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Conserved domains on  [gi|116812584|ref|NP_060169|]
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SID1 transmembrane family member 1 isoform 2 precursor [Homo sapiens]

Protein Classification

SID1 transmembrane family member( domain architecture ID 10623302)

SID1 transmembrane family member similar to Caenorhabditis elegans systemic RNA interference defective protein 1 (SID1) that plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 184-806 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


:

Pssm-ID: 464057  Cd Length: 599  Bit Score: 964.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  184 SQPQYFLYKFPKDVDSVIIKVVSEMAYpCSVVSVQNIMCPVYDLDHNVEFNGVYQSMTKKAAITLQKKDFPGEQFFVVFV 263
Cdd:pfam13965   1 SEPQYFFYDFPQNVDSVIVKVTSDDDI-CAVVSIQDANCPVYDLDNNVAFNGRYQTFTKKAGITVQKKDIPSFKFFVVFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  264 IKPEDYACGGSFFIQEkenqtwNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRfqrksiDGS 343
Cdd:pfam13965  80 VKPDDSACSGSLSRKP------LPNRTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVTFFNYKR------RRS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  344 FGSNDGSGNMVASHPIaastpegsnygtidesssspgrqmsssdgGPPGQSDTDSSVEE-SDFDTMPDIESDKNIIRTKM 422
Cdd:pfam13965 148 ENEDEGSGTLASSHPI-----------------------------PPTCNSNSDSSVEEdSDYDTLADIESDKNVVRTKA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  423 FLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNL 502
Cdd:pfam13965 199 FLYVSDLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAHPLGELSAFNNIISNI 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  503 GHVLLGFLFLLIVLRRDILHRRaleaKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPNYSNFQFDTSFMYMIA 582
Cdd:pfam13965 279 GYVLLGLLFLLIVLRREILHRR----NPIPATEYGIPKHFGLFYAMGLALIMEGILSACYHVCPNYSNFQFDTSFMYVIA 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  583 GLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYYMGRFKIDLGIFRR 662
Cdd:pfam13965 355 GLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNVRFWIAFSIIHVLASLCLSTQIYYMGRWKLDSGIFRR 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  663 AAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVLPV 742
Cdd:pfam13965 435 HLMILYTDCKKQCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYLLGIFIGNLILYLAFYIIMKLRSRERILPL 514

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116812584  743 PLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSATALFFSF 806
Cdd:pfam13965 515 ALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDLWHFLSAIALFFSF 578
 
Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 184-806 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 464057  Cd Length: 599  Bit Score: 964.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  184 SQPQYFLYKFPKDVDSVIIKVVSEMAYpCSVVSVQNIMCPVYDLDHNVEFNGVYQSMTKKAAITLQKKDFPGEQFFVVFV 263
Cdd:pfam13965   1 SEPQYFFYDFPQNVDSVIVKVTSDDDI-CAVVSIQDANCPVYDLDNNVAFNGRYQTFTKKAGITVQKKDIPSFKFFVVFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  264 IKPEDYACGGSFFIQEkenqtwNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRfqrksiDGS 343
Cdd:pfam13965  80 VKPDDSACSGSLSRKP------LPNRTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVTFFNYKR------RRS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  344 FGSNDGSGNMVASHPIaastpegsnygtidesssspgrqmsssdgGPPGQSDTDSSVEE-SDFDTMPDIESDKNIIRTKM 422
Cdd:pfam13965 148 ENEDEGSGTLASSHPI-----------------------------PPTCNSNSDSSVEEdSDYDTLADIESDKNVVRTKA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  423 FLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNL 502
Cdd:pfam13965 199 FLYVSDLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAHPLGELSAFNNIISNI 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  503 GHVLLGFLFLLIVLRRDILHRRaleaKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPNYSNFQFDTSFMYMIA 582
Cdd:pfam13965 279 GYVLLGLLFLLIVLRREILHRR----NPIPATEYGIPKHFGLFYAMGLALIMEGILSACYHVCPNYSNFQFDTSFMYVIA 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  583 GLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYYMGRFKIDLGIFRR 662
Cdd:pfam13965 355 GLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNVRFWIAFSIIHVLASLCLSTQIYYMGRWKLDSGIFRR 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  663 AAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVLPV 742
Cdd:pfam13965 435 HLMILYTDCKKQCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYLLGIFIGNLILYLAFYIIMKLRSRERILPL 514

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116812584  743 PLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSATALFFSF 806
Cdd:pfam13965 515 ALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDLWHFLSAIALFFSF 578
 
Name Accession Description Interval E-value
SID-1_RNA_chan pfam13965
dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated ...
 184-806 0e+00

dsRNA-gated channel SID-1; This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps. They are required for systemic RNA interference. This family of proteins belong to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 464057  Cd Length: 599  Bit Score: 964.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  184 SQPQYFLYKFPKDVDSVIIKVVSEMAYpCSVVSVQNIMCPVYDLDHNVEFNGVYQSMTKKAAITLQKKDFPGEQFFVVFV 263
Cdd:pfam13965   1 SEPQYFFYDFPQNVDSVIVKVTSDDDI-CAVVSIQDANCPVYDLDNNVAFNGRYQTFTKKAGITVQKKDIPSFKFFVVFV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  264 IKPEDYACGGSFFIQEkenqtwNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRfqrksiDGS 343
Cdd:pfam13965  80 VKPDDSACSGSLSRKP------LPNRTKTVTVTVKPSIDSSSYVVAMLFMLAVFLSFYLIVLLVTFFNYKR------RRS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  344 FGSNDGSGNMVASHPIaastpegsnygtidesssspgrqmsssdgGPPGQSDTDSSVEE-SDFDTMPDIESDKNIIRTKM 422
Cdd:pfam13965 148 ENEDEGSGTLASSHPI-----------------------------PPTCNSNSDSSVEEdSDYDTLADIESDKNVVRTKA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  423 FLYLSDLSRKDRRIVSKKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNL 502
Cdd:pfam13965 199 FLYVSDLSRKDKRILKKKYLIYLWNILTIAVFYALPVLQLVITYQNVVNVTGNQDMCYYNFLCAHPLGELSAFNNIISNI 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  503 GHVLLGFLFLLIVLRRDILHRRaleaKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCPNYSNFQFDTSFMYMIA 582
Cdd:pfam13965 279 GYVLLGLLFLLIVLRREILHRR----NPIPATEYGIPKHFGLFYAMGLALIMEGILSACYHVCPNYSNFQFDTSFMYVIA 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  583 GLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYYMGRFKIDLGIFRR 662
Cdd:pfam13965 355 GLCMLKLYQTRHPDINASAYTAFALLAVVIFLALIGVVFGKSNVRFWIAFSIIHVLASLCLSTQIYYMGRWKLDSGIFRR 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116812584  663 AAMVFYTDCIQQCSRPLYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVLPV 742
Cdd:pfam13965 435 HLMILYTDCKKQCSRPMYKDRMVLLVVGNLVNWSLAVFGLIYHPNDFASYLLGIFIGNLILYLAFYIIMKLRSRERILPL 514

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116812584  743 PLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLSATALFFSF 806
Cdd:pfam13965 515 ALFCILLAAVVWAAALYFFFQDLSSWTLTPAESRELNKPCILLGFFDSHDLWHFLSAIALFFSF 578
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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