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Conserved domains on  [gi|8393259|ref|NP_036275|]
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tuftelin-interacting protein 11 isoform 1 [Homo sapiens]

Protein Classification

G-patch and GCFC domain-containing protein( domain architecture ID 10575582)

protein containing domains TIP_N, G-patch, and GCFC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
 397-666 1.50e-132

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


:

Pssm-ID: 400273  Cd Length: 275  Bit Score: 396.05  E-value: 1.50e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    397 LDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADA 476
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDILSRWRKLLEPDVSSDDTGGRESMDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    477 FHRLIWEVWMPFVRN-IVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTV-----PIHS 550
Cdd:pfam07842  81 YETMLWEGWLPSYRSsIISTWDPRDPDPMLALLEAWAPLLPSWILDNILEQLILPKLTAAVEEWDPLSDTVtrnlvPIHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    551 WIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSsAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ 630
Cdd:pfam07842 161 WIHPWLPLLGARLEPLYPDIRRKLRQALDAWHPSRS-ALAGLKPWKDVFSPGEWDKFLRRHILPKLALALQEFVINPRQQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 8393259    631 HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVL 666
Cdd:pfam07842 240 SLELFRNVLKWKDLLPPSVLADLLEKEFFPKWLQVL 275
TIP_N pfam12457
Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is ...
 23-104 5.96e-26

Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralization of enamel - tuftelin.


:

Pssm-ID: 463593  Cd Length: 94  Bit Score: 102.45  E-value: 5.96e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259     23 NFEI-TDWDLQNEFNPNRQR-HWQTKEEATYGVWAERDSDDERPSFGGKRAR-----DYSAPVNFISAGLKKGAAEEAEL 95
Cdd:pfam12457   6 RFDIeNDYDLDGEFNYKRRRrRRQTKEDAIYGIFADDDSDDDEGGRRSSKRDlrgrkDYTKPVAFVSGGIQQPGKKDKEI 85


                  ....*....
gi 8393259     96 EDSDDEEKP 104
Cdd:pfam12457  86 DDDSDDEEE 94
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 149-193 4.82e-18

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 77.93  E-value: 4.82e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 8393259    149 TKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 193
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
 
Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
 397-666 1.50e-132

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


Pssm-ID: 400273  Cd Length: 275  Bit Score: 396.05  E-value: 1.50e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    397 LDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADA 476
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDILSRWRKLLEPDVSSDDTGGRESMDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    477 FHRLIWEVWMPFVRN-IVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTV-----PIHS 550
Cdd:pfam07842  81 YETMLWEGWLPSYRSsIISTWDPRDPDPMLALLEAWAPLLPSWILDNILEQLILPKLTAAVEEWDPLSDTVtrnlvPIHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    551 WIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSsAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ 630
Cdd:pfam07842 161 WIHPWLPLLGARLEPLYPDIRRKLRQALDAWHPSRS-ALAGLKPWKDVFSPGEWDKFLRRHILPKLALALQEFVINPRQQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 8393259    631 HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVL 666
Cdd:pfam07842 240 SLELFRNVLKWKDLLPPSVLADLLEKEFFPKWLQVL 275
TIP_N pfam12457
Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is ...
 23-104 5.96e-26

Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralization of enamel - tuftelin.


Pssm-ID: 463593  Cd Length: 94  Bit Score: 102.45  E-value: 5.96e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259     23 NFEI-TDWDLQNEFNPNRQR-HWQTKEEATYGVWAERDSDDERPSFGGKRAR-----DYSAPVNFISAGLKKGAAEEAEL 95
Cdd:pfam12457   6 RFDIeNDYDLDGEFNYKRRRrRRQTKEDAIYGIFADDDSDDDEGGRRSSKRDlrgrkDYTKPVAFVSGGIQQPGKKDKEI 85


                  ....*....
gi 8393259     96 EDSDDEEKP 104
Cdd:pfam12457  86 DDDSDDEEE 94
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 149-193 4.82e-18

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 77.93  E-value: 4.82e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 8393259    149 TKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 193
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 148-193 7.68e-16

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 71.81  E-value: 7.68e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 8393259     148 HTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 193
Cdd:smart00443   2 STSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47
 
Name Accession Description Interval E-value
GCFC pfam07842
GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a ...
 397-666 1.50e-132

GC-rich sequence DNA-binding factor-like protein; This entry describes a domain found in a number of GC-rich sequence DNA-binding factor proteins and homologs, as well as in a number of other proteins including Tuftelin-interacting protein 11. While the function of the domain is unknown, some of the proteins it is found in are reported to be involved in pre-mRNA splicing. This domain is also found in Sip1, a septin interacting protein.


Pssm-ID: 400273  Cd Length: 275  Bit Score: 396.05  E-value: 1.50e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    397 LDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADA 476
Cdd:pfam07842   1 LDEIADIFERLQRKYPEEYKEAELSLLAPSLVHPLLRLELLEWDPLKDPTYGVDILSRWRKLLEPDVSSDDTGGRESMDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    477 FHRLIWEVWMPFVRN-IVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTV-----PIHS 550
Cdd:pfam07842  81 YETMLWEGWLPSYRSsIISTWDPRDPDPMLALLEAWAPLLPSWILDNILEQLILPKLTAAVEEWDPLSDTVtrnlvPIHS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259    551 WIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSsAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ 630
Cdd:pfam07842 161 WIHPWLPLLGARLEPLYPDIRRKLRQALDAWHPSRS-ALAGLKPWKDVFSPGEWDKFLRRHILPKLALALQEFVINPRQQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 8393259    631 HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVL 666
Cdd:pfam07842 240 SLELFRNVLKWKDLLPPSVLADLLEKEFFPKWLQVL 275
TIP_N pfam12457
Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is ...
 23-104 5.96e-26

Tuftelin interacting protein N terminal; This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralization of enamel - tuftelin.


Pssm-ID: 463593  Cd Length: 94  Bit Score: 102.45  E-value: 5.96e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393259     23 NFEI-TDWDLQNEFNPNRQR-HWQTKEEATYGVWAERDSDDERPSFGGKRAR-----DYSAPVNFISAGLKKGAAEEAEL 95
Cdd:pfam12457   6 RFDIeNDYDLDGEFNYKRRRrRRQTKEDAIYGIFADDDSDDDEGGRRSSKRDlrgrkDYTKPVAFVSGGIQQPGKKDKEI 85


                  ....*....
gi 8393259     96 EDSDDEEKP 104
Cdd:pfam12457  86 DDDSDDEEE 94
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 149-193 4.82e-18

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 77.93  E-value: 4.82e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 8393259    149 TKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 193
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 148-193 7.68e-16

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 71.81  E-value: 7.68e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 8393259     148 HTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAY 193
Cdd:smart00443   2 STSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 151-192 4.35e-06

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 44.58  E-value: 4.35e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 8393259    151 GIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGA 192
Cdd:pfam12656  16 EFGAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGA 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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