View
Concise Results
Standard Results
Full Results
heat shock protein 75 kDa, mitochondrial isoform 1 precursor [Homo sapiens]
Protein Classification
Hsp90 family chaperone protein ( domain architecture ID 11480452 )
Hsp90 (heat shock protein 90) family chaperone protein, such as molecular chaperone HtpG (high-temperature protein G) that facilitates the folding and conformational changes of a wide array of proteins
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
87-702
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 695.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 87 KH EFQAE T K K LL DIVAR SLYS E KE V F I RELISNASDA LE KLR HKLVS D --- GQALPEME I HLQTNA E KG T I TI Q D T GIGM 163
Cdd:PRK05218 5 TG EFQAE V K Q LL HLMIH SLYS N KE I F L RELISNASDA ID KLR FEALT D pal YEGDGDLK I RISFDK E AR T L TI S D N GIGM 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 164 T Q EE LVS NLGTIA R SG S K A FL DA L QNQAEAS S KI IGQFGVGFYSAFMVAD R V E V YS RSA A P GSLGYQ W L SDG S G VFE I A E 243
Cdd:PRK05218 85 T R EE VIE NLGTIA K SG T K E FL EK L KGDQKKD S QL IGQFGVGFYSAFMVAD K V T V IT RSA G P AAEAVR W E SDG E G EYT I E E 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 244 ASGVRT GT K I II HLK S D CK EF SS E A R V R DVVT KYS N F VSF P LY L NG --- RRM N TLQ A I W MMDPKDVREWQHE EFY RYV A Q 320
Cdd:PRK05218 165 IEKEER GT E I TL HLK E D ED EF LD E W R I R SIIK KYS D F IPV P IK L EK eee ETI N SAS A L W TRSKSEITDEEYK EFY KHL A H 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 321 AH D K P RYTL H YKTDA P LNIRSIF Y V P DMK P sm FD V - S R ELGSSVA LY SRK V L I QTK A TDI LP KW LRF IR GV V DSED I PLN 399
Cdd:PRK05218 245 DF D D P LFWI H NNVEG P FEYTGLL Y I P KKA P -- FD L f N R DRKGGLK LY VKR V F I MDD A EEL LP EY LRF VK GV I DSED L PLN 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 400 L SRE L LQE SALIR K L R DVLQQRLIKFFIDQS K K D A EKY A KF FEDY G LFMR EG IVTATEQ ev K E DI AKLLR YE S SA lp S G Q 479
Cdd:PRK05218 323 V SRE I LQE DRVVK K I R KAITKKVLDELEKLA K N D R EKY E KF WKEF G PVLK EG LYEDFAN -- R E KL AKLLR FA S TH -- E G K 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 480 LT SL S EY AS RM RA G TRN IYY LCAPN R HL A EH SP YY E AM KKK DT EVL FCFEQF DE LTLLH L R EFD K K KLI SV e TDIVV D HY 559
Cdd:PRK05218 399 YV SL A EY VE RM KE G QKK IYY ITGDS R EA A KN SP HL E LF KKK GI EVL LLTDPI DE FWISY L E EFD G K PFK SV - ARGDL D LG 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 560 KE EKF E D rsp AAECLS E K E TEE L MAWMRNV LG SR V TN V KVTL RL DTH PA MVTVL E MG aarhfl RMQ Q LA K TQEERA Q LL - 638
Cdd:PRK05218 478 KE DEE E K --- EEKEEA E E E FKP L LERLKEA LG DK V KD V RLSH RL TDS PA CLVAD E GD ------ MST Q ME K LLKAAG Q EV p 548
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 155722983 639 -- Q P T LEINP R H A L I KKL nq LRASEPGLAQL L VDQI Y EN A MI A A G L - VD DP R A M V G RLNELL V K A L E 702
Cdd:PRK05218 549 es K P I LEINP N H P L V KKL -- ADEADEAKFKD L AELL Y DQ A LL A E G G s LE DP A A F V K RLNELL L K L L A 613
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
87-702
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 695.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 87 KH EFQAE T K K LL DIVAR SLYS E KE V F I RELISNASDA LE KLR HKLVS D --- GQALPEME I HLQTNA E KG T I TI Q D T GIGM 163
Cdd:PRK05218 5 TG EFQAE V K Q LL HLMIH SLYS N KE I F L RELISNASDA ID KLR FEALT D pal YEGDGDLK I RISFDK E AR T L TI S D N GIGM 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 164 T Q EE LVS NLGTIA R SG S K A FL DA L QNQAEAS S KI IGQFGVGFYSAFMVAD R V E V YS RSA A P GSLGYQ W L SDG S G VFE I A E 243
Cdd:PRK05218 85 T R EE VIE NLGTIA K SG T K E FL EK L KGDQKKD S QL IGQFGVGFYSAFMVAD K V T V IT RSA G P AAEAVR W E SDG E G EYT I E E 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 244 ASGVRT GT K I II HLK S D CK EF SS E A R V R DVVT KYS N F VSF P LY L NG --- RRM N TLQ A I W MMDPKDVREWQHE EFY RYV A Q 320
Cdd:PRK05218 165 IEKEER GT E I TL HLK E D ED EF LD E W R I R SIIK KYS D F IPV P IK L EK eee ETI N SAS A L W TRSKSEITDEEYK EFY KHL A H 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 321 AH D K P RYTL H YKTDA P LNIRSIF Y V P DMK P sm FD V - S R ELGSSVA LY SRK V L I QTK A TDI LP KW LRF IR GV V DSED I PLN 399
Cdd:PRK05218 245 DF D D P LFWI H NNVEG P FEYTGLL Y I P KKA P -- FD L f N R DRKGGLK LY VKR V F I MDD A EEL LP EY LRF VK GV I DSED L PLN 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 400 L SRE L LQE SALIR K L R DVLQQRLIKFFIDQS K K D A EKY A KF FEDY G LFMR EG IVTATEQ ev K E DI AKLLR YE S SA lp S G Q 479
Cdd:PRK05218 323 V SRE I LQE DRVVK K I R KAITKKVLDELEKLA K N D R EKY E KF WKEF G PVLK EG LYEDFAN -- R E KL AKLLR FA S TH -- E G K 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 480 LT SL S EY AS RM RA G TRN IYY LCAPN R HL A EH SP YY E AM KKK DT EVL FCFEQF DE LTLLH L R EFD K K KLI SV e TDIVV D HY 559
Cdd:PRK05218 399 YV SL A EY VE RM KE G QKK IYY ITGDS R EA A KN SP HL E LF KKK GI EVL LLTDPI DE FWISY L E EFD G K PFK SV - ARGDL D LG 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 560 KE EKF E D rsp AAECLS E K E TEE L MAWMRNV LG SR V TN V KVTL RL DTH PA MVTVL E MG aarhfl RMQ Q LA K TQEERA Q LL - 638
Cdd:PRK05218 478 KE DEE E K --- EEKEEA E E E FKP L LERLKEA LG DK V KD V RLSH RL TDS PA CLVAD E GD ------ MST Q ME K LLKAAG Q EV p 548
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 155722983 639 -- Q P T LEINP R H A L I KKL nq LRASEPGLAQL L VDQI Y EN A MI A A G L - VD DP R A M V G RLNELL V K A L E 702
Cdd:PRK05218 549 es K P I LEINP N H P L V KKL -- ADEADEAKFKD L AELL Y DQ A LL A E G G s LE DP A A F V K RLNELL L K L L A 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
87-702
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 682.62
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 87 KH EFQAE T K K LLD IVAR SLYS E KE V F I RELISNASDA LE KLR HKLVS D GQAL --- PEME I HLQTNA E KG T I TI Q D T GIGM 163
Cdd:COG0326 5 TG EFQAE V K Q LLD LMIH SLYS N KE I F L RELISNASDA ID KLR FLALT D PELK eed GDLK I RIEVDK E AK T L TI S D N GIGM 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 164 T Q EE LVS NLGTIA R SG SKA FL DA L QNQAEAS S KI IGQFGVGFYSAFMVAD R VEV YS RSA APGSLGYQ W L SDG S G VFE I A E 243
Cdd:COG0326 85 T R EE VIE NLGTIA K SG TRE FL EK L KGDQKKD S DL IGQFGVGFYSAFMVAD K VEV VT RSA GEDAEAVR W E SDG D G EYT I E E 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 244 A SGVRT GT K I II HLK S D CK EF SS E A R V R DVVT KYS N F VSF P LYLN G -------- RRM N TLQ A I W MMDPKDVREWQHE EFY 315
Cdd:COG0326 165 A EKAER GT E I TL HLK E D AE EF LE E W R L R EIIK KYS D F IPV P IKME G eeeeteed ETI N SAT A L W TRSKSEITDEEYK EFY 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 316 RYVAQAHDK P RYTL H YKTDA P LNIRSIF Y V P DMK P sm FD V - S R ELGSSVA LY SRK V L I QTK A T D I LP KW LRF I RGVVDS E 394
Cdd:COG0326 245 KHLFHDFED P LFWI H LNVEG P FEYTGLL Y I P KKA P -- FD L y D R DRKGGIK LY VKR V F I MDD A E D L LP EY LRF V RGVVDS P 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 395 D I PLN L SRE L LQE SALIR K L R DVLQQRLIKFFIDQS K K D A EKY A KF FEDY GL FMR EG I vt ATEQEVK E D IA K LLR Y ES SA 474
Cdd:COG0326 323 D L PLN V SRE I LQE DRQLK K I R KAITKKVLDELEKLA K N D R EKY E KF WKEF GL VLK EG A -- LEDFKNR E K IA D LLR F ES TK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 475 lp S G QLTS L S EY AS RM RA G TRN IYY LCAPN R HL AE H SP YY E AM K K K DT EVL FCFEQF DE LTLL HL R EFD K KK LI SV ETDI 554
Cdd:COG0326 401 -- E G GYVT L A EY VE RM KE G QKK IYY ITGES R EA AE Q SP HL E IF K A K GI EVL LLTDPI DE FLIS HL E EFD G KK FK SV DSGD 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 555 V vdhy KEE K F E D rs PAAECLS E K E TEE L MAWMRNV LG SR V TN V K V TL RL DTH PA MVTVL E MGAA R HFLR M QQLAKTQEER 634
Cdd:COG0326 479 L ---- DLD K L E E -- KKESEEE E E E FKP L LERFKEA LG DK V KD V R V SA RL TDS PA CLVAD E GDMS R RMEK M LKAMGQDMPE 552
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 155722983 635 A qll Q P T LEINP R H A L I KKL nq LRASEPG L AQL L VDQI Y EN A MI A A G - L VD DP R A M V G RLN E LL V KAL E 702
Cdd:COG0326 553 A --- K P I LEINP N H P L V KKL -- AAEEDEE L FKD L AELL Y DQ A LL A E G g L LE DP A A F V K RLN K LL E KAL G 616
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
95-281
5.76e-100
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 304.83
E-value: 5.76e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 95 KK LLD IVAR SLYS E KE V F I RELISNASDAL E KLR HKLVS D GQA L --- PE M EI HLQTNA E KG T I TI Q DTGIGMT Q EEL VS N 171
Cdd:cd16927 1 NQ LLD LIIH SLYS N KE I F L RELISNASDAL D KLR YLSLT D PSL L ddd PE L EI RISPDK E NR T L TI S DTGIGMT K EEL IN N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 172 LGTIARSG S KAFL D ALQ NQ A EA S S k I IGQFGVGFYSAFMVAD R V E V YSR SA A p GSL GY Q W L SDG S G VFE I A EA S G - VRT G 250
Cdd:cd16927 81 LGTIARSG T KAFL E ALQ EG A KD S D - L IGQFGVGFYSAFMVAD K V T V TTK SA G - DDE GY R W E SDG G G SYT I E EA E G e LGR G 158
170 180 190
....*....|....*....|....*....|.
gi 155722983 251 TKI II HLK S D C KEF SS EAR VRDV V T KYS N F V 281
Cdd:cd16927 159 TKI TL HLK E D A KEF LE EAR IKEL V K KYS D F I 189
HSP90
pfam00183 Hsp90 protein;
263-701
2.33e-95
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 304.48
E-value: 2.33e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 263 E FSS E ARVRDV V T KYS N F VS FP L YL --------------------------------------------------- NGRR 291
Cdd:pfam00183 1 E YLE E KKIKEL V K KYS E F IN FP I YL wvekeeevevpdeeeeeeeeeeeeedddpkveeedeeeekkktkkvketvw EWEL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 292 M N TLQA IW MMD PK D V R E WQHE EFY RYVAQAHDK P RYTL H YKTDAPLNIR S IFYV P DMK P S - M F D v SRELGSSVA LY S R K V 370
Cdd:pfam00183 81 L N KTKP IW TRN PK E V T E EEYA EFY KSLSKDWED P LAVK H FSVEGEVEFK S LLFI P KRA P F d L F E - NKKKKNNIK LY V R R V 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 371 L I QTKAT D IL P KW L R F IR GVVDS E D I PLN L SRE L LQ ESALIRKLRDV L QQRLIKF F IDQSKKD a E K Y A KF FEDY G LFMRE 450
Cdd:pfam00183 160 F I TDDFE D LI P EY L N F VK GVVDS D D L PLN V SRE T LQ QNKILKVIKKK L VRKALDM F KEIAEEK - E D Y K KF WKEF G KNLKL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 451 GI VTATEQEV K ed I AKLLR YE SS ALP s GQ LTSL SE Y A SRM RA G TRN IYY LCAPNRHLA E H SP YY E AM KKK DT EVL FCFEQ 530
Cdd:pfam00183 239 GI IEDSSNRN K -- L AKLLR FY SS KSG - DE LTSL DD Y V SRM KE G QKH IYY ITGESKEEV E N SP FL E RL KKK GY EVL YLTDP 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 531 F DE LTLLH L R EFD K KKL IS V --- ETDIVV D HYKEE K F E DR spaaecls E KE T E E L MA W MRN VLG SR V TN V K V TL RL DTH P 607
Cdd:pfam00183 316 I DE YAVQQ L K EFD G KKL VN V ake GLELEE D EEEKK K D E EL -------- K KE F E P L TK W LKD VLG DK V EK V V V SN RL VDS P 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 608 AMVTVLEM G - A A rhfl R M QQLA K T Q EE R AQ ------ LLQP - TLEINPRH AL IK K L NQLRASEPG -- L A QL L VDQI YE N A M 677
Cdd:pfam00183 388 CVLVTSQY G w S A ---- N M ERIM K A Q AL R KD ssmssy MSSK k TLEINPRH PI IK E L LKRVEADKD dk T A KD L ALLL YE T A L 463
490 500
....*....|....*....|....*
gi 155722983 678 IAA G - LVD DP RAMVG R LNEL L VKA L 701
Cdd:pfam00183 464 LRS G f SLE DP ASFAS R IYRM L KLG L 488
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
113-258
3.26e-07
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 49.18
E-value: 3.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 113 IRE L IS NA SDA leklrhklvsd GQALPEMEIH L QTNAEKGT IT IQ D T G I G MTQ E E L vsnlgtiarsg S K A F LDAL qn QAE 192
Cdd:smart00387 10 LSN L LD NA IKY ----------- TPEGGRITVT L ERDGDHVE IT VE D N G P G IPP E D L ----------- E K I F EPFF -- RTD 65
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 155722983 193 AS S KI IG QF G V G FYSAFMVADRVEV ysrsaapgslgyqwlsdgsgvf EI AEA S GVRT GT KII I H L K 258
Cdd:smart00387 66 KR S RK IG GT G L G LSIVKKLVELHGG ---------------------- EI SVE S EPGG GT TFT I T L P 109
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
87-702
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 695.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 87 KH EFQAE T K K LL DIVAR SLYS E KE V F I RELISNASDA LE KLR HKLVS D --- GQALPEME I HLQTNA E KG T I TI Q D T GIGM 163
Cdd:PRK05218 5 TG EFQAE V K Q LL HLMIH SLYS N KE I F L RELISNASDA ID KLR FEALT D pal YEGDGDLK I RISFDK E AR T L TI S D N GIGM 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 164 T Q EE LVS NLGTIA R SG S K A FL DA L QNQAEAS S KI IGQFGVGFYSAFMVAD R V E V YS RSA A P GSLGYQ W L SDG S G VFE I A E 243
Cdd:PRK05218 85 T R EE VIE NLGTIA K SG T K E FL EK L KGDQKKD S QL IGQFGVGFYSAFMVAD K V T V IT RSA G P AAEAVR W E SDG E G EYT I E E 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 244 ASGVRT GT K I II HLK S D CK EF SS E A R V R DVVT KYS N F VSF P LY L NG --- RRM N TLQ A I W MMDPKDVREWQHE EFY RYV A Q 320
Cdd:PRK05218 165 IEKEER GT E I TL HLK E D ED EF LD E W R I R SIIK KYS D F IPV P IK L EK eee ETI N SAS A L W TRSKSEITDEEYK EFY KHL A H 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 321 AH D K P RYTL H YKTDA P LNIRSIF Y V P DMK P sm FD V - S R ELGSSVA LY SRK V L I QTK A TDI LP KW LRF IR GV V DSED I PLN 399
Cdd:PRK05218 245 DF D D P LFWI H NNVEG P FEYTGLL Y I P KKA P -- FD L f N R DRKGGLK LY VKR V F I MDD A EEL LP EY LRF VK GV I DSED L PLN 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 400 L SRE L LQE SALIR K L R DVLQQRLIKFFIDQS K K D A EKY A KF FEDY G LFMR EG IVTATEQ ev K E DI AKLLR YE S SA lp S G Q 479
Cdd:PRK05218 323 V SRE I LQE DRVVK K I R KAITKKVLDELEKLA K N D R EKY E KF WKEF G PVLK EG LYEDFAN -- R E KL AKLLR FA S TH -- E G K 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 480 LT SL S EY AS RM RA G TRN IYY LCAPN R HL A EH SP YY E AM KKK DT EVL FCFEQF DE LTLLH L R EFD K K KLI SV e TDIVV D HY 559
Cdd:PRK05218 399 YV SL A EY VE RM KE G QKK IYY ITGDS R EA A KN SP HL E LF KKK GI EVL LLTDPI DE FWISY L E EFD G K PFK SV - ARGDL D LG 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 560 KE EKF E D rsp AAECLS E K E TEE L MAWMRNV LG SR V TN V KVTL RL DTH PA MVTVL E MG aarhfl RMQ Q LA K TQEERA Q LL - 638
Cdd:PRK05218 478 KE DEE E K --- EEKEEA E E E FKP L LERLKEA LG DK V KD V RLSH RL TDS PA CLVAD E GD ------ MST Q ME K LLKAAG Q EV p 548
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 155722983 639 -- Q P T LEINP R H A L I KKL nq LRASEPGLAQL L VDQI Y EN A MI A A G L - VD DP R A M V G RLNELL V K A L E 702
Cdd:PRK05218 549 es K P I LEINP N H P L V KKL -- ADEADEAKFKD L AELL Y DQ A LL A E G G s LE DP A A F V K RLNELL L K L L A 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
87-702
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 682.62
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 87 KH EFQAE T K K LLD IVAR SLYS E KE V F I RELISNASDA LE KLR HKLVS D GQAL --- PEME I HLQTNA E KG T I TI Q D T GIGM 163
Cdd:COG0326 5 TG EFQAE V K Q LLD LMIH SLYS N KE I F L RELISNASDA ID KLR FLALT D PELK eed GDLK I RIEVDK E AK T L TI S D N GIGM 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 164 T Q EE LVS NLGTIA R SG SKA FL DA L QNQAEAS S KI IGQFGVGFYSAFMVAD R VEV YS RSA APGSLGYQ W L SDG S G VFE I A E 243
Cdd:COG0326 85 T R EE VIE NLGTIA K SG TRE FL EK L KGDQKKD S DL IGQFGVGFYSAFMVAD K VEV VT RSA GEDAEAVR W E SDG D G EYT I E E 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 244 A SGVRT GT K I II HLK S D CK EF SS E A R V R DVVT KYS N F VSF P LYLN G -------- RRM N TLQ A I W MMDPKDVREWQHE EFY 315
Cdd:COG0326 165 A EKAER GT E I TL HLK E D AE EF LE E W R L R EIIK KYS D F IPV P IKME G eeeeteed ETI N SAT A L W TRSKSEITDEEYK EFY 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 316 RYVAQAHDK P RYTL H YKTDA P LNIRSIF Y V P DMK P sm FD V - S R ELGSSVA LY SRK V L I QTK A T D I LP KW LRF I RGVVDS E 394
Cdd:COG0326 245 KHLFHDFED P LFWI H LNVEG P FEYTGLL Y I P KKA P -- FD L y D R DRKGGIK LY VKR V F I MDD A E D L LP EY LRF V RGVVDS P 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 395 D I PLN L SRE L LQE SALIR K L R DVLQQRLIKFFIDQS K K D A EKY A KF FEDY GL FMR EG I vt ATEQEVK E D IA K LLR Y ES SA 474
Cdd:COG0326 323 D L PLN V SRE I LQE DRQLK K I R KAITKKVLDELEKLA K N D R EKY E KF WKEF GL VLK EG A -- LEDFKNR E K IA D LLR F ES TK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 475 lp S G QLTS L S EY AS RM RA G TRN IYY LCAPN R HL AE H SP YY E AM K K K DT EVL FCFEQF DE LTLL HL R EFD K KK LI SV ETDI 554
Cdd:COG0326 401 -- E G GYVT L A EY VE RM KE G QKK IYY ITGES R EA AE Q SP HL E IF K A K GI EVL LLTDPI DE FLIS HL E EFD G KK FK SV DSGD 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 555 V vdhy KEE K F E D rs PAAECLS E K E TEE L MAWMRNV LG SR V TN V K V TL RL DTH PA MVTVL E MGAA R HFLR M QQLAKTQEER 634
Cdd:COG0326 479 L ---- DLD K L E E -- KKESEEE E E E FKP L LERFKEA LG DK V KD V R V SA RL TDS PA CLVAD E GDMS R RMEK M LKAMGQDMPE 552
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 155722983 635 A qll Q P T LEINP R H A L I KKL nq LRASEPG L AQL L VDQI Y EN A MI A A G - L VD DP R A M V G RLN E LL V KAL E 702
Cdd:COG0326 553 A --- K P I LEINP N H P L V KKL -- AAEEDEE L FKD L AELL Y DQ A LL A E G g L LE DP A A F V K RLN K LL E KAL G 616
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
85-697
3.72e-130
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 401.36
E-value: 3.72e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 85 T SKHE FQAE TKK L LDIVARSL YS E KE V F I RELISNASDA LE K L R HKLVS D GQA L --- P EME I HLQTNA E KG T I T IQ D T GI 161
Cdd:PTZ00272 2 T ETFA FQAE INQ L MSLIINTF YS N KE I F L RELISNASDA CD K I R YQSLT D PSV L ges P RLC I RVVPDK E NK T L T VE D N GI 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 162 GMT QEE LV S NLGTIARSG S KAF LD AL QNQAEA S sk I IGQFGVGFYSA FM VADRV E V Y S RSAAPG S lg Y Q W L S DGS G V F E I 241
Cdd:PTZ00272 82 GMT KAD LV N NLGTIARSG T KAF ME AL EAGGDM S -- M IGQFGVGFYSA YL VADRV T V T S KNNSDE S -- Y V W E S SAG G T F T I 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 242 AEA -- S GVRT GT K I II HLK S D CK E FSSEA R VRDVVT K Y S N F VSFPLY L NGRR ---------------------------- 291
Cdd:PTZ00272 158 TST pe S DMKR GT R I TL HLK E D QM E YLEPR R LKELIK K H S E F IGYDIE L MVEK ttekevtdedeedtkkadedgeepkvee 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 292 ------------------------ M N TLQAI W MM DPKDV REWQHEE FY RYVAQAHDK P RY T L H YKTDAP L NI RSI FY VP D 347
Cdd:PTZ00272 238 vkegdegkkkktkkvkevtkeyev Q N KHKPL W TR DPKDV TKEEYAA FY KAISNDWED P AA T K H FSVEGQ L EF RSI MF VP K 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 348 MK P - S MF DVSREL g SSVA LY S R K V L I QTKAT D IL P K WL R F IR GVVDSED I PLN L SRE L LQ ESALIRKL R DVLQQRLIKF F 426
Cdd:PTZ00272 318 RA P f D MF EPNKKR - NNIK LY V R R V F I MDNCE D LC P D WL G F VK GVVDSED L PLN I SRE N LQ QNKILKVI R KNIVKKCLEM F 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 427 i D QSKKDA E K Y AK F F E DY G LFMRE GI VTA T EQEV K ed IAK LLR YE S SA lp SG Q - L T S L SE Y AS RM R AG TRN IYY LCAPNR 505
Cdd:PTZ00272 397 - D EVAENK E D Y KQ F Y E QF G KNIKL GI HED T ANRK K -- LME LLR FY S TE -- SG E e M T T L KD Y VT RM K AG QKS IYY ITGDSK 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 506 HLA E H SP YY E AMKKKDT EVLF CF E QF DE LTLLHLRE F DK KK LISVETDI V vd H YK E EKF E DRSPAA E cls EKET E E L MAW 585
Cdd:PTZ00272 472 KKL E T SP FI E QARRRGL EVLF MT E PI DE YVMQQVKD F ED KK FACLTKEG V -- H FE E SEE E KQQREE E --- KAAC E K L CKT 546
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 586 M RN VLG SR V TN V K V TL RL D T H P AMVTVL E M G AAR H F --- L R M Q Q L AKTQEERAQLLQP T L E I NPRH AL IK K L N - QLR A S E 661
Cdd:PTZ00272 547 M KE VLG DK V EK V I V SE RL S T S P CILVTS E F G WSA H M eqi M R N Q A L RDSSMAQYMMSKK T M E L NPRH PI IK E L R r RVG A D E 626
650 660 670
....*....|....*....|....*....|....*...
gi 155722983 662 PGL A - QL LV DQIYENAMIAA G L - VD DP RAMVG R L N ELL 697
Cdd:PTZ00272 627 NDK A v KD LV FLLFDTSLLTS G F q LE DP TGYAE R I N RMI 664
PTZ00130
PTZ00130 heat shock protein 90; Provisional
75-682
2.19e-104
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 337.01
E-value: 2.19e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 75 I SST E SVQGSTSK H EF Q A E TKK L L DI VAR SLY SE KEVF I RELISNA S DALEK L R HKLV SD GQA L P E --- M EI HLQT N A EK 151
Cdd:PTZ00130 55 I EDG E KPTSGIEQ H QY Q T E VTR L M DI IVN SLY TQ KEVF L RELISNA A DALEK I R FLSL SD ESV L G E ekk L EI RISA N K EK 134
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 152 GTIT I Q DTGIGMT Q E E L VS NLGTIA R SG SKA FL D A L q NQAEASSKI IGQFGVGFYSAF M VAD R V E VY SRSAAPGS lg Y Q W 231
Cdd:PTZ00130 135 NILS I T DTGIGMT K E D L IN NLGTIA K SG TSN FL E A I - SKSGGDMSL IGQFGVGFYSAF L VAD K V I VY TKNNNDEQ -- Y I W 211
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 232 L S DGSGV F E I --- AEA S GVRT GT K I II HLK S D CKEFSSEARVR D VVT KYS N F VSF P L YL --------------------- 287
Cdd:PTZ00130 212 E S TADAK F T I ykd PRG S TLKR GT R I SL HLK E D ATNLMNDKKLV D LIS KYS Q F IQY P I YL lhenvyteevladiakemend 291
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 288 -------------------------- NGRR MN TLQA IW MMD PK DVREWQHEE F YRYVAQAH D K P R Y TL H YKTDAPLNIRS 341
Cdd:PTZ00130 292 pnydsvkveetddpnkktrtvekkvk KWKL MN EQKP IW LRP PK ELTDEDYKK F FSVLSGFN D E P L Y HI H FFAEGEIEFKC 371
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 342 IF Y V P DMK PS MF D VSRELGS S VA LY S R K VL IQTKATDI LP KWLR F IR GVVDS E D I PLN L SRE L LQ ESA -------- LI RK 413
Cdd:PTZ00130 372 LI Y I P SRA PS IN D HLFTKQN S IK LY V R R VL VADEFVEF LP RYMS F VK GVVDS D D L PLN V SRE Q LQ QNK ilkavskr IV RK 451
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 414 LR D V -------------- L QQR L I K FFIDQS KK DAE K ------- Y AKFFED Y GLFMRE G ivt AT E QEV - KED I A KLL RYE 471
Cdd:PTZ00130 452 IL D T frtlykegkknket L RAE L A K ETDEEK KK EIQ K kinepst Y KLIYKE Y RKYLKT G --- CY E DDI n RNK I V KLL LFK 528
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 472 SSAL P SG ql T SL SE Y ASR M RAGTRN IYY LCAPNRHLAEHS P YYEAM KKK DTE V L F CF E QF DE LTLLHLR E F D K KK LI S VE 551
Cdd:PTZ00130 529 TMLH P KS -- I SL DT Y IEN M KPDQKF IYY ASGDSYEYLSKI P QLQIF KKK NID V V F LT E SV DE SCVQRVQ E Y D G KK FK S IQ 606
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 552 T - D I VVDHYKE EK FEDRS paaecl SE K ETEE L MAWMRNV L GSRVTN V KVTL RL DTH P AM V TVL E M G AARHFLRMQQLAKT 630
Cdd:PTZ00130 607 K g E I TFELTED EK KKEEK ------ VK K MYKA L IDVISDT L RNQIFK V EISR RL VDA P CA V VST E W G LSGQMEKLMKINVN 680
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*.
gi 155722983 631 QEERAQLL -- Q PT LEINP R H ALIKK L NQLRA S E P GLA QL L -- VDQ IY EN A MI A A G L 682
Cdd:PTZ00130 681 NSDQIKAM sg Q KI LEINP D H PIMID L LKRSV S N P KDS QL T es IKI IY QS A KL A S G F 736
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
95-281
5.76e-100
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 304.83
E-value: 5.76e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 95 KK LLD IVAR SLYS E KE V F I RELISNASDAL E KLR HKLVS D GQA L --- PE M EI HLQTNA E KG T I TI Q DTGIGMT Q EEL VS N 171
Cdd:cd16927 1 NQ LLD LIIH SLYS N KE I F L RELISNASDAL D KLR YLSLT D PSL L ddd PE L EI RISPDK E NR T L TI S DTGIGMT K EEL IN N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 172 LGTIARSG S KAFL D ALQ NQ A EA S S k I IGQFGVGFYSAFMVAD R V E V YSR SA A p GSL GY Q W L SDG S G VFE I A EA S G - VRT G 250
Cdd:cd16927 81 LGTIARSG T KAFL E ALQ EG A KD S D - L IGQFGVGFYSAFMVAD K V T V TTK SA G - DDE GY R W E SDG G G SYT I E EA E G e LGR G 158
170 180 190
....*....|....*....|....*....|.
gi 155722983 251 TKI II HLK S D C KEF SS EAR VRDV V T KYS N F V 281
Cdd:cd16927 159 TKI TL HLK E D A KEF LE EAR IKEL V K KYS D F I 189
HSP90
pfam00183 Hsp90 protein;
263-701
2.33e-95
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 304.48
E-value: 2.33e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 263 E FSS E ARVRDV V T KYS N F VS FP L YL --------------------------------------------------- NGRR 291
Cdd:pfam00183 1 E YLE E KKIKEL V K KYS E F IN FP I YL wvekeeevevpdeeeeeeeeeeeeedddpkveeedeeeekkktkkvketvw EWEL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 292 M N TLQA IW MMD PK D V R E WQHE EFY RYVAQAHDK P RYTL H YKTDAPLNIR S IFYV P DMK P S - M F D v SRELGSSVA LY S R K V 370
Cdd:pfam00183 81 L N KTKP IW TRN PK E V T E EEYA EFY KSLSKDWED P LAVK H FSVEGEVEFK S LLFI P KRA P F d L F E - NKKKKNNIK LY V R R V 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 371 L I QTKAT D IL P KW L R F IR GVVDS E D I PLN L SRE L LQ ESALIRKLRDV L QQRLIKF F IDQSKKD a E K Y A KF FEDY G LFMRE 450
Cdd:pfam00183 160 F I TDDFE D LI P EY L N F VK GVVDS D D L PLN V SRE T LQ QNKILKVIKKK L VRKALDM F KEIAEEK - E D Y K KF WKEF G KNLKL 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 451 GI VTATEQEV K ed I AKLLR YE SS ALP s GQ LTSL SE Y A SRM RA G TRN IYY LCAPNRHLA E H SP YY E AM KKK DT EVL FCFEQ 530
Cdd:pfam00183 239 GI IEDSSNRN K -- L AKLLR FY SS KSG - DE LTSL DD Y V SRM KE G QKH IYY ITGESKEEV E N SP FL E RL KKK GY EVL YLTDP 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 531 F DE LTLLH L R EFD K KKL IS V --- ETDIVV D HYKEE K F E DR spaaecls E KE T E E L MA W MRN VLG SR V TN V K V TL RL DTH P 607
Cdd:pfam00183 316 I DE YAVQQ L K EFD G KKL VN V ake GLELEE D EEEKK K D E EL -------- K KE F E P L TK W LKD VLG DK V EK V V V SN RL VDS P 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 608 AMVTVLEM G - A A rhfl R M QQLA K T Q EE R AQ ------ LLQP - TLEINPRH AL IK K L NQLRASEPG -- L A QL L VDQI YE N A M 677
Cdd:pfam00183 388 CVLVTSQY G w S A ---- N M ERIM K A Q AL R KD ssmssy MSSK k TLEINPRH PI IK E L LKRVEADKD dk T A KD L ALLL YE T A L 463
490 500
....*....|....*....|....*
gi 155722983 678 IAA G - LVD DP RAMVG R LNEL L VKA L 701
Cdd:pfam00183 464 LRS G f SLE DP ASFAS R IYRM L KLG L 488
PRK14083
PRK14083 HSP90 family protein; Provisional
88-499
3.73e-42
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 162.03
E-value: 3.73e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 88 H E FQ AETKKLL D IVA R S LYS EKE V FI REL IS NA S DA LEK l R HK L vs D GQ A LPEME I H L q T N A EK GT ITIQ D T GIG M T Q EE 167
Cdd:PRK14083 3 H R FQ VDLRGVI D LLS R H LYS SPR V YV REL LQ NA V DA ITA - R RA L -- D PT A PGRIR I E L - T D A GG GT LIVE D N GIG L T E EE 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 168 LVSN L G TI A RS g SK A fl D ALQNQ A ea SSKII GQFG V G FY S A F M VAD RVE V Y SRSA AP G S l GYQ W L -- S DG SGVFEIA E AS 245
Cdd:PRK14083 79 VHEF L A TI G RS - SK R -- D ENLGF A -- RNDFL GQFG I G LL S C F L VAD EIV V V SRSA KD G P - AVE W R gk A DG TYSVRKL E TE 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 246 GVRT GT KIIIHLKS D CK E FSSEAR V RDVVT KY SNFVSF P LYLN G R -- RM N TLQAI W MM D PK D VREWQ h E EFYR Y V aqahd 323
Cdd:PRK14083 153 RAEP GT TVYLRPRP D AE E WLERET V EELAK KY GSLLPV P IRVE G E kg GV N ETPPP W TR D YP D PETRR - E ALLA Y G ----- 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 324 kp RYT L HYK - T D A - PL N ----- IRSIF YV PDMKP S M fdv SRELGSS V al Y SRKV L IQTK A TDI LP K W LR F I R G VV DSEDI 396
Cdd:PRK14083 227 -- EEL L GFT p L D V i PL D vpsgg LEGVA YV LPYAV S P --- AARRKHR V -- Y LKRM L LSEE A ENL LP D W AF F V R C VV NTDEL 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 397 PLNL SRE L L Q E SALIRKL R DV L QQRLI K FF I DQSKK D A E KYAKFFEDYG L FMRE giv T A TE - Q E VKED I AKL L RY E SS al 475
Cdd:PRK14083 300 RPTA SRE A L Y E DDALAAV R EE L GEAIR K WL I GLATT D P E RLRRLLAVHH L GVKA --- L A SH d D E LLRL I LPW L PF E TT -- 374
410 420
....*....|....*....|....
gi 155722983 476 p S G QL T s L S E YAS R mrag TRN I Y Y 499
Cdd:PRK14083 375 - D G RM T - L A E IRR R ---- HGV I R Y 392
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
113-258
3.26e-07
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 49.18
E-value: 3.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 113 IRE L IS NA SDA leklrhklvsd GQALPEMEIH L QTNAEKGT IT IQ D T G I G MTQ E E L vsnlgtiarsg S K A F LDAL qn QAE 192
Cdd:smart00387 10 LSN L LD NA IKY ----------- TPEGGRITVT L ERDGDHVE IT VE D N G P G IPP E D L ----------- E K I F EPFF -- RTD 65
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 155722983 193 AS S KI IG QF G V G FYSAFMVADRVEV ysrsaapgslgyqwlsdgsgvf EI AEA S GVRT GT KII I H L K 258
Cdd:smart00387 66 KR S RK IG GT G L G LSIVKKLVELHGG ---------------------- EI SVE S EPGG GT TFT I T L P 109
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
110-220
5.00e-06
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 46.56
E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 110 E VFIR ELI S N AS DA LEK lrhklvsdgqalp EME I HLQT N AEK GT - I T I Q D T G I GM TQ EEL VSN L G t I A R S GSK afldalq 188
Cdd:pfam13589 2 E GALA ELI D N SI DA DAT ------------- NIK I EVNK N RGG GT e I V I E D D G H GM SP EEL INA L R - L A T S AKE ------- 60
90 100 110
....*....|....*....|....*....|...
gi 155722983 189 nq A EAS S KII G QF G V G FYS A - FMVADRVE V Y S R 220
Cdd:pfam13589 61 -- A KRG S TDL G RY G I G LKL A s LSLGAKLT V T S K 91
HATPase_MutL-MLH-PMS-like
cd16926 Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
113-292
2.36e-05
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.
Pssm-ID: 340403 [Multi-domain]
Cd Length: 188
Bit Score: 45.51
E-value: 2.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 113 IR EL IS N AS DA leklrhklvsdg Q A l PEMEIHLQ t NAEKGT I TIQ D T G I G MTQ E E L V snlgtiarsgs K AF L dalqnq AE 192
Cdd:cd16926 18 VK EL VE N SI DA ------------ G A - TRIDVEIE - EGGLKL I RVT D N G S G ISR E D L E ----------- L AF E ------ RH 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 193 A S SKI -------- I GQF gv GF ----- Y S AFM V A d R VEVYS R S A A p GSL G YQWLS DG S G VF E IAEASGVRT GT KIIIH --- 256
Cdd:cd16926 67 A T SKI ssfedlfs I TTL -- GF rgeal A S IAS V S - R LTITT R T A D - DDV G TRLVV DG G G II E EVKPAAAPV GT TVTVR dlf 142
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 155722983 257 --------- LKS DCK E F S sea RVR D V V TKYS --- NF VSF P L YLN G RRM 292
Cdd:cd16926 143 yntparrkf LKS PKT E L S --- KIL D L V QRLA lah PD VSF S L THD G KLV 187
HATPase_TopVIB-like
cd16933 Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
89-220
5.63e-05
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain]
Cd Length: 203
Bit Score: 44.65
E-value: 5.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 89 EF QAET K KL L -- D IVA RSLY S ekev FI REL IS N AS DA L E klrhklvs DGQA LP EMEIHL - QTNAEKGTITIQ D T G I G MTQ 165
Cdd:cd16933 2 EF FRKN K EM L gf D NPI RSLY T ---- TV REL VE N SL DA T E -------- EAGI LP DIKVEI e EIGKDHYKVIVE D N G P G IPE 69
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 155722983 166 E ELVSNL G TIA r S GSK A fl DAL Q NQ aeasskii GQ F G V G FYS A F ---- M VADR - VE VY S R 220
Cdd:cd16933 70 E QIPKVF G KVL - Y GSK Y -- HNK Q SR -------- GQ Q G L G ISA A V lysq M TTGK p VE II S S 118
COG4191
COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
116-168
3.53e-03
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain]
Cd Length: 361
Bit Score: 40.17
E-value: 3.53e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 155722983 116 L IS NA S DA L E klrhklvsd GQALPEME I HLQTNAEKGT I TIQ D T G I G MTQ E E L 168
Cdd:COG4191 264 L LI NA I DA M E --------- EGEGGRIT I STRREGDYVV I SVR D N G P G IPP E V L 307
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
