:cd01701 208 YHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkEKLQKVLGPKTGEK-LYDYCRGIDDRPVT 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 408 RDGERKSMSVERTFSEISKTEEQ-YSLCQELCAELAHDLQKEGLKGRTVTIKLKN------------------VNFevkT 468
Cdd:cd01701 285 GEKERKSVSAEINYGIRFTNVDDvEQFLQRLSEELSKRLEESNVTGRQITLKLMKrapgapieppkymghgicDSF---S 361
|
410 420
....*....|....*....|....*
gi 6753636 469 RASTVPAAISTAEEIFAIAKELLRT 493
Cdd:cd01701 362 KSSTLGVATDDSGVIGTEAKKLFRD 386
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
105-324 |
2.71e-46 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 162.36 E-value: 2.71e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 181
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 182 EILAEY-DPNFMAMSLDEAYLnitqhlqerqdwpedkrryfikmgnylkidtprqeanELTEYERsisplLFEDSppdlq 260
Cdd:pfam00817 81 EILRRFsTPKVEQASIDEAFL-------------------------------------DLTGLEK-----LFGAE----- 113
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6753636 261 pqgspfqlnseeqnnpqiaqnsvvfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 324
Cdd:pfam00817 114 -----------------------------EALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
102-528 |
5.71e-37 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 143.99 E-value: 5.71e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLATSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 175
Cdd:PRK03103 5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 176 VSKEVKEILAEYDPNFMAMSLDEAYLNITQhlqerqdwpedkrryfikmgnylkidtprqeanelteyersiSPLLFeds 255
Cdd:PRK03103 84 VSLQITRILEDFTDLVEPFSIDEQFLDVTG------------------------------------------SQKLF--- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 256 ppdlqpqGSPFqlnseeqnnpQIAQNsvvfgtsaeevvkeIRFRIEQKTTLTASAGIAPNTMLAKVCSD---KNKPNGQY 332
Cdd:PRK03103 119 -------GSPL----------EIAQK--------------IQQRIMRETGVYARVGIGPNKLLAKMACDnfaKKNPDGLF 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 333 QIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyqqrALLSLLFSETSW----HYFLHIALGLGSTDLAR 408
Cdd:PRK03103 168 TL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLWRTANGIDYSPVTP 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 409 DG--ERKSMSVERTF-SEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKT---RASTVPAAISTAEE 482
Cdd:PRK03103 242 HSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAME 321
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 6753636 483 IFAIAKELLRTEVNvGSPhplrLRLMGVRMSTFSSED-------DRKHQQRSI 528
Cdd:PRK03103 322 VYEAACKLFHRHWD-GKP----VRRVGVTLSNLVSDDvwqlslfGDRERKRSL 369
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
102-511 |
2.05e-35 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 137.85 E-value: 2.05e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK03352 7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylkidtprqeanelteyersispllfED 254
Cdd:PRK03352 87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD------------------------------------------------TD 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 255 SPpdlqpqgspfqlnseeqnnpqiaqnsvvfgtsaEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 334
Cdd:PRK03352 119 DP---------------------------------EALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRL 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 335 lpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTEL-YQQRALLSLLFSETSWHYFLHIALGLGSTDL-ARDGER 412
Cdd:PRK03352 166 --TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGDTEVsAEPWVP 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 413 KSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELL 491
Cdd:PRK03352 244 RSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTKIRKLPEPTTDPDVIEAAALDVL 323
|
410 420
....*....|....*....|
gi 6753636 492 rTEVNVGSPhplrLRLMGVR 511
Cdd:PRK03352 324 -DRFELDRP----VRLLGVR 338
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
103-378 |
6.43e-34 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 134.52 E-value: 6.43e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 181
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 182 EILAEYDPNFMA--MSLDEAYLNITqhlqerqdwpeDKRryfikmgnylkidtprqeanelteyersispLLFedsppdl 259
Cdd:cd01703 81 RLLRSYSWNDRVerLGFDENFMDVT-----------EMR-------------------------------LLV------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 260 qpqGSpfqlnseeqnnpQIAQnsvvfgtsaeevvkEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILP-SR 338
Cdd:cd01703 112 ---AS------------HIAY--------------EMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPpSC 162
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 6753636 339 SAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ 378
Cdd:cd01703 163 ADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEF 202
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
103-492 |
9.90e-34 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 133.21 E-value: 9.90e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 168
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 169 ---------NFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLnitqhlqerqdwpedkrryfikmgnylkidtprqeane 239
Cdd:cd01702 81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYL-------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 240 lteyersispllfedsppDLqpqgspfqlnseeqnnpqiaqnsvvfgtsAEEVVKEIRFRIEQKTTLTASAGIAPNTMLA 319
Cdd:cd01702 123 ------------------DL-----------------------------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLA 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 320 KVCSDKNKPNGQyQILPSrSAVMDFIKDLPIRKVSGI-GKVTEKMLMALGIVTCTELYQQRALLSLL---FSET--SWHY 393
Cdd:cd01702 156 KLASGMNKPNAQ-TILRN-DAVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWLY 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 394 flHIALGLGSTDLARDGERKSMSVERTFS--EISKTEEQYSLCQELCAELAHDLQKE----GLKGRTVTIKLKNVNFEVK 467
Cdd:cd01702 234 --NLLRGIDHEPVKPRPLPKSMGSSKNFPgkTALSTEDVQHWLLVLASELNSRLEDDryenNRRPKTLVLSLRQRGDGVR 311
|
410 420
....*....|....*....|....*
gi 6753636 468 TRASTvPAAISTAEEIFAIAKELLR 492
Cdd:cd01702 312 RSRSC-ALPRYDAQKIVKDAFKLIK 335
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
102-369 |
2.00e-31 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 126.44 E-value: 2.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITQhlqerqdwpedkrryfiKMGNYlkidtprQEANELTeyersispllfed 254
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISD-----------------KVKNY-------QDAYNLG------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 255 sppdlqpqgspfqlnseeqnnpqiaqnsvvfgtsaeevvKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 334
Cdd:PRK01216 126 ---------------------------------------LEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVI 166
|
250 260 270
....*....|....*....|....*....|....*
gi 6753636 335 LPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGI 369
Cdd:PRK01216 167 DDEE--VKRFINELDIADIPGIGDITAEKLKKLGV 199
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
105-492 |
9.29e-27 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 112.26 E-value: 9.29e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNyHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRAVSKE 179
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVLSnndGCVIARSP-EAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGDMSRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 180 VKEILAEYDPNFMAMSLDEAylnitqhlqerqdwpedkrryFIKMGNYLKIDTPRqeanelteyersispllfedsppdl 259
Cdd:cd01700 82 IMSILERFSPDVEVYSIDES---------------------FLDLTGSLRFGDLE------------------------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 260 qpqgspfqlnseeqnnpqiaqnsvvfgtsaeEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD----KNKPNGQYQIL 335
Cdd:cd01700 116 -------------------------------ELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPYGGVVDLT 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 336 --PSRSAVMdfiKDLPIRKVSGIGKVTEKMLMALGIVT-----CTELYQQRALLSLLFSETSWHyfLHialGLGSTDLAR 408
Cdd:cd01700 165 deEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LN---GIDCLPLEE 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 409 -DGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNF--EVKTRASTVPAAISTAE--E 482
Cdd:cd01700 237 yPPPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFsrQPKYYSATNTLPYPTNDtrE 316
|
410
....*....|
gi 6753636 483 IFAIAKELLR 492
Cdd:cd01700 317 IVKAALRLLY 326
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
412-519 |
2.57e-23 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 95.32 E-value: 2.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 412 RKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKEL 490
Cdd:pfam11799 1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80
|
90 100
....*....|....*....|....*....
gi 6753636 491 LRTEVnvgspHPLRLRLMGVRMSTFSSED 519
Cdd:pfam11799 81 LRRLY-----RGRPVRLLGVSLSNLVPEG 104
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
620-645 |
1.60e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 42.21 E-value: 1.60e-05
10 20
....*....|....*....|....*.
gi 6753636 620 FICPVCFREqegVSLEAFNEHVDECL 645
Cdd:smart00734 2 VQCPVCFRE---VPENLINSHLDSCL 24
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
338-369 |
4.58e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 40.84 E-value: 4.58e-05
10 20 30
....*....|....*....|....*....|..
gi 6753636 338 RSAVMDFIKDLPIRKVSGIGKVTEKMLMALGI 369
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
761-787 |
5.03e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 40.67 E-value: 5.03e-05
10 20
....*....|....*....|....*..
gi 6753636 761 ALVCPVCNLEQetsDLTLFNIHVDICL 787
Cdd:smart00734 1 LVQCPVCFREV---PENLINSHLDSCL 24
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
104-378 |
6.24e-05 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 46.30 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 104 HVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNyHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSK 178
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgcVIARSA-EAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 179 EVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpedkrryfikmgnylKIDTPRqeanELTEYERsispllfedsppd 258
Cdd:PRK03609 83 RVMSTLEELSPRVEIYSIDEAFCDLT------------------------GVRNCR----DLTDFGR------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 259 lqpqgspfqlnseeqnnpqiaqnsvvfgtsaeevvkEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKpngQYQilPSR 338
Cdd:PRK03609 122 ------------------------------------EIRATVLQRTHLTVGVGIAQTKTLAKLANHAAK---KWQ--RQT 160
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 6753636 339 SAVMD---------FIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ 378
Cdd:PRK03609 161 GGVVDlsnlerqrkLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
296-492 |
3.01e-03 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 40.83 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 296 IRFRIEQKTT-LTASAGIAPNTMLAKVCSDKNKPNGQYQIlPSRSAVMDFIKDLPIRkVSGIGKVTEKMLMALGIVT--- 371
Cdd:cd03468 119 ASLRAALATLgLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgd 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753636 372 CTELYqqRALLSLLFSE--TSWHYFLhialgLGSTDLARDG----ERKSMSVERTF-SEISKTEEQysLCQELCAELAHD 444
Cdd:cd03468 197 LAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQLeEPIARGLLF--PLRRLLEQLCAF 267
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 6753636 445 LQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLR 492
Cdd:cd03468 268 LALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
|
|
| |
