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Conserved domains on  [gi|7662102|ref|NP_056379|]
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leucine-rich repeat transmembrane neuronal protein 2 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-312 1.88e-31

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.88e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   56 PNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNqistvkeDAFQGLYKLKELILSSNKIFYLPNTtFTQLINL 135
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  136 QNLDLSFNQLSSLHPELFyGLRKLQTLHLRSNSLRTIPvRLFWDCRSLEFLDLSTNRLRSLArNGFAGLIKLRELHLEHN 215
Cdd:COG4886 139 KELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  216 QLTKINFAhFLRLSSLHTLFLQWNKISNLTCGMEWTwgTLEKLDLTGNEIKaiDLTVFETMPNLKILLMDNNKLNSLDSK 295
Cdd:COG4886 216 QLTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLTDLKLK 290

                       250
                ....*....|....*..
gi 7662102  296 ILNSLRSLTTVGLSGNL 312
Cdd:COG4886 291 ELELLLGLNSLLLLLLL 307
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 284-351 1.05e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.99  E-value: 1.05e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102     284 MDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGR--WEHSILCHSPDHTQGEDIL 351
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKvrQPEAALCAGPGALAGQPLL 71
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-312 1.88e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.88e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   56 PNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNqistvkeDAFQGLYKLKELILSSNKIFYLPNTtFTQLINL 135
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  136 QNLDLSFNQLSSLHPELFyGLRKLQTLHLRSNSLRTIPvRLFWDCRSLEFLDLSTNRLRSLArNGFAGLIKLRELHLEHN 215
Cdd:COG4886 139 KELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  216 QLTKINFAhFLRLSSLHTLFLQWNKISNLTCGMEWTwgTLEKLDLTGNEIKaiDLTVFETMPNLKILLMDNNKLNSLDSK 295
Cdd:COG4886 216 QLTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLTDLKLK 290

                       250
                ....*....|....*..
gi 7662102  296 ILNSLRSLTTVGLSGNL 312
Cdd:COG4886 291 ELELLLGLNSLLLLLLL 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-265 9.23e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 9.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   66 LSLRHNHITELErdQFASFSQLTWLHLDHNQIStvKEDAFQGLYKLKELILSSNKIfylpnttfTQLINLQNldlsfnql 145
Cdd:cd21340  29 LYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNRI--------SVVEGLEN-------- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  146 sslhpelfygLRKLQTLHLRSNSLRTiPVRLFWDCRS-------LEFLDLSTNRLRSLarNGFAGLIKLRELHLEHNQLT 218
Cdd:cd21340  89 ----------LTNLEELHIENQRLPP-GEKLTFDPRSlaalsnsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 7662102  219 KIN-FAHFLRlsslhtlflqwnkisnltcgmewTWGTLEKLDLTGNEI 265
Cdd:cd21340 156 DLEeLLDLLS-----------------------SWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
134-193 1.83e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.93  E-value: 1.83e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-316 2.34e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    82 ASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQT 161
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFK 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   162 LHLRSNSLRT-IPVRLfWDCRSLE------------------------FLDLSTNRLR----------------SLARNG 200
Cdd:PLN00113 385 LILFSNSLEGeIPKSL-GACRSLRrvrlqdnsfsgelpseftklplvyFLDISNNNLQgrinsrkwdmpslqmlSLARNK 463

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   201 FAGLI-------KLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVF 273
Cdd:PLN00113 464 FFGGLpdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASF 543

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 7662102   274 ETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECS 316
Cdd:PLN00113 544 SEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGS 586
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 284-351 1.05e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.99  E-value: 1.05e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102     284 MDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGR--WEHSILCHSPDHTQGEDIL 351
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKvrQPEAALCAGPGALAGQPLL 71
LRR smart00370
Leucine-rich repeats, outliers;
132-155 3.28e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 3.28e-03
                           10        20
                   ....*....|....*....|....
gi 7662102     132 LINLQNLDLSFNQLSSLHPELFYG 155
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-312 1.88e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 1.88e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   56 PNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNqistvkeDAFQGLYKLKELILSSNKIFYLPNTtFTQLINL 135
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNL 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  136 QNLDLSFNQLSSLHPELFyGLRKLQTLHLRSNSLRTIPvRLFWDCRSLEFLDLSTNRLRSLArNGFAGLIKLRELHLEHN 215
Cdd:COG4886 139 KELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  216 QLTKINFAhFLRLSSLHTLFLQWNKISNLTCGMEWTwgTLEKLDLTGNEIKaiDLTVFETMPNLKILLMDNNKLNSLDSK 295
Cdd:COG4886 216 QLTDLPEP-LANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLTDLKLK 290

