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Conserved domains on  [gi|119360352|ref|NP_058620|]
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RWD domain-containing protein 2B [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 158-286 1.50e-59

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


:

Pssm-ID: 467814  Cd Length: 122  Bit Score: 185.54  E-value: 1.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352 158 FTRLWIYSHHIYNKCKRRNILEWAKELSLTGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPLDGtag 237
Cdd:cd24163    1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119360352 238 gmegqRKFPILEEKAFSVHGARGNHMD-FGQLYQFLNARGCGDVFQMFFG 286
Cdd:cd24163   78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 6-137 1.31e-52

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


:

Pssm-ID: 467663  Cd Length: 129  Bit Score: 168.14  E-value: 1.31e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352   6 QAEAQLSELDLLASMFPSENELIVNDQLALAELKDCIEKRTMEGRSSQVYFTINVSLDLSEaavVTFSLSCILPFKYPTV 85
Cdd:cd23829    1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKIEEPK---VKVELSVTLPHEYPSV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 119360352  86 LPEITVRSVSLSRSQQTQLNTDLIAYLQKNCLGDVCILNATEWVKEHAFDYV 137
Cdd:cd23829   78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
 
Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 158-286 1.50e-59

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 185.54  E-value: 1.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352 158 FTRLWIYSHHIYNKCKRRNILEWAKELSLTGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPLDGtag 237
Cdd:cd24163    1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119360352 238 gmegqRKFPILEEKAFSVHGARGNHMD-FGQLYQFLNARGCGDVFQMFFG 286
Cdd:cd24163   78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 6-137 1.31e-52

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 168.14  E-value: 1.31e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352   6 QAEAQLSELDLLASMFPSENELIVNDQLALAELKDCIEKRTMEGRSSQVYFTINVSLDLSEaavVTFSLSCILPFKYPTV 85
Cdd:cd23829    1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKIEEPK---VKVELSVTLPHEYPSV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 119360352  86 LPEITVRSVSLSRSQQTQLNTDLIAYLQKNCLGDVCILNATEWVKEHAFDYV 137
Cdd:cd23829   78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 161-283 2.25e-24

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 95.44  E-value: 2.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352  161 LWIYSHHIYNKCKRRNILEWAKELSLTGFSMPGKP-GVVCVEGPQSACEEFWSR-LRKLNWKRILIRHREDIPLDGTAGG 238
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPfGLVVVEGGEKSIKKYKKLmLRRIKWTENPHEDFEAMKEITFEWD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119360352  239 MEGQRKFPI----------LEEKAFSVHGARgNHMDFGQLYQFLNARGCGDVFQM 283
Cdd:pfam06544  81 NDEDNEGEDnkcelvwegeVKERAFRKWKFK-VCETEGEAREFLKKHGVEHYWDL 134
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 13-136 6.92e-18

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 77.40  E-value: 6.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352    13 ELDLLASMFPSENELIVNDqlalaelkdciekrtmeGRSSQVYFTINVSLDLSEAAVVTFSLSCILPFKYPTVLPEITVR 92
Cdd:smart00591   1 ELEALESIYPEDFEVIDED-----------------ARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLL 63

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 119360352    93 SVS-LSRSQQTQLNTDLIAYLQKNcLGDVCILNATEWVKEHAFDY 136
Cdd:smart00591  64 NSEgLSDEQLAELLKKLEEIAEEN-LGEVMIFELVEKLQEFLSEF 107
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 8-133 1.05e-15

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 71.59  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352    8 EAQLSELDLLASMFPsENELIVNDQlalaelkdciekrtmEGRSSQVYFTINVSLDLSEAAV-VTFSLSCILPFKYPTVL 86
Cdd:pfam05773   1 EEQEEELEALESIYP-DEFEVISDS---------------PYESLEIEIKLSLDSDESDSSHlPPLVLKFTLPEDYPDEP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 119360352   87 PEITVRSV-SLSRSQQTQLNTDLIAYLQKNcLGDVCILNATEWVKEHA 133
Cdd:pfam05773  65 PKISLSSPwNLSDEQVLSLLEELEELAEEN-LGEVMIFELIEWLQENL 111
PRK14422 PRK14422
acylphosphatase; Provisional
 181-215 1.37e-03

acylphosphatase; Provisional


Pssm-ID: 237712  Cd Length: 93  Bit Score: 37.41  E-value: 1.37e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 119360352 181 AKELSLTGFSMPGKPGVVCV--EGPQSACEEFWSRLR 215
Cdd:PRK14422  29 ALELGLTGYAANLADGRVQVvaEGPRAACEKLLQLLR 65
 
Name Accession Description Interval E-value
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 158-286 1.50e-59

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 185.54  E-value: 1.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352 158 FTRLWIYSHHIYNKCKRRNILEWAKELSLTGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPLDGtag 237
Cdd:cd24163    1 LGRRWIYSHHIYSKKKRKDIVEWAKELGLTGFSKPGKPGVICVEGDEEDVDEYVRRIRRLRWKKIQVRGEEVIEVPR--- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119360352 238 gmegqRKFPILEEKAFSVHGARGNHMD-FGQLYQFLNARGCGDVFQMFFG 286
Cdd:cd24163   78 -----FFGEEEDEERALPGGFRELHEDlMGELAAFLEEAGLEELFLTLFG 122
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 6-137 1.31e-52

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 168.14  E-value: 1.31e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352   6 QAEAQLSELDLLASMFPSENELIVNDQLALAELKDCIEKRTMEGRSSQVYFTINVSLDLSEaavVTFSLSCILPFKYPTV 85
Cdd:cd23829    1 CLELQLSEIEMLQSMFPNEGELKLDDPSAVADLKRFLEGDTDSPLPSRLEFTINLKIEEPK---VKVELSVTLPHEYPSV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 119360352  86 LPEITVRSVSLSRSQQTQLNTDLIAYLQKNCLGDVCILNATEWVKEHAFDYV 137
Cdd:cd23829   78 PPEIFVRSDSLSRSQQRQLNEDLSEYISSLERGELCILQIVQWLQDNASSYI 129
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 158-286 6.96e-31

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 111.97  E-value: 6.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352 158 FTRLWIYSHHIYNKCKRRNILEWAKELSLTGFSMPGK-PGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPLDGTa 236
Cdd:cd24140    1 YHCKVFHFKHLQNKKKRFKIKENSKELSLKGLCMRIRdPGIIIVVGNEKSCKEYENLVKKRKWNEDFELHTNTGDIKEK- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119360352 237 ggmegqrkfpiLEEKAFSVHGaRGNHMDFGQLYQFLNARGCGDVFQMFFG 286
Cdd:cd24140   80 -----------CHNNSISKTW-EGYLQDCKFKGWFLKVCNDQYSLLRTLG 117
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 161-283 2.25e-24

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 95.44  E-value: 2.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352  161 LWIYSHHIYNKCKRRNILEWAKELSLTGFSMPGKP-GVVCVEGPQSACEEFWSR-LRKLNWKRILIRHREDIPLDGTAGG 238
Cdd:pfam06544   1 AVFRIKSLSNPKHRFKIDKNAKQLGLTGFCILGPPfGLVVVEGGEKSIKKYKKLmLRRIKWTENPHEDFEAMKEITFEWD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119360352  239 MEGQRKFPI----------LEEKAFSVHGARgNHMDFGQLYQFLNARGCGDVFQM 283
Cdd:pfam06544  81 NDEDNEGEDnkcelvwegeVKERAFRKWKFK-VCETEGEAREFLKKHGVEHYWDL 134
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 13-136 6.92e-18

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 77.40  E-value: 6.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352    13 ELDLLASMFPSENELIVNDqlalaelkdciekrtmeGRSSQVYFTINVSLDLSEAAVVTFSLSCILPFKYPTVLPEITVR 92
Cdd:smart00591   1 ELEALESIYPEDFEVIDED-----------------ARIPEITIKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLL 63

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 119360352    93 SVS-LSRSQQTQLNTDLIAYLQKNcLGDVCILNATEWVKEHAFDY 136
Cdd:smart00591  64 NSEgLSDEQLAELLKKLEEIAEEN-LGEVMIFELVEKLQEFLSEF 107
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 8-133 1.05e-15

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 71.59  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352    8 EAQLSELDLLASMFPsENELIVNDQlalaelkdciekrtmEGRSSQVYFTINVSLDLSEAAV-VTFSLSCILPFKYPTVL 86
Cdd:pfam05773   1 EEQEEELEALESIYP-DEFEVISDS---------------PYESLEIEIKLSLDSDESDSSHlPPLVLKFTLPEDYPDEP 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 119360352   87 PEITVRSV-SLSRSQQTQLNTDLIAYLQKNcLGDVCILNATEWVKEHA 133
Cdd:pfam05773  65 PKISLSSPwNLSDEQVLSLLEELEELAEEN-LGEVMIFELIEWLQENL 111
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 13-132 1.73e-12

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 62.73  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352  13 ELDLLASMFPSENELIVNDQLALAELkdciekrtmegrssqVYFTINVSLDLSEAAVVtFSLSCILPFKYPTVLPEITVR 92
Cdd:cd23819    2 ELSVLQAIFCGPGEFEVLSSSETSDG---------------VSFKIQISVEGFDEDIV-LKLTFHLSPNYPSSLPDISVS 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 119360352  93 SVSLSRSQQTQLNTDLIAYLQKNcLGDVCILNATEWVKEH 132
Cdd:cd23819   66 SEQLTRAQCNDLQDSLLEYANSL-LGEPMVLELVLWLQEN 104
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 7-131 2.13e-07

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 48.75  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352   7 AEAQLSELDLLASMFPSENELIvndqlalaelkdciekRTMEGRSSQVYFTINV--SLDLSEAAVVTFSLSCILPFKYPT 84
Cdd:cd23823    1 EEEQEEELEALQSIYGDDFEDL----------------SSKKAVWSPPEFRIRLrpQEGESEENHVSVDLHVKFPPTYPD 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119360352  85 VLPEITVRSVS-LSRSQQTQLNTDLIAYLQKNcLGDVCILNATEWVKE 131
Cdd:cd23823   65 VPPEIELENVKgLSDEQLEELLKELEELAKEL-LGEEMIFELAEAVQE 111
RWD_DRWD_ELF-like cd11605
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 16-129 5.38e-07

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


Pssm-ID: 467641  Cd Length: 94  Bit Score: 46.79  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352  16 LLASMFPseNELIVNDQlalaelkdciekrtmegrSSQVYFTINVSLDLSEAAVvTFSLSCILPFKY-PTVLPEITVRSV 94
Cdd:cd11605    1 ALESIYG--DELEVLSD------------------DSPLRFSIRLSPEEEEDDP-PLELEFTLPPGYpPEEPPLITLRSP 59

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 119360352  95 SLSRSQQTQLNTDLIAYLQKNCLGDVCILNATEWV 129
Cdd:cd11605   60 KLSSAERLSLLKLELEEAAEENLGEPMLFDLVEAL 94
RWD_RNF14 cd23820
RWD domain of RING finger protein 14 (RNF14) and related proteins; RNF14, also called androgen ...
 10-134 6.71e-05

RWD domain of RING finger protein 14 (RNF14) and related proteins; RNF14, also called androgen receptor (AR)-associated protein 54 (ARA54), HFB30, or Triad2 protein, is an RBR-type E3 ubiquitin-protein ligase (EC 2.3.2.31) that is highly expressed in the testis and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3). Its differential localization may play an important role in testicular development and spermatogenesis in humans. RNF14 functions as a transcriptional regulator of mitochondrial and immune function in muscles. It is a ligand-dependent AR co-activator that enhances AR-dependent transcriptional activation. It also may participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1. Moreover, RNF14 is crucial for colon cancer cell survival. It acts as a new enhancer of Wnt-dependent transcriptional outputs that act at the level of the T-cell factor/lymphoid enhancer factor (TCF/LEF)-beta-catenin complex.


