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Conserved domains on  [gi|51092264|ref|NP_036667|]
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prolactin-3B1 precursor [Rattus norvegicus]

Protein Classification

prolactin_like domain-containing protein( domain architecture ID 10178934)

prolactin_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
24-221 1.25e-77

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


:

Pssm-ID: 198438  Cd Length: 199  Bit Score: 231.77  E-value: 1.25e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  24 LWEQVTSAPNYRMSTGSLYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSPCHTAAIPTPENSEQVHQAKSEDL 103
Cdd:cd10288   1 LPICPAGNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 104 LKVSITILQAWQEPLKHIVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQPGAVG-SDYTFWSEWSDLQSSD 182
Cdd:cd10288  81 LKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEEnEDYPVWSGLPSLQSSD 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 51092264 183 KSTKNGVLSVLYRCMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:cd10288 161 EDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
 
Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
24-221 1.25e-77

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 231.77  E-value: 1.25e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  24 LWEQVTSAPNYRMSTGSLYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSPCHTAAIPTPENSEQVHQAKSEDL 103
Cdd:cd10288   1 LPICPAGNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 104 LKVSITILQAWQEPLKHIVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQPGAVG-SDYTFWSEWSDLQSSD 182
Cdd:cd10288  81 LKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEEnEDYPVWSGLPSLQSSD 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 51092264 183 KSTKNGVLSVLYRCMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:cd10288 161 EDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
Hormone_1 pfam00103
Somatotropin hormone family;
17-221 1.14e-62

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 194.13  E-value: 1.14e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264    17 LAVSTLLLWEQVTSAPN-------YRMSTGSLYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSPCHTAAIPTP 89
Cdd:pfam00103   1 LLVSNLLLWENVASCPScapdnvgCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGYFIRRTTSCHTNSIHTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264    90 ENSEQVHQAKSEDLLKVSITILQAWQEPLKHIVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQPGA--VGS 167
Cdd:pfam00103  81 ENREKAQQTSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIDPErtENE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 51092264   168 DYTFWSEWSDLQSSDKSTKNGVLSVLYRCMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:pfam00103 161 AYPAWSGLSSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKDSC 214
 
Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
24-221 1.25e-77

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 231.77  E-value: 1.25e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  24 LWEQVTSAPNYRMSTGSLYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSPCHTAAIPTPENSEQVHQAKSEDL 103
Cdd:cd10288   1 LPICPAGNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 104 LKVSITILQAWQEPLKHIVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQPGAVG-SDYTFWSEWSDLQSSD 182
Cdd:cd10288  81 LKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEEnEDYPVWSGLPSLQSSD 160
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 51092264 183 KSTKNGVLSVLYRCMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:cd10288 161 EDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
Hormone_1 pfam00103
Somatotropin hormone family;
17-221 1.14e-62

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 194.13  E-value: 1.14e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264    17 LAVSTLLLWEQVTSAPN-------YRMSTGSLYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSPCHTAAIPTP 89
Cdd:pfam00103   1 LLVSNLLLWENVASCPScapdnvgCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGYFIRRTTSCHTNSIHTP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264    90 ENSEQVHQAKSEDLLKVSITILQAWQEPLKHIVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQPGA--VGS 167
Cdd:pfam00103  81 ENREKAQQTSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIDPErtENE 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 51092264   168 DYTFWSEWSDLQSSDKSTKNGVLSVLYRCMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:pfam00103 161 AYPAWSGLSSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKDSC 214
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
41-214 1.63e-34

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 121.06  E-value: 1.63e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  41 LYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSPCHTAAIPTPENSEQVHQAKSEDLLKVSITILQAWQEPLKH 120
Cdd:cd10284   1 LFDRAIPHAERVYHLSSEAYAEFEEKYIPGENPPNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSEPLLH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 121 IVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQPGAV--GSDYTFWSEWSDLQSSDKSTKNGVLSvlyrCMR 198
Cdd:cd10284  81 LHTVLANSKGTSLALLPKAKQVSEMLKLLEDGVETLSERIKDLPLefNSVGALWSVDETHNSLRRMHDYDLLS----CFK 156
                       170
                ....*....|....*.
gi 51092264 199 RDTHKVDNFLKVLKCR 214
Cdd:cd10284 157 KDAHKVETYLKILKCR 172
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
41-221 8.69e-25

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 96.10  E-value: 8.69e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  41 LYQRVVELSHYTHDLASKVFIEFDMKFGRTVwtHNLMLSPCHTAAIPTPENSEQVHQAKSEDLLKVSITILQAWQEPLKH 120
Cdd:cd10287   4 LFDRVIQHSSRMHSLSSELHWELEQYFLPSR--NIRRKRKCHTAGILTPNGKENAQKLEREELTEVILRLLGAWREPLSH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 121 IVAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVQP-GAVGSDYTF-WSEWSDLQSSDKSTKNGVLSVLYRCMR 198
Cdd:cd10287  82 FHQSMGHDKDFNSYSPGKAKQMSDMVHELRDGVEKVTEKMQLlGVISNSLGGlSPEDAGPSAISGHLDAMSDYDLLHCFR 161
                       170       180
                ....*....|....*....|...
gi 51092264 199 RDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:cd10287 162 RDSNKVQNYLKILKCRIFPESSC 184
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
41-221 1.52e-17

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 77.10  E-value: 1.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  41 LYQRVVELSHYTHDLASKVFIEFDMKFGRTVWTHNLMLSP---CHTAAIPTPENSEQVHQAKSEDLLKVSITILQAWQEP 117
Cdd:cd10285   1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPaafCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLKP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 118 LKHI--VAAVATLPDGSDTLLSRTKELEERIQGLLEGLETILSRVqPGAVGSDYTFWSEwsDLQSSDKSTKNGVLsvLYr 195
Cdd:cd10285  81 VQFLssVFTNQLHFGSSDRIYEKLKDLEEGIQTLIRELEDGSPRG-GQLLKQTYSKFDV--NLRSDEALLKNYGL--LS- 154
                       170       180
                ....*....|....*....|....*.
gi 51092264 196 CMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:cd10285 155 CFKKDMHKVETYLRVMKCRRFPESNC 180
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
36-221 2.86e-11

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 60.64  E-value: 2.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264  36 MSTGSLYQRVV---ELSHYTHDLASKVFIEFDMKFGrTVWTHNLMLSPCHTAAIPTPENSEQVHQAKSEDLLKVSITILQ 112
Cdd:cd10286  18 ISLEKLLDRAIqhaELIYRVSEESCTLFEEMFIPFS-VRALLIQEGNACSTKTVSIPTSKTEIQQISDKWLLHSVLILVQ 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092264 113 AWQEPLKHIVAAVATLPDGSDTLLSRTKELEERIQGLLEGLeTILSRVQPGAvGSDYTFWSEWSDLQSSDKS-TKNGVL- 190
Cdd:cd10286  97 FWIDPLVDLQTSLDRYDNAPSALLNKTKWMSTKLMNLEQGV-LVLIRKMLGE-GMLLNNESPADTLDHFVMSdMLESVLr 174
                       170       180       190
                ....*....|....*....|....*....|...
gi 51092264 191 --SVLYrCMRRDTHKVDNFLKVLKCRDIYNNNC 221
Cdd:cd10286 175 dyTLLS-CFKKDAHKVETFLKLLKCRQTDRLNC 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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