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Conserved domains on  [gi|122114646|ref|NP_061199|]
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natural killer cell receptor 2B4 isoform 1 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein; immunoglobulin domain-containing protein( domain architecture ID 10568663)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets| immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 22-129 4.08e-62

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


:

Pssm-ID: 288342  Cd Length: 108  Bit Score: 195.18  E-value: 4.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646   22 CPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQgSHRKIE-ILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAK 100
Cdd:pfam11465   1 CQDSSEEVVGVSGKPVQLRPSNIQTKVVSIAWKKLLP-SHNGFHhILKWENGSLPSNNMCSSDIYGFIVKNFALSIKSAK 79

                          90       100
                  ....*....|....*....|....*....
gi 122114646  101 LQDSGHYLLEITNTGGKVCNKNFQLLILD 129
Cdd:pfam11465  80 LQDSGHYLLEITNISGKVCTKNFQVLIFD 108
 
Name Accession Description Interval E-value
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 22-129 4.08e-62

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 195.18  E-value: 4.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646   22 CPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQgSHRKIE-ILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAK 100
Cdd:pfam11465   1 CQDSSEEVVGVSGKPVQLRPSNIQTKVVSIAWKKLLP-SHNGFHhILKWENGSLPSNNMCSSDIYGFIVKNFALSIKSAK 79

                          90       100
                  ....*....|....*....|....*....
gi 122114646  101 LQDSGHYLLEITNTGGKVCNKNFQLLILD 129
Cdd:pfam11465  80 LQDSGHYLLEITNISGKVCTKNFQVLIFD 108
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 25-127 4.22e-38

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 132.64  E-value: 4.22e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646  25 SSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGShRKIEILNWYN--DGPSWSNvSFSDIYGFDYgDFALSIKSAKLQ 102
Cdd:cd05741    1 SSEQFYGAEGKNVLLLVPNLQTPLKSVSWYKGKQVS-RNDEIAEYENssDEFRAGS-AFSGREYIYT-NGSLLIQNITLS 77

                         90       100
                 ....*....|....*....|....*
gi 122114646 103 DSGHYLLEITNTGGKVCNKNFQLLI 127
Cdd:cd05741   78 DTGFYTLESTNIGGKTESATFQLHV 102
 
Name Accession Description Interval E-value
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 22-129 4.08e-62

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 195.18  E-value: 4.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646   22 CPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQgSHRKIE-ILNWYNDGPSWSNVSFSDIYGFDYGDFALSIKSAK 100
Cdd:pfam11465   1 CQDSSEEVVGVSGKPVQLRPSNIQTKVVSIAWKKLLP-SHNGFHhILKWENGSLPSNNMCSSDIYGFIVKNFALSIKSAK 79

                          90       100
                  ....*....|....*....|....*....
gi 122114646  101 LQDSGHYLLEITNTGGKVCNKNFQLLILD 129
Cdd:pfam11465  80 LQDSGHYLLEITNISGKVCTKNFQVLIFD 108
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 25-127 4.22e-38

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 132.64  E-value: 4.22e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646  25 SSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGShRKIEILNWYN--DGPSWSNvSFSDIYGFDYgDFALSIKSAKLQ 102
Cdd:cd05741    1 SSEQFYGAEGKNVLLLVPNLQTPLKSVSWYKGKQVS-RNDEIAEYENssDEFRAGS-AFSGREYIYT-NGSLLIQNITLS 77

                         90       100
                 ....*....|....*....|....*
gi 122114646 103 DSGHYLLEITNTGGKVCNKNFQLLI 127
Cdd:cd05741   78 DTGFYTLESTNIGGKTESATFQLHV 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 25-128 1.29e-31

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 115.52  E-value: 1.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646  25 SSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQgshrkiEILNWY-NDGPSWSNvSFSDIYGFDYGDFALSIKSAKLQD 103
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQDDIDEIKWKKTKD------KIVEWEnNIGPTYFG-SFKDRVLLDKESGSLTIKNLTKED 73

                         90       100
                 ....*....|....*....|....*
gi 122114646 104 SGHYLLEITNTGGKVCNKNFQLLIL 128
Cdd:cd05775   74 SGTYELEITSTNGKVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 25-128 5.27e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 5.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646   25 SSEEVVGVSGKPVQLR---PSNIQTKDVSVQWKKTEQGSHRKIEILNWYNDGPswsNVSFSDIY----GFDYGDFALSIK 97
Cdd:pfam07686   2 TPREVTVALGGSVTLPctySSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGSE---EGVKKGRFsgrgDPSNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 122114646   98 SAKLQDSGHYLLEITNTGGKVCNKNFQLLIL 128
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
 29-113 3.50e-03

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 36.76  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114646  29 VVGVSGKPVQLRPSNIQTKDVSVQWKKTEQgshrkIEILNWYND----GPSWSNVSF-SDIYGFDYGDFALSIKSAKLQD 103
Cdd:cd07690    4 VLGKKGDTAELPCTASQKKSIQFHWKNSNQ-----IKILGNQGSfltkGPSKLNDRAdSRRNLWDQGSFPLIIKNLKIED 78

                         90
                 ....*....|
gi 122114646 104 SGHYLLEITN 113
Cdd:cd07690   79 SDTYICEVED 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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