Pssm-ID: 467656 [Multi-domain]  Cd Length: 125  Bit Score: 41.58  E-value: 6.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352  10 QLSELDLLASMFPSENELIVNDQLALAELKDCIEkrtmegrsSQVYFTINVSLDLSEAAVVTFSLSC--------ILPFK 81
Cdd:cd23820    1 QEDELEALEAIYPDDLVVDSDSSSGRGSLEIPVE--------LEPPLSVVLSSDGSDEGERTLKVSHlppitlrfSLPPG 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119360352  82 YP-TVLPEITVRSVSLSRSQQTQLNTDLIAYLQKNClGDVCILNATEWVKEHAF 134
Cdd:cd23820   73 YPsTSPPEFTLECSWLSPEQLSALCERLDELWEENG-GDVVLFSWIDFLQDEAL 125
PRK14422 PRK14422
acylphosphatase; Provisional
 181-215 1.37e-03

acylphosphatase; Provisional


Pssm-ID: 237712  Cd Length: 93  Bit Score: 37.41  E-value: 1.37e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 119360352 181 AKELSLTGFSMPGKPGVVCV--EGPQSACEEFWSRLR 215
Cdd:PRK14422  29 ALELGLTGYAANLADGRVQVvaEGPRAACEKLLQLLR 65
RWD_IMPACT cd23821
RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene ...
 56-133 1.45e-03

RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene protein homolog, acts as a translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation. It plays a role as a negative regulator of EIF2AK4/GCN2 kinase activity. It impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. IMPACT may be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, IMPACT plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.


Pssm-ID: 467657  Cd Length: 101  Bit Score: 37.22  E-value: 1.45e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119360352  56 FTINVSLDLSEAAVVTfsLSCILPFKYP-TVLPEITVRSVSLSRSQQTQLNTDLIAyLQKNCLGDVCILNATEWVKEHA 133
Cdd:cd23821   25 FVIRIELDGPHLPPLV--LRVHLPPDYPsHSPPIFELSAPWLSGEERSELCAELDE-IWEENAGEPVLFQWVEWLREYL 100
RWD_RNF25 cd23818
RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also ...
 11-132 2.67e-03

RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also known as AO7, is a putative E3 ubiquitin-protein ligase that was initially identified as an interacting protein of the E2 ubiquitin-conjugating enzyme, Ubc5B. It is ubiquitously expressed in various tissues and is predominantly localized in the nucleus. RNF25 activates nuclear factor (NF)-kappaB-dependent gene expression upon stimulation with interleukin-1 beta (IL-1beta), or tumor necrosis factor (TNF), or overexpression of NF-kappaB-inducing kinase. It interacts with the p65 transactivation domain (TAD) and modulates its transcriptional activity.


Pssm-ID: 467654  Cd Length: 109  Bit Score: 36.75  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119360352  11 LSELDLLASMFPseNELIVND-QLALAELKDCIEKRTMEGRSSQ-VYFTINVsldlseaavvtfslscILPFKYPTVLPE 88
Cdd:cd23818    2 EEELEALEAIYP--DELKVVSeDGAPTELSITLHPATADDESEQyVRLTLVI----------------TLPPGYPEEPPK 63

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 119360352  89 ITVR-SVSLSRSQQTQLNTDLIAYLQKnCLGDVCILNATEWVKEH 132
Cdd:cd23818   64 ISLRnPRGLSDARLARLLSLLKELAEE-RAGEPMLFELIELAKEF 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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