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Conserved domains on  [gi|7662436|ref|NP_055749|]
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cilium assembly protein DZIP1 isoform 1 [Homo sapiens]

Protein Classification

ATP-binding protein; MDR family MFS transporter( domain architecture ID 13845362)

ATP-binding protein containing an AAA (ATPases Associated with various cellular Activities) domain, may function as the toxin for a type IV toxin-antitoxin resistance system| MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dzip-like_N pfam13815
Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in ...
58-178 1.29e-46

Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.


:

Pssm-ID: 433498 [Multi-domain]  Cd Length: 118  Bit Score: 162.11  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     58 FQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHcqsGVDPVLLKLIRLAQFTIEYLLHSQEF 137
Cdd:pfam13815   1 FQFRPRSERLDWRKLASVDVDRVARDTDVDTLQRNIENITFCNLTREEAPH---FVDPHFLKLFRLAQLTIEYLLHSQEC 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 7662436    138 LTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 178
Cdd:pfam13815  78 LATILVKLEERLQEAQQRAEELEKELGRLEEELKKLKKESR 118
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
144-440 4.93e-04

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   144 TLEERLRLSHCDGEQSKK---LLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANyyqchfCDKAFMNQAFLQSHIQRR 220
Cdd:PRK03918 256 KLEEKIRELEERIEELKKeieELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE------IEKRLSRLEEEINGIEER 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   221 HTEENShfeyqKNAQIEKLRSEIVVLKEELqltrSELEAAHhasavrfsKEYEMQKTKEEDFLKLFDRWKEEEKEKLV-- 298
Cdd:PRK03918 330 IKELEE-----KEERLEELKKKLKELEKRL----EELEERH--------ELYEEAKAKKEELERLKKRLTGLTPEKLEke 392
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   299 -DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGT------LKDAHEFKEDRSPYPQDFHNV---MQLLD 368
Cdd:PRK03918 393 lEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrELTEEHRKELLEEYTAELKRIekeLKEIE 472
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662436   369 SQESKWTARVQAIHQEHKKEkgRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK 440
Cdd:PRK03918 473 EKERKLRKELRELEKVLKKE--SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIK 542
 
Name Accession Description Interval E-value
Dzip-like_N pfam13815
Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in ...
58-178 1.29e-46

Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.


Pssm-ID: 433498 [Multi-domain]  Cd Length: 118  Bit Score: 162.11  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     58 FQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHcqsGVDPVLLKLIRLAQFTIEYLLHSQEF 137
Cdd:pfam13815   1 FQFRPRSERLDWRKLASVDVDRVARDTDVDTLQRNIENITFCNLTREEAPH---FVDPHFLKLFRLAQLTIEYLLHSQEC 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 7662436    138 LTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 178
Cdd:pfam13815  78 LATILVKLEERLQEAQQRAEELEKELGRLEEELKKLKKESR 118
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
144-440 4.93e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   144 TLEERLRLSHCDGEQSKK---LLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANyyqchfCDKAFMNQAFLQSHIQRR 220
Cdd:PRK03918 256 KLEEKIRELEERIEELKKeieELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE------IEKRLSRLEEEINGIEER 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   221 HTEENShfeyqKNAQIEKLRSEIVVLKEELqltrSELEAAHhasavrfsKEYEMQKTKEEDFLKLFDRWKEEEKEKLV-- 298
Cdd:PRK03918 330 IKELEE-----KEERLEELKKKLKELEKRL----EELEERH--------ELYEEAKAKKEELERLKKRLTGLTPEKLEke 392
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   299 -DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGT------LKDAHEFKEDRSPYPQDFHNV---MQLLD 368
Cdd:PRK03918 393 lEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrELTEEHRKELLEEYTAELKRIekeLKEIE 472
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662436   369 SQESKWTARVQAIHQEHKKEkgRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK 440
Cdd:PRK03918 473 EKERKLRKELRELEKVLKKE--SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIK 542
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
231-534 1.50e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     231 QKNAQIEKLRSEIVVLKEELQLTRSELEAAHHAsavrfskeyemQKTKEEDFLKLfdRWKEEEKEKLVDEMEKVKEMFMK 310
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKE-----------LEELEEELEQL--RKELEELSRQISALRKDLARLEA 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     311 EFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA-HEFKEDRSPYPQDFHNVMQLLDSQESKWTArVQAIHQEHKKEK 389
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEElAEAEAEIEELEAQIEQLKEELKALREALDE-LRAELTLLNEEA 819
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     390 GRLLSHIEKLRTSMIDdlnasnvfYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEpkvnapalhtLETKSSL 469
Cdd:TIGR02168  820 ANLRERLESLERRIAA--------TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE----------LEALLNE 881
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7662436     470 PMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSnSSLTKGLRTMVEQNLMEKL 534
Cdd:TIGR02168  882 RASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ-LELRLEGLEVRIDNLQERL 945
COG5022 COG5022
Myosin heavy chain [General function prediction only];
178-470 3.05e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.22  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   178 KRRKKMISTQQLMieaKANYYQCHFCDKAFMNQAFlqsHIQRRHTEENSHFEY-QKNAQIEKLRSEIV---VLKEELQLT 253
Cdd:COG5022  766 QALKRIKKIQVIQ---HGFRLRRLVDYELKWRLFI---KLQPLLSLLGSRKEYrSYLACIIKLQKTIKrekKLRETEEVE 839
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   254 RSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEK-LVDEMEKVKEmfmkeFKELTSKNSALEYQLSEI--- 329
Cdd:COG5022  840 FSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqLQELKIDVKS-----ISSLKLVNLELESEIIELkks 914
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   330 QKSNMQIKSnigtlkdahEFKEDRSPYPQDFHNVMQLLDSQEskwtarvqaIHQEHKKEKGRLLSHIEKLRTS------M 403
Cdd:COG5022  915 LSSDLIENL---------EFKTELIARLKKLLNNIDLEEGPS---------IEYVKLPELNKLHEVESKLKETseeyedL 976
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662436   404 IDDLNASNVFYKKRIEELGQRLQEQNEliitQRQQIKDFTcnplNSISEPKVNAPALHTLETKSSLP 470
Cdd:COG5022  977 LKKSTILVREGNKANSELKNFKKELAE----LSKQYGALQ----ESTKQLKELPVEVAELQSASKII 1035
 
Name Accession Description Interval E-value
Dzip-like_N pfam13815
Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in ...
58-178 1.29e-46

Iguana/Dzip1-like DAZ-interacting protein N-terminal; The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.


Pssm-ID: 433498 [Multi-domain]  Cd Length: 118  Bit Score: 162.11  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     58 FQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHcqsGVDPVLLKLIRLAQFTIEYLLHSQEF 137
Cdd:pfam13815   1 FQFRPRSERLDWRKLASVDVDRVARDTDVDTLQRNIENITFCNLTREEAPH---FVDPHFLKLFRLAQLTIEYLLHSQEC 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 7662436    138 LTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECK 178
Cdd:pfam13815  78 LATILVKLEERLQEAQQRAEELEKELGRLEEELKKLKKESR 118
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
144-440 4.93e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   144 TLEERLRLSHCDGEQSKK---LLTKQAGEIKTLKEECKRRKKMISTQQLMIEAKANyyqchfCDKAFMNQAFLQSHIQRR 220
Cdd:PRK03918 256 KLEEKIRELEERIEELKKeieELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE------IEKRLSRLEEEINGIEER 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   221 HTEENShfeyqKNAQIEKLRSEIVVLKEELqltrSELEAAHhasavrfsKEYEMQKTKEEDFLKLFDRWKEEEKEKLV-- 298
Cdd:PRK03918 330 IKELEE-----KEERLEELKKKLKELEKRL----EELEERH--------ELYEEAKAKKEELERLKKRLTGLTPEKLEke 392
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   299 -DEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGT------LKDAHEFKEDRSPYPQDFHNV---MQLLD 368
Cdd:PRK03918 393 lEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrELTEEHRKELLEEYTAELKRIekeLKEIE 472
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662436   369 SQESKWTARVQAIHQEHKKEkgRLLSHIEKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIK 440
Cdd:PRK03918 473 EKERKLRKELRELEKVLKKE--SELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIK 542
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
231-534 1.50e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     231 QKNAQIEKLRSEIVVLKEELQLTRSELEAAHHAsavrfskeyemQKTKEEDFLKLfdRWKEEEKEKLVDEMEKVKEMFMK 310
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKE-----------LEELEEELEQL--RKELEELSRQISALRKDLARLEA 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     311 EFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDA-HEFKEDRSPYPQDFHNVMQLLDSQESKWTArVQAIHQEHKKEK 389
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEElAEAEAEIEELEAQIEQLKEELKALREALDE-LRAELTLLNEEA 819
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436     390 GRLLSHIEKLRTSMIDdlnasnvfYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEpkvnapalhtLETKSSL 469
Cdd:TIGR02168  820 ANLRERLESLERRIAA--------TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE----------LEALLNE 881
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7662436     470 PMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSnSSLTKGLRTMVEQNLMEKL 534
Cdd:TIGR02168  882 RASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ-LELRLEGLEVRIDNLQERL 945
COG5022 COG5022
Myosin heavy chain [General function prediction only];
178-470 3.05e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.22  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   178 KRRKKMISTQQLMieaKANYYQCHFCDKAFMNQAFlqsHIQRRHTEENSHFEY-QKNAQIEKLRSEIV---VLKEELQLT 253
Cdd:COG5022  766 QALKRIKKIQVIQ---HGFRLRRLVDYELKWRLFI---KLQPLLSLLGSRKEYrSYLACIIKLQKTIKrekKLRETEEVE 839
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   254 RSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEK-LVDEMEKVKEmfmkeFKELTSKNSALEYQLSEI--- 329
Cdd:COG5022  840 FSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqLQELKIDVKS-----ISSLKLVNLELESEIIELkks 914
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662436   330 QKSNMQIKSnigtlkdahEFKEDRSPYPQDFHNVMQLLDSQEskwtarvqaIHQEHKKEKGRLLSHIEKLRTS------M 403
Cdd:COG5022  915 LSSDLIENL---------EFKTELIARLKKLLNNIDLEEGPS---------IEYVKLPELNKLHEVESKLKETseeyedL 976
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662436   404 IDDLNASNVFYKKRIEELGQRLQEQNEliitQRQQIKDFTcnplNSISEPKVNAPALHTLETKSSLP 470
Cdd:COG5022  977 LKKSTILVREGNKANSELKNFKKELAE----LSKQYGALQ----ESTKQLKELPVEVAELQSASKII 1035
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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