NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|7705592|ref|NP_057144|]
View 

mediator of RNA polymerase II transcription subunit 31 [Homo sapiens]

Protein Classification

mediator of RNA polymerase II transcription subunit 31( domain architecture ID 10529302)

mediator of RNA polymerase II transcription subunit 31 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Med31 pfam05669
SOH1; The family consists of Saccharomyces cerevisiae SOH1 homologs. SOH1 is responsible for ...
 15-109 5.29e-58

SOH1; The family consists of Saccharomyces cerevisiae SOH1 homologs. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.


:

Pssm-ID: 428575  Cd Length: 95  Bit Score: 174.63  E-value: 5.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705592     15 RLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCA 94
Cdd:pfam05669   1 KTRFELELEFVQSLANPQYLNHLAQNGYLEDPAFINYLKYLQYWKEPEYAKFLTYPHCLHFLDLLQNEEFRQEISNPDFA 80

                          90
                  ....*....|....*
gi 7705592     95 KFIDEQQILHWQHYS 109
Cdd:pfam05669  81 KFLMDQQYLHWQTYR 95
 
Name Accession Description Interval E-value
Med31 pfam05669
SOH1; The family consists of Saccharomyces cerevisiae SOH1 homologs. SOH1 is responsible for ...
 15-109 5.29e-58

SOH1; The family consists of Saccharomyces cerevisiae SOH1 homologs. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.


Pssm-ID: 428575  Cd Length: 95  Bit Score: 174.63  E-value: 5.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705592     15 RLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCA 94
Cdd:pfam05669   1 KTRFELELEFVQSLANPQYLNHLAQNGYLEDPAFINYLKYLQYWKEPEYAKFLTYPHCLHFLDLLQNEEFRQEISNPDFA 80

                          90
                  ....*....|....*
gi 7705592     95 KFIDEQQILHWQHYS 109
Cdd:pfam05669  81 KFLMDQQYLHWQTYR 95
SOH1 COG5088
Rad5p-binding protein [General function prediction only];
17-105 3.14e-31

Rad5p-binding protein [General function prediction only];


Pssm-ID: 227420  Cd Length: 114  Bit Score: 107.28  E-value: 3.14e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705592   17 RFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKF 96
Cdd:COG5088  16 RFEVELEFVQSLANPQYLTLLTQQQIFESENFKNYLKYLEYWRNPEYSQFIVYPNCLFILKLLNGFMESAIVSEDGLLEG 95


                ....*....
gi 7705592   97 IDEQQILHW 105
Cdd:COG5088  96 LDELQYPQW 104
 
Name Accession Description Interval E-value
Med31 pfam05669
SOH1; The family consists of Saccharomyces cerevisiae SOH1 homologs. SOH1 is responsible for ...
 15-109 5.29e-58

SOH1; The family consists of Saccharomyces cerevisiae SOH1 homologs. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.


Pssm-ID: 428575  Cd Length: 95  Bit Score: 174.63  E-value: 5.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705592     15 RLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCA 94
Cdd:pfam05669   1 KTRFELELEFVQSLANPQYLNHLAQNGYLEDPAFINYLKYLQYWKEPEYAKFLTYPHCLHFLDLLQNEEFRQEISNPDFA 80

                          90
                  ....*....|....*
gi 7705592     95 KFIDEQQILHWQHYS 109
Cdd:pfam05669  81 KFLMDQQYLHWQTYR 95
SOH1 COG5088
Rad5p-binding protein [General function prediction only];
17-105 3.14e-31

Rad5p-binding protein [General function prediction only];


Pssm-ID: 227420  Cd Length: 114  Bit Score: 107.28  E-value: 3.14e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7705592   17 RFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKF 96
Cdd:COG5088  16 RFEVELEFVQSLANPQYLTLLTQQQIFESENFKNYLKYLEYWRNPEYSQFIVYPNCLFILKLLNGFMESAIVSEDGLLEG 95


                ....*....
gi 7705592   97 IDEQQILHW 105
Cdd:COG5088  96 LDELQYPQW 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH