NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|34335253|ref|NP_055717|]
View 

disks large-associated protein 4 isoform a [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
GKAP super family cl24154
Guanylate-kinase-associated protein (GKAP) protein;
647-989 1.81e-148

Guanylate-kinase-associated protein (GKAP) protein;


The actual alignment was detected with superfamily member pfam03359:

Pssm-ID: 460897  Cd Length: 341  Bit Score: 444.17  E-value: 1.81e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   647 GTLTSSESHPEAAPKRKLSSIGIQERTRRNGSHLSEDNGPKAidvmapssessvpshsmssRRDTDSDTQD-ANDSSCKS 725
Cdd:pfam03359  14 CIETVSDSDEESKPLREFQSIGVQVEDDKRRARFKRSNSVTA-------------------AVQADLELEGfPGLSLEVP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   726 SERS-LPDCTPHPNSISIDAGPRQ--APKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG-ACRRDG 801
Cdd:pfam03359  75 TEDKgLQFGGSFQRHSSEPASTSQysIQRSVHTQGQWAYREDYDPALDPSSLPPPDPWLEDGPRSLPDSGRASpVCRRDG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   802 YWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGF 881
Cdd:pfam03359 155 EWFLKLLQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPNANPRPTSQDLAGF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   882 WDLLQLSIEDISMKFDELYHLKANSWQLVeTPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAK 961
Cdd:pfam03359 235 WDLLQLSIEDISMKFDELHQLKANNWKLE-DPPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQRQEARKRLMAAK 313
                         330       340
                  ....*....|....*....|....*...
gi 34335253   962 RAASVRQNSATESADSIEIYVPEAQTRL 989
Cdd:pfam03359 314 RAASVRQNSATESADSIEIYIPEAQTRL 341
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
647-989 1.81e-148

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 444.17  E-value: 1.81e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   647 GTLTSSESHPEAAPKRKLSSIGIQERTRRNGSHLSEDNGPKAidvmapssessvpshsmssRRDTDSDTQD-ANDSSCKS 725
Cdd:pfam03359  14 CIETVSDSDEESKPLREFQSIGVQVEDDKRRARFKRSNSVTA-------------------AVQADLELEGfPGLSLEVP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   726 SERS-LPDCTPHPNSISIDAGPRQ--APKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG-ACRRDG 801
Cdd:pfam03359  75 TEDKgLQFGGSFQRHSSEPASTSQysIQRSVHTQGQWAYREDYDPALDPSSLPPPDPWLEDGPRSLPDSGRASpVCRRDG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   802 YWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGF 881
Cdd:pfam03359 155 EWFLKLLQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPNANPRPTSQDLAGF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   882 WDLLQLSIEDISMKFDELYHLKANSWQLVeTPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAK 961
Cdd:pfam03359 235 WDLLQLSIEDISMKFDELHQLKANNWKLE-DPPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQRQEARKRLMAAK 313
                         330       340
                  ....*....|....*....|....*...
gi 34335253   962 RAASVRQNSATESADSIEIYVPEAQTRL 989
Cdd:pfam03359 314 RAASVRQNSATESADSIEIYIPEAQTRL 341
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
647-989 1.81e-148

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 444.17  E-value: 1.81e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   647 GTLTSSESHPEAAPKRKLSSIGIQERTRRNGSHLSEDNGPKAidvmapssessvpshsmssRRDTDSDTQD-ANDSSCKS 725
Cdd:pfam03359  14 CIETVSDSDEESKPLREFQSIGVQVEDDKRRARFKRSNSVTA-------------------AVQADLELEGfPGLSLEVP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   726 SERS-LPDCTPHPNSISIDAGPRQ--APKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG-ACRRDG 801
Cdd:pfam03359  75 TEDKgLQFGGSFQRHSSEPASTSQysIQRSVHTQGQWAYREDYDPALDPSSLPPPDPWLEDGPRSLPDSGRASpVCRRDG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   802 YWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGF 881
Cdd:pfam03359 155 EWFLKLLQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPNANPRPTSQDLAGF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335253   882 WDLLQLSIEDISMKFDELYHLKANSWQLVeTPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAK 961
Cdd:pfam03359 235 WDLLQLSIEDISMKFDELHQLKANNWKLE-DPPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQRQEARKRLMAAK 313
                         330       340
                  ....*....|....*....|....*...
gi 34335253   962 RAASVRQNSATESADSIEIYVPEAQTRL 989
Cdd:pfam03359 314 RAASVRQNSATESADSIEIYIPEAQTRL 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH