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Conserved domains on  [gi|70995241|ref|NP_060134|]
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ankyrin repeat domain-containing protein 10 isoform 1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 3.18e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 3.18e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666  90 LLHAAARNGDLEIVKLLLEA--GADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGN 165

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666 166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 3.18e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 3.18e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666  90 LLHAAARNGDLEIVKLLLEA--GADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGN 165

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666 166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
97-179 3.77e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241    97 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANgAHVDLRNaSGLTAADIAQTQGFQECAQF 176
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  ...
gi 70995241   177 LLN 179
Cdd:pfam12796  80 LLE 82
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 22-162 6.80e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 6.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   22 LRFPLHRACRDGDLATLCSLLQQTPHAhlasEDSFY--GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAqTPAHIA 99
Cdd:PHA02875  68 IESELHDAVEEGDVKAVEELLDLGKFA----DDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF-SPLHLA 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 70995241  100 AFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162
Cdd:PHA02875 143 VMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-86 2.16e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 70995241     57 YGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 54-178 1.84e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241    54 DSFY-GWTPVHWAAHFGKLECLVQLVRAGATLNVSTT-------------RYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
Cdd:TIGR00870 123 SEFTpGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241   120 KPDCEGETPIHKAA---------RSGSLECISALVANGAHVD-------LRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:TIGR00870 203 TADSLGNTLLHLLVmenefkaeyEELSCQMYNFALSLLDKLRdskelevILNHQGLTPLKLAAKEGRIVLFRLKL 277
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 3.18e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 3.18e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666  90 LLHAAARNGDLEIVKLLLEA--GADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGN 165

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666 166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-179 3.57e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.13  E-value: 3.57e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  25 PLHRACRDGDLATLCSLLQQTPHAHLASEDsfyGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDG---GNTLLHAAARNGDLEIVKLLLEAGADVNA-RDKDGETPLHLAAYNGN 132

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:COG0666 133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-180 3.37e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.57  E-value: 3.37e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEA--GADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNA-RDNDGETPLHLAAENGH 198

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 70995241 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
Cdd:COG0666 199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-192 2.15e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.78  E-value: 2.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  19 LLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSfygwTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHI 98
Cdd:COG0666  18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALG----ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  99 AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:COG0666  94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                       170
                ....*....|....
gi 70995241 179 NlQNCHLNHFYNNG 192
Cdd:COG0666 174 E-AGADVNARDNDG 186
Ank_2 pfam12796
Ankyrin repeats (3 copies);
97-179 3.77e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241    97 HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANgAHVDLRNaSGLTAADIAQTQGFQECAQF 176
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  ...
gi 70995241   177 LLN 179
Cdd:pfam12796  80 LLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
63-155 2.37e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.00  E-value: 2.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241    63 HWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQaGANINKpDCEGETPIHKAARSGSLECIS 142
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLE-HADVNL-KDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 70995241   143 ALVANGAHVDLRN 155
Cdd:pfam12796  79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-162 4.02e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 4.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241  25 PLHRACRDGDLATLCSLLQQtpHAHLASEDSfYGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGH 104
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEA--GADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGN 231

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 70995241 105 PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162
Cdd:COG0666 232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
26-122 1.01e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241    26 LHRACRDGDLATLCSLLQQTPHAHLASEDsfyGWTPVHWAAHFGKLECLVQLVragATLNVSTTRYAQTPAHIAAFGGHP 105
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN---GRTALHLAAKNGHLEIVKLLL---EHADVNLKDNGRTALHYAARSGHL 74

                          90
                  ....*....|....*..
gi 70995241   106 QCLVWLIQAGANINKPD 122
Cdd:pfam12796  75 EIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
94-145 7.81e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 7.81e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 70995241    94 TPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 22-162 6.80e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 6.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   22 LRFPLHRACRDGDLATLCSLLQQTPHAhlasEDSFY--GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAqTPAHIA 99
Cdd:PHA02875  68 IESELHDAVEEGDVKAVEELLDLGKFA----DDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF-SPLHLA 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 70995241  100 AFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAA 162
Cdd:PHA02875 143 VMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
Ank_5 pfam13857
Ankyrin repeats (many copies);
111-165 1.72e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 1.72e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 70995241   111 LIQAG-ANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 24-165 2.30e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   24 FPLHRACRDGDLATLCSLLQQTPHAHLaseDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRyAQTPAHIAAFgg 103
Cdd:PHA02874 159 YPIHIAIKHNFFDIIKLLLEKGAYANV---KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN-GFTPLHNAII-- 232

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 70995241  104 HPQCLVWLIQAGANINKPDCEGETPIHKAAR-SGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:PHA02874 233 HNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_4 pfam13637
Ankyrin repeats (many copies);
127-178 3.45e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 3.45e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 70995241   127 TPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-178 7.28e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.87  E-value: 7.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   65 AAHFGKLECLVQLVRAGATLNVSTTRyAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI--------HK----- 131
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhHKifril 610

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241  132 ------------------AARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:PLN03192 611 yhfasisdphaagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_4 pfam13637
Ankyrin repeats (many copies);
58-112 8.49e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 8.49e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 70995241    58 GWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLI 112
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 57-164 2.12e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   57 YGWTPVHWAAHFGKLECL--VQ-LVRAGATLNVsTTRYAQTPAHI-AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKA 132
Cdd:PHA03095  46 YGKTPLHLYLHYSSEKVKdiVRlLLEAGADVNA-PERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVY 124

                         90       100       110
                 ....*....|....*....|....*....|....
gi 70995241  133 ARSGSL--ECISALVANGAHVDLRNASGLTAADI 164
Cdd:PHA03095 125 LSGFNInpKVIRLLLRKGADVNALDLYGMTPLAV 158
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 77-212 9.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 9.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   77 LVRAGATLNVSTtRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156
Cdd:PHA02874 110 ILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 70995241  157 SGLTAADIAQTQGFQECAQFLLNlqncHLNHfynngILNGGHQNVFPNHISVGTNR 212
Cdd:PHA02874 189 NGESPLHNAAEYGDYACIKLLID----HGNH-----IMNKCKNGFTPLHNAIIHNR 235
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 77-165 1.34e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.26  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   77 LVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156
Cdd:PHA02878 153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK 232


                 ....*....
gi 70995241  157 SGLTAADIA 165
Cdd:PHA02878 233 CGNTPLHIS 241
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-160 1.64e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYgwtPVHWAAHFGKLECLVQLVRAGATLNVSTTrYAQTPAHIAAFGGHP 105
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCY---PIHIAIKHNFFDIIKLLLEKGAYANVKDN-NGESPLHNAAEYGDY 203

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 70995241  106 QCLVWLIQAGANINKPDCEGETPIHKAA---RSgslecISALVANGAHVDLRNASGLT 160
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIihnRS-----AIELLINNASINDQDIDGST 256
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-155 2.51e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 2.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   25 PLHRACR-DGDLATLCSLLQQTphAHLASEDsFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAqTPAHIAAFGG 103
Cdd:PHA02876 344 PLHQASTlDRNKDIVITLLELG--ANVNARD-YCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG-TALHFALCGT 419

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 70995241  104 HPQCLV-WLIQAGANINKPDCEGETPIHKAARSG-SLECISALVANGAHVDLRN 155
Cdd:PHA02876 420 NPYMSVkTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAIN 473
Ank_2 pfam12796
Ankyrin repeats (3 copies);
129-179 3.04e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.11  E-value: 3.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 70995241   129 IHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 26-152 7.22e-06

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 45.64  E-value: 7.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   26 LHRACRDGDLATLCSLLQQTPHA--HLASEDSFYGWTPVHWAAHFGKL---ECLVQLVRAGATLNVSTTRYAQTPAHIAA 100
Cdd:PHA02736  21 LHYLCRNGGVTDLLAFKNAISDEnrYLVLEYNRHGKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKERVFGNTPLHIAV 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 70995241  101 FGGHPQCLVWLI-QAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:PHA02736 101 YTQNYELATWLCnQPGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGAQCK 153
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 111-186 7.84e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 7.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 70995241  111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 60-192 2.94e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLE 139
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 70995241  140 CISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNlQNCHLNHFYNNG 192
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNG 201
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-152 3.12e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.21  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   25 PLHRACRDGDLATLC-SLLQQTPHAhlaSEDSFYGWTPVHWAAHFG-KLECLVQLVRAGATLNVSTTRYaQTPAHIAA-F 101
Cdd:PHA02876 276 PLHHASQAPSLSRLVpKLLERGADV---NAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLY-ITPLHQAStL 351

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 70995241  102 GGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:PHA02876 352 DRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE 402
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-86 4.68e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 4.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 70995241    23 RFPLHRACRDGDLATLCSLLQqtphaHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLE-----HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
Ank_5 pfam13857
Ankyrin repeats (many copies);
77-132 4.81e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 4.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 70995241    77 LVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKA 132
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-129 5.19e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 5.19e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 70995241   58 GWTPVHWAAHFGKLECLV--QLVRAGATLNvSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI 129
Cdd:PHA03095 222 GNTPLHSMATGSSCKRSLvlPLLIAGISIN-ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 23-147 9.62e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 9.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   23 RFPLHRACRDGDLATLCSLLQQTphahlASED--SFYGWTPVHWAAHFGK-LECLVQLVRAGATLNVSTTRYAQTPAHIA 99
Cdd:PHA02878 202 NSPLHHAVKHYNKPIVHILLENG-----ASTDarDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSYILGLTALHSS 276

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 70995241  100 AFGghPQCLVWLIQAGANINKPDCEGETPIHKAARSGS-LECISALVAN 147
Cdd:PHA02878 277 IKS--ERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRILISN 323
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-86 2.16e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 70995241     57 YGWTPVHWAAHFGKLECLVQLVRAGATLNV 86
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
25-74 2.56e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 2.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 70995241    25 PLHRACRDGDLATLCSLLQQTPHAHLASEDsfyGWTPVHWAAHFGKLECL 74
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGN---GETALHFAASNGNVEVL 50
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 111-165 6.47e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 6.47e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 70995241  111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 72-165 6.72e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 6.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   72 ECLVQLVRAGATLNvSTTRYAQTPAHIAAFGGHPQCLVW--LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGA 149
Cdd:PHA03095 203 RIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281

                         90
                 ....*....|....*.
gi 70995241  150 HVDLRNASGLTAADIA 165
Cdd:PHA03095 282 DINAVSSDGNTPLSLM 297
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-155 7.92e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   77 LVRAGATLNVsTTRYAQTPAHIAAFG--GHPQCLVWLIQAGANINKPDCEGETPIHKAARSGS--LECISALVANGAHVD 152
Cdd:PHA03100  92 LLEYGANVNA-PDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDIN 170


                 ...
gi 70995241  153 LRN 155
Cdd:PHA03100 171 AKN 173
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 124-152 1.27e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*....
gi 70995241   124 EGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 124-155 1.47e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 70995241   124 EGETPIHKAA-RSGSLECISALVANGAHVDLRN 155
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 54-178 1.84e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241    54 DSFY-GWTPVHWAAHFGKLECLVQLVRAGATLNVSTT-------------RYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
Cdd:TIGR00870 123 SEFTpGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADIL 202

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70995241   120 KPDCEGETPIHKAA---------RSGSLECISALVANGAHVD-------LRNASGLTAADIAQTQGFQECAQFLL 178
Cdd:TIGR00870 203 TADSLGNTLLHLLVmenefkaeyEELSCQMYNFALSLLDKLRdskelevILNHQGLTPLKLAAKEGRIVLFRLKL 277
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 111-161 2.18e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 70995241  111 LIQAGANINKPDCEGETPIHKAA--RSGSLECISALVANGAHVDLRNASGLTA 161
Cdd:PHA03100  92 LLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENL 144
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 57-119 2.45e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 2.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 70995241   57 YGWTPVHWAAHFGKLECLVQLVRAGATLNVsTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 91-152 2.45e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 2.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70995241   91 YAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 94-120 2.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 2.45e-03
                           10        20
                   ....*....|....*....|....*..
gi 70995241     94 TPAHIAAFGGHPQCLVWLIQAGANINK 120
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 77-144 2.54e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 70995241   77 LVRAGATLNvSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
Cdd:PTZ00322 101 LLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 111-165 2.94e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.05  E-value: 2.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 70995241  111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 93-122 3.71e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 3.71e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 70995241    93 QTPAHIAA-FGGHPQCLVWLIQAGANINKPD 122
Cdd:pfam00023   3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 124-153 4.60e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 4.60e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 70995241    124 EGETPIHKAARSGSLECISALVANGAHVDL 153
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 49-134 8.54e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.04  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   49 HLASEDSFYgwTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETP 128
Cdd:PHA02884  63 FPLSENSKT--NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTP 140


                 ....*.
gi 70995241  129 IHKAAR 134
Cdd:PHA02884 141 IELALM 146
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 77-161 9.70e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.12  E-value: 9.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70995241   77 LVRAGATLNVSTTrYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNA 156
Cdd:PHA02876 164 LLEGGADVNAKDI-YCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDL 242


                 ....*
gi 70995241  157 SGLTA 161
Cdd:PHA02876 243 SLLKA 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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