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Conserved domains on  [gi|41872703|ref|NP_056081|]
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sodium/hydrogen exchanger 8 isoform 2 [Homo sapiens]

Protein Classification

cation:proton antiporter family protein( domain architecture ID 3846)

cation:proton antiporter family protein functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_H_Exchanger super family cl01133
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
64-542 3.89e-100

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


The actual alignment was detected with superfamily member TIGR00840:

Pssm-ID: 470090 [Multi-domain]  Cd Length: 559  Bit Score: 314.79  E-value: 3.89e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703    64 FSLLVLAICI--ILVHLlIRYRLHFLPESVAVVSLGILMGAVIKiiefkkLANWKEEEMFRPNMFFLLLLPPIIFESGYS 141
Cdd:TIGR00840  11 FILWILLASLakIGFHL-THKVIRAVPESVLLIVYGLLVGGIIK------ASPHIDPPTLDSSYFFLYLLPPIVLDAGYF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   142 LHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQ--ADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLN 219
Cdd:TIGR00840  84 MPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLigGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNEKLY 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   220 MLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLkMFFGSAALGTLTGLISALVLKHIDLRKTpsLEF 299
Cdd:TIGR00840 164 IIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASFFV-VTCGGLLVGVVFGFLVAFITRFTHHIRQ--IEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   300 GMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEI 379
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   380 SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFT 459
Cdd:TIGR00840 321 AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   460 ILLLGGSTMPLIRLMDIEdakahrrnKKDVNLSKTEKMGNTVESEHLSELTEE--EYEAHYIRRQDLKGFvwlDAKYLNP 537
Cdd:TIGR00840 401 VIFQGGTIKPLVEVLKVK--------KGCISKTKINEELHDREFDHLLPGIEDicGQIGHDRAIDKLNGF---DIKYLLK 469

                  ....*
gi 41872703   538 FFTRR 542
Cdd:TIGR00840 470 PLIRR 474
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
64-542 3.89e-100

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 314.79  E-value: 3.89e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703    64 FSLLVLAICI--ILVHLlIRYRLHFLPESVAVVSLGILMGAVIKiiefkkLANWKEEEMFRPNMFFLLLLPPIIFESGYS 141
Cdd:TIGR00840  11 FILWILLASLakIGFHL-THKVIRAVPESVLLIVYGLLVGGIIK------ASPHIDPPTLDSSYFFLYLLPPIVLDAGYF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   142 LHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQ--ADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLN 219
Cdd:TIGR00840  84 MPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLigGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNEKLY 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   220 MLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLkMFFGSAALGTLTGLISALVLKHIDLRKTpsLEF 299
Cdd:TIGR00840 164 IIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASFFV-VTCGGLLVGVVFGFLVAFITRFTHHIRQ--IEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   300 GMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEI 379
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   380 SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFT 459
Cdd:TIGR00840 321 AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   460 ILLLGGSTMPLIRLMDIEdakahrrnKKDVNLSKTEKMGNTVESEHLSELTEE--EYEAHYIRRQDLKGFvwlDAKYLNP 537
Cdd:TIGR00840 401 VIFQGGTIKPLVEVLKVK--------KGCISKTKINEELHDREFDHLLPGIEDicGQIGHDRAIDKLNGF---DIKYLLK 469

                  ....*
gi 41872703   538 FFTRR 542
Cdd:TIGR00840 470 PLIRR 474
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
60-523 8.12e-64

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 217.53  E-value: 8.12e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  60 MTIFFSLLVLAICIILVHLLIRyRLHfLPESVAVVSLGILMGAVIKIIEFkklanwkeEEMFRPNMFFLLLLPPIIFESG 139
Cdd:COG0025   1 MELLLLILLLLLLGLLSQWLAR-RLK-LPAPLLLLLAGILLGPGLGLELD--------PELGDLEPLLELFLPPLLFEAA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 140 YSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQadviskLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLN 219
Cdd:COG0025  71 LNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLLG------LPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLR 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 220 MLVFGESILNDAVSIVLTNTAEGLTrknmsdVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDlrkTPSLEF 299
Cdd:COG0025 145 TILEGESLLNDATALVLFVLALAAA------LGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRLP---DPLLEI 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 300 GMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSI-FSFPHKFE 378
Cdd:COG0025 216 LLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLpLILLGALG 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 379 ISFVIWCIVLVLFGRAVNIFPLSYLlnffRDHKITPKMMFIMWFSGLRGAIP--YALSL-HLDLEPMEKRQLIGTTTIVI 455
Cdd:COG0025 296 LGGILLVLLALLVVRPLWVFLSLAL----RGSRLSWRERLFLSWGGPRGIVSlaLALSLpLHGGAGFPGRDLILALAFGV 371
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41872703 456 VLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQD 523
Cdd:COG0025 372 ILLTLVLQGLTLPPLARRLGLREDEPEGEELEAALARAALLELLAAELLADDEEVVLRAARRARRRRE 439
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
62-472 1.67e-52

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 184.00  E-value: 1.67e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703    62 IFFSLLVLAICIILVHLLiryrlhFLPESVAVVSLGILMGAVIKiiefkklaNWKEEEMFRPNMFFLLLLPPIIFESGYS 141
Cdd:pfam00999   1 IVLLILLALLAPLLARRL------KLPPIVGLIIAGILLGPSGL--------GLISEVDEDLEVLSNLGLPPLLFLAGLE 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   142 LHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLgqadvISKLNMTDSFAFGSLISAVDPVATIAIF-NALHVDPVLNM 220
Cdd:pfam00999  67 LDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLL-----GLGIPLLEALLFGAILSATSPVVVLAILkELGRVPERLGT 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   221 LVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQaldyFLKMFFGSAALGTLTGLISALVLKHIDlrKTPSLEFG 300
Cdd:pfam00999 142 LLLGESVLNDGVAVVLLAVLLALAQGVGGGSDLGWLLLI----FLVVAVGGLLLGLLIGWLLRLITRFTD--DDRELEVL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   301 MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLspvtqiLMQQTLRTVAFLCETCVFAFLGLSIF-SFPHKFEI 379
Cdd:pfam00999 216 LVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANK------LSEKLEPFGYGLFNPLFFVLVGLSLDlSSLLLSVW 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   380 SFVIWCIVLVLFGRAVNIFPLSYLLnffrdhKITPKMMFIMWFSGL-RGAIPYALSLHLDLEPMEKRQLIgTTTIVIVLF 458
Cdd:pfam00999 290 ILVLLALVAILLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIARELY-PLLIVVVLF 362
                         410
                  ....*....|....
gi 41872703   459 TILLLGGSTMPLIR 472
Cdd:pfam00999 363 TVLVQGITLKPLLF 376
PRK05326 PRK05326
potassium/proton antiporter;
60-478 5.49e-11

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 65.22  E-value: 5.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   60 MTIFFSLLVLAICIILVHLLIRYRLhflPESVAVVSLGILMG-AVIKIIEFK--KLANwkeeemfrpnMFFLLLLPPIIF 136
Cdd:PRK05326   6 SLLLIGALLLLLSILASRLSSRLGI---PSLLLFLAIGMLAGeDGLGGIQFDnyPLAY----------LVGNLALAVILF 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  137 ESGYSLHKGNFFQNIG-SITLfAVFGTAISAFVVGGGIYFLgqadviSKLNMTDSFAFGSLISAVDPVATIAIFNAL--- 212
Cdd:PRK05326  73 DGGLRTRWSSFRPALGpALSL-ATLGVLITAGLTGLFAHWL------LGLDWLEGLLLGAIVGSTDAAAVFSLLRGKgln 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  213 ---HVDPVLNMlvfgESILNDAVSIVLTNTAEGLtrknMSDVSGWQTFLQALDYFLKMFFGsAALGTLTGLISALVLKHI 289
Cdd:PRK05326 146 lkeRVASTLEI----ESGSNDPMAVFLTITLIEL----ITGGETGLSWGFLLLFLQQFGLG-ALIGLLGGWLLVQLLNRI 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  290 DLRktpslEFGMMIIF----AYLPYGLAEGISLSGIMAILFSGIVMS----HYTHHNLSpvtqilmqqTLRTVAFLCETC 361
Cdd:PRK05326 217 ALP-----AEGLYPILvlagALLIFALTAALGGSGFLAVYLAGLVLGnrpiRHRHSILR---------FFDGLAWLAQIG 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  362 VFAFLGLsiFSFPHKFeISFVIWCIV----LVLFGRAVNIFPlsyLLNFFRdhkITPK-MMFIMWfSGLRGAIPYALSLH 436
Cdd:PRK05326 283 MFLVLGL--LVTPSRL-LDIALPALLlalfLILVARPLAVFL---SLLPFR---FNLReKLFISW-VGLRGAVPIVLATF 352
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 41872703  437 LDLEPMEKRQLIGTTTIVIVLFTiLLLGGSTMPLI-RLMDIED 478
Cdd:PRK05326 353 PMMAGLPNAQLIFNVVFFVVLVS-LLLQGTTLPWAaRKLGVVV 394
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
64-542 3.89e-100

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 314.79  E-value: 3.89e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703    64 FSLLVLAICI--ILVHLlIRYRLHFLPESVAVVSLGILMGAVIKiiefkkLANWKEEEMFRPNMFFLLLLPPIIFESGYS 141
Cdd:TIGR00840  11 FILWILLASLakIGFHL-THKVIRAVPESVLLIVYGLLVGGIIK------ASPHIDPPTLDSSYFFLYLLPPIVLDAGYF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   142 LHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQ--ADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLN 219
Cdd:TIGR00840  84 MPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLigGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNEKLY 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   220 MLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLkMFFGSAALGTLTGLISALVLKHIDLRKTpsLEF 299
Cdd:TIGR00840 164 IIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASFFV-VTCGGLLVGVVFGFLVAFITRFTHHIRQ--IEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   300 GMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEI 379
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   380 SFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFT 459
Cdd:TIGR00840 321 AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   460 ILLLGGSTMPLIRLMDIEdakahrrnKKDVNLSKTEKMGNTVESEHLSELTEE--EYEAHYIRRQDLKGFvwlDAKYLNP 537
Cdd:TIGR00840 401 VIFQGGTIKPLVEVLKVK--------KGCISKTKINEELHDREFDHLLPGIEDicGQIGHDRAIDKLNGF---DIKYLLK 469

                  ....*
gi 41872703   538 FFTRR 542
Cdd:TIGR00840 470 PLIRR 474
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
60-523 8.12e-64

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 217.53  E-value: 8.12e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  60 MTIFFSLLVLAICIILVHLLIRyRLHfLPESVAVVSLGILMGAVIKIIEFkklanwkeEEMFRPNMFFLLLLPPIIFESG 139
Cdd:COG0025   1 MELLLLILLLLLLGLLSQWLAR-RLK-LPAPLLLLLAGILLGPGLGLELD--------PELGDLEPLLELFLPPLLFEAA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 140 YSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQadviskLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLN 219
Cdd:COG0025  71 LNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLLG------LPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLR 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 220 MLVFGESILNDAVSIVLTNTAEGLTrknmsdVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDlrkTPSLEF 299
Cdd:COG0025 145 TILEGESLLNDATALVLFVLALAAA------LGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRLP---DPLLEI 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 300 GMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSI-FSFPHKFE 378
Cdd:COG0025 216 LLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLpLILLGALG 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 379 ISFVIWCIVLVLFGRAVNIFPLSYLlnffRDHKITPKMMFIMWFSGLRGAIP--YALSL-HLDLEPMEKRQLIGTTTIVI 455
Cdd:COG0025 296 LGGILLVLLALLVVRPLWVFLSLAL----RGSRLSWRERLFLSWGGPRGIVSlaLALSLpLHGGAGFPGRDLILALAFGV 371
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41872703 456 VLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQD 523
Cdd:COG0025 372 ILLTLVLQGLTLPPLARRLGLREDEPEGEELEAALARAALLELLAAELLADDEEVVLRAARRARRRRE 439
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
62-472 1.67e-52

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 184.00  E-value: 1.67e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703    62 IFFSLLVLAICIILVHLLiryrlhFLPESVAVVSLGILMGAVIKiiefkklaNWKEEEMFRPNMFFLLLLPPIIFESGYS 141
Cdd:pfam00999   1 IVLLILLALLAPLLARRL------KLPPIVGLIIAGILLGPSGL--------GLISEVDEDLEVLSNLGLPPLLFLAGLE 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   142 LHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLgqadvISKLNMTDSFAFGSLISAVDPVATIAIF-NALHVDPVLNM 220
Cdd:pfam00999  67 LDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLL-----GLGIPLLEALLFGAILSATSPVVVLAILkELGRVPERLGT 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   221 LVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQaldyFLKMFFGSAALGTLTGLISALVLKHIDlrKTPSLEFG 300
Cdd:pfam00999 142 LLLGESVLNDGVAVVLLAVLLALAQGVGGGSDLGWLLLI----FLVVAVGGLLLGLLIGWLLRLITRFTD--DDRELEVL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   301 MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLspvtqiLMQQTLRTVAFLCETCVFAFLGLSIF-SFPHKFEI 379
Cdd:pfam00999 216 LVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANK------LSEKLEPFGYGLFNPLFFVLVGLSLDlSSLLLSVW 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   380 SFVIWCIVLVLFGRAVNIFPLSYLLnffrdhKITPKMMFIMWFSGL-RGAIPYALSLHLDLEPMEKRQLIgTTTIVIVLF 458
Cdd:pfam00999 290 ILVLLALVAILLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIARELY-PLLIVVVLF 362
                         410
                  ....*....|....
gi 41872703   459 TILLLGGSTMPLIR 472
Cdd:pfam00999 363 TVLVQGITLKPLLF 376
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
66-482 1.80e-29

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 122.30  E-value: 1.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703    66 LLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGavikiiefkkLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKG 145
Cdd:TIGR00831   1 VEIIELVMLATAVAVTVKFIRLPYPIALILAGLLLG----------LAGLLPEVPLDREIVLFLFLPPLLFEAAMNTDLR 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   146 NFFQNIGSITLFAVFGTAISAFVVGGGIYFlgqadvISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGE 225
Cdd:TIGR00831  71 ELRENFRPIALIAFLLVVVTTVVVGFSLNW------ILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGE 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   226 SILNDAVSIVLTNTAEGltrknMSDVSGWQTFLQALDYFLKMFFGSAALGTLTG-LISALVLKHIDlrkTPSLEFGMMII 304
Cdd:TIGR00831 145 SLLNDGAALVVFAIAVA-----VALGKGVFDPLNAALDFAVVCVGGIAAGLAVGyLAYRLLRAKID---DPLVEIALTIL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   305 FAYLPYGLAEGISLSGIMAILFSGIVMSHY-THHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFS--FPHKFEISF 381
Cdd:TIGR00831 217 APFAGFLLAERFHFSGVIAVVAAGLILTNYgRDFSMSPTTRLIALDFWSVIVFLVNGIIFILIGVQTPGtiFSAWKEILV 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   382 VIWCIVLVLFGRAVNIFPLSYLLNFF--------RDHKITPKMMFIMW-----FSGLRGAIPYALSLH-----LDLEPME 443
Cdd:TIGR00831 297 APAAVILALFTNAFVIYPVMTYVRFLwtmkpfsnRFLKKKPMEFGTRWkhvvsWAGLRGAIPLALALSfpnqlLSGMAFP 376
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 41872703   444 KRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAH 482
Cdd:TIGR00831 377 ARYELVFLAAGVILFSLLVQGISLPIFVKRKFVSEHSER 415
PRK05326 PRK05326
potassium/proton antiporter;
60-478 5.49e-11

