NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|150456465|ref|NP_056166|]
View 

tetratricopeptide repeat protein 9A [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1000094)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
124-213 1.31e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 124 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDT 198
Cdd:COG0457   67 QALELDpddaeALNNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                         90
                 ....*....|....*
gi 150456465 199 NVIRYIQLTEMKLSR 213
Cdd:COG0457  145 DALYNLGIALEKLGR 159
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
124-213 1.31e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 124 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDT 198
Cdd:COG0457   67 QALELDpddaeALNNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                         90
                 ....*....|....*
gi 150456465 199 NVIRYIQLTEMKLSR 213
Cdd:COG0457  145 DALYNLGIALEKLGR 159
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 117-213 1.27e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465  117 EEQSKTVEAIEIDCYNSLAACLLQAELV----NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEART 192
Cdd:TIGR02917 244 EEAEKHADALLKKAPNSPLAHYLKALVDfqkkNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILK 323

                          90       100
                  ....*....|....*....|.
gi 150456465  193 QQPTDTNVIRYIQLTEMKLSR 213
Cdd:TIGR02917 324 YAPNSHQARRLLASIQLRLGR 344
TPR_1 pfam00515
Tetratricopeptide repeat;
165-197 7.09e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 7.09e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 150456465  165 KALYRSGVAFYHLGDYDKALYYLKEARTQQPTD 197
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 164-197 1.46e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 1.46e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 150456465   164 FKALYRSGVAFYHLGDYDKALYYLKEARTQQPTD 197
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
lysogeny_AimR NF038310
AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR ...
 129-221 2.55e-03

AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR (arbitrium receptor), is a DNA-binding phage regulatory protein that acts as a receptor for a 6-amino acid signaling peptide cleaved from the C-terminus of AimP. AimR controls expression of AimX, the third member of the quorum sensing-like arbitrium system and an inhibitor of phage lysogeny.


Pssm-ID: 468467  Cd Length: 363  Bit Score: 38.28  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 129 DCYNS-----LAACLLQAElvNYERVKEYCLKVLKKEGE--NFKAlyrsgVAFYHLG------DYDKALYYLKEArtqqp 195
Cdd:NF038310 183 DSYEYrikelLAYAYLRRN--ELEEAREYCNEIINSANNfpLLKA-----TAYYCLGesyifeDYEKALKYLEKS----- 250

                         90       100
                 ....*....|....*....|....*.
gi 150456465 196 tdtnvirYIQLTEMKLSRCSQREKEA 221
Cdd:NF038310 251 -------LELLKKIKNKKIERKYKAF 269
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
124-213 1.31e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 124 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDT 198
Cdd:COG0457   67 QALELDpddaeALNNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                         90
                 ....*....|....*
gi 150456465 199 NVIRYIQLTEMKLSR 213
Cdd:COG0457  145 DALYNLGIALEKLGR 159
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
124-213 4.90e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 124 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDT 198
Cdd:COG0457   33 KALELDpddaeALYNLGLAYLRLG--RYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                         90
                 ....*....|....*
gi 150456465 199 NVIRYIQLTEMKLSR 213
Cdd:COG0457  111 EALYNLGLALLELGR 125
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 131-199 1.09e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 1.09e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 150456465 131 YNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDTN 199
Cdd:COG4235   54 LLDLAEALLAAG--DTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 117-213 1.27e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465  117 EEQSKTVEAIEIDCYNSLAACLLQAELV----NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEART 192
Cdd:TIGR02917 244 EEAEKHADALLKKAPNSPLAHYLKALVDfqkkNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILK 323

                          90       100
                  ....*....|....*....|.
gi 150456465  193 QQPTDTNVIRYIQLTEMKLSR 213
Cdd:TIGR02917 324 YAPNSHQARRLLASIQLRLGR 344
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 134-200 3.89e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.40  E-value: 3.89e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 150456465 134 LAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDTNV 200
Cdd:COG4783   10 LAQALLLAG--DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA 74
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
129-197 4.60e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 4.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 150456465 129 DCYNSLAACLLQaeLVNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTD 197
Cdd:COG0457    9 EAYNNLGLAYRR--LGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 145-213 5.64e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 5.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 150456465 145 NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDTNVIRYIQLTEMKLSR 213
Cdd:COG5010   69 DFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
TPR_1 pfam00515
Tetratricopeptide repeat;
165-197 7.09e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 7.09e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 150456465  165 KALYRSGVAFYHLGDYDKALYYLKEARTQQPTD 197
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 124-210 7.70e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 7.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 124 EAIEIDcYNSLAACLLQAELV----NYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDTN 199
Cdd:COG2956  169 KALKLD-PDCARALLLLAELYleqgDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL 247

                         90
                 ....*....|.
gi 150456465 200 VIRYIQLTEMK 210
Cdd:COG2956  248 LLALADLLERK 258
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
46-211 1.24e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465  46 AAAEPAELIRRAHEFKSQGAQCYKDKKFREAIGKYHRALLELKGLLPppgeRERDSRPASPAGALKP---------GRLS 116
Cdd:COG4785    8 LLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALA----AAALAAERIDRALALPdlaqlyyerGVAY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 117 EEQSKTVEAIE------------IDCYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKAL 184
Cdd:COG4785   84 DSLGDYDLAIAdfdqaleldpdlAEAYNNRGLAYLLLG--DYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAI 161

                        170       180
                 ....*....|....*....|....*..
gi 150456465 185 YYLKEARTQQPTDTNVIRYIQLTEMKL 211
Cdd:COG4785  162 ADLEKALELDPNDPERALWLYLAERKL 188
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 164-197 1.46e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 1.46e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 150456465   164 FKALYRSGVAFYHLGDYDKALYYLKEARTQQPTD 197
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
lysogeny_AimR NF038310
AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR ...
 129-221 2.55e-03

AimR family lysis-lysogeny pheromone receptor; The founding member of this family, AimR (arbitrium receptor), is a DNA-binding phage regulatory protein that acts as a receptor for a 6-amino acid signaling peptide cleaved from the C-terminus of AimP. AimR controls expression of AimX, the third member of the quorum sensing-like arbitrium system and an inhibitor of phage lysogeny.


Pssm-ID: 468467  Cd Length: 363  Bit Score: 38.28  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150456465 129 DCYNS-----LAACLLQAElvNYERVKEYCLKVLKKEGE--NFKAlyrsgVAFYHLG------DYDKALYYLKEArtqqp 195
Cdd:NF038310 183 DSYEYrikelLAYAYLRRN--ELEEAREYCNEIINSANNfpLLKA-----TAYYCLGesyifeDYEKALKYLEKS----- 250

                         90       100
                 ....*....|....*....|....*.
gi 150456465 196 tdtnvirYIQLTEMKLSRCSQREKEA 221
Cdd:NF038310 251 -------LELLKKIKNKKIERKYKAF 269
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 145-195 9.31e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 34.97  E-value: 9.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 150456465 145 NYERVKEYCLKVLKKEGENFK---ALYRSGVAFYHLGDYDKALYYLKEARTQQP 195
Cdd:COG1729   45 DYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDYDKARATLEELIKKYP 98
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
124-195 9.71e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 34.38  E-value: 9.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 150456465 124 EAIEID-----CYNSLAACLLQAElvNYERVKEYcLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQP 195
Cdd:COG3063   17 KALELDpdnadALNNLGLLLLEQG--RYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
124-191 9.82e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.14  E-value: 9.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 150456465 124 EAIEID-----CYNSLAACLLQAElvNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEAR 191
Cdd:COG0457  101 KALELDpddaeALYNLGLALLELG--RYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLE 171
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 164-196 9.87e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 32.88  E-value: 9.87e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 150456465  164 FKALYRSGVAFYHLGDYDKALYYLKEARTQQPT 196
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH