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Conserved domains on  [gi|6981428|ref|NP_037146|]
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persephin precursor [Rattus norvegicus]

Protein Classification

TGF-beta family protein( domain architecture ID 14443714)

transforming growth factor-beta (TGF-beta) family protein may control proliferation, differentiation, and other functions in many cell types

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 66-156 1.99e-40

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


:

Pssm-ID: 381652  Cd Length: 99  Bit Score: 131.05  E-value: 1.99e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCPQeVRTQHSLVLARLRGQGRA-------HGRPCCQPTSYADVTFLDDH 138
Cdd:cd19382   3 CRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPR-ARTNHDLTLSRLLQKGDLpslgekiFGGPCCRPTHYEDVAFLDDN 81

                        90
                ....*....|....*...
gi 6981428  139 HHWQQLPQLSAAACGCGG 156
Cdd:cd19382  82 HRWHTVEKLSAAACACVG 99
 
Name Accession Description Interval E-value
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 66-156 1.99e-40

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 131.05  E-value: 1.99e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCPQeVRTQHSLVLARLRGQGRA-------HGRPCCQPTSYADVTFLDDH 138
Cdd:cd19382   3 CRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPR-ARTNHDLTLSRLLQKGDLpslgekiFGGPCCRPTHYEDVAFLDDN 81

                        90
                ....*....|....*...
gi 6981428  139 HHWQQLPQLSAAACGCGG 156
Cdd:cd19382  82 HRWHTVEKLSAAACACVG 99
TGF_beta pfam00019
Transforming growth factor beta like domain;
65-154 2.55e-15

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 67.35  E-value: 2.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428     65 LCRLWSLTLPVAELGLG--YASEEKIIFRYCAGSCPQEV-----RTQHSLVLARLRGQG-RAHGRPCCQPTSYADVTFL- 135
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCPSHLnpqlsATNHAILQSLLHSLKpANVPKPCCVPTKLSPLSVLy 80

                          90       100
                  ....*....|....*....|..
gi 6981428    136 ---DDHHHWQQLPQLSAAACGC 154
Cdd:pfam00019  81 yddEGNVVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 66-156 1.99e-40

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 131.05  E-value: 1.99e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCPQeVRTQHSLVLARLRGQGRA-------HGRPCCQPTSYADVTFLDDH 138
Cdd:cd19382   3 CRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPR-ARTNHDLTLSRLLQKGDLpslgekiFGGPCCRPTHYEDVAFLDDN 81

                        90
                ....*....|....*...
gi 6981428  139 HHWQQLPQLSAAACGCGG 156
Cdd:cd19382  82 HRWHTVEKLSAAACACVG 99
TGF_beta_GDNF_like cd13750
transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived ...
 66-154 1.86e-37

transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived neurotrophic factor (GDNF) family of ligands; GDNF family of ligands includes GDNF, Artemin, Neurturin, and Persephin. They plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.


Pssm-ID: 381628  Cd Length: 95  Bit Score: 123.72  E-value: 1.86e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCPQEvRTQHSLVLARLRGQGRAH-----GRPCCQPTSY-ADVTFLDDHH 139
Cdd:cd13750   2 CVLRELHLRVTDLGLGYASEEEVIFRYCAGSCEAA-RTNYDLILANLRGWRRLRsdrkvGQPCCRPTAYdDDVSFLDDNS 80

                        90
                ....*....|....*
gi 6981428  140 HWQQLPQLSAAACGC 154
Cdd:cd13750  81 RYHILRKLSAKACGC 95
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 66-154 2.25e-33

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 113.22  E-value: 2.25e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCpQEVRTQHSLVLARLRGQG----RAHGR----PCCQPTSYADVTFLDD 137
Cdd:cd19381   2 CRLRSLRVKVRDLGLGYESDEIVLFKYCSGSC-QRARTNYDLTLNSLLKQGaippGPHERvssqPCCRPTRYENVSFMDV 80

                        90
                ....*....|....*..
gi 6981428  138 HHHWQQLPQLSAAACGC 154
Cdd:cd19381  81 QNVWQTVEKLSAAECSC 97
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 66-155 5.71e-28

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 99.77  E-value: 5.71e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCPQEVRTqHSLVLARLRGQGR--------AHGRPCCQPTSY-ADVTFLD 136
Cdd:cd19383   7 CSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRN-YDLTLKHMRGKKSlkkgrkdkVRARPCCRPTAYeDDVSFLD 85

                        90
                ....*....|....*....
gi 6981428  137 DHHHWQQLPQLSAAACGCG 155
Cdd:cd19383  86 NNNRYHTIQELSAKECGCV 104
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 66-154 2.33e-19

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 77.58  E-value: 2.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRYCAGSCpQEVRTQHSLVLARLRGQGR----AHGRPCCQPTSYAD-VTFLDDHHH 140
Cdd:cd19380   4 CVLTEIHLNVTDLGLGYETKEELIFRYCSGSC-DAAETTYDKILKNLTRNKKlvsdKVGQACCRPIAFDDdLSFLDDNLV 82

                        90
                ....*....|....
gi 6981428  141 WQQLPQLSAAACGC 154
Cdd:cd19380  83 YHTLKKHSAKKCGC 96
TGF_beta pfam00019
Transforming growth factor beta like domain;
65-154 2.55e-15

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 67.35  E-value: 2.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428     65 LCRLWSLTLPVAELGLG--YASEEKIIFRYCAGSCPQEV-----RTQHSLVLARLRGQG-RAHGRPCCQPTSYADVTFL- 135
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCPSHLnpqlsATNHAILQSLLHSLKpANVPKPCCVPTKLSPLSVLy 80

                          90       100
                  ....*....|....*....|..
gi 6981428    136 ---DDHHHWQQLPQLSAAACGC 154
Cdd:pfam00019  81 yddEGNVVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 66-154 1.03e-10

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 55.40  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGyaseEKIIF------RYCAGSCPQEV-----RTQHSLVLARLRGQGRAH--GRPCCQPTSYADV 132
Cdd:cd13756   1 CRRRPLYVDFSDLGWD----DWIIApkgynaNYCAGSCPFPLsshanATNHAILQALLHSLNPKKsvPKPCCVPTKYSPL 76

                        90       100
                ....*....|....*....|....*.
gi 6981428  133 TFL--DDHHHW--QQLPQLSAAACGC 154
Cdd:cd13756  77 SVLyyDEDGNVvlKTYPDMVVEECGC 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 86-154 1.37e-09

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 52.10  E-value: 1.37e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6981428   86 EKIIFRYCAGSCPQEV--RTQHSLVLARLRGQG---RAHGRPCCQPTSYADVTFLDDHHHWQQ----LPQLSAAACGC 154
Cdd:cd08698  23 SGFTANYCRGSCNSESsaTTNHTKLLQWSRTRRhtpREELKPCCVPTSYEPLSILYYDNNGTVvetlLPNLIVTECGC 100
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 66-154 6.62e-08

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 47.69  E-value: 6.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVA-ELGLGYASEEKII-FRYCAGSCP--QEVRTQHSLVLARLRGQG-RAHGRPCCQPTSYADVTFL---DD 137
Cdd:cd13753   1 CCLRPLYINFRrDLGWKWIHEPKGFnANYCAGACPylWSADTQHSTVLQLYNRLNpVASAAPCCSPRELEPLTILyydGR 80

                        90
                ....*....|....*..
gi 6981428  138 HHHWQQLPQLSAAACGC 154
Cdd:cd13753  81 NPKIETLSNMIVTSCKC 97
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 92-154 3.66e-07

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 45.72  E-value: 3.66e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6981428   92 YCAGSCPQEV---RTQHSLVLARLRGQGRAHG--RPCCQPTSYADVTFL----DDHHHWQQLPQLSAAACGC 154
Cdd:cd13752  29 YCKGSCSGSSspfRSHHTTILQKYLSKNKAKSelTPCCTPTKMSPLSLLyydsDGNIVKKDLPNMIVESCGC 100
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 92-154 9.28e-04

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 36.48  E-value: 9.28e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6981428   92 YCAGSCPQEVRTQ--HSLvLARLRGQGRAHGrPCCQPTSYADVTFL--DDHH--HWQQLPQLSAAACGC 154
Cdd:cd13751  30 YCSGECPFVYLQSypHTH-LVQQANPRGSAG-PCCTPTKMSPLSMLyfDEDGniIYGTLPDMVVERCGC 96
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 92-154 1.22e-03

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 36.57  E-value: 1.22e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981428   92 YCAGSCP----QEVR-TQHSLV--LARLRGQGRAHGRPCCQPTSYADVTFL--DDHHH--WQQLPQLSAAACGC 154
Cdd:cd13765  31 HCKGSCPfplgQNQKpTNHATVqsIVHALKLAKGVEMPCCVPDKLYSISLLyfDDDENvvLKQYDDMVAASCGC 104
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 66-154 1.30e-03

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 36.19  E-value: 1.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGYASEEKIIFRyCAGSC-----PQEVRTQHSLVLARLRGQGRAHGR-PCCQPTSYAD---VTFLD 136
Cdd:cd13757   2 CRLRELSVSLRSEKFILSPKRYNINN-CQGPCrfplsDRPRYNNHAVLLLKMQERGLPLQRaPCCVPVAYEEllvVELSD 80

                        90
                ....*....|....*...
gi 6981428  137 DHHHWQQLPQLSAAACGC 154
Cdd:cd13757  81 EGTEISLKPNMVATECGC 98
TGF_beta_BMP3_like cd13763
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 66-154 2.78e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381641  Cd Length: 103  Bit Score: 35.41  E-value: 2.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981428   66 CRLWSLTLPVAELGLGyaseEKII----F--RYCAGSCP----QEVR-TQHSLVLARLRGQGRAHG--RPCCQPTSYADV 132
Cdd:cd13763   1 CSRRPLTVDFADIGWS----DWIIspksFdaYYCAGSCPfpltKELRpSNHATIQSIVHAVGIQPGvpAPCCVPDKMSSL 76

                        90       100
                ....*....|....*....|....*.
gi 6981428  133 TFL----DDHHHWQQLPQLSAAACGC 154
Cdd:cd13763  77 TLLyfdeNRNVVLKNYPNMTVESCAC 102
TGF_beta_maverick cd13755
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 92-140 3.20e-03

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.


Pssm-ID: 381633  Cd Length: 102  Bit Score: 35.36  E-value: 3.20e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6981428   92 YCAGSCPQEVR--TQHSLVLARLRGQGRAHGRPCCQPTSYA--DVTFLDDHHH 140
Cdd:cd13755  32 YCKGRCPPRYNyaNNHALIQSLLRRMKKKVPRPCCAPSKLEslEVLHYDESDS 84
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 92-154 6.59e-03

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 34.47  E-value: 6.59e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6981428   92 YCAGSC----PQEVR-TQHSLV--LARLRGQGRAhGRPCCQPTSYADVTFL--DDHHHWQ--QLPQLSAAACGC 154
Cdd:cd13761  30 YCSGECsfplNSHMNaTNHAIVqtLVHLMNPNRV-PKPCCAPTKLSPISVLyyDDNSNVVlkKYKNMVVESCGC 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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