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 65.22  E-value: 5.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703   60 MTIFFSLLVLAICIILVHLLIRYRLhflPESVAVVSLGILMG-AVIKIIEFK--KLANwkeeemfrpnMFFLLLLPPIIF 136
Cdd:PRK05326   6 SLLLIGALLLLLSILASRLSSRLGI---PSLLLFLAIGMLAGeDGLGGIQFDnyPLAY----------LVGNLALAVILF 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  137 ESGYSLHKGNFFQNIG-SITLfAVFGTAISAFVVGGGIYFLgqadviSKLNMTDSFAFGSLISAVDPVATIAIFNAL--- 212
Cdd:PRK05326  73 DGGLRTRWSSFRPALGpALSL-ATLGVLITAGLTGLFAHWL------LGLDWLEGLLLGAIVGSTDAAAVFSLLRGKgln 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  213 ---HVDPVLNMlvfgESILNDAVSIVLTNTAEGLtrknMSDVSGWQTFLQALDYFLKMFFGsAALGTLTGLISALVLKHI 289
Cdd:PRK05326 146 lkeRVASTLEI----ESGSNDPMAVFLTITLIEL----ITGGETGLSWGFLLLFLQQFGLG-ALIGLLGGWLLVQLLNRI 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  290 DLRktpslEFGMMIIF----AYLPYGLAEGISLSGIMAILFSGIVMS----HYTHHNLSpvtqilmqqTLRTVAFLCETC 361
Cdd:PRK05326 217 ALP-----AEGLYPILvlagALLIFALTAALGGSGFLAVYLAGLVLGnrpiRHRHSILR---------FFDGLAWLAQIG 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  362 VFAFLGLsiFSFPHKFeISFVIWCIV----LVLFGRAVNIFPlsyLLNFFRdhkITPK-MMFIMWfSGLRGAIPYALSLH 436
Cdd:PRK05326 283 MFLVLGL--LVTPSRL-LDIALPALLlalfLILVARPLAVFL---SLLPFR---FNLReKLFISW-VGLRGAVPIVLATF 352
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 41872703  437 LDLEPMEKRQLIGTTTIVIVLFTiLLLGGSTMPLI-RLMDIED 478
Cdd:PRK05326 353 PMMAGLPNAQLIFNVVFFVVLVS-LLLQGTTLPWAaRKLGVVV 394
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
60-347 4.14e-05

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 45.91  E-value: 4.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703  60 MTIFFSL-LVLAICIILVHLLIRYRLhflPESVAVVSLGILMG-AVIKIIEfkklanwkEEEMFRP--NMFFLLLLppii 135
Cdd:COG0475   3 ASLLLQLgLLLLAAVLAGLLARRLGL---PSVLGYILAGILLGpSGLGLIE--------DSEALELlaELGVVLLL---- 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 136 FESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGqadviskLNMTDSFAFGSLISAVDPVATIAIFNALHV- 214
Cdd:COG0475  68 FLIGLELDLKRLRKMGRRALGIGLLQVLLPFLLGFLLALLLG-------LSLAAALFLGAALAATSTAIVLKVLKELGLl 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872703 215 DPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAalgtltgLISALVLKHIDLRKT 294
Cdd:COG0475 141 KTPLGQLILGVALFDDIAAILLLALVPALAGGGSVAGSLLLALLKALLFLALLLLVGR-------YLLRRLFRLVARTRS 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 41872703 295 PSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMS-----HYTHHNLSPVTQILM 347
Cdd:COG0475 214 RELFLLFALLLVLLAAALAELLGLSAALGAFLAGLVLAeseyrHELEEKIEPFGDLFL 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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