                       250
                ....*....|....*..
gi 7662102  296 ILNSLRSLTTVGLSGNL 312
Cdd:COG4886 291 ELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-342 4.45e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 116.19  E-value: 4.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   66 LSLRHNHITELErDQFASFSQLTWLHLDHNQISTVKEdAFQGLYKLKELILSSNKIFYLPNTtFTQLINLQNLDLSFNQL 145
Cdd:COG4886 141 LDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQL 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  146 SSLhPELFYGLRKLQTLHLRSNSLRTIPVrlFWDCRSLEFLDLSTNRLRSLarNGFAGLIKLRELHLEHNQLTKINFAHF 225
Cdd:COG4886 218 TDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKEL 292

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  226 LRLSSL--HTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSL 303
Cdd:COG4886 293 ELLLGLnsLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 7662102  304 TTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSP 342
Cdd:COG4886 373 GLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-265 9.23e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 9.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   66 LSLRHNHITELErdQFASFSQLTWLHLDHNQIStvKEDAFQGLYKLKELILSSNKIfylpnttfTQLINLQNldlsfnql 145
Cdd:cd21340  29 LYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNRI--------SVVEGLEN-------- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  146 sslhpelfygLRKLQTLHLRSNSLRTiPVRLFWDCRS-------LEFLDLSTNRLRSLarNGFAGLIKLRELHLEHNQLT 218
Cdd:cd21340  89 ----------LTNLEELHIENQRLPP-GEKLTFDPRSlaalsnsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 7662102  219 KIN-FAHFLRlsslhtlflqwnkisnltcgmewTWGTLEKLDLTGNEI 265
Cdd:cd21340 156 DLEeLLDLLS-----------------------SWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
134-193 1.83e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.93  E-value: 1.83e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    134 NLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-311 1.81e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 1.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  151 ELFYGLRKLQTLHLRSNSLRTIPVRLFwdCRSLEFLDLSTNRLRSLarNGFAGLIKLRELHLEHNQLTKINfaHFLRLSS 230
Cdd:cd21340  18 DNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTN 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  231 LHTLFLQWNkisNLTCGMEWTW---------GTLEKLDLTGNEIKaiDLTVFETMPNLKILLMDNNKLNSLD--SKILNS 299
Cdd:cd21340  92 LEELHIENQ---RLPPGEKLTFdprslaalsNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEelLDLLSS 166

                       170
                ....*....|..
gi 7662102  300 LRSLTTVGLSGN 311
Cdd:cd21340 167 WPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
110-169 1.59e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 1.59e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    110 KLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSL 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
85-145 8.68e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 8.68e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7662102     85 SQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQL 145
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-121 5.73e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 5.73e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7662102     66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKI 121
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-316 2.34e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 2.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    82 ASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQT 161
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFK 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   162 LHLRSNSLRT-IPVRLfWDCRSLE------------------------FLDLSTNRLR----------------SLARNG 200
Cdd:PLN00113 385 LILFSNSLEGeIPKSL-GACRSLRrvrlqdnsfsgelpseftklplvyFLDISNNNLQgrinsrkwdmpslqmlSLARNK 463

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   201 FAGLI-------KLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVF 273
Cdd:PLN00113 464 FFGGLpdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASF 543

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 7662102   274 ETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECS 316
Cdd:PLN00113 544 SEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGS 586
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-311 5.05e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 5.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    80 QFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIF-YLPNTTFTqLINLQNLDLSFNQLSSLHPELFYGLRK 158
Cdd:PLN00113 231 EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   159 LQTLHLRSNSLR-TIPVRL----------FWDCR-------------SLEFLDLSTNRLRS----------------LAR 198
Cdd:PLN00113 310 LEILHLFSNNFTgKIPVALtslprlqvlqLWSNKfsgeipknlgkhnNLTVLDLSTNNLTGeipeglcssgnlfkliLFS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   199 NGFAGLI--------KLRELHLEHNQL--------TKINFAHFLRLS----------------SLHTLFLQWNKISNltc 246
Cdd:PLN00113 390 NSLEGEIpkslgacrSLRRVRLQDNSFsgelpsefTKLPLVYFLDISnnnlqgrinsrkwdmpSLQMLSLARNKFFG--- 466

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662102   247 GMEWTWGT--LEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Cdd:PLN00113 467 GLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-218 1.85e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 1.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    68 LRHNHIT-ELERDqFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIF-YLPNTTFTQliNLQNLDLSFNQL 145
Cdd:PLN00113 411 LQDNSFSgELPSE-FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQF 487

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7662102   146 SSLHPELFYGLRKLQTLHLRSNSLR-TIPVRLFwDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLT 218
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSENKLSgEIPDELS-SCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
181-241 1.99e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.99e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7662102    181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKI 241
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-324 4.85e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.67  E-value: 4.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   73 ITELERDQFASFSQLTWLHLDHNqisTVKEDAFQGLYK-------LKELILSSNKIFYLPNTT------FTQLINLQNLD 139
Cdd:cd00116  11 KTERATELLPKLLCLQVLRLEGN---TLGEEAAKALASalrpqpsLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELD 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  140 LSFNQLSSLHPELFYGLRK---LQTLHLRSNSLRTIPVRLFwdCRSL-------EFLDLSTNRL-----RSLArNGFAGL 204
Cdd:cd00116  88 LSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLL--AKGLkdlppalEKLVLGRNRLegascEALA-KALRAN 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  205 IKLRELHLEHNQLTKINFAHFLR----LSSLHTLFLQWNKIsnltcgmewtwgtlekldltgNEIKAIDLT-VFETMPNL 279
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEglkaNCNLEVLDLNNNGL---------------------TDEGASALAeTLASLKSL 223

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 7662102  280 KILLMDNNKLNSLD-SKILNSLRSLTTVGLSGNLWECSarICALAS 324
Cdd:cd00116 224 EVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCND--ITDDGA 267
LRR_8 pfam13855
Leucine rich repeat;
254-312 1.37e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.37e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 7662102    254 TLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 79-311 1.57e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    79 DQFASFSQLTWLHLDHNQISTVKEDAFqgLYKLKELILSSNKI---FYLPNTTFTqliNLQNLDLSFNQLSSLHPELFYG 155
Cdd:PLN00113 112 DIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTN 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   156 LRKLQTLHLRSNSLR-TIPVRLfWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTL 234
Cdd:PLN00113 187 LTSLEFLTLASNQLVgQIPREL-GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYL 265

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662102   235 FLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Cdd:PLN00113 266 FLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 74-208 1.67e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 50.24  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102     74 TELERDQFASfSQLTWLHLDhNQISTVKEDAFQGLYKLKELILSSNkIFYLPNTTFTQlINLQNLDLSfNQLSSLHPELF 153
Cdd:pfam13306   1 TSIGSYAFYN-CSLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN-CSLTSITIP-SSLTSIGEYAF 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 7662102    154 YGLRKLQTLHLrSNSLRTIPVRLFWDCrSLEFLDLSTNrLRSLARNGFAGLIKLR 208
Cdd:pfam13306  76 SNCSNLKSITL-PSNLTSIGSYAFSNC-SLKSITIPSS-VTTIGSYAFSNCSNLK 127
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-312 3.07e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.87  E-value: 3.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   50 QGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTvkedafQGLYKLKElILSSNKifylpnttf 129
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGD------EGIEELAE-ALTQNT--------- 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  130 tqliNLQNLDLSFNQLSSLHPELFY----GLRKLQTLHLRSNSLRTIPVRLFWDC----RSLEFLDLSTNRL-----RSL 196
Cdd:COG5238 209 ----TVTTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIgaegaIAL 284

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  197 ArNGFAGLIKLRELHLEHNQLTK---INFAHFLRLSS-LHTLFLQWNKISNLtcGME------WTWGTLEKLDLTGNEIK 266
Cdd:COG5238 285 A-KALQGNTTLTSLDLSVNRIGDegaIALAEGLQGNKtLHTLNLAYNGIGAQ--GAIalakalQENTTLHSLDLSDNQIG 361

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 7662102  267 ---AIDL-TVFETMPNL-KILLMDNNKLNSLDSKILNSLR--SLTTVGLSGNL 312
Cdd:COG5238 362 degAIALaKYLEGNTTLrELNLGKNNIGKQGAEALIDALQtnRLHTLILDGNL 414
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-304 1.53e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    24 LKMLPALGMACPPKCRCEKLLFYC----DSQGFHSVPNATDKGSL---GLSLRHNHITELERDQFASFSQ---------L 87
Cdd:PRK15370  72 LRMLAFPAYADNIQYSRGGADQYCilseNSQEILSIVFNTEGYTVeggGKSVTYTRVTESEQASSASGSKdavnyeliwS 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    88 TWLHLDHNQISTVKEDAFQGLYK-LK----ELILSSNKIFYLPNTTFTQLINLQnldLSFNQLSSLhPELFYGlrKLQTL 162
Cdd:PRK15370 152 EWVKEAPAKEAANREEAVQRMRDcLKnnktELRLKILGLTTIPACIPEQITTLI---LDNNELKSL-PENLQG--NIKTL 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   163 HLRSNSLRTIPVRLfwdCRSLEFLDLSTNRLRSLARNGFAGLiklRELHLEHNQLTKI--NFAHFLRLSSLHTlflqwnk 240
Cdd:PRK15370 226 YANSNQLTSIPATL---PDTIQEMELSINRITELPERLPSAL---QSLDLFHNKISCLpeNLPEELRYLSVYD------- 292

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7662102   241 iSNLTCGMEWTWGTLEKLDLTGNEIKAIDltvfETMP-NLKILLMDNNKLNSLDSKILNSLRSLT 304
Cdd:PRK15370 293 -NSIRTLPAHLPSGITHLNVQSNSLTALP----ETLPpGLKTLEAGENALTSLPASLPPELQVLD 352
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 134-267 7.49e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 7.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102  134 NLQNLDLSFNQLS--SLHP--ELFYGLRKLQTLHLRSNSLRTIPVRL----FWDCRSLEFLDLSTNRLRS-----LArNG 200
Cdd:cd00116 138 ALEKLVLGRNRLEgaSCEAlaKALRANRDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDegasaLA-ET 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7662102  201 FAGLIKLRELHLEHNQLTKINFAHFL-----RLSSLHTLFLQWNKISNLTCGMEWTW----GTLEKLDLTGNEIKA 267
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGAAALAsallsPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
206-289 3.23e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    206 KLRELHLEHNQLTKINFAHFLRLSSLhtlflqwnkisnltcgmewtwgtlEKLDLTGNEIKAIDLTVFETMPNLKILLMD 285
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNL------------------------KVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 7662102    286 NNKL 289
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-169 8.63e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 8.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQL 145
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559

                         90       100
                 ....*....|....*....|....
gi 7662102   146 SSLHPELFYGLRKLQTLHLRSNSL 169
Cdd:PLN00113 560 SGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-311 1.02e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   138 LDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLR-TIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLikLRELHLEHNQ 216
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   217 LTKINFAHFLRLSSLHTLFLQWN--------KISNLTcgmewtwgTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNK 288
Cdd:PLN00113 152 LSGEIPNDIGSFSSLKVLDLGGNvlvgkipnSLTNLT--------SLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNN 223

                        170       180
                 ....*....|....*....|...
gi 7662102   289 LNSLDSKILNSLRSLTTVGLSGN 311
Cdd:PLN00113 224 LSGEIPYEIGGLTSLNHLDLVYN 246
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 110-311 1.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   110 KLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHP-ELFYGLRKLQTLHLRSNSLR-TIPvRLFWDC------- 180
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPdDIFTTSSSLRYLNLSNNNFTgSIP-RGSIPNletldls 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   181 ---------------RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNkisNLT 245
Cdd:PLN00113 149 nnmlsgeipndigsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN---NLS 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7662102   246 CGMEWTWG---TLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Cdd:PLN00113 226 GEIPYEIGgltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN 294
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 284-351 1.05e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 41.99  E-value: 1.05e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102     284 MDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGR--WEHSILCHSPDHTQGEDIL 351
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKvrQPEAALCAGPGALAGQPLL 71
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-171 1.15e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 7662102    134 NLQNLDLSFNQLSSLhpELFYGLRKLQTLHLRSNSLRT 171
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
PLN03150 PLN03150
hypothetical protein; Provisional
 61-169 1.28e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102    61 KGSLGLSLR----------HNHITELERDQFASFSQlTW----LHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPN 126
Cdd:PLN03150 381 KSSLGLPLRfgwngdpcvpQQHPWSGADCQFDSTKG-KWfidgLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIP 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 7662102   127 TTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSL 169
Cdd:PLN03150 460 PSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PLN03150 PLN03150
hypothetical protein; Provisional
 138-218 1.97e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662102   138 LDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLR-TIPVRlFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQ 216
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501


                 ..
gi 7662102   217 LT 218
Cdd:PLN03150 502 LS 503
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 255-293 2.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 7662102    255 LEKLDLTGNEIKAIDLtvFETMPNLKIL-LMDNNKLNSLD 293
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLdLSGNNKITDLS 40
LRR smart00370
Leucine-rich repeats, outliers;
132-155 3.28e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 3.28e-03
                           10        20
                   ....*....|....*....|....
gi 7662102     132 LINLQNLDLSFNQLSSLHPELFYG 155
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
132-155 3.28e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 3.28e-03
                           10        20
                   ....*....|....*....|....
gi 7662102     132 LINLQNLDLSFNQLSSLHPELFYG 155
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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