TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1666305150  665 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 708
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1666305150 1538 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1581
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1666305150   875 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGY 905
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1666305150  1163 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 1194
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1666305150  1080 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQlvNGTMCE 1120
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|.
gi 1666305150   606 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 635
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150 1038 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1068
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1666305150  1430 DADECVLFGPalCQNG-RCLNIVPGYICLCNPGYH 1463
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1666305150  665 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 708
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1666305150 1538 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1581
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150 1248 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1280
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1666305150   955 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 986
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150  875 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 906
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150 1163 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 1194
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1163 DVDECA-ATDPCP-GGHCVNTEGSFSCLCETG 1192
Cdd:pfam07645    1 DVDECAtGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1080 DVDECEGPQSSC-RGGECKNTEGSYQCLCHQG 1110
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1666305150 1121 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFAsaegGTRCQ 1162
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1248 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1278
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1666305150 1080 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVN 1115
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1666305150  606 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 639
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1666305150 1719 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1753
Cdd:cd00054      1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1666305150 1719 DVNECEDlngPAALC-AHGHCENTEGSYRCHCSPG 1752
Cdd:pfam07645    1 DVDECAT---GTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1666305150   915 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 946
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1666305150  1430 DADECVLFGPalCQNG-RCLNIVPGYICLCNPGYH 1463
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1121 DVNECVGEEH-CAPHGECLNSLGSFFCLCAPG 1151
Cdd:pfam07645    1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1666305150  665 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 708
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1666305150 1538 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1581
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150 1248 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1280
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1666305150   955 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 986
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150  875 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 906
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1666305150 1163 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 1194
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1163 DVDECA-ATDPCP-GGHCVNTEGSFSCLCETG 1192
Cdd:pfam07645    1 DVDECAtGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1080 DVDECEGPQSSC-RGGECKNTEGSYQCLCHQG 1110
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1666305150 1121 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFAsaegGTRCQ 1162
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150 1248 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1278
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1666305150 1080 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVN 1115
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1666305150  606 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 639
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1666305150 1719 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1753
Cdd:cd00054      1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32

Epidermal growth factor-like domain;

                            10        20
                    ....*....|....*....|....*....
gi 1666305150   958 ECLTPGICTHGRCINMEGSFRCSCEPGYE 986
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1666305150  875 DIDECEQPG-VC-SGGRCSNTEGSYHCECDRG 904
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1666305150 1038 DLDECAFPGVC-PTGVCTNTVGSFSCkDCDRGYRpnplGNRCE 1079
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1666305150 1251 ECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1280
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1666305150  545 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 579
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35