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Conserved domains on  [gi|16445426|ref|NP_060353|]
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WD repeat-containing protein 13 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-483 2.99e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.99e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 172 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 251
Cdd:COG2319 120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 252 IREIPDPDSAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 329
Cdd:COG2319 197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 330 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEgTLQLKRSFpiEQSSHPVR 409
Cdd:COG2319 271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLA-TGKLLRTL--TGHTGAVR 334

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16445426 410 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319 335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-483 2.99e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.99e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 172 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 251
Cdd:COG2319 120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 252 IREIPDPDSAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 329
Cdd:COG2319 197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 330 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEgTLQLKRSFpiEQSSHPVR 409
Cdd:COG2319 271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLA-TGKLLRTL--TGHTGAVR 334

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16445426 410 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319 335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-481 8.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 8.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 175 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 254
Cdd:cd00200  12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 255 IPDpDSAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 334
Cdd:cd00200  89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 335 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLN---KLLLYRVVDNEGTLQLKRSFPIEQSSHPVRSI 411
Cdd:cd00200 164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDgtiKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 412 FCplmsfrqgacvvTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 481
Cdd:cd00200 234 LA------------SGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-244 3.18e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.18e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 16445426    206 PPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
208-244 7.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 16445426   208 TVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-483 2.99e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.99e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 172 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 251
Cdd:COG2319 120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 252 IREIPDPDSAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 329
Cdd:COG2319 197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 330 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEgTLQLKRSFpiEQSSHPVR 409
Cdd:COG2319 271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLA-TGKLLRTL--TGHTGAVR 334

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16445426 410 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319 335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
95-483 3.25e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 3.25e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426  95 DFEDDPRALGARGHRRSVSRGSYQLQAQMNRAVYEDRPPGSVVPTSAAEASRAMAGDTSLSENYAFAGMYHVFDQHVDEA 174
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 175 VPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 254
Cdd:COG2319  81 VLSVAFSPDGR-LLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 255 IPDPDSAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKggssKLTG---RVLALSFDAPGRLLWAGDDRGSVfsF 331
Cdd:COG2319 158 LTGHSGA-VTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR----TLTGhtgAVRSVAFSPDGKLLASGSADGTV--R 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 332 LFDMATGKLTkakRLVVHEGSPVTSISarswVSreaRDPSLLINACLNKLLlyRVVDNEGTLQLKRsfpIEQSSHPVRSI 411
Cdd:COG2319 230 LWDLATGKLL---RTLTGHSGSVRSVA----FS---PDGRLLASGSADGTV--RLWDLATGELLRT---LTGHSGGVNSV 294

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16445426 412 -FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319 295 aFSP-----DGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-481 8.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 8.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 175 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 254
Cdd:cd00200  12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 255 IPDpDSAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 334
Cdd:cd00200  89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 335 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLN---KLLLYRVVDNEGTLQLKRSFPIEQSSHPVRSI 411
Cdd:cd00200 164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDgtiKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 412 FCplmsfrqgacvvTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 481
Cdd:cd00200 234 LA------------SGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 210-481 9.38e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 9.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 210 LRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIPDPdSAELLCCTFQPVNNNLTVVGNAKhNVHVMN 289
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDK-TIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 290 ISTGKKVkggsSKLTG---RVLALSFDAPGRLL-WAGDDrGSVfsFLFDMATGKLTKAkrLVVHEGsPVTSISARSwvsr 365
Cdd:cd00200  80 LETGECV----RTLTGhtsYVSSVAFSPDGRILsSSSRD-KTI--KVWDVETGKCLTT--LRGHTD-WVNSVAFSP---- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 366 earDPSLLINACLNKLLlyRVVDNEgTLQLKRSFPIEQSshPVRSI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKA 444
Cdd:cd00200 146 ---DGTFVASSSQDGTI--KLWDLR-TGKCVATLTGHTG--EVNSVaFSP-----DGEKLLSSSSDGTIKLWDL--STGK 210

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 16445426 445 AVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 481
Cdd:cd00200 211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-244 3.18e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.18e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 16445426    206 PPTVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
208-244 7.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 16445426   208 TVLRVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 446-480 1.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 16445426    446 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 480
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
446-480 1.31e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 16445426   446 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 480
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
166-342 1.59e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 166 VFDQHVDEAVPRVRFANDDRHRLACCSLDGSISLCQLVPAPPTVLRVLRGHTRGVSDFAWSLSNDIL-VSTSLDATMRIW 244
Cdd:COG3391  16 LALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16445426 245 ASEDGRCIREIPDPDSAELLCctFQPVNNNLTVVGNAKHNVHVMNISTGKKVKggSSKLTGRVLALSFDAPGRLLW---A 321
Cdd:COG3391  96 DLATGKVVATIPVGGGPRGLA--VDPDGGRLYVADSGNGRVSVIDTATGKVVA--TIPVGAGPHGIAVDPDGKRLYvanS 171

                       170       180
                ....*....|....*....|.
gi 16445426 322 GDDRGSVFSFLFDMATGKLTK 342
Cdd:COG3391 172 GSNTVSVIVSVIDTATGKVVA 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-484 3.76e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 3.76e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16445426 424 VVTGSEDMCVHFFDVERAAKaaVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRREQ 484
Cdd:cd00200  24 LATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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