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Conserved domains on  [gi|188219649|ref|NP_058051|]
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sulfotransferase 1 family member D1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-288 1.55e-114

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 330.46  E-value: 1.55e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649   38 PDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYK---RVPFMELI----IPGITNGVEMLNNMPSPRIVKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYpgdtYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  111 VQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEPGTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKEYRILY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  191 LFYEDMKENPKCEIQKILKFLEKDIPEEILNKILYHSSFSVMKENPSANYTTMMKEemdhsVSPFMRKGISGDWKNQFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 188219649  271 AQYEKFEEDYVKKMEDST 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-288 1.55e-114

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 330.46  E-value: 1.55e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649   38 PDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYK---RVPFMELI----IPGITNGVEMLNNMPSPRIVKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYpgdtYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  111 VQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEPGTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKEYRILY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  191 LFYEDMKENPKCEIQKILKFLEKDIPEEILNKILYHSSFSVMKENPSANYTTMMKEemdhsVSPFMRKGISGDWKNQFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 188219649  271 AQYEKFEEDYVKKMEDST 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 32-269 2.49e-31

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 119.64  E-value: 2.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  32 ESFEARPDDILISTYPKSGTTWVSEILDLI-----YNNGDAEKCKRDAiYKRVPFMELIIPGITNgVEMLNNMPSPrIVK 106
Cdd:PLN02164  73 EFFQARPNDFLVCSYPKTGTTWLKALTFAIanrsrFDDSSNPLLKRNP-HEFVPYIEIDFPFFPS-VDVLKDKGNT-LFS 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649 107 THLPVQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEP-GTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKE 185
Cdd:PLN02164 150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649 186 Y--RILYLFYEDMKENPKCEIQKILKFLEKDIPEE-----ILNKILYHSSFSVMKeNPSANYTTMMKEEMD--HSVSPFM 256
Cdd:PLN02164 230 NpdRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavYANSAYF 308

                        250
                 ....*....|...
gi 188219649 257 RKGISGDWKNQFT 269
Cdd:PLN02164 309 RKGKVGDWQNYLT 321
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-288 1.55e-114

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 330.46  E-value: 1.55e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649   38 PDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYK---RVPFMELI----IPGITNGVEMLNNMPSPRIVKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYpgdtYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  111 VQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEPGTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKEYRILY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  191 LFYEDMKENPKCEIQKILKFLEKDIPEEILNKILYHSSFSVMKENPSANYTTMMKEemdhsVSPFMRKGISGDWKNQFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 188219649  271 AQYEKFEEDYVKKMEDST 288
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 32-269 2.49e-31

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 119.64  E-value: 2.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649  32 ESFEARPDDILISTYPKSGTTWVSEILDLI-----YNNGDAEKCKRDAiYKRVPFMELIIPGITNgVEMLNNMPSPrIVK 106
Cdd:PLN02164  73 EFFQARPNDFLVCSYPKTGTTWLKALTFAIanrsrFDDSSNPLLKRNP-HEFVPYIEIDFPFFPS-VDVLKDKGNT-LFS 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649 107 THLPVQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEP-GTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKE 185
Cdd:PLN02164 150 THIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQE 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188219649 186 Y--RILYLFYEDMKENPKCEIQKILKFLEKDIPEE-----ILNKILYHSSFSVMKeNPSANYTTMMKEEMD--HSVSPFM 256
Cdd:PLN02164 230 NpdRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavYANSAYF 308

                        250
                 ....*....|...
gi 188219649 257 RKGISGDWKNQFT 269
Cdd:PLN02164 309 RKGKVGDWQNYLT 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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