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Conserved domains on  [gi|7706702|ref|NP_057668|]
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interleukin-23 subunit alpha precursor [Homo sapiens]

Protein Classification

IL23 domain-containing protein( domain architecture ID 11244618)

IL23 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL23 pfam16649
Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer ...
 28-184 9.89e-116

Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.


:

Pssm-ID: 465217  Cd Length: 158  Bit Score: 325.38  E-value: 9.89e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706702     28 PAWTQCQQLSQKLCTLAWSAHPLVGHMDL-REEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGS 106
Cdd:pfam16649   1 PAWTQCQQLSQKLCTLAWSAHPPVGHMDLpREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIRQGLVFYEKLLGS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7706702    107 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 184
Cdd:pfam16649  81 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 158
 
Name Accession Description Interval E-value
IL23 pfam16649
Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer ...
 28-184 9.89e-116

Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.


Pssm-ID: 465217  Cd Length: 158  Bit Score: 325.38  E-value: 9.89e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706702     28 PAWTQCQQLSQKLCTLAWSAHPLVGHMDL-REEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGS 106
Cdd:pfam16649   1 PAWTQCQQLSQKLCTLAWSAHPPVGHMDLpREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIRQGLVFYEKLLGS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7706702    107 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 184
Cdd:pfam16649  81 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 158
 
Name Accession Description Interval E-value
IL23 pfam16649
Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer ...
 28-184 9.89e-116

Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.


Pssm-ID: 465217  Cd Length: 158  Bit Score: 325.38  E-value: 9.89e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706702     28 PAWTQCQQLSQKLCTLAWSAHPLVGHMDL-REEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGS 106
Cdd:pfam16649   1 PAWTQCQQLSQKLCTLAWSAHPPVGHMDLpREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIRQGLVFYEKLLGS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7706702    107 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 184
Cdd:pfam16649  81